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1 ively active eGFP-Galphai1 was predominantly dimeric.
5 -labeling approach enabled resolution of the dimeric 5'-UTR in complex with the RHA N-terminal domain
6 ribosome is a poorly understood form of the dimeric 70S particle that has been linked to pathogenesi
7 bition of FKBP65 PPIase activity reduced the dimeric (active) form of LH2 but did not affect the bind
9 at the catalyst resting state is an inactive dimeric aggregate that must dissociate and then reassemb
10 TRAIL and poor apoptosis-inducing potency of dimeric agonist mAbs despite their long serum half-lives
13 h two clearly widespread types of enzymes: a dimeric (alpha2) species present in some bacteria, archa
15 ing dynamics of the peptide and formation of dimeric and higher order oligomeric receptor multimers.
16 active states of most bulb-type lectins are dimeric and it is thus important to elucidate the short-
17 al nucleus (n*) decreases from tetrameric to dimeric and monomeric as length increases from Q18 to Q2
19 cies correspond to disulfide bond-containing dimeric and monomeric PMEL isoforms that contain no othe
21 phosphorylation or SHP-1 recruitment between dimeric and monomeric Siglec-E expressed on HEK293A cell
22 es structural transitions between monomeric, dimeric and oligomeric states visualized by quantitative
23 itant with decreases in tetrahydrobiopterin, dimeric and phosphorylated neuronal nitric oxide synthas
25 lactoglobulin, dimeric superoxide dismutase, dimeric and tetrameric concanavalin A, and heptameric Gr
26 gs provide a basis to categorize ASADHs into dimeric and tetrameric enzymes, adopting a different ori
27 d enantioselective formal syntheses of eight dimeric and three monomeric nuphar alkaloids were achiev
28 s accomplished via the formation of distinct dimeric and trimeric fluorescent carbocations, character
31 of a variety of proteins, both monomeric and dimeric, and in multiple organisms, namely Escherichia c
33 and its oligomeric state as being monomeric, dimeric, and/or multimeric, but the native cellular stoi
34 gineering the biosynthesis of novel, potent, dimeric anthraquinones and structurally related compound
35 Our 2.05 A resolution data further reveal a dimeric architecture for this FH that resembles a heart,
42 using cavitands that assemble into distinct dimeric assemblies, we show that this approach, which we
43 ral metal binding is not compulsory for PerR dimeric assembly and for regulating peroxide stress.
44 om those of other K(+) channels, including a dimeric assembly constituted of nonidentical domains and
48 roposed that the pore is associated with the dimeric ATP synthase and the oligomycin sensitivity conf
60 oevolving polar residues at the interface of dimeric bulb-type lectins are largely absent in the doub
62 n of ethene, but-1-ene, and hex-1-ene with a dimeric calcium hydride-react with protio and deutero be
63 ion is to genetically engineer monomeric and dimeric CaMKII and evaluate how their activity compares
64 crease in hydrodynamic volume in both WT and dimeric CaMKII without altering subunit stoichiometry or
67 carboxylate at the equatorial region of the dimeric capsule, and the reverse turn of the chain and t
68 nds typically signal through homo- or hetero-dimeric cell surface receptors via Janus Kinase (JAK/TYK
69 The equilibrium dissociation constant of the dimeric clamp varies with salt concentration as predicte
71 sults in the tighter association between the dimeric CM domains and the tetrameric DAH7PS, occluding
72 1536 peptide sequences based on the parallel dimeric coiled-coil motif and varied residues known to b
77 ely binds AU base pairs informed design of a dimeric compound (2AU-2) that targets the pathogenic RNA
78 c binding, proved that the monomeric and the dimeric compound bind to the orthosteric binding site (a
79 In the structure, RctB adopts a head-to-head dimeric configuration that likely reflects the arrangeme
81 (EREG) and epigen (EPGN) stabilize different dimeric conformations of the EGFR extracellular region.
86 e in which a pair of ISD11 subunits form the dimeric core of the SDA complex, which clarifies the cri
87 Two Cas1 dimers assemble on a Cas2 domain dimeric core, which is flanked by two Cas3 domains formi
88 y, this structure differs from the published dimeric crystal structure of the equivalent region from
90 tion, and biological evaluation of two novel dimeric cyclic RGD-based molecular probes for the target
91 methodology to the formal total syntheses of dimeric cyclotyrptamine alkaloids (+/-)-chimonanthine (3
95 e concise, biomimetic total synthesis of the dimeric, Diels-Alder natural product griffipavixanthone
99 t photo-activation of a cleavable air-stable dimeric dopant can result in kinetically stable and effi
100 h recombinant human TRAIL (native TRAIL) and dimeric DR4/DR5 agonist monoclonal antibodies (mAbs) fai
102 We describe a photoswitchable DNA-based dimeric dye that visibly changes fluorescence from green
104 e vesicle populations via the formation of a dimeric E/K coiled-coil complex can be rationalized, the
107 udies show that the observable tetrasolvated dimeric enolate undergoes reversible deaggregation, with
109 er, other binding pockets are found near the dimeric enzyme interface, some of which are occupied by
110 furanosidase (XdINV)is a highly glycosylated dimeric enzyme that hydrolyzes sucrose and releases fruc
112 Furthermore, we show that overexpression of dimeric ERdj3 exacerbates ER stress-dependent reductions
116 We determined the structure of a complete, dimeric F1Fo-ATP synthase from yeast Yarrowia lipolytica
117 both ligands, CD80 and CD86, and screened as dimeric Fc fusions directly in functional assays to iden
120 ock protein from Salmonella typhimurium in a dimeric form and two higher oligomeric forms: an 18-mer
121 loped for the monomeric form, binds also the dimeric form but with a strikingly different kinetics.
122 Moreover, we also found that FaEO occurs in dimeric form in vivo and, as frequently observed for cal
125 Together, this study demonstrates that the dimeric form of the C-terminal module plays important si
127 io was lowered to 1:30, ALM was found in the dimeric form, indicating that the supramolecular organiz
129 odel whereby switching between monomeric and dimeric forms allows LIMP-2 to engage distinct binding p
130 l, including the structures of monomeric and dimeric forms, the mechanism of dimerization, features t
134 Here, we have modeled the 3D structure of dimeric, full-length LRRK2 by combining domain-based hom
139 tion of its DBD and LBD architecture and the dimeric geometry from its hypothesized Streptomyces homo
140 mined the crystal structures of the isolated dimeric globin domains of the active Fe(III)-CN(-) and i
144 esized as large precursors from which mature dimeric growth factors are released proteolytically.
149 ndary messenger c-di-GMP (Bis-(3'-5')-cyclic dimeric guanosine monophosphate), to make a vital choice
150 s by modulating levels of bis-(3',5')-cyclic-dimeric-guanosine (c-di-GMP), a second messenger that st
151 acterial second messenger bis-(3'-5')-cyclic-dimeric-guanosine monophosphate (c-di-GMP) acts as an in
155 ermolecular interactions in the full-length, dimeric HIV-1 5'-leader (688 nucleotides; 230 kDa).
157 t the 1.95 A resolution crystal structure of dimeric holo-ScNsrR and show that the cluster is coordin
159 These effects are similar in monomeric and dimeric Hv1 channels, suggesting that the Zn(2+)-binding
164 s reveal a head to head dimer with one major dimeric interface through the N-terminal HEAT (named aft
165 large glycan binding pocket extends into the dimeric interface, and docking of LDNF identified key re
172 an engineered form of sTie2, which presents dimeric ligand binding sites, inhibits Angpt1 signalling
174 ected using defined recombinant soluble (rs) dimeric low-affinity ectodomains (rsFcgammaR) that have
177 Preferential expression of the low-activity (dimeric) M2 isoform of pyruvate kinase (PK) over its con
179 epidermal growth factor receptor (EGFR) is a dimeric membrane protein that regulates key aspects of c
180 ed to successfully identify hitherto unknown dimeric methylalumina surface species during atomic laye
186 l evidence indicates that each tip link is a dimeric molecule, associated on average with two channel
188 vement of fluorescently labeled, processive, dimeric motor proteins and propose a unified algorithm t
191 nomeric unprocessed proMPO versus the mature dimeric MPO and the functional role of the propeptide.
192 14-3-3 family of intracellular proteins are dimeric, multifunctional adaptor proteins that bind to a
194 es in response to activation with CaM in the dimeric mutant, WT-holoenzyme, and a monomeric CaMKII ol
197 ained simulation that takes into account the dimeric nature of many nucleoid-associated proteins by a
198 ilament length distribution; and 4) that the dimeric nature of the motors needs to be considered when
201 oxidation states contrast with the cationic dimeric Ni analogue, in which both Ni centers are equiva
203 roportion of the receptor was present within dimeric/oligomeric complexes and that increased expressi
206 own galectins in mammalian cells, which have dimeric or tandem-repeated CRDs enabling multivalency fo
207 trates the ability of Vps75 to interact with dimeric or tetrameric H3-H4 using the same interaction s
208 issociate quickly, while cooperatively bound dimeric or trimeric clusters of gp32 bind much more tigh
210 ands represent a powerful tool for targeting dimeric OTR in neurodevelopmental and psychiatric disord
213 the identification and characterization of a dimeric Pd(I) species in two prototypical Pd-catalyzed a
217 ,3-triazolium-type side chain was studied on dimeric peptoid models with various patterns: alphaalpha
218 MARV VP40 (mVP40) has been shown to be a dimeric peripheral protein with a broad and flat basic s
222 iates and led to the characterization of new dimeric products in subsequent lignin depolymerization s
225 ystal structure reveals that this novel homo-dimeric protein has no identifiable structural homologue
226 4-10 fusion protein is a 70 kDa glycosylated dimeric protein that retains the functional activity of
230 protein corresponding to the symmetry of the dimeric protein; this model relaxes this assumption by a
231 d for the study of monomeric, dimerizing, or dimeric proteins but have limitations in discerning the
232 , we have demonstrated that a constitutively dimeric Prx1m mutant impairs the survival of Leishmania
233 The structure reveals interactions of the dimeric pseudonuclease core of TEFM with mobile structur
234 onane core skeleton of massadine and related dimeric pyrrole-imidazole alkaloids is a synthetic chall
235 ructure of B. thailandensis DNase II shows a dimeric quaternary structure which appears capable of bi
236 ferential potency on the two subunits of the dimeric receptor, which interact in an asymmetric manner
238 eceptor ephrinB2 and show that monomeric and dimeric receptors activate distinct conformational chang
239 monic generation, we show that monomeric and dimeric receptors activate distinct conformational chang
241 an in vitro tubulogenic assay; furthermore, dimeric-RGD conjugate 3 strongly inhibited in vivo angio
242 gen to give triphenylphosphine oxide and the dimeric rhenium(VII) complex fac,anti-(ONO(Cat))Re(O)(mu
247 surface-expressed FcgammaRs, the binding of dimeric rsFcgammaR ectodomains to Ab immune complexes wa
248 ed influenza A hemagglutinin correlated with dimeric rsFcgammaRIIIa binding activity but not with Ab
249 t with DNA as the cause of cell death, while dimeric Ru(ii) polypyridyl complexes are classified acco
250 In this Review, we present monomeric and dimeric Ru(ii) polypyridyl complexes, which have been fo
251 hlutine (2b), a set of hemiaminal containing dimeric sesquiterpenes isolated from yellow water lilies
252 that enable the full combinatorial scope of dimeric signaling receptors encoded within the human gen
254 the equilibrium mixture to two complexes: a dimeric species in which the Me2DAF bridges the two Pd c
257 archaeal box C/D sRNPs have demonstrated the dimeric sRNP (di-sRNP) architecture, which has been corr
260 trimeric complexes with HNO3 regenerates the dimeric starting complexes with the release of SO2 and N
261 alpha is kept in an inactive and exclusively dimeric state but undergoes rapid phosphorylation-induce
263 glucocerebrosidase-binding monomer toward a dimeric state that preferentially binds anionic phosphat
269 h the arm domain in the other monomer in the dimeric structure (i.e. the prodomain arm domain and GF
270 lorostibine complex [PdCl2(SbMe2Cl)2]2 has a dimeric structure in the solid state, stabilized by hype
271 ally tagged ATP7B variants indicate that the dimeric structure is retained during ATP7B trafficking b
272 a native tetramer that is distinct from the dimeric structure observed for other HSP40 co-chaperones
273 ked mutations tend to destabilize the native dimeric structure of SOD1, and plaques containing misfol
274 mputations and experiments differed from the dimeric structure resolved for the bacterial homolog, Le
275 cysteines with serine residues retained its dimeric structure, but diminished Asp f3's peroxidase ac
276 in which the (Cap)1G 5'-leader RNA adopts a dimeric structure, the (Cap)2G and (Cap)3G 5'-leader RNA
279 attention has been paid to the synthesis of dimeric structures, which combine two units of artemisin
281 We investigated dimeric beta-lactoglobulin, dimeric superoxide dismutase, dimeric and tetrameric con
286 4-5 orders of magnitude superior to that of dimeric TRAIL-Fc, but also manifests more favorable phar
289 ta2, and delta subunits were concatenated to dimeric, trimeric, and, in some cases, pentameric subuni
290 H10 is responsible for peripheral binding of dimeric tubulin to biomimetic "mitochondrial" membranes
292 entrifuge glargine was shown to be primarily dimeric under solvent conditions used in current formula
294 photoreception causes rapid dissociation of dimeric UVR8 into monomers that interact with CONSTITUTI
295 t with our previous hypothesis that specific dimeric viral RNA-Gag interactions are the nucleation ev
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