ライフサイエンスコーパス: dimerization interface

1 by surface residues that face away from the dimerization interface.

2 n of charged residues in the hydrophobic BAR-dimerization interface.

3 ting through specific surface charges at the dimerization interface.

4 s of Glu50 and Arg64 residues located on the dimerization interface.

5 ture in a heptapeptide strand that forms the dimerization interface.

6 e MD-2/TLR4 interaction surface opposite the dimerization interface.

7 Site 2 metal binding sites are formed at the dimerization interface.

8 e, and this requires the predicted Cse4-Cse4 dimerization interface.

9 t human, TLR4 (Lys(367) and Arg(434)) at the dimerization interface.

10 ry structure of the homodimer, affecting the dimerization interface.

11 istal surface away from the bound DNA as the dimerization interface.

12 n interaction is trans, where it adds to the dimerization interface.

13 appears to brace the principal helix of the dimerization interface.

14 ut reveals an unexpected twist and a complex dimerization interface.

15 ing pocket and had allosteric effects on the dimerization interface.

16 the hormone-binding site or the amino domain dimerization interface.

17 eric transporter that binds substrate at the dimerization interface.

18 thetic binding pocket within an interhelical dimerization interface.

19 n the two antiparallel alpha6 helices at the dimerization interface.

20 that likely involves occlusion of the H3-H3 dimerization interface.

21 oiled coil domain that serves as its primary dimerization interface.

22 esting that the C terminus forms part of the dimerization interface.

23 th the substrate-binding site as well as the dimerization interface.

24 /mol) being mediated by the mutations at the dimerization interface.

25 lly disrupted by single mutations in the RXR dimerization interface.

26 large domain rearrangement that exposes this dimerization interface.

27 ical active site capping domain and a unique dimerization interface.

28 itors aimed at binding to the monomer at the dimerization interface.

29 cture emerges of the C linker as a potential dimerization interface.

30 erminus of AR, which lies in a groove at the dimerization interface.

31 me face of an alpha-helix that constitutes a dimerization interface.

32 tracellular end, is likely to be part of the dimerization interface.

33 ed coil formed by two long helices along the dimerization interface.

34 at places the B7 binding sites distal to the dimerization interface.

35 the protein, and changes in residues in the dimerization interface.

36 the altered residues reside at the putative dimerization interface.

37 ever, is not uniformly distributed along the dimerization interface.

38 dependent on disorder or variability in the dimerization interface.

39 ressor may also be distinct from that of its dimerization interface.

40 ther VirB8 homologs but displayed an altered dimerization interface.

41 made of four distinct domains and a flexible dimerization interface.

42 ons lie along their evolutionarily conserved dimerization interface.

43 affinity to an extended hairpin loop at the dimerization interface.

44 IT acts on an allosteric site other than the dimerization interface.

45 the core domain, some 20 degrees against the dimerization interface.

46 smembrane helix 4 (TM4) provides the primary dimerization interface.

47 unknown function that appears to extend the dimerization interface.

48 residues strategically positioned within the dimerization interface.

49 ar relevance to drug binding and part of the dimerization interface.

50 hain of the AHL is in close proximity to the dimerization interfaces.

51 A1 require two previously identified TIR-TIR dimerization interfaces.

52 activity by structure-based targeting of the dimerization interfaces.

53 are stabilized by multiple, relatively weak dimerization interfaces.

54 omain-not from the intertwined nature of the dimerization interface; (2) residues 2-66 contain all of

55 ases involving three types of interface: the dimerization interface, a primary substrate-like interac

56 Mutations in the N-domain dimerization interface abolished assembly of nonphosphor

57 he ATPase domain by disrupting the off-state dimerization interface along the helical linker region b

58 ll molecule previously shown to bind the Nef dimerization interface also reduced Nef interactions wit

59 establish the stem region of MT6-MMP as the dimerization interface, an event whose outcome imparts p

60 relaxation in other regions, including a PAS dimerization interface and a segment in the H-NOX domain

61 ins (LBDs), which reveals an unusually large dimerization interface and a small CAR ligand binding po

62 f KCC2 with variable anchoring points at the dimerization interface and an important C-ter extremity

63 tated residues that comprise the core of the dimerization interface and characterized the ability of

64 is shows that QsIA binding occupies the LasR dimerization interface and consequently disrupts LasR di

65 lution to re-engineer the serine recombinase dimerization interface and generate a recombinase archit

66 e beta and gamma subunits contributes to the dimerization interface and has been implicated in effect

67 t this motif was buried within the channel's dimerization interface and identified two cytoplasmicall

68 combination of computational analysis of the dimerization interface and in silico screening, we ident

69 ligand-binding pocket and at loops near the dimerization interface and interlobe hinge region.

70 nded enzyme propagate some 20 to 25 A to the dimerization interface and lead to a rearrangement of mo

71 ation inhibitors are usually targeted to the dimerization interface and need to compete with the attr

72 ved in previous studies due to the extensive dimerization interface and presence of lipopolysaccharid

73 R confirms the feasibility of a close-packed dimerization interface and suggests a possible solution

74 of BTN3A molecules identified as a possible dimerization interface and that is located close to the

75 s energy of stabilization is provided by the dimerization interface and that the isolated subunits ar

76 rbonate ions simultaneously bind to both the dimerization interface and the allosteric sites.

77 The protein-DNA contacts, the dimerization interface and the DNA curvature in the RXR-

78 ement (HRE), and is globally affected by the dimerization interfaces and interdomain interactions.

79 of these domains contributed residues to the dimerization interface, and competition experiments reve

80 at hinge opening starts from one side of the dimerization interface, and is coordinated by highly con

81 al amphipathic helix constitutes part of the dimerization interface, and similar N-terminal helices a

82 at the heme-proximal side, the globin domain-dimerization interface, and the ATP-binding site are imp

83 e the same Oct-1 residues that form the MORE dimerization interface are also used for OBF-1/Oct-1 int

84 s predicted to be the most disruptive at the dimerization interface are found to be less specific to

85 homodimer, and the residues involved in the dimerization interface are similar to those implicated i

86 d local 3-fold symmetry axes, and in CTD-CTD dimerization interfaces are less significant.

87 The data indicate that different dimerization interfaces are used for v-ErbA homodimeriza

88 ith retinoid X receptor alpha, and different dimerization interfaces are used on differently oriented

89 ation domain, but not those that involve the dimerization interface, are disrupted following ligand b

90 il to down-regulate CD4 and validate the Nef dimerization interface as a target site for antiretrovir

91 op, which contains residue 225, could form a dimerization interface as was observed in the P450 2C8 c

92 Together with another dimerization interface at D1, a band-like one-dimensiona

93 Our results suggest for an Asn in the dimerization interface at least a pair of hydrophobic in

94 The unique solution dimerization interface at low ionic strength was mapped

95 ond, hitherto unidentified, helix-turn-helix dimerization interface at the C-terminal end of the olig

96 molecular-dynamics simulations, we propose a dimerization interface between alpha-helices 4 and 5 and

97 aper in this issue of Proceedings, reveals a dimerization interface between catalytic domains.

98 suggesting differences in the intermolecular dimerization interface between curved and planar CA latt

99 to and is predicted to disrupt the proposed dimerization interface between FLT3L monomers exhibits a

100 These data demonstrate that the dimerization interface between TAP1 and TAP2 and the tap

101 ystem for further structural analysis of the dimerization interface between the RAR and RXR ligand bi

102 odurans phytochrome, we demonstrate that two dimerization interfaces between sister GAF and HK domain

103 Mutations at the predicted dimerization interface block dimerization and reduce the

104 merization; and (6) F1443 is involved in the dimerization interface but is exposed to the solvent.

105 n to the output module likely depends on the dimerization interface but its architecture and response

106 s variants is not a result of defects in the dimerization interface but rather disparate global prope

107 g domains are covalently linked across their dimerization interface by a disulfide bond formed by a h

108 f the model, disruption of the known PhoB(N) dimerization interface by mutation led to markedly slowe

109 al capsid CTD but uses an entirely different dimerization interface caused by swapping the MHR-like e

110 ing motifs in the active site and a distinct dimerization interface compared with other ATP sulfuryla

111 ace that does not directly contribute to the dimerization interface completely abolishes this couplin

112 within a highly symmetrical region at the IN dimerization interface, composed of a four-tiered aromat

113 ion decreased upon adding EGF fall along the dimerization interface, consistent with models derived f

114 coexpressed support the idea that the CA-CTD dimerization interface consists of two reciprocal intera

115 tions were enabled by charge reversal at the dimerization interface, defining the basis of lipid IV(A

116 n site determinants (Ser74 and Phe76) in the dimerization interface destabilized the dimer in solutio

117 rast to the localized folding induced in the dimerization interface, DNA binding leads to unfolding o

118 binds an ephrin ligand through an expansive dimerization interface dominated by the insertion of an

119 Mutations in the Nef dimerization interface dramatically reduced both Nef-ind

120 boring residues have evolved to engineer its dimerization interface, enabling it to subserve specific

121 Existing structural data suggest that two dimerization interfaces exist between the GAF and HK dom

122 argest RR subfamily, which share a conserved dimerization interface for phosphorylation-mediated tran

123 lice site of TyrRSDeltaE2-3 prevented either dimerization interface from forming, and yielded a predo

124 precise nature of the functional form of CTD dimerization interface has been a subject of considerabl

125 omain (residues 1-105), lacking a C-terminal dimerization interface, has been constructed and the NMR

126 hile many of the binding interactions at the dimerization interface have been extensively studied, th

127 al high-resolution structures of the CTD-CTD dimerization interface have been reported, based on X-ra

128 ance and structural requirements to form the dimerization interface have yet to be elucidated.

129 on the heme-proximal side (helix H5), at the dimerization interface (helices H6 and H7 and loop L7) o

130 S1, S2), as well as residues located at the dimerization interface (helices H9 and H10).

131 ed the solvent exposure of the globin domain-dimerization interface (helix H6) as well as the flexibi

132 ulation of residues involved in the receptor dimerization interface identified one residue (position

133 0 proteins, and we have defined an extensive dimerization interface in A20.

134 ed MHR residues and other amino acids at the dimerization interface in CTD folding, stability, and di

135 Our crystal structure also reveals a dimerization interface in GATA that has previously been

136 This sequence was originally found at the dimerization interface in glycophorin A, and it promotes

137 This energetic dissection of the dimerization interface in MHR-swapped CTD may also facil

138 Here we show that a novel dimerization interface in the E2 transcription activatio

139 One element corresponds to a dimerization interface in the ETS domain and the second

140 ns exist between lipid IV(A) and TLR4 at the dimerization interface in the mouse complex only.

141 o a unique high-resolution structure for the dimerization interface in the noncrystalline lattice of

142 therapeutic that stabilizes an ATP-dependent dimerization interface in topo II to block enzyme activi

143 describe solid state NMR measurements on the dimerization interface in tubular CA assemblies, which c

144 CAM-1 IgSF domains (D) 3-5 revealed a unique dimerization interface in which D4s of two protomers fus

145 results suggest functional importance of the dimerization interfaces in bacteriophytochromes.

146 a sequence analysis tool to predict possible dimerization interfaces in GPCRs.

147 roves our understanding of the role of these dimerization interfaces in the mechanism of action not o

148 bation of the substrate binding site and the dimerization interface, indicating that this small molec

149 Contrary to previous predictions, the dimerization interface involves the carboxyl terminus of

150 The structure shows a unique dimerization interface involving the DD-loop and EE-loop

151 oss-subunit" arrangement containing multiple dimerization interfaces involving both domains of each s

152 A key feature of the PKR dimerization interface is a salt bridge interaction betw

153 We further demonstrate that this unique dimerization interface is crucial for their biological a

154 rbB3 extracellular domain (ECD) in which the dimerization interface is exposed.

155 tor chaperones dimerize, the location of the dimerization interface is in dispute.

156 The structure reveals a dimer, in which the dimerization interface is mediated by the cleavage domai

157 Therefore, identification of the TLR4-TIR dimerization interface is one key to the rational design

158 cryogenic electron microscopy (cryoEM), the dimerization interface is substantially disordered.

159 This dimerization interface is validated by peptide mapping t

160 The existence of both dimerization interfaces is critical for thermal reversio

161 We find that the dimerization interface lies on a surface region remote f

162 nique heterodimerization that is mediated by dimerization interfaces located in their DNA-binding dom

163 ly more favorable target sites away from the dimerization interface may also lead to subunit dissocia

164 This C-terminal dimerization interface might be important for the assemb

165 Rather, mutating the dimerization interface mitigates DNA-induced changes in

166 imerization was probed further by generating dimerization interface mutants (N381A and R385A) of V. c

167 ation, we used confocal imaging to show that dimerization interface mutants of M fail to assemble int

168 Dimerization interface mutations destabilize the M dimer

169 ause MD-2 residues 122 and 125 reside at the dimerization interface near the pocket entrance, surface

170 The DNA-binding domain dimerization interface observed in our structures is ess

171 The dimerization interface observed in the X-ray structure w

172 The GxxxG motif is frequently found at the dimerization interface of a transmembrane structural mot

173 otypes altered residues located close to the dimerization interface of BirA.

174 elix transition that extends the coiled-coil dimerization interface of CAP by 3 turns of helix and co

175 ibitors that function through binding to the dimerization interface of caspases.

176 motifs including a domain homologous to the dimerization interface of cyclic adenosine monophosphate

177 the role of hydrophobic interactions in the dimerization interface of Gcn2p.

178 se that the new anion binding site along the dimerization interface of HICA is an "escort" site that

179 The focus of our studies is to target the dimerization interface of HIV-1 protease because disrupt

180 biomedically significant PPIs, including the dimerization interface of HIV-1 protease.

181 sulfated N terminus of CCR2 destabilizes the dimerization interface of inactive dimeric MCP-1, thus i

182 gly similar to that of Mad2 and binds at the dimerization interface of Mad2.

183 inding site partially overlaps with the homo-dimerization interface of Nup145C, suggesting competing

184 ing A'alpha-helix that comprises part of the dimerization interface of PAS1 prevent transmission of t

185 tal structure also reveals a protein-protein dimerization interface of PCBP2 KH1 located on the oppos

186 e location of the mutation suggests that the dimerization interface of PcrH mirrors that of the Yersi

187 The dimerization interface of PfAOP is representative of an

188 apeptide sequence (TSFTYTS) adapted from the dimerization interface of protein NuG2 [PDB ID: 1mio].

189 The dimerization interface of rA3G-CD1 is important for olig

190 on domain and the previously identified main dimerization interface of RXR act autonomously to affect

191 with caspase-7 reveals that it binds to the dimerization interface of the caspase, another common st

192 , nucleolytic center formed at an N-terminal dimerization interface of the cleavage core.

193 electrostatic interactions found within the dimerization interface of the Nef X-ray crystal structur

194 H hydrolase activity and is localized to the dimerization interface of the protein, suggesting a rela

195 ynamics simulations, we find that the N lobe dimerization interface of the wild-type EGFR kinase doma

196 ormation, mutations were introduced into the dimerization interface of v-Rel to generate v-Rel mutant

197 ked to cellular transformation and implicate dimerization interfaces of oncogenes as potential drug t

198 f IAPP by controlling access to the putative dimerization interface on the hydrophobic face of the am

199 is currently available, the location of the dimerization interface on the protein structure is not k

200 The dimerization interfaces on PKR and GCN2 were localized t

201 Interaction with RXR occurs via two dimerization interfaces, one in the DNA-binding domain a

202 n at, or immediately adjacent to, either the dimerization interface or the hormone-binding site.

203 t some cancer-linked mutations distal to the dimerization interface, particularly the widespread L834

204 vealed that FX interacts with hBD6 along the dimerization interface, primarily contacting the alpha-h

205 ral observations, mutations that disrupt the dimerization interface produced IRE1alpha molecules that

206 Our model describes E1-E2 ectodomain dimerization interfaces, provides a structural explanati

207 containing segment forms a major part of the dimerization interface, providing a structural mechanism

208 ding of DNA facilitates opening of an enzyme dimerization interface, providing visual evidence for a

209 ls an autoinhibited configuration, where the dimerization interface recently identified in activated

210 e-chains corresponding to the matching HIV-1 dimerization interface regions were prepared; all four i

211 large part of helix H10, a component of the dimerization interface, remained undetectable even after

212 Mutations in the nuclear export sequence or dimerization interface render cells temperature sensitiv

213 mask the substrate-binding site, but not the dimerization interface, rendering reduced zinc-free Hsp3

214 tumor derived p53 mutations reveals that the dimerization interface represents a third hot spot for m

215 At the dimerization interface, residues located at the carboxy

216 dditional 103 residues N-terminal to the Pbx dimerization interface restored heterodimerization with

217 and ninth-heptad mutants via a heterologous dimerization interface restores both corepressor interac

218 Site-directed mutations in its putative dimerization interface result in a dimerization-deficien

219 earing of contacts within the CENP-A:CENP-A' dimerization interface results in a weaker four helix bu

220 The dimerization interface revealed here was unanticipated a

221 main (MET567), which is assembled around the dimerization interface seen in the crystal structure of

222 n in the amino domain, particularly at their dimerization interface segments.

223 In addition to the coiled coil dimerization interface (Sir4CC interface), a crystallogr

224 Structural analysis identified an extensive dimerization interface stabilized by hydrogen bonds and

225 The dimerization interface structure in noncrystalline CA as

226 and binds in an elongated cleft spanning the dimerization interface such that the HIP and CoA moietie

227 The structural mapping of the dimerization interface suggests that Tyr10, His13, Phe30

228 s in the carbohydrate recognition domain and dimerization interface that are involved in immune funct

229 erved residues on the surface and within the dimerization interface that are required for the Rock-Sh

230 Although this helix in ERK2 forms a dimerization interface that becomes protected from HX up

231 This C-terminal domain is also a novel dimerization interface that functions independently of t

232 hat of the Yersinia homolog SycD and not the dimerization interface that had previously been reported

233 talytic triad residues and reveal an altered dimerization interface that is not conserved in the amid

234 y structure elements and in the "lasso/post" dimerization interface that may be functionally importan

235 action surface of RasGRP1 is hidden within a dimerization interface that may be stabilized by the C-t

236 minal to this inhibitory helix exposed a Pbx dimerization interface that orchestrated cooperative DNA

237 Here we study the roles of two dimerization interfaces, the so-called strand-swap and X

238 in some cases, TLR1, at the vicinity of the dimerization interface; the cationic headgroups form mul

239 es of MS-DesK, triggering a switching of the dimerization interface to allow the formation of a serin

240 steric network linking a cryptic site at the dimerization interface to enzyme function.

241 elease of the regulatory region from the NBD dimerization interface to promote dimerization and there

242 e involving helix-12 which forms part of the dimerization interface used to bind transcriptional coac

243 cognition helix (Lys(179), Met(186)) and the dimerization interface (Val(197), Leu(201)) that are imp

244 Further, we found that an intact GR dimerization interface was a prerequisite for the suppre

245 In contrast, only one dimerization interface was found for a fusion-inactive p

246 Through deletion analysis, the dimerization interface was mapped to the DNA-binding dom

247 orm inter-molecular salt bridges in the CtBP dimerization interface were swapped.

248 he second zinc binding domain that forms the dimerization interface when RXR binds as a dimer to a di

249 region has an autoinhibitory function and a dimerization interface, which appears to mediate positiv

250 341, and Glu-348, buried within the interior dimerization interface, which complement with three Nuf2

251 nt mutation located in the C-lobe asymmetric dimerization interface, which shows enhanced phosphoryla

252 ution, and the crystal structure reveals the dimerization interface, which we validate by mutagenesis

253 ers bind DNA sequentially and assemble their dimerization interface while bound to DNA.

254 ers bind DNA sequentially and assemble their dimerization interface while bound to DNA.

255 onomers bind DNA sequentially and form their dimerization interface while bound to DNA.

256 unit bind bicarbonate ion exclusively at the dimerization interface, while the remaining 10 chains bi

257 bilin-binding region of BphP also provides a dimerization interface with the C-terminal kinase domain

258 HP1a and HP1b differ in the dimerization interface, with HP1a having an Arg at posit

259 make a contact that likely represents the DH dimerization interface within an intact PKS.

260 Our results reveal a large dimerization interface within the membrane environment,