ライフサイエンスコーパス: diindolylmethane

1 84 but so also can molecules related to 3,3'-diindolylmethane.

2 the action of decanoic acid but not of 3,3'-diindolylmethane.

3 3, 3-Diindolylmethane-14 (DIM-14), a novel lipophilic derivat

4 DIM (3,3'-diindolylmethane), a small molecule compound, is a propo

5 In addition, we discovered that 3,3'-diindolylmethane, a dietary molecule from cruciferous ve

6 Because other methylene-substituted diindolylmethane analogues have been shown to transactiv

7 3,3'-Diindolylmethane and decanoic acid acted as strong posit

8 ncentrations of either decanoic acid or 3,3'-diindolylmethane and was not affected adversely by mutat

9 Together, these findings suggest that diindolylmethanes are a new class of compounds that sele

10 onist actions of both decanoic acid and 3,3'-diindolylmethane at GPR84.

11 3,3'-Diindolylmethanes bearing small lipophilic residues at t

12 studies on a series of methylene-substituted diindolylmethanes (C-DIM) have identified 1,1-bis(3'-ind

13 tion of Egr-1/NAG-1 by methylene-substituted diindolylmethanes (C-DIMs) was phosphatidylinositol 3-ki

14 te the efficacy of a novel anti-inflammatory diindolylmethane class compound, 1,1-bis(3'-indolyl)-1-(

15 Selected diindolylmethane compounds (C-DIMs) have been shown to a

16 ults suggest that targeting survivin by 3,3'-diindolylmethane could be a new and novel approach for t

17 n-regulation of survivin as observed by 3,3'-diindolylmethane could be an important approach for the

18 tion of a newly synthesized ring-substituted diindolylmethane derivative, 1,1-bis[3'-(5-methoxyindoly

19 We synthesized a broad range of diindolylmethane derivatives by condensation of indoles

20 Thus, this series of methylene-substituted diindolylmethane derivatives simultaneously activate mul

21 deficient rho(0) MCF-7 cells, in which 3,3'-diindolylmethane did not stimulate ROS production.

22 Rosiglitazone and diindolylmethane (DIM) analogues did not affect expressi

23 We also find that the diindoles, diindolylmethane (DIM) and diindolylethane (DIE) selecti

24 rmylindolo-[3,2-b]carbazole (FICZ), and 3-3'-diindolylmethane (DIM) and then analyzed with a combinat

25 Indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM) are two bioactive compounds from

26 nzo-p-dioxin (TCDD) (reference) or 25 microM diindolylmethane (DIM) as AhR agonists in MCF-7 cells.

27 3,3'-Diindolylmethane (DIM) has been known to have cancer che

28 3,3'-Diindolylmethane (DIM) has been shown to repress neovasc

29 We evaluated the effect of 3,3'-diindolylmethane (DIM) in ovarian cancer cells.

30 oliferative and proapoptotic effects of 3,3'-diindolylmethane (DIM) in prostate cancer cells.

31 3,3'-Diindolylmethane (DIM) is a major digestive product of i

32 3,3'-Diindolylmethane (DIM) is a promising anticancer agent d

33 The indole-3-carbinol (I3C) metabolite 3,3'-diindolylmethane (DIM) is a proposed cancer prevention a

34 3,3'-Diindolylmethane (DIM) is an anticancer agent that induc

35 phane (SFN) and indole-3-carbinol (I3C)/3,3'-diindolylmethane (DIM) on breast cancer risk, prognosis,

36 eatment of cells with "natural agents" [3,3'-diindolylmethane (DIM) or isoflavone] could affect the e

37 s major acid-catalyzed reaction product 3,3'-diindolylmethane (DIM) showed anticancer activity mediat

38 liferative and pro-apoptotic effects of 3,3'-diindolylmethane (DIM) through regulation of Akt and and

39 Finally, 3,3'-Diindolylmethane (DIM), a known chemoprevention agent, i

40 3,3'-Diindolylmethane (DIM), a major in vivo acid-catalyzed c

41 3,3'-Diindolylmethane (DIM), a natural autolytic product in p

42 sitization of pancreatic cancer cells by 3,3-diindolylmethane (DIM), a natural compound that can be e

43 Furthermore, we found that 3,3'-diindolylmethane (DIM), a vegetable autolysis product, p

44 es, and its major condensation product, 3,3'-diindolylmethane (DIM), against lung tumorigenesis induc

45 cancer cells by different concentrations of diindolylmethane (DIM), an active ingredient of crucifer

46 in vitro gastrointestinal digestion for 3,3-diindolylmethane (DIM), indole-3-carbinol (I3C) and sulf

47 hR ligands (indole-3-carbinol [I3C] and 3,3'-diindolylmethane [DIM]) and an endogenous AhR ligand, 6-

48 ed that I3C, but not its natural dimer, 3,3'-diindolylmethane, disrupts proteolytic processing of the

49 ate the molecular mechanism(s) by which 3,3'-diindolylmethane exerts its effects on breast cancer cel

50 uced p21 overexpression, we showed that 3,3'-diindolylmethane failed to induce p21 overexpression in

51 The anti-inflammatory effect of 3,3'-diindolylmethane in RAW264.7 cells was shown to be parti

52 s studies in our laboratory showed that 3,3'-diindolylmethane induced a G(1) cell cycle arrest in hum

53 , antioxidants significantly attenuated 3,3'-diindolylmethane-induced activation of p38 and JNK and i

54 survivin by cDNA transfection abrogated 3,3'-diindolylmethane-induced cell growth inhibition and apop

55 NH(2)-terminal kinase (JNK) pathways in 3,3'-diindolylmethane-induced p21 mRNA transcription.

56 To further support the role of ROS in 3,3'-diindolylmethane-induced p21 overexpression, we showed t

57 f enhanced mitochondrial ROS release in 3,3'-diindolylmethane-induced p21 up-regulation in human brea

58 ple molecular approaches and found that 3,3'-diindolylmethane inhibited cell growth and induced apopt

59 We show for the first time that 3,3'-diindolylmethane is a strong mitochondrial H(+)-ATPase i

60 3,3'-Diindolylmethane, one of the active products derived fro

61 trast, the chemopreventative AHR ligand 3,3'-diindolylmethane promotes AHR nuclear translocation and

62 rile, indole-3-carbinol, ascorbigen and 3,3'-diindolylmethane released from glucobrassicin and 4-meth

63 her and analysis showed the affinity of 3,3'-diindolylmethane to be at least 100 fold higher.

64 found a total of 1,238 genes altered in 3,3'-diindolylmethane-treated cells, among which 550 genes we

65 3,3'-Diindolylmethane treatment induced hyperpolarization of

66 urvivin by small interfering RNA before 3,3'-diindolylmethane treatment resulted in enhanced cell gro

67 Recently, 3,3'-diindolylmethane was identified as a heterocyclic, nonli