ライフサイエンスコーパス: dimerization

1 Mutagenesis of Cys-298 confirmed its role in dimerization.

2 lowing the caspase-like domain inhibits this dimerization.

3 in which double-stranded RNA mediates enzyme dimerization.

4 ness of the helical foldamers as well as HCA dimerization.

5 sought to determine whether it functions via dimerization.

6 lecular disulfide bonds, leading to receptor dimerization.

7 l they are trapped in a fixed orientation by dimerization.

8 their HH domains, which then triggers U-box dimerization.

9 ed by a synthetic peptide that inhibits CtBP dimerization.

10 tions, is known to mediate light-induced VVD dimerization.

11 role of the transmembrane domain in receptor dimerization.

12 C-Raf dimerization, but rather, they precede dimerization.

13 of spiperone and haloperidol to disrupt D3R dimerization.

14 hosphorylation depended on asymmetric kinase dimerization.

15 han EGF-making them partial agonists of EGFR dimerization.

16 that disulfide bridges are involved in KCC2 dimerization.

17 rically modulated under conditions promoting dimerization.

18 both of which provide key interfaces for D3R dimerization.

19 e but did so without interfering with kinase dimerization.

20 formation of bispyrylium species by radical dimerization.

21 served KCC2 C-ter may be at the interface of dimerization.

22 We show that FKF1 can inhibit COP1 homo-dimerization.

23 implying that cFLIPL acted upstream of IRF7 dimerization.

24 lying that Wnt binding mediates FZD receptor dimerization.

25 re compact form rather than a ligand-induced dimerization.

26 itopes important for receptor binding or DBP dimerization.

27 and 4, but not TMD5, 6, and 7, disrupted APJ dimerization.

28 pparent site size requirement for sequential dimerization.

29 factors, membrane localization, and receptor dimerization.

30 pha in a 1:2 complex and stabilizes ER-alpha dimerization.

31 ular region (ECR) in ligand-induced receptor dimerization.

32 sters the dimer initiation signal preventing dimerization.

33 ix 4 (TM4) that is known to be important for dimerization.

34 ysis is to study relative levels of receptor dimerization.

35 y blocking blue light-dependent cryptochrome dimerization.

36 2 is essential for its role in dNTP-induced dimerization.

37 Disruption of GTPase domain dimerization abolishes the fusogenic activity of MFN1.

38 acetylation/deacetylimination disrupts Stat3 dimerization, abolishes Stat3 transcription activity, an

39 Disruption of PKD dimerization abrogates secretion of PAUF, a protein carr

40 d1 phosphoregulation, and consequently Hand1 dimerization affinities, results in a severe truncation

41 revealing a nearly eightfold enhancement in dimerization affinity at low pH.

42 idine kinase-related domain known to promote dimerization and a conserved patch just upstream of an N

43 impair ATP-induced nucleotide-binding domain dimerization and ABCB4 function.

44 -binding kinase 1 (TBK1) by facilitating its dimerization and ability to phosphorylate the selective

45 We find that Ang1-induced Tie2 dimerization and activation occurs via the formation of

46 the ZNF767-BRAF fusion protein promotes RAF dimerization and activation of the MAPK pathway.

47 th factor beta receptor (PDGFbetaR), causing dimerization and activation of the receptor.

48 k and Torso-like, which cooperate to mediate dimerization and activation of Torso at the ends of the

49 horylate TBK1 at Tyr354/394, to prevent TBK1 dimerization and activation.

50 and TLR6 have an essential role in receptor dimerization and activation.

51 scovery of the mechanism involved in channel dimerization and biophysical coupling could open the doo

52 this interface interfere with both Pcdh cis-dimerization and cell surface transport.

53 pTRS1 did not block PKR dimerization and could bind and inhibit a constitutively

54 All variants underwent dimerization and crossover concurrently, and at wild-typ

55 demonstrate how E5 binding induces receptor dimerization and define a molecular mechanism of recepto

56 We identify the region involved in the dimerization and demonstrate that 14-3-3 protein mediate

57 and the Cupin domain, thereby promoting CuxR dimerization and DNA binding.

58 nal pH below this threshold, increasing OmpR dimerization and DNA binding.

59 oring protein AKAP18alpha, revealed that the dimerization and docking domain of RIIbeta is between it

60 The formation of olefins by the eliminative dimerization and eliminative cross-coupling of carbenoid

61 inhibition by sorafenib rapidly leads to RAF dimerization and ERK activation in HCCs, which contribut

62 ated, oncogenic Ras isoforms can promote Raf dimerization and fully activate MAPK signaling.

63 ct iron-sulfur cluster was required for HemW dimerization and HemW-catalyzed heme transfer but not fo

64 first insight into the relationship between dimerization and ILEI function as well as indicate an in

65 FR-ERK pathway by blocking EGF-mediated EGFR dimerization and internalization but also suppressed cel

66 tional impact inhibiting Hsp90alpha N-domain dimerization and involving a region of the middle domain

67 we examined the possible mechanisms of hDAT dimerization and its dynamics in a lipid bilayer.

68 We find that Swi6 and Chp2 have similar dimerization and oligomerization equilibria, and that Sw

69 While the effect of these nt-pairings on dimerization and packaging has been documented their eff

70 and elevates tetrahydrobiopterin levels, the dimerization and phosphorylation of neuronal nitric oxid

71 titution of all tryptophan residues ablating dimerization and self-renewal function completely.

72 t microcompartments sustains robust receptor dimerization and signalling.

73 We identify point mutations that disrupt dimerization and Skp1 binding in vitro and find that the

74 N-linked glycans on CD146 and induced CD146 dimerization and subsequent activation of AKT signaling.

75 results allowed us to single out the role of dimerization and that of the C-terminus in the complete

76 F-independent self-renewal, the mechanism of dimerization and the effect of modulating dimerization s

77 this increase in s - either a ligand induced dimerization and/or compaction of the monomer are consid

78 well as electronic preferences of oxidative dimerization, and a mechanism involving amine radical ca

79 h Src family inhibitors blocks growth, basal dimerization, and ERK activation in these cells.

80 ity for inhibiting STAT3 phosphorylation and dimerization, and inducing apoptosis to constitutively a

81 , through autoinhibition, positive feedback, dimerization, and interactions with a suite of small GTP

82 n, because channel gating involves NBD1/NBD2 dimerization, and NBD2 contains the catalytically active

83 lations (phospho-Y341) is required for C-Raf dimerization, and this action can be replicated by phosp

84 In particular, devices based on radical dimerization are appropriate because of the effectivenes

85 d show the potential of inhibiting TLR4-TLR6 dimerization as a treatment of Alzheimer's disease.

86 ctivity of Fic is, in part, regulated by Fic dimerization, as loss of this dimerization increases AMP

87 TRPM7's exchange domain that mediates kinase dimerization, as potential regulatory sites.

88 re we couple mutagenesis with functional and dimerization assays to show that the number of tryptopha

89 The mechanism involves trans-dimerization between GTPase heads and a favorable crosso

90 hermore, A673V mutation resulted in stronger dimerization between mutant and wild-type APP, enhanced

91 Furthermore, A673V mutation caused stronger dimerization between mutant and wild-type APP, enhanced

92 This unique dimerization-binding mode opens new prospects for the op

93 Y2 homo-oligomerization and CRY2-CIB1 hetero-dimerization, both of which have been widely used to opt

94 ith retromer did not interfere with retromer dimerization but was essential for association of RidL w

95 these N-region sites does not require C-Raf dimerization, but rather, they precede dimerization.

96 r, reveals efficient ligand-induced receptor dimerization by all ligands, largely independent of rece

97 These fragments have reduced dimerization capacity, compete with intact Pen a 1 for b

98 lutions are found to help both the oxidative dimerization cascade and the intramolecular Diels-Alder

99 Whereas PLX8394 decreased BRAF-fusion dimerization, CRAF-fusion dimerization is unaffected pri

100 Instead, ParA-AMPPNP dimerization creates a multifaceted DNA-binding surface,

101 icient in the screening and the shape of the dimerization curve in small-angle X-ray scattering (SAXS

102 A dimerization-defective mutant of Nef failed to interact

103 c explanation for previous observations that dimerization-defective Nef mutants fail to down-regulate

104 y2 locus was verified to promote cooperative dimerization designating Sprouty2 as a potential target

105 Dimerization did not act through a physical clustering-b

106 As sequential dimerization did not occur with the ETS domain of Ets-1,

107 nt lesions we identified activate BRAF V600E dimerization directly or by elevating RAS-GTP.

108 ic mice also expressing RARalpha linked to a dimerization domain (p50-RARalpha model) exhibited a dou

109 ely, these data highlight roles for the Stu2 dimerization domain as a scaffold for factor binding tha

110 Nanog protein exists as a dimer with the dimerization domain composed of a simple repeat region i

111 phenotype was dependent on the presence of a dimerization domain contained within the CRY2-fused tran

112 The HKRD is a dimerization domain for PHYB homo and heterodimerization

113 oteins with diverse activities through their dimerization domain, the chromoshadow domain.

114 de formation within the PKGIalpha N-terminal dimerization domain.

115 Conversely, when IkappaBalpha binds to the dimerization domains, amide exchange throughout the DNA-

116 partial dissociation of PsbV, regulation of dimerization, downsizing of phycobilisomes rods and regu

117 nge is likely caused by a lack of CH3 domain dimerization (due to the three "hole" point mutations),

118 mechanistically arises from altered receptor dimerization dynamics due to extracellular binding chang

119 Unexpectedly, this weakened dimerization elicits more sustained EGFR signaling than

120 For each of these hominid A3C enzymes, dimerization enables processivity on single-stranded DNA

121 calculations were used for evaluation of the dimerization energies and for interpretation of the phot

122 e Hammett para substituent parameter and the dimerization equilibrium constant, with para electron-do

123 alized pathway involving fast cation radical dimerization following electron transfer, followed by di

124 Moreover, based on the requirement of dimerization for strong fluorogen activation, a prototyp

125 ient limitation, bacterial ribosomes undergo dimerization, forming a 100S complex that is translation

126 was proposed to act as a GTPase activated by dimerization (GAD), while recent reports suggest LRRK2 t

127 The role of this region in cyclase dimerization has been a subject of debate.

128 ilizing, but their energetic contribution to dimerization has yet to be determined experimentally.

129 Assessment of dimerization heterogeneity of these TM domains demonstra

130 acteristic for human ATP7B, does not disrupt dimerization, i.e. the dimer interface is formed by the

131 How transcription factor dimerization impacts DNA-binding specificity is poorly u

132 onfigurations can support functional Sox/Oct dimerization in addition to known composite motifs.

133 a combination of truncations and artificial dimerization in budding yeast to define the minimal CPC

134 NMR studies of dimerization in C6 D6 find aromaticity-modulated H-bondi

135 re the structural basis of Ang1-induced Tie2 dimerization in cis and provide mechanistic insights on

136 and ERK1/2 and remarkably disrupted the TLR4 dimerization in LPS-induced RAW264.7 macrophages.

137 ne of them (dimer 1) in soluble Tie2 (sTie2) dimerization in solution but suggests that both could pl

138 formational changes to promote GTPase domain dimerization in the transition state.

139 shoot cell-wall enzymes did not affect RG-II dimerization in vitro.

140 gulated by Fic dimerization, as loss of this dimerization increases AMPylation and reduces deAMPylati

141 Our findings support TLR4-TLR6 dimerization induced by Abeta.

142 The resultant mutant protein had increased dimerization, induced elevated VEGFR-2 signaling, and ca

143 Antitumor GO peptides have been designed as dimerization inhibitors of prominent oncoprotein mucin 1

144 on the heme-proximal side (helix H5), at the dimerization interface (helices H6 and H7 and loop L7) o

145 ed the solvent exposure of the globin domain-dimerization interface (helix H6) as well as the flexibi

146 ll molecule previously shown to bind the Nef dimerization interface also reduced Nef interactions wit

147 f KCC2 with variable anchoring points at the dimerization interface and an important C-ter extremity

148 of BTN3A molecules identified as a possible dimerization interface and that is located close to the

149 il to down-regulate CD4 and validate the Nef dimerization interface as a target site for antiretrovir

150 therapeutic that stabilizes an ATP-dependent dimerization interface in topo II to block enzyme activi

151 We further demonstrate that this unique dimerization interface is crucial for their biological a

152 The GxxxG motif is frequently found at the dimerization interface of a transmembrane structural mot

153 The dimerization interface structure in noncrystalline CA as

154 steric network linking a cryptic site at the dimerization interface to enzyme function.

155 Further, we found that an intact GR dimerization interface was a prerequisite for the suppre

156 at the heme-proximal side, the globin domain-dimerization interface, and the ATP-binding site are imp

157 ion decreased upon adding EGF fall along the dimerization interface, consistent with models derived f

158 region has an autoinhibitory function and a dimerization interface, which appears to mediate positiv

159 istal surface away from the bound DNA as the dimerization interface.

160 made of four distinct domains and a flexible dimerization interface.

161 ons lie along their evolutionarily conserved dimerization interface.

162 by surface residues that face away from the dimerization interface.

163 in some cases, TLR1, at the vicinity of the dimerization interface; the cationic headgroups form mul

164 ement (HRE), and is globally affected by the dimerization interfaces and interdomain interactions.

165 Our model describes E1-E2 ectodomain dimerization interfaces, provides a structural explanati

166 A1 require two previously identified TIR-TIR dimerization interfaces.

167 ree energy calculations indicated that K-Ras dimerization involves direct but weak protein-protein in

168 We propose that dimerization is a predictor of A3C enzyme activity.

169 GPCR dimerization is a well-established phenomenon that can a

170 The activation energy (35 kJ/mol) for dimerization is almost identical to this enthalpy differ

171 Octamer dimerization is consistent with the adhesive function of

172 the phosphorylation of Y341 in promoting Raf dimerization is distinct from its well-known function in

173 in solution, consistent with the notion that dimerization is facilitated by membrane binding.

174 ction and stability in vivo, indicating that dimerization is functionally important for the biologica

175 g artificial membranes confirm that receptor dimerization is governed by the two-dimensional ligand-r

176 ure displays a dimeric architecture in which dimerization is mediated by centralized Gate domains.

177 Dimerization is mediated by membrane-proximal fibronecti

178 Dimerization is thought to contribute to their elevated

179 reased BRAF-fusion dimerization, CRAF-fusion dimerization is unaffected primarily because of robust p

180 toxidation conditions and undergo very rapid dimerization (k = 5 x 10(9) M(-1) s(-1)) in lieu of reac

181 ligomers at equilibrium and to determine the dimerization kinetics.

182 n importance of E73 in VDAC physiology, VDAC dimerization likely plays a significant role in mitochon

183 ion of cysteines at these positions enhanced dimerization likely through the formation of an intermol

184 Thus, dimerization may serve as a unique mechanism for fine-tu

185 sis suggested that this region facilitates a dimerization mode that is conserved between PEAK1 and pr

186 tified SHED region may promote an unexpected dimerization mode.

187 is is the first method that identifies helix dimerization modes and ranks them based on the calculate

188 ains, Tie2(FNIIIa-c), revealing two possible dimerization modes that primarily involve the third FNII

189 e tail-truncated myosin-X without artificial dimerization motif (BAP-M10(1-979)HMM).

190 caterpillars that could be linked to the MIA dimerization observed in intestinal tracts.

191 Dimerization occurred with sub-second lifetimes, which w

192 pre-dimerization to ligand-induced receptor dimerization occurring only after receptor uptake into e

193 lkyl- and 6-aryluracils was developed by the dimerization of 3-alkyl- and 3-aryl-2-propynamides promo

194 Using this method, we observe ligand-induced dimerization of a receptor tyrosine kinase at the cell s

195 On H-ZSM-5, dimerization of adsorbed pentenes occurs at a slower rat

196 They efficiently promote the catalytic dimerization of aryl acetylenes giving the corresponding

197 CRAF but not BRAF, and Figure 4A, where the dimerization of BRAF and CRAF was modulated by the RAF i

198 ise to complex biofilm architecture, whereas dimerization of BslA is required to render the community

199 Dimerization of BslA, mediated by disulfide bond formati

200 c cancer cell lines, the phosphorylation and dimerization of C-Raf are basally elevated.

201 [2+2] Photocycloaddition, for example, the dimerization of chalcones and cinnamic acid derivatives,

202 CS: small molecules that can induce the homo-dimerization of E3 ubiquitin ligases and cause their pro

203 These data suggest that CaM-induced dimerization of ER-alpha is required for estrogen-stimul

204 tal-organic framework (MOF) catalyst for the dimerization of ethylene has a combination of selectivit

205 , with or without pertuzumab (which inhibits dimerization of HER2 with HER3) or a specific antibody a

206 ering studies indicated that heparin induced dimerization of hIL-12.

207 A D1040V mutation, which disrupts the dimerization of HKRD and the interaction between C-termi

208 the binding of Ca(2+) to hSCGN promotes the dimerization of hSCGN via the formation of a Cys193-Cys1

209 Ca(2+)-induced structural changes promoting dimerization of hSCGN.

210 Dimerization of IreB was confirmed in vivo.

211 in live cells, we show that WNT5A stimulates dimerization of membrane-anchored FZD4 CRDs and oligomer

212 Herein, we report a specific pH-dependent dimerization of murine VDAC1 (mVDAC1) identified by doub

213 The dimerization of Nab2 induced by RNA binding provides a b

214 od of substituted azoxybenzenes by reductive dimerization of nitrosobenzenes.

215 idin (gA) channel formation is transmembrane dimerization of nonconducting subunits that reside in op

216 mono Au(I)-catalyzed pendant to the radical dimerization of nonconjugated alkyne units has not been

217 n-derived dodecasaccharide is able to induce dimerization of OPG monomers with a stoichiometry of 1:1

218 Further, we observe the dimerization of P. aeruginosa outer domains without any

219 ne fusion mediated by RHD3 requires a proper dimerization of RHD3 through the GTPase domain (GD) and

220 family of alkaloids,2,3 all of which employ dimerization of symmetric monomers to form the aforement

221 ing bases were required to invoke sequential dimerization of the bound protein.

222 a 2-AR), folding of the FiP35 WW domain, and dimerization of the E. coli molybdopterin synthase subun

223 y and strength of the previously established dimerization of the important glycopeptide antibiotic va

224 H)-treated hepatocytes is caused by impaired dimerization of the largest Golgi matrix protein, gianti

225 some favorable enthalpic contribution to the dimerization of the monomeric complex units, large flexi

226 While dimers were virtually unbreakable, dimerization of the monomeric population was promoted th

227 cargo binding dynein tail and show how self-dimerization of the motor domains locks them in a confor

228 ucleotide-free states reveals how reversible dimerization of the nucleotide binding domains drives op

229 lization, beta-elimination of the ynone, and dimerization of the resultant alpha-amino carbonyls all

230 monstrate that differently from LPS-mediated dimerization of the TLR4-MD2 complex, palmitate binds a

231 YAP blocked dimerization of the transcription factor IRF3 and impede

232 Competitive homo- and hetero-dimerization of their amino-terminal domains (ATDs) is a

233 ing to Toll-like receptors (TLRs) results in dimerization of their cytosolic Toll/interleukin-1 recep

234 ive hydroxylation of phenylboronic acids and dimerization of thiophenol demonstrate the capabilities

235 ations, we describe the mono Au(I)-catalyzed dimerization of two alkyne units as well as the transann

236 Dimerization of yeast Sgt1 occurs via an insertion that

237 tural methods, that binding A11G RNA induces dimerization of Zn fingers 5-7 mediated by the novel spa

238 e energetics and reaction mechanisms for the dimerizations of two different polyfluorinated precursor

239 opto-Dab1) by using the blue light-sensitive dimerization/oligomerization property of A. thaliana Cry

240 (Coop-seq) approach to interrogate Sox2/Pax6 dimerization on a DNA library where five positions of th

241 ng the membrane-spanning domains but not the dimerization or HATPase domain, is sufficient to complem

242 cells that explores the chemically inducible dimerization paradigm.

243 unaffected by the presence or absence of its dimerization partner.

244 ntagonist effect of calixarenes on TLR4/MD-2 dimerization, pointing at the calixarene moiety as a pot

245 This dimerization points to a certain degree of regioselectiv

246 pH-driven dimerization proceeded with characteristic fast kinetics

247 The study reveals specific dimerization profiles of different Sox factors with Oct4

248 In contrast, dimerization promotes recruitment to clustered binding s

249 n bonding predicts the experimental trend of dimerization propensities.

250 Guided by protein dimerization properties, we examined DNA binding specifi

251 Herein, we identify c-JUN-dimerization protein 2 (JDP2) as a novel repressor of GN

252 The dimerization rate (6.0 x 10(8) M(-1) s(-1)) and half-lif

253 In a closed system, the dimerization rate is first order in the concentration of

254 inhibits topo II by preventing ATPase domain dimerization rather than stabilizing it.

255 iral 1,3-dienes and 3 acrylates, this hetero-dimerization reaction is tolerant of a number of common

256 e method to realize the intermolecular [2+2] dimerization reaction of these acyclic olefins to constr

257 t, in the absence of tricin, more monolignol dimerization reactions occur.

258 ivated upon ligand binding-leads to receptor dimerization, recruitment of protein complexes, and acti

259 acts dimer formation by associating with the dimerization region intramolecularly.

260 monoclonal antibody targeting the AGR2 self-dimerization region, and combined treatment with bevaciz

261 ate a highly unusual all alpha-helical split-dimerization region, termed here the split helical dimer

262 s mediated by the disruption of CD45 protein dimerization regulated by sialic acid.

263 APJ dimerization resulted in novel functional characteristic

264 rane at a time), binding of ATP promotes NBD dimerization, resulting in external accessibility of the

265 nvolves a novel 5-exo-dig cycloisomerization-dimerization sequence to afford formal Diels-Alder adduc

266 zation region, termed here the split helical dimerization (SHED) region.

267 aptogenic activity, involving trans-synaptic dimerization, similar to other synaptic cell adhesion mo

268 This effect depends on protein dimerization, since monomeric Gal-1 fails to stimulate a

269 ven receptor subtype based on the receptor's dimerization state.

270 fferent EGFR ligands are defined by receptor dimerization strength and signaling dynamics.

271 of dimerization and the effect of modulating dimerization strength have been unclear.

272 nal change in the retinoschisin octamer upon dimerization, suggesting that the octamer provides a sta

273 in their final orientations independently of dimerization, suggesting that wholesale topological inve

274 h native Sli15 is not oligomeric, artificial dimerization suppressed the biorientation defect and let

275 O)3(CH3CN)](OTf), which prevents Mn(0)-Mn(0) dimerization, the [(MeO)2Ph]2bpy ligand introduces an ad

276 res the ectodomain cysteines needed for BST2 dimerization, the putative BST2 tetramerization residue

277 Compound-induced RAF dimerization through stabilization of the RAF ON/active

278 ranging from ligand-independent receptor pre-dimerization to ligand-induced receptor dimerization occ

279 In this study, we used chemically induced dimerization to rapidly relocalize proteins from the cyt

280 dulate stability in GASright and finely tune dimerization to support biological function.

281 We used chemically-induced dimerization to translocate inositol polyphosphate 5-pho

282 Thus, pro-domain dimerization, together with partial rearrangement of the

283 ased SCF partial agonist that impaired c-Kit dimerization, truncating downstream signaling amplitude.

284 C bonds in the kinetically relevant step for dimerization turnovers on protons within TON (0.57 nm) a

285 By interfering with TLR4-TLR6 dimerization using a TLR4-derived peptide, we show that

286 The promotion of protein dimerization using the aggregation properties of a prote

287 By perturbing dimerization using various means, we show that the membr

288 uctures reveal that compound 19 induces MDM2 dimerization via the aliphatic linker.

289 member of the myosin superfamily that, upon dimerization, walks processively toward the pointed end

290 says of downstream signaling activity, Torso dimerization was detected using bimolecular fluorescence

291 A key biomimetic Diels-Alder dimerization was found to occur at ambient temperature a

292 he bonding thermodynamic parameters for self-dimerization were determined from van't Hoff plots obtai

293 The stably folded NTD also promotes dimerization, which is pertinent to the protein's activi

294 emble exclusively through stalk and G-domain dimerizations, which generates an expanded helical symme

295 y of a single Cas9 ortholog and induces Cas9 dimerization while preventing binding to the target DNA.

296 one sequesters the gag start codon promoting dimerization while the other sequesters the dimer initia

297 The Duffy binding protein (DBP) dimerization with its cognate receptor is vital for junc

298 ing by Pax6 need to be mutated for effective dimerization with Sox2.

299 Disrupting motor dimerization with structure-based mutagenesis drives dyn

300 ic cleavage of the C-terminal extension, and dimerization with the small subunit.