ライフサイエンスコーパス: digitoxin

1 ulators of RNA splicing, such as digoxin and digitoxin.

2 he direct synthesis of digitoxin and C1'-epi-digitoxin.

3 - and disaccharide analogues of digoxose and digitoxin.

4 The specific mechanism of digitoxin action is to block phosphorylation of the inhi

5 Digitoxin also has effects on global gene expression in

6 Digitoxin and acetyldigitoxin were found to bind to a co

7 accharide glycal for the direct synthesis of digitoxin and C1'-epi-digitoxin.

8 n-approved, small-molecule compounds such as digitoxin and digoxin have been in clinical usage for co

9 that multiple cardiac glycosides, including digitoxin and digoxin, are significantly more toxic to h

10 an assay was developed for quantification of digitoxin and its metabolites from human serum samples a

11 ative analysis of the cardiac glycoside drug digitoxin and its three main metabolites digitoxigenin-b

12 annels may be part of the mechanism by which digitoxin and other active cardiac glycosides, such as d

13 Digitoxin and other cardiac glycosides are important, ce

14 The cardiac glycosides (CGs) digoxin, digitoxin and ouabain, which directly inhibit ATP1A1 fun

15 58 genes, 36 (62%) are similarly affected by digitoxin and related active analogues.

16 Digitoxin and structurally related cardiac glycoside dru

17 c glycoside compounds like ouabain, digoxin, digitoxin, and gitoxin with their aglycones.

18 eroids already in use in humans, digoxin and digitoxin, are potent inhibitors of multiple adenovirus

19 These agents included acetyldigitoxin and digitoxin as probes for the digitoxin site, phenol red a

20 We show here that digitoxin, at sub nM concentrations, can suppress hypers

21 Digitoxin belongs to a naturally occurring class of card

22 hanthidin) or digoxin-like CTS (digoxigenin, digitoxin, bufalin).

23 We propose that these digitoxin calcium channels may be part of the mechanism

24 We interpret this result to suggest that digitoxin can also partially mimic the genomic consequen

25 try of the lipid affects the kinetics of the digitoxin channel activity, but not the cation selectivi

26 These digitoxin channels are blocked by Al(3+) and La(3+) but

27 bodies against digitoxin promptly neutralize digitoxin channels in both cells and bilayers.

28 Digoxin and digitoxin concentrations close to or at the therapeutic

29 In isolated rat ventricular myocytes, the CG digitoxin (DGT) increased the incidence of arrhythmogeni

30 utants were analyzed for binding to digoxin, digitoxin, digoxigenin, and ouabain resulting in the gen

31 inhibitor reduces ERK phosphorylation, while digitoxin disrupts ion gradients, altering plasma membra

32 MEK inhibitor and digitoxin do not induce cell death in human melanocytes

33 Inhibition of alternative splicing with digitoxin followed by immunoprecipitation and immunoblot

34 trisaccharide natural products digoxose and digitoxin has been developed.

35 Thus, before digitoxin implementation in designing and developing saf

36 ch to evaluate the anti-cancer mechanisms of digitoxin in real-time.

37 anding the mechanism(s) by which digoxin and digitoxin inhibit adenovirus replication will guide the

38 occurring class of cardiac glycosides (CG); digitoxin is clinically approved for heart failure and k

39 ctivation is used, the glycorandomization of digitoxin leads to analogs that display significantly en

40 f these drugs, and we have hypothesized that digitoxin might mediate calcium entry into cells.

41 Multimers of digitoxin molecules also are able to form calcium channe

42 We report here that digitoxin molecules mediate calcium entry into intact ce

43 Three of these (digitoxin, nerifolin and peruvoside) are structurally an

44 All other antiinflammatory effects of digitoxin on NF-kappaB and c-Jun N-terminal kinase pathw

45 Antibodies against digitoxin promptly neutralize digitoxin channels in both

46 and prior to genome replication, digoxin and digitoxin show potential as antiviral agents for treatme

47 tyldigitoxin and digitoxin as probes for the digitoxin site, phenol red as a probe for the bilirubin

48 ction combinatorial relations we showed that digitoxin targets cancer cells in a time and dose-depend

49 Uniquely, 1B3 has a higher affinity for digitoxin than digoxin, the immunizing hapten, and a str

50 glycoside family, ouabain, gitoxigenin, and digitoxin, that inhibit placental sFlt1 production at na

51 additively or synergistically combined with digitoxin to induce cell death, inhibiting growth of pat

52 MEK inhibitor and digitoxin together cause intracellular acidification, mi

53 een successfully applied to the synthesis of digitoxin trisaccharide glycal for the direct synthesis

54 19 total steps from achiral 2-acylfuran, and digitoxin was fashioned in 15 steps starting from digito

55 otoxin was even more potent than digoxin and digitoxin when tested with HAdV-C5.

56 ac glycosides, such as ouabain, digoxin, and digitoxin, which is highly conserved among species rangi

57 We therefore suggest that digitoxin, with its lengthy history of human use, deserv