ライフサイエンスコーパス: dimer formation

1 r formation) or the homoallylic double bond (dimer formation).

2 which was attributable to cysteine-mediated dimer formation.

3 uptake, consistent with a role for alphaB in dimer formation.

4 -dependent catalysis, and by modulating eNOS dimer formation.

5 orting motifs and is a process that enhances dimer formation.

6 perone, phosducin-like protein 1 (PhLP1) for dimer formation.

7 from the sensor kinase PhoR was enhanced by dimer formation.

8 xists in a closed conformation that inhibits dimer formation.

9 atalytic domain, contribute to the PRK2-PRK2 dimer formation.

10 ysteine residue at the N-terminus to mediate dimer formation.

11 c TCR for surface expression and allow mixed dimer formation.

12 ge of the 30S head domain that promotes 100S dimer formation.

13 trate that CerS activity can be modulated by dimer formation.

14 he N terminus of CtIP, which is required for dimer formation.

15 mutant exhibited a significant reduction in dimer formation.

16 ch suggests that this region is critical for dimer formation.

17 ys(4) that resulted in substantially reduced dimer formation.

18 oposed ED dimer interfaces have no effect on dimer formation.

19 sociation of myosin VIIA to vesicles and the dimer formation.

20 inucleotide binding domain that orchestrates dimer formation.

21 t bind dsRNA and one that is responsible for dimer formation.

22 isulfide bond formation is not essential for dimer formation.

23 e almost abolished iNOS activity and reduced dimer formation.

24 ones influence the specificity of Gbetagamma dimer formation.

25 but this interaction does not contribute to dimer formation.

26 er TonB, ExbB nor pmf were required for ExbD dimer formation.

27 alponin homology domain but does not require dimer formation.

28 Hda domains in a conformation that promotes dimer formation.

29 s of microtubule formation without affecting dimer formation.

30 hese proteins and wild-type SecA in terms of dimer formation.

31 termolecular contacts that are important for dimer formation.

32 egments in MYA1 contributed significantly to dimer formation.

33 re extended hydrophobic surfaces involved in dimer formation.

34 tive site and help explain the importance of dimer formation.

35 ificant contributions to the active site and dimer formation.

36 o helices from another subunit, resulting in dimer formation.

37 g step in the fibrillization pathway was tau dimer formation.

38 Glu-49-Asn-53 loop, which, in turn, disrupts dimer formation.

39 portance of protein-protein interactions for dimer formation.

40 nd long-range recognition mechanism for this dimer formation.

41 ereas the fourth helices participate only in dimer formation.

42 ng hydrophobic contribution to the energy of dimer formation.

43 omeric cadherin pool, thereby inhibiting new dimer formation.

44 in receptor-receptor interactions underlying dimer formation.

45 deR variant that showed reduced affinity for dimer formation.

46 ine 286 and aspartates 96 and 107 are key to dimer formation.

47 dant formulation efficiently reduced thymine dimer formation.

48 to the adjacent unit to promote noncovalent dimer formation.

49 es that determine the efficacy of Gbetagamma dimer formation.

50 predicted coiled-coil region does not drive dimer formation.

51 H2-terminal region is not required for MEKK2 dimer formation.

52 ys-662 and -716 conferred protection against dimer formation.

53 mice, suggesting that CD45-AP inhibits CD45 dimer formation.

54 a molecular dynamics approach to study Abeta dimer formation.

55 ve charge of the arginine/lysine residue for dimer formation.

56 in the FGF14.Nav1.6 complex and FGF14:FGF14 dimer formation.

57 membrane domain of GPA are important for GPA dimer formation.

58 unodeficiency virus type 1 protease prevents dimer formation.

59 mains of CFHR5 contact properdin and mediate dimer formation.

60 npi* excited states does not lead to thymine dimer formation.

61 Ac at potential glycosylation sites inhibits dimer formation.

62 g to Nav1.6 but had no effect on FGF14:FGF14 dimer formation.

63 are found to disrupt the dimer interface and dimer formation.

64 lations might be important for efficient DAO dimer formation.

65 raction while it is dispensable for S18-2/S6 dimer formation.

66 ii) phosphorylation of H379 in PRD2 disrupts dimer formation.

67 nds and likely responsible for initial Abeta dimer formation.

68 hanges in photophysics of a chromophore upon dimer formation.

69 ting the role of protonated E73 in enhancing dimer formation.

70 evolutionary origin of matched isotype mixed dimer formation.

71 ss and PI3K effector interactions, abolishes dimer formation.

72 nced agonists with respect to selectivity of dimer formation.

73 sion increased with concentration because of dimer formation.

74 the Ad-FX interaction showed no evidence of dimer formation.

75 t Moco is necessary and sufficient to induce dimer formation.

76 nhibit DPPIV was through blocking the active dimer formation.

77 dimers, and their activity is dependent upon dimer formation.

78 e N-terminal residues, which are involved in dimer formation.

79 active site geometry, rather than preventing dimer formation.

80 The fusion does not disrupt dimer formation, a necessity for catalytic activity.

81 nd in plasma, lipids and proteins "catalyze" dimer formation, a process that could occur either intra

82 dence from the intrinsic kinase activity and dimer formation ability of EGFR, and it largely avoided

83 oxidative stress-dependent decrease in Mge1 dimer formation accompanied by a concomitant decrease in

84 These results support the idea that dimer formation allosterically activates unphosphorylate

85 clot stiffness, in particular through gamma-dimer formation; alpha-gamma hybrid cross-links had the

86 s at different time points revealed covalent dimer formation already 15 min after fibrillation reacti

87 free energy difference is 13.8 kcal/mol for dimer formation and 27 kcal/mol for tetramer formation,

88 he52 and Arg69 are the major determinants of dimer formation and a single mutation at either position

89 The ability of CD to induce actin dimer formation and actin-catalyzed ATP hydrolysis may b

90 n interact with a full-length GPCR, blocking dimer formation and affecting its function.

91 1 or alpha1gamma1 interaction sites for homo-dimer formation and assembly in vitro of beta and gamma

92 rine hearts prevented the p38-MKK3 disulfide dimer formation and attenuated H2O2-induced contractile

93 he interface of the DLC dimer, disrupts DLC1 dimer formation and consequently impairs its interaction

94 Increased J- and H-type dimer formation and decreased fluorescence emission were

95 helix formation decreased apparent Zq domain dimer formation and decreased Zq interaction with the al

96 zation, defining a thin reaction shell where dimer formation and dissociation take place.

97 These systems describe dimer formation and dissociation, protein preduction and

98 t the cells' resistance to agents that cause dimer formation and DNA strand breaks.

99 rmed the correlation between in vitro ED RNA dimer formation and efficient virus replication, thus in

100 A detailed characterization of dimer formation and estimates of the free energy of asso

101 The C15-124 disulfides are not critical for dimer formation and have insignificant impact on the dit

102 These peptides efficiently blocked MMP-9 dimer formation and inhibited motility of COS-1 cells ov

103 -19, and Ser-20) is necessary for Gbetagamma dimer formation and is believed to be mediated by the pr

104 of the U-box dimer interface abrogates U-box dimer formation and is lethal in vivo.

105 ides a framework for understanding secondary dimer formation and lateral signaling in the EGF recepto

106 or positively charged lysine did not affect dimer formation and maintained around 60% of iNOS activi

107 ovide unique mechanistic insights into K-Ras dimer formation and membrane organization as well as the

108 eness of this mutant does not correlate with dimer formation and monomerisation, indicating that mono

109 RET-TM underlies - and may be required for - dimer formation and oncogenic activation of juxtamembran

110 3/M3-S2 linker of GluN1, but not GluN2, show dimer formation and oxidation-induced changes in current

111 t in the midnanomolar range, suggesting that dimer formation and possibly also disulfide bond formati

112 although both proteins influence holoenzyme dimer formation and precursor tRNA recognition to differ

113 fic disulfide reductant, both decreased Arr1 dimer formation and protected photoreceptors from light-

114 nt complementation to measure ligand-induced dimer formation and radioligand binding to study the eff

115 Thus, dimer formation and secretion of abnormal tetramers can

116 on sites at the monomer-monomer interface on dimer formation and stability were determined.

117 ated the functional significance of Hpo homo-dimer formation and subcellular localization in living c

118 te that deprotonation of His 55 is linked to dimer formation and that mutation of His 55 to a small n

119 chemical mechanisms that determine NF-kappaB dimer formation and the signal-processing characteristic

120 A639G/A641R mutations significantly reduced dimer formation and transforming activity in this otherw

121 nterface may hinder or facilitate asymmetric dimer formation and transphosphorylation, respectively.

122 appear to have the greatest affinity for QD dimer formation and, therefore, gave the greatest yields

123 RNA sites without perturbing RNA folding and dimer formation, and a total of 17 internitroxide distan

124 ative injury led to Hsp27mRNA up-regulation, dimer formation, and Hsp27 phosphorylation in ARPE-19 ce

125 rect involvement of the polyalanine tract in dimer formation, and indicate that mutated proteins reta

126 ssays for atlastin-catalyzed GTP hydrolysis, dimer formation, and membrane fusion.

127 se voltage must pass a certain threshold for dimer formation, and pulse polarity determines the yield

128 tion model of ezrin, elucidate the basis for dimer formation, and reveal that a mutant generally cons

129 that disulfides play only a marginal role in dimer formation, and that the stability imparted by the

130 double bond isomerization, elimination, and dimer formation are competitive undesired pathways.

131 Tubulin folding and dimer formation are complex processes requiring a variet

132 requirements, mechanism, and specificity of dimer formation are still incompletely understood, but r

133 eractions between protein species, caused by dimer formation, are effectively negative.

134 Here, we identify RKIP dimer formation as an important mechanistic feature in t

135 The velvet domain is also involved in dimer formation as seen in the solved crystal structures

136 r the Cx43CT at pH 5.8 and 6.5, with limited dimer formation at a more neutral pH.

137 ependent IgG4 structures in addition to IgG4 dimer formation at high concentration in heavy water.

138 the Aer receptor of Escherichia coli showed dimer formation at the membrane anchor and in the putati

139 rativity decreases and the dominant mode for dimer formation becomes interglutamine hydrogen bonding.

140 rstanding of the mechanism of radical cation dimer formation between constitutionally different TTF u

141 mechanism for activation is via drug-induced dimer formation between CRAF and kinase suppressor of Ra

142 s showed heterotrimer assembly to begin with dimer formation between globular G2alpha2 and the G2alph

143 he interlocking aromatic residues eliminates dimer formation but does not affect PXR's ability to int

144 utated to asparagine is strongly impaired in dimer formation but mediates UV-B responses in vivo with

145 pecially, both the V1 and V2 domains reduced dimer formation but promoted aggregation rather than tri

146 bunits and that CCT/TRiC mediates Gbetagamma dimer formation by an ATP-dependent reaction.

147 ts were predominantly monomers with impaired dimer formation by analytical ultracentrifugation (K(d)=

148 conserved segment in HUWE1 that counteracts dimer formation by associating with the dimerization reg

149 They do not form dimer contacts but enable dimer formation by inducing a strong membrane curvature

150 A comparison with studies of dimer formation by other physical techniques indicates t

151 ions in the domain-swap interface diminished dimer formation by the FOXP3 forkhead domain without com

152 tion, and patch-clamp recording, showed that dimer formation by the ligand binding cores is required

153 These data provide the first evidence for dimer formation by the Na (+)-Ca (2+) exchanger.

154 penultimate positions in this chain rescued dimer formation by the phosphomimic.

155 namics, surface corrugation, and competing H-dimers formation by means of ab initio molecular dynamic

156 Active dimer formation can be induced by increasing the protein

157 We find that pi-dimer formation can proceed via an asynchronous concerte

158 letion removes the crucial cysteine, so that dimer formation cannot occur and the abnormal molecule i

159 of tissue plasminogen activator, and lower d-dimer formation compared with nondiabetic AdMSCs.

160 The probability of coiled coil dimer formation computed for RetGC1/NPRA chimeras, even

161 Interestingly, the impaired FGG-dimer formation could be restored in NEC plasma by the a

162 hemical behavior of o-fluoranil has revealed dimer formation, cycloaddition to alkenes, and hydrogen

163 otect the T75C tetramer against heat-induced dimer formation, demonstrating the contribution of catio

164 SAT-6 with CFP10 under conditions that favor dimer formation did not affect inhibition of IFN-gamma.

165 ligands may result from partial agonism for dimer formation, differences in the kinetic pathway util

166 ive, the reaction was rendered selective for dimer formation (dimer/trimer > or = 16:1).

167 units, respectively, which are necessary for dimer formation) display a striking resistance to PTP op

168 We further show that disulfide-bond-mediated dimer formation does not affect and is not responsible f

169 anslation, which shifts the equilibrium from dimer formation dramatically in favor of viral capsid as

170 The turbidity and the rate of gamma-gamma dimer formation for BbetaD432A were indistinguishable co

171 e TMs, but it did increase the efficiency of dimer formation for the Ste2-V183C mutant.

172 JAM-A mutants incapable of dimer formation form complexes with the sigma1 head that

173 83Leu) and a variant with a severe defect in dimer formation (fXI-Gly350Glu) have little effect on wi

174 eins and carries the potential risk of mixed dimer formation giving rise to a new TCR with unpredicta

175 Finally, mutations that disrupted dimer formation had reduced calcium mobilization in resp

176 ns, none of which had a noticeable effect on dimer formation; however deletion of the C-terminal tail

177 e coiled-coil domain in COP1, which prevents dimer formation, impairs COP1 function in coordinating f

178 embrane domain greatly reduce SDS-stable GPA dimer formation, implying that regions outside the trans

179 lecular masses with a reduced propensity for dimer formation in a cross-linking reaction.

180 Transfected CD45-AP inhibited CD45 dimer formation in ALST-1 cells in proportion to the amo

181 ations to study monomer folding dynamics and dimer formation in CI2-polyQ chimeras with insertion len

182 studies support the preeminence of enhanced dimer formation in quercetin's mechanism of action.

183 identified disulfide bond-mediated PHD2 homo-dimer formation in response to oxidative stress caused b

184 bi-component leukocidins, are essential for dimer formation in solution and receptor binding.

185 In contrast, dimer formation in solution is observed only in the pres

186 FCS measurements for probing dimer formation in solution over a range of protein conc

187 A tendency toward ED-B-dependent dimer formation in solution was supported by size exclus

188 in-distribution results in a selective sigma-dimer formation in solution, as confirmed by 2D NMR spec

189 envelope of PECAM-1 IgL1-6 supported such a dimer formation in solution.

190 ggests that there is a preference for hetero-dimer formation in the GKs from these two polychaetes.

191 Da and equilibrium association constants for dimer formation in the range 2 x 10(3)-6 x 10(5) M(-1).

192 ht into the amino acid residues that mediate dimer formation in the wild-type protein.

193 e data show that acidification causes Cx43CT dimer formation in vitro.

194 n system, we further demonstrated that MEKK2 dimer formation in vivo augmented MEKK2-dependent JNK ac

195 tion of the C-terminal tail region prevented dimer formation in vivo.

196 link nonspecific DNA backbone contacts with dimer formation, in addition to providing a new role for

197 Excision-seq to identify sites of pyrimidine dimer formation induced by UV light exposure, where the

198 Asymmetric dimer formation induces an allosteric conformational cha

199 Moreover, prevention of MEKK2 dimer formation inhibited MEKK2-mediated JNK activation.

200 Mutation of arginine 286 to alanine impairs dimer formation, interaction with COP1 and function in v

201 gest that the increased RNA affinity through dimer formation is a crucial parameter enabling these pr

202 In these catalytic reactions, Pd(I) mu-allyl dimer formation is a deleterious process which removes t

203 Dimer formation is accelerated for the pathogenic A30P a

204 Dimer formation is achieved through mutual pairing of G1

205 Whether dimer formation is an important structural component of

206 The frequency of chromosome dimer formation is approximately 15% per generation in w

207 The dimer formation is critical for Hsp40 molecular chaperon

208 This dimer formation is eliminated here by covalent attachmen

209 ies of chronophin(A194K,A195K) revealed that dimer formation is essential for an intermolecular argin

210 These studies suggest that CtIP dimer formation is essential for its recruitment to DSBs

211 e serious consequences arise when chromosome dimer formation is increased, or their resolution effici

212 a membrane-miscible lipid tail, we show that dimer formation is mediated by protein interactions and

213 In Escherichia coli, 100S dimer formation is mediated by ribosome modulation facto

214 nstitutive homodimers in live cells and that dimer formation is not modulated by SERCA conformational

215 activity and salt-dependence indicates that dimer formation is of functional significance in both ca

216 mer during DNA repair, but it is unclear how dimer formation is regulated or what the functions of th

217 Therefore, OPG dimer formation is required for the mechanism of inhibit

218 e calculations support the view that the R6G dimer formation is the most plausible cause for the comp

219 Inhibition of cyclic dimer formation is vital for increasing the yield of lin

220 which dictates the selectivity of the sigma-dimer formation, is rationalized by evaluating the aroma

221 activity of E2-25K, as measured by ubiquitin dimer formation, is strikingly enhanced when added to pe

222 nterface domains of the EGFR can induce EGFR dimer formation, leading to aberrant receptor activation

223 meras we find that the residues required for dimer formation lie between amino acids 751 and 998 of (

224 Dimer formation may also involve TSPN-1 domains from two

225 sual for this enzyme class and suggests that dimer formation may contribute to light activation of th

226 ecting E-cadherin cellular localization, cis-dimer formation, molecular assembly and stability of the

227 epidermal growth factor repeats can promote dimer formation, most surface Notch molecules in mammali

228 Dimer formation occurs by specific interaction between i

229 Gbetagamma dimer formation occurs early in the assembly of heterotr

230 tion of the first step of amyloid initiation-dimer formation of a seven residue peptide (NHVTLSQ) fro

231 acentrifugation to obtain an apparent Kd for dimer formation of about 55 microM.

232 Noncovalent dimer formation of abundant components has not previousl

233 o-6-hydroxypyrimidine during shear inhibited dimer formation of endothelial NO synthase, increased en

234 These results also suggest that stable dimer formation of gamma-globin chains must not occur in

235 ) or DsrA(DII) and suggests that RNA-induced dimer formation of Hfq(6) is a common feature of Hfq-RNA

236 the mechanism of formation and regulation of dimer formation of iNOS.

237 The spontaneous hydroxy-bridged dimer formation of metalloporphyrins in ion-selective me

238 We further indicate a lipid-dependent dimer formation of MraY translocase correlating with the

239 These results suggest that dimer formation of myosin VIIA is important for its carg

240 ormational stabilization by disulfide-linked dimer formation of synthetic V1V2 peptides were required

241 tipulates whether, in the absence of ligand, dimer formation of the aptamer competes with intramolecu

242 T efficiency and estimate the free energy of dimer formation of the G380R mutants of fibroblast growt

243 Residues associated with p53 dimer formation on DNA are poorly conserved in the p63 a

244 Here we report Ras dimer formation on membranes by Type II photosensitizati

245 By measuring the free-energy cost of dimer formation on monolayers of increasing uniaxial str

246 two subdomains of PLC-beta3 are involved in dimer formation, one in the catalytic X and Y domains an

247 on of the unpaired cysteine does not inhibit dimer formation or biological activity.

248 Neither dimer formation or dissociation are clearly favored, and

249 not due to structural perturbation, impaired dimer formation or the loss of plasminogen binding.

250 ting different types of information, such as dimer formation or the presence of open binding faces on

251 e in the triple-helical domain important for dimer formation prior to secretion.

252 In summary, disrupted eNOS dimer formation rather than impaired insulin mediated eN

253 Dimer formation reappeared when arginine mutants were mi

254 re only modestly affected by solvation or by dimer formation, remaining in the range of 9-12 kcal/mol

255 CAPS dimer formation required its C2 domain based on mutation

256 For EF-hand 4, dimer formation requires only one of the monomers to be

257 ns, CA(N) and CA(C), which drive hexamer and dimer formations, respectively, to form a capsid lattice

258 Because the mutations leading to dimer formation resulted in poor thermostability of the

259 r ligands, AREG showed biphasic kinetics for dimer formation, suggesting that its path for EGF recept

260 nic DJ-1 mutants exhibit impairments in homo-dimer formation, suggesting that parkin may bind to mono

261 sed whereas the C162S mutation increased the dimer formation, suggesting that these two Cys residues

262 The effect of ligand on dimer formation suggests that dimers are formed in the r

263 form a wiring diagram to delineate NF-kappaB dimer formation that emphasizes that inflammatory and de

264 ially by maintaining stability of the hetero-dimer formation that might have been related to dietary

265 Herein, we outline a unique strategy for dimer formation that obviates these difficulties, one wh

266 HARPIN bound caspase 1 and disrupted p20/p10 dimer formation, the last step of caspase 1 processing,

267 and structurally alphaE- and alphaN-catenin dimer formation, their interaction with beta-catenin and

268 A reduced level of dimer formation then results from the reduced ratio of t

269 g with the alpha helix and loose coiled coil dimer formation, then the formation of tetrameric specie

270 nformations act as competitive inhibitors of dimer formation, thus lowering affinities even when the

271 These results link the loss of dimer formation to a loss of PAR4 signaling.

272 quilibrium model, we estimate the DeltaG for dimer formation to be -10.2 +/- 2.3 kJ/mol.

273 Cross-linking assays confirmed dimer formation to be enhanced in the presence of elevat

274 e probability and rate of beta-sheet amyloid dimer formation to be higher and faster at the air-water

275 However, most mutations affect dimer formation (to enhance or weaken).

276 ential affinity of alpha2(IV) NC1 domain for dimer formation underlies the driving force in the mecha

277 the FGF14.Nav1.6 complex and the FGF14:FGF14 dimer formation using a luciferase assay.

278 n which kinetic mechanisms control NF-kappaB dimer formation via processing and assembly of large com

279 resulted in pro-hIAPP dimer formation, while dimer formation was absent or reduced dramatically in ce

280 170, the role of hydrophilic interactions in dimer formation was also demonstrated.

281 The quantum yield of cyclobutane pyrimidine dimer formation was calculated as the number of dimeriza

282 In the PhLP1-depleted rods, Gbetagamma dimer formation was decreased 50-fold, resulting in a >1

283 Moreover, UV-induced cyclobutane pyrimidine dimer formation was markedly enhanced in ribonucleotide-

284 were mutated one at a time to cysteine, and dimer formation was measured by the rate of disulfide bo

285 tic light scattering experiments showed that dimer formation was not disrupted, nor did higher-order

286 tic light scattering experiments showed that dimer formation was not interrupted.

287 Such a dimer formation was not observed at the C-2.

288 Dimer formation was shown to be dependent on micelle com

289 Decamers of amyloid beta peptide capable of dimer formation were selected as a test system.

290 atenin is in a unique unfurled mode allowing dimer formation when bound to vinculin.

291 l terminus displayed the fastest kinetics of dimer formation, whereas an intracellular loop 3 cystein

292 extent of cross-linking is limited mostly to dimer formation, whereas mutants in which Y39 along with

293 as glutaraldehyde and found no preferential dimer formation, whether chemical cross-linking was perf

294 prevented MEKK2 activation by blocking MEKK2 dimer formation, which in turn blocked JNKK2, c-Jun N-te

295 with the NS5A protein of HCV and inhibit its dimer formation, which is essential for HCV replication.

296 murine beta cell line resulted in pro-hIAPP dimer formation, while dimer formation was absent or red

297 s been proposed to play an important role in dimer formation with another protein from the Fo-sector.

298 omain to only the C-terminal part of CaM (b) dimer formation with fragments of the K+-channel (c) ins

299 otypes require phosphorylation of Y(711) and dimer formation with full-length Stat92E.

300 a cysteine reporter diagnostic for trimer-of-dimer formation yielded cross-linking products upon trea