ライフサイエンスコーパス: dihydropyridine receptor

1 CACNL1A3, encoding the alpha-subunit of the dihydropyridine receptor.

2 il of the voltage sensor of EC coupling, the dihydropyridine receptor.

3 lpha) subunit, and the alpha2 subunit of the dihydropyridine receptor.

4 d because RyR1s are under the control of the dihydropyridine receptor.

5 presence of a normal pattern of triadin and dihydropyridine receptor.

6 g embryos lacking the alpha1S subunit of the dihydropyridine receptor.

7 he II-III loop of the alpha 1 subunit of the dihydropyridine receptor.

8 d by the localization of actin filaments and dihydropyridine receptors.

9 l coupling with the t-tubule voltage-sensing dihydropyridine receptors.

10 (endo)plasmic reticulum calcium-ATPase1, and dihydropyridine receptors.

11 d depolarizations in the presence of the 1,4-dihydropyridine receptor agonist +/-Bay K 8644.

12 ng various regions of the II-III loop of the dihydropyridine receptor alpha 1 subunit, only one pepti

13 90 of the II-III loop of the skeletal muscle dihydropyridine receptor alpha(1) subunit (DHPR, alpha(1

14 eptor (RyR1) and the alpha(1) subunit of the dihydropyridine receptor (alpha(1S)).

15 Glu(724)-Pro(760) (peptide C) region of the dihydropyridine receptor alpha1 II-III loop is important

16 ting and blocking) of the II-III loop of the dihydropyridine receptor alpha1 subunit.

17 We conclude that dihydropyridine receptor alpha1S and beta1 subunits part

18 The skeletal muscle dihydropyridine receptor alpha1S subunit plays a key rol

19 nsgenic variants of the alpha subunit of the dihydropyridine receptor (alpha1sDHPR) resulted in appro

20 The alpha2/delta1 subunit forms part of the dihydropyridine receptor, an essential protein complex f

21 peptide (termed peptide A (pA)) of alpha(1s)-dihydropyridine receptor and are thought to act at a com

22 a functional linkage between the sarcolemmal dihydropyridine receptor and the SR ryanodine receptor.

23 elease caused by peripheral coupling between dihydropyridine receptors and RyR1.

24 interactions with the L-type Ca(2+) channel (dihydropyridine receptor) and FK506-binding protein 12 a

25 n Ca2+ sparks is mediated by the sarcolemmal dihydropyridine receptor but is also independent of Ca2+

26 Controls indicated that similar dihydropyridine receptor charge movements were expressed

27 may be vital for the targeting of the muscle dihydropyridine receptor complex to the transverse tubul

28 king of CaV1.1, the principal subunit of the dihydropyridine receptor (DHPR) (L-type Ca(2+) channel),

29 (mdg/mdg), a mutation of the skeletal muscle dihydropyridine receptor (DHPR) alpha 1 subunit, has ser

30 reases the expression of the skeletal muscle dihydropyridine receptor (DHPR) alpha(1) subunit by regu

31 -III cytoplasmic loop of the skeletal muscle dihydropyridine receptor (DHPR) alpha(1)-subunit is esse

32 been described in the cytosolic loops of the dihydropyridine receptor (DHPR) alpha1S pore subunit and

33 FRU) in rat cardiac muscle consisting of one dihydropyridine receptor (DHPR) and eight ryanodine rece

34 The skeletal muscle dihydropyridine receptor (DHPR) and ryanodine receptor (

35 on between the voltage-gated calcium channel dihydropyridine receptor (DHPR) and the ryanodine recept

36 In skeletal muscle, coupling between the 1,4-dihydropyridine receptor (DHPR) and the type 1 ryanodine

37 involves conformational coupling between the dihydropyridine receptor (DHPR) and the type 1 ryanodine

38 in EC coupling mode are not due to shifts in dihydropyridine receptor (DHPR) and/or ryanodine recepto

39 ockout cells lacking the beta subunit of the dihydropyridine receptor (DHPR) are devoid of slow L-typ

40 imeras consisting of the homologous skeletal dihydropyridine receptor (DHPR) beta1a subunit and the h

41 The dihydropyridine receptor (DHPR) beta1a subunit is crucia

42 t of myotubes from mice lacking the skeletal dihydropyridine receptor (DHPR) beta1a subunit, was inve

43 2+) content, or RyR1-mediated enhancement of dihydropyridine receptor (DHPR) channel activity.

44 1a subunit is a cytoplasmic component of the dihydropyridine receptor (DHPR) complex that plays an es

45 The beta-subunit of the dihydropyridine receptor (DHPR) enhances the Ca(2+) chan

46 de (KKERKLARTA) is a fragment of the cardiac dihydropyridine receptor (DHPR) from the cytosolic loop

47 The proposed mimicry by IpTx(a) of the dihydropyridine receptor (DHPR) II-III loop, thought to

48 The L-type Ca(2+) channel (dihydropyridine receptor (DHPR) in skeletal muscle acts

49 between ryanodine receptor type 1 (RyR1) and dihydropyridine receptor (DHPR) in skeletal muscle serve

50 The dihydropyridine receptor (DHPR) in the skeletal muscle p

51 The skeletal muscle dihydropyridine receptor (DHPR) in the t-tubular membran

52 ests that the cytoplasmic II-III loop of the dihydropyridine receptor (DHPR) is the primary source of

53 The plasmalemmal dihydropyridine receptor (DHPR) is the voltage sensor in

54 The dihydropyridine receptor (DHPR) of skeletal muscle funct

55 revious studies have shown that the skeletal dihydropyridine receptor (DHPR) pore subunit Ca(V)1.1 (a

56 region of the beta1a subunit of the skeletal dihydropyridine receptor (DHPR) to the mechanism of exci

57 ation then dissociates them from the tubular dihydropyridine receptor (DHPR) voltage sensors that pro

58 oupling, the four-domain pore subunit of the dihydropyridine receptor (DHPR) was cut in the cytoplasm

59 ceptor 1 and dysgenic myotubes that lack the dihydropyridine receptor (DHPR), and is independent of t

60 d TBBPA on ryanodine receptor type 1 (RyR1), dihydropyridine receptor (DHPR), and sarcoplasmic/endopl

61 between the ryanodine receptor (RyR) and the dihydropyridine receptor (DHPR), two proteins essential

62 e CICR cascade by increasing the fidelity of dihydropyridine receptor (DHPR)--ryanodine receptor (RyR

63 ne potential or following treatment with the dihydropyridine receptor (DHPR)-blocker nifedipine.

64 rboxy-terminal tail of the transverse tubule dihydropyridine receptor (DHPR).

65 We found that a functional skeletal muscle dihydropyridine receptor (DHPR, the L-type Ca(2+) channe

66 ticulum Ca(2+) release channel) and alpha(1S)dihydropyridine receptor (DHPR, the surface membrane vol

67 traction coupling involves the activation of dihydropyridine receptors (DHPR) and type-1 ryanodine re

68 The dihydropyridine receptors (DHPR) are L-type voltage-gate

69 l" coupling of ryanodine receptors (RyR) and dihydropyridine receptors (DHPR).

70 g from a reduction in L-type Ca(2+) channel (dihydropyridine receptor, DHPR) charge movement.

71 tage-gated L-type calcium channel (Ca(v)1.1; dihydropyridine receptor, DHPR) was determined using ele

72 ) essential for bidirectional signaling with dihydropyridine receptors (DHPRs) and for the organizati

73 in muscle relies on the interaction between dihydropyridine receptors (DHPRs) and RyRs within Ca(2+)

74 Rs): those at the periphery colocalized with dihydropyridine receptors (DHPRs) and those at the cell

75 c calcium release units, dCRUs) that contain dihydropyridine receptors (DHPRs) and triadin, two essen

76 In skeletal muscle, dihydropyridine receptors (DHPRs) in the plasma membrane

77 cle involves conformational coupling between dihydropyridine receptors (DHPRs) in the plasma membrane

78 quires communication between voltage-sensing dihydropyridine receptors (DHPRs) in transverse tubule m

79 tly targeted to junctions and interacts with dihydropyridine receptors (DHPRs) inducing their arrange

80 d by 2 well-identified calcium channels: the dihydropyridine receptors (DHPRs) that act as voltage se

81 echnique and expression of truncated/mutated dihydropyridine receptors (DHPRs) to investigate whether

82 ontrol: plasma membrane calcium channels, or dihydropyridine receptors (DHPRs), and SR calcium releas

83 Rs): those at the periphery colocalized with dihydropyridine receptors (DHPRs), and those at the cell

84 pective roles of ryanodine receptors (RyRs), dihydropyridine receptors (DHPRs), inositol-1,4,5-trisph

85 tain two proteins essential to e-c coupling: dihydropyridine receptors (DHPRs), L-type Ca(2+) channel

86 Rs), or SR calcium release channels, and the dihydropyridine receptors (DHPRs), or L-type calcium cha

87 sensors of membrane potential for VICaR are dihydropyridine receptors (DHPRs).

88 ntraction (EC) coupling function to chimeric dihydropyridine receptors (DHPRs).

89 r of ryanodine receptors (RyR1) uncoupled to dihydropyridine receptors (DHPRs).

90 Coupling between L-type Ca(2+) channels (dihydropyridine receptors, DHPRs) and ryanodine receptor

91 skeletal muscle, L-type calcium channels (or dihydropyridine receptors, DHPRs) are coupled functional

92 ) and the surface membrane calcium channels (dihydropyridine receptors, DHPRs) in myocardium from the

93 action of surface membrane calcium channels (dihydropyridine receptors; DHPRs) with the calcium relea

94 chb1 gene encoding the beta 1 subunit of the dihydropyridine receptor have been characterized.

95 , and possibly in RyR's interaction with the dihydropyridine receptor in excitation-contraction coupl

96 n of the skeletal muscle L-type Ca2+ channel/dihydropyridine receptor in response to insulin-like gro

97 Dihydropyridine receptors in vertebrate skeletal muscle

98 and Ca(2+)-CaM at a critical region for RYR1-dihydropyridine receptor interaction are suggestive of a

99 In skeletal muscle the dihydropyridine receptor is the voltage sensor for excit

100 , including alpha-actinin, the Ca-ATPase and dihydropyridine receptors, is not affected, even at site

101 An allosteric interaction between RyR1 and dihydropyridine receptors located in the plasma membrane

102 line receptors, whereas relaxed mutants lack dihydropyridine receptor-mediated release of internal ca

103 We cloned a dihydropyridine receptor (named Fgalpha1S) from frog ske

104 ons or junctions), where the voltage-sensing dihydropyridine receptor of the surface membrane interac

105 evels or in SERCA2b (smooth muscle isoform), dihydropyridine receptor, or alpha-actin mRNA levels in

106 Understanding which cytosolic domains of the dihydropyridine receptor participate in excitation-contr

107 lcium channels to be cloned, skeletal muscle dihydropyridine receptors remain the only ones not funct

108 the L-type voltage-gated Ca(2+) channel (1,4-dihydropyridine receptor) serves as the voltage sensor f

109 S6 and IVS6 interact to form a high affinity dihydropyridine receptor site on L-type Ca2+ channels.

110 The addition of the beta1a dihydropyridine receptor subunit enhanced FRET to the II

111 Thus, we conclude that the alpha(2)delta(1) dihydropyridine receptor subunit is physiologically nece

112 A) partial knockdown of the alpha(2)delta(1) dihydropyridine receptor subunits cause a significant in

113 nd III of the alpha1 subunit of the skeletal dihydropyridine receptor (the II-III loop) interacts wit

114 2/delta, beta 1, and gamma) skeletal muscle dihydropyridine receptor transduces transverse tubule me

115 diment with membrane vesicles containing the dihydropyridine receptor, which is consistent with earli