ライフサイエンスコーパス: diindolylmethane

1 84 but so also can molecules related to 3,3'-diindolylmethane.

2 the action of decanoic acid but not of 3,3'-diindolylmethane.

3 3, 3-Diindolylmethane-14 (DIM-14), a novel lipophilic derivat

4 DIM (3,3'-diindolylmethane), a small molecule compound, is a propo

5 In addition, we discovered that 3,3'-diindolylmethane, a dietary molecule from cruciferous ve

6 Because other methylene-substituted diindolylmethane analogues have been shown to transactiv

7 3,3'-Diindolylmethane and decanoic acid acted as strong posit

8 ncentrations of either decanoic acid or 3,3'-diindolylmethane and was not affected adversely by mutat

9 Together, these findings suggest that diindolylmethanes are a new class of compounds that sele

10 onist actions of both decanoic acid and 3,3'-diindolylmethane at GPR84.

11 3,3'-Diindolylmethanes bearing small lipophilic residues at t

12 studies on a series of methylene-substituted diindolylmethanes (C-DIM) have identified 1,1-bis(3'-ind

13 tion of Egr-1/NAG-1 by methylene-substituted diindolylmethanes (C-DIMs) was phosphatidylinositol 3-ki

14 te the efficacy of a novel anti-inflammatory diindolylmethane class compound, 1,1-bis(3'-indolyl)-1-(

15 Selected diindolylmethane compounds (C-DIMs) have been shown to a

16 ults suggest that targeting survivin by 3,3'-diindolylmethane could be a new and novel approach for t

17 n-regulation of survivin as observed by 3,3'-diindolylmethane could be an important approach for the

18 tion of a newly synthesized ring-substituted diindolylmethane derivative, 1,1-bis[3'-(5-methoxyindoly

19 We synthesized a broad range of diindolylmethane derivatives by condensation of indoles

20 Thus, this series of methylene-substituted diindolylmethane derivatives simultaneously activate mul

21 deficient rho(0) MCF-7 cells, in which 3,3'-diindolylmethane did not stimulate ROS production.

22 Rosiglitazone and diindolylmethane (DIM) analogues did not affect expressi

23 rmylindolo-[3,2-b]carbazole (FICZ), and 3-3'-diindolylmethane (DIM) and then analyzed with a combinat

24 Indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM) are two bioactive compounds from

25 nzo-p-dioxin (TCDD) (reference) or 25 microM diindolylmethane (DIM) as AhR agonists in MCF-7 cells.

26 3,3'-Diindolylmethane (DIM) has been known to have cancer che

27 3,3'-Diindolylmethane (DIM) has been shown to repress neovasc

28 We evaluated the effect of 3,3'-diindolylmethane (DIM) in ovarian cancer cells.

29 oliferative and proapoptotic effects of 3,3'-diindolylmethane (DIM) in prostate cancer cells.

30 3,3'-Diindolylmethane (DIM) is a major digestive product of i

31 3,3'-Diindolylmethane (DIM) is a promising anticancer agent d

32 The indole-3-carbinol (I3C) metabolite 3,3'-diindolylmethane (DIM) is a proposed cancer prevention a

33 3,3'-Diindolylmethane (DIM) is an anticancer agent that induc

34 eatment of cells with "natural agents" [3,3'-diindolylmethane (DIM) or isoflavone] could affect the e

35 s major acid-catalyzed reaction product 3,3'-diindolylmethane (DIM) showed anticancer activity mediat

36 liferative and pro-apoptotic effects of 3,3'-diindolylmethane (DIM) through regulation of Akt and and

37 Finally, 3,3'-Diindolylmethane (DIM), a known chemoprevention agent, i

38 3,3'-Diindolylmethane (DIM), a major in vivo acid-catalyzed c

39 3,3'-Diindolylmethane (DIM), a natural autolytic product in p

40 sitization of pancreatic cancer cells by 3,3-diindolylmethane (DIM), a natural compound that can be e

41 Furthermore, we found that 3,3'-diindolylmethane (DIM), a vegetable autolysis product, p

42 es, and its major condensation product, 3,3'-diindolylmethane (DIM), against lung tumorigenesis induc

43 cancer cells by different concentrations of diindolylmethane (DIM), an active ingredient of crucifer

44 hR ligands (indole-3-carbinol [I3C] and 3,3'-diindolylmethane [DIM]) and an endogenous AhR ligand, 6-

45 ed that I3C, but not its natural dimer, 3,3'-diindolylmethane, disrupts proteolytic processing of the

46 ate the molecular mechanism(s) by which 3,3'-diindolylmethane exerts its effects on breast cancer cel

47 uced p21 overexpression, we showed that 3,3'-diindolylmethane failed to induce p21 overexpression in

48 The anti-inflammatory effect of 3,3'-diindolylmethane in RAW264.7 cells was shown to be parti

49 s studies in our laboratory showed that 3,3'-diindolylmethane induced a G(1) cell cycle arrest in hum

50 , antioxidants significantly attenuated 3,3'-diindolylmethane-induced activation of p38 and JNK and i

51 survivin by cDNA transfection abrogated 3,3'-diindolylmethane-induced cell growth inhibition and apop

52 NH(2)-terminal kinase (JNK) pathways in 3,3'-diindolylmethane-induced p21 mRNA transcription.

53 To further support the role of ROS in 3,3'-diindolylmethane-induced p21 overexpression, we showed t

54 f enhanced mitochondrial ROS release in 3,3'-diindolylmethane-induced p21 up-regulation in human brea

55 ple molecular approaches and found that 3,3'-diindolylmethane inhibited cell growth and induced apopt

56 We show for the first time that 3,3'-diindolylmethane is a strong mitochondrial H(+)-ATPase i

57 3,3'-Diindolylmethane, one of the active products derived fro

58 trast, the chemopreventative AHR ligand 3,3'-diindolylmethane promotes AHR nuclear translocation and

59 rile, indole-3-carbinol, ascorbigen and 3,3'-diindolylmethane released from glucobrassicin and 4-meth

60 her and analysis showed the affinity of 3,3'-diindolylmethane to be at least 100 fold higher.

61 found a total of 1,238 genes altered in 3,3'-diindolylmethane-treated cells, among which 550 genes we

62 3,3'-Diindolylmethane treatment induced hyperpolarization of

63 urvivin by small interfering RNA before 3,3'-diindolylmethane treatment resulted in enhanced cell gro

64 Recently, 3,3'-diindolylmethane was identified as a heterocyclic, nonli