ライフサイエンスコーパス: dihydropyrimidine dehydrogenase

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1 tumours, consistent with the inactivation of dihydropyrimidine dehydrogenase: a selective decrease in

2 Eniluracil (776C85), a potent inactivator of dihydropyrimidine dehydrogenase, allows fluorouracil (5-

3 ples include thiopurine S-methyltransferase, dihydropyrimidine dehydrogenase and flavin monooxygenase

4 5-Fluorouracil is inactivated by dihydropyrimidine dehydrogenase and targets thymidylate

5 Dihydropyrimidine dehydrogenase catalyzes the rate-limit

6 bolite 5-methyl tetrahydrofolate (MTHF), and dihydropyrimidine dehydrogenase (DPD) activity in periph

7 Dihydropyrimidine dehydrogenase (DPD) activity was deter

8 Dihydropyrimidine dehydrogenase (DPD) catabolizes endoge

9 Dihydropyrimidine dehydrogenase (DPD) deficiency constit

10 cause of intolerance to fluoropyrimidines is dihydropyrimidine dehydrogenase (DPD) deficiency, which

11 Dihydropyrimidine dehydrogenase (DPD) is a major determi

12 Dihydropyrimidine dehydrogenase (DPD) is the initial and

13 Dihydropyrimidine dehydrogenase (DPD) is the initial, ra

14 ve reported a correlation between intratumor dihydropyrimidine dehydrogenase (DPD) messenger RNA (mRN

15 ected dose of 5-FU is rapidly inactivated by dihydropyrimidine dehydrogenase (DPD) to therapeutically

16 ficiency of the pyrimidine catabolic enzyme, dihydropyrimidine dehydrogenase (DPD), has been shown to

17 e uracil in UFT slows degradation of 5-FU by dihydropyrimidine dehydrogenase (DPD), which results in

18 Dihydropyrimidine dehydrogenase (DPD, encoded by DPYD) r

19 in the fluoropyrimidine metabolizing enzyme dihydropyrimidine dehydrogenase (DPD; ie, DPYD*2A) is st

20 ral regimen of eniluracil (which inactivates dihydropyrimidine dehydrogenase [DPD]), 5-FU, and leucov

21 enzyme in the pyrimidine catabolic pathway, dihydropyrimidine dehydrogenase (DPYD) and its effect on

22 n addition, AEG-1 enhances the expression of dihydropyrimidine dehydrogenase (DPYD) that catalyzes th

23 Dihydropyrimidine dehydrogenase (DPYD), a pyrimidine-deg

24 red study with eniluracil, an inactivator of dihydropyrimidine dehydrogenase, enabling catabolite cor

25 Thus, by inactivating dihydropyrimidine dehydrogenase, EU prolonged the half-l

26 Tumoral dihydropyrimidine dehydrogenase expression is a promisin

27 acy; in the XELOX group, for high versus low dihydropyrimidine dehydrogenase expression levels, DFS H

28 shown the prognostic impact of several rare dihydropyrimidine dehydrogenase gene (DPYD) variants on

29 The dihydropyrimidine dehydrogenase gene (DPYD) was isolated

30 e to progression (TTP) of an oral regimen of dihydropyrimidine dehydrogenase inhibitory fluoropyrimid

31 Low tumor expression of dihydropyrimidine dehydrogenase may be predictive for XE

32 pidermal growth factor receptor mutation, or dihydropyrimidine dehydrogenase polymorphism) may differ

33 and other drug metabolizing enzymes such as dihydropyrimidine dehydrogenase represents a major innov

34 acil (776C85) is an effective inactivator of dihydropyrimidine dehydrogenase that allows continuous l

35 acil is being developed as an inactivator of dihydropyrimidine dehydrogenase, the enzyme that brings

36 routine use of p53, ras, thymidine synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase

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