ライフサイエンスコーパス: dihydrosphingosine

1 vented by supplementation with the precursor dihydrosphingosine.

2 able of phosphorylating both sphingosine and dihydrosphingosine.

3 -dependent reduction of 3-ketosphinganine to dihydrosphingosine.

4 pecifically dephosphorylate DHS-1-P to yield dihydrosphingosine.

5 al (TRP) channel by modulating the levels of dihydrosphingosine 1 phosphate (DHS1P) and sphingosine 1

6 a protein that specifically dephosphorylates dihydrosphingosine 1-phosphate (DHS-1-P), and we refer t

7 interaction between the sphingolipid agonist dihydrosphingosine 1-phosphate (dhS1P) and the transform

8 that another product of sphingosine kinase, dihydrosphingosine 1-phosphate (dhS1P), has an opposite

9 t increased levels of dihydrosphingosine and dihydrosphingosine 1-phosphate (DHS1P).

10 generates sphingosine 1-phosphate (S1P) and dihydrosphingosine 1-phosphate (dhS1P).

11 ignaling, sphingosine-1 phosphate (S1P), and dihydrosphingosine 1-phosphate (dhS1P).

12 of SPP and the related phosphorylated lipids dihydrosphingosine 1-phosphate and lysophosphatidic acid

13 pecific, dose-dependent, and competed off by dihydrosphingosine 1-phosphate and lysophosphatidic acid

14 ther structurally related compounds, such as dihydrosphingosine 1-phosphate and lysophosphatidic acid

15 ae, phosphorylated long chain bases, such as dihydrosphingosine 1-phosphate and phytosphingosine 1-ph

16 SB649146 displaced the S1P1 receptor agonist dihydrosphingosine 1-phosphate from membranes expressing

17 ive in both YSR2 and SUR2, which accumulated dihydrosphingosine 1-phosphate only, grew poorly.

18 YSR2 conferred sphingosine resistance to the dihydrosphingosine-1-P lyase-defective mutant (JS16) of

19 mentable carbon source at 25 degreesC, while dihydrosphingosine-1-phosphate (DHS-1-P) is only barely

20 Sphingosine-1-phosphate (S1P) and dihydrosphingosine-1-phosphate (DHS1P) are important sig

21 cenal, whereas hexadecanal is the product of dihydrosphingosine-1-phosphate (DHS1P) degradation.

22 ion, we propose that enhanced degradation of dihydrosphingosine-1-phosphate allows an alternative pro

23 base phosphate (LCB-P) lyase, encoded by the dihydrosphingosine-1-phosphate lyase1 (AtDPL1) gene and

24 e (DHS-1-P), and we refer to this protein as dihydrosphingosine-1-phosphate phosphatase.

25 ken together, these results identify YSR2 as dihydrosphingosine-1-phosphate phosphatase.

26 osphingosine into sphingosine-1-phosphate or dihydrosphingosine-1-phosphate respectively.

27 D-erythro-4, 5-Dihydrosphingosine 1c and D-erythro-4,5-dihydroceramide

28 atment led to pronounced dihydroceramide and dihydrosphingosine accumulation, which preceded morpholo

29 Moreover, increasing dihydrosphingosine activates Mef2 activity through PDK1

30 Treatment of cells with dihydrosphingosine activates transcription of the TPS2 g

31 long chain bases (LCBs) phytosphingosine and dihydrosphingosine also suppressed the DspA/E-induced ye

32 Another SphK inhibitor, D,L-threo-dihydrosphingosine, also induced apoptosis and produced

33 inhibition of PKC by acute coexposure to the dihydrosphingosine analog safingol.

34 ansient increase in the concentration of C18-dihydrosphingosine and C18-phytosphingosine, more than a

35 re than a 100-fold transient increase in C20-dihydrosphingosine and C20-phytosphingosine, and a more

36 Subsequently dihydrosphingosine and dhS1P decrease at 48 h consistent

37 stitute an appreciable proportion of cardiac dihydrosphingosine and dihydroceramide, with distinct bi

38 ses occurred in more than one-third of total dihydrosphingosine and dihydroceramides in myocardium, a

39 sphingosine, and S1P but increased levels of dihydrosphingosine and dihydrosphingosine 1-phosphate (D

40 eramide formation from a free fatty acid and dihydrosphingosine and no activity with phytosphingosine

41 nt, the saturated long-chain sphingoid bases dihydrosphingosine and phytosphingosine (Phyto-Sph).

42 FA synthesis, accumulation of high levels of dihydrosphingosine and phytosphingosine, and accumulatio

43 nism by which sphingosine and its analogues, dihydrosphingosine and phytosphingosine, inhibit polymor

44 ) exhibited both an enormous accumulation of dihydrosphingosine and sphingosine and a reduction in ph

45 Vmax of 0.3 micromol/min/mg), but d-erythro-dihydrosphingosine and the three unnatural stereoisomers

46 The molecular species of dihydrosphingosines and phytosphingosines and their 1-ph

47 malian SphK1 efficiently phosphorylated Sph, dihydrosphingosine, and 4,8-sphingadienine, but not the

48 ted the sphingoid bases phytosphingosine and dihydrosphingosine as the likely mediators of Cha1 up-re

49 ro-2-N-[12'-(1''-pyridinium)-dodecanoyl]-4,5-dihydrosphingosine bromide (C(12)-dhCCPS) to its 4,5-des

50 ollowing in vivo labeling with D-erythro-[3H]dihydrosphingosine, but it slightly affected labeling of

51 ingosine, phytosphingosine, sphingosine, and dihydrosphingosine, but not N-acetyldihydrosphingosine,

52 lecules, including 3-ketodihydrosphingosine, dihydrosphingosine, C(2)-phytoceramide (PHC), and steary

53 In contrast to long-chain bases (dihydrosphingosine [d18:0] and 4,8-sphingadienine [d18:2

54 and clinical isolates demonstrated elevated dihydrosphingosine (DHS) and phytosphingosine (PHS) leve

55 hich encodes an exporter of long chain bases dihydrosphingosine (DHS) and phytosphingosine (PHS), and

56 Here we show that dihydrosphingosine (DHS) and phytosphingosine (PHS), two

57 Increased generation of dihydrosphingosine (DHS), a bioactive sphingolipid, has

58 We report herein that DL-threo-dihydrosphingosine (DHS), a competitive inhibitor of sph

59 The sphingosine analogue, D-L-threo-dihydrosphingosine (DHS), inhibits the SK enzyme competi

60 However, DL-lactosylceramides containing dihydrosphingosine did not bind.

61 C8-Cer) stereoisomers, N-octanoyl-DL-erythro-dihydrosphingosine (DL-e-DHC8-Cer), and a new ceramide d

62 , sphingoid phosphate phosphatase, lyase, or dihydrosphingosine hydroxylase were found to display the

63 duction of the levels of sphingosine but not dihydrosphingosine in response to PMA, and 4) induction

64 Dihydrosphingosine induces expression of a STRE-LacZ rep

65 ecrease in the incorporation of radiolabeled dihydrosphingosine into ceramide and complex sphingolipi

66 catalysing the conversion of sphingosine or dihydrosphingosine into sphingosine-1-phosphate or dihyd

67 Here our data suggest that accumulation of dihydrosphingosine is responsible for this phenotype.

68 nositol, diacylglycerol, ceramide, D,L-threo-dihydrosphingosine or N, N-dimethylsphingosine.

69 ntial for growth in the absence of exogenous dihydrosphingosine or phytosphingosine.

70 hingosine (DMS) and phytosphingosine but not dihydrosphingosine or sphingosine 1-phosphate.

71 f ceramide resulting from the N-acylation of dihydrosphingosine or sphingosine by ceramide synthase i

72 inositol, diacylglycerol, ceramide, DL-threo-dihydrosphingosine, or N,N-dimethylsphingosine.

73 is reversed by supplying 3-ketosphinganine, dihydrosphingosine, or phytosphingosine in the growth me

74 Both enzymes can use phytosphingosine, dihydrosphingosine, or sphingosine as substrate.

75 DPL1, the structural gene for dihydrosphingosine phosphate lyase, was selected as a hi

76 [(3)H]Dihydrosphingosine radiolabeling studies demonstrated th

77 [(3)H]inositol and [(3)H]dihydrosphingosine radiolabeling studies demonstrated th

78 romoter contains four STREs that may mediate dihydrosphingosine responsiveness.

79 whether cytotoxicity was enhanced by l-threo-dihydrosphingosine (safingol); (e) whether physiological

80 Labeling yeast cells with [(3)H]dihydrosphingosine showed that IPS were increased in the

81 nd L-erythro- was not as potent as D-erythro-dihydrosphingosine showing stereospecificity.

82 he inhibitor of sphingosine kinase, DL-threo-dihydrosphingosine, significantly increased the percenta

83 es and the sphingoid bases phytosphingosine, dihydrosphingosine, sphingosine, and sphingosine 1-phosp

84 d C4 hydroxylase catalyzes the conversion of dihydrosphingosine to phytosphingosine.

85 SUR2 catalyzes conversion of dihydrosphingosine to phytosphingosine.

86 d-erythro-dihydrosphingosine was a better substrate than d-erythro

87 Surprisingly, d, l-threo-dihydrosphingosine was also phosphorylated by SPHK2.

88 st sphingoid backbones, phytosphingosine and dihydrosphingosine, were found to be most potent in this

89 strain upon labeling with D-erythro-[4, 5-3H]dihydrosphingosine, whereas overexpression of YSR2 incre

90 ons) and much stronger than that by DL-threo-dihydrosphingosine, which had been considered to be the

91 phingoid bases, C20 phytosphingosine and C20 dihydrosphingosine, which increased 6.4- and 10.8-fold o

92 tive inhibitor of ceramide synthase 2 toward dihydrosphingosine with an apparent K(i) of 2.15 microm.