ライフサイエンスコーパス: dimethylglycine

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1 t induces transcription in response to GB or dimethylglycine.

2 nors such as serine, glycine, sarcosine, and dimethylglycine.

3 elated with clinical stage of HCC, were NAA, dimethylglycine, 1-methylnicotinamide, methionine, acety

4 ine, N-ethylglycine, and L-proline), but N,N-dimethylglycine, a tertiary amine, is not a substrate.

5 erase activity of BHMT-2 is not inhibited by dimethylglycine and betaine, whereas the former is a pot

6 ptors such as nitrate or fumarate, producing dimethylglycine and CO2 as products.

7 roup from betaine to homocysteine to produce dimethylglycine and methionine, respectively.

8 converts glycine betaine and cob(I)alamin to dimethylglycine and methylcobalamin.

9 reductive and oxidative half-reactions using dimethylglycine and O2 as substrates.

10 d higher concentrations of choline, betaine, dimethylglycine, and sarcosine (12-46%; P </= 0.08) in b

11 gues were prepared from pentaerythritol, N,N-dimethylglycine, and their corresponding fatty acyl grou

12 ma folate, cobalamin, free choline, betaine, dimethylglycine, and total homocysteine (tHcy) were meas

13 ers of choline metabolism [choline, betaine, dimethylglycine, and trimethylamine N-oxide (TMAO)] and

14 es after facile one-step derivatization with dimethylglycine based on the principles of multidimensio

15 nium, N,N-dimethylaminoethanol, choline, N,N-dimethylglycine, betaine, acetylcholine, (3-carboxypropy

16 tus, low status was associated with a higher dimethylglycine/betaine ratio from 15 GW and with lower

17 though formate production from sarcosine and dimethylglycine (choline metabolites) was significantly

18 Betaine and dimethylglycine concentrations were also significantly h

19 Dimethylglycine dehydrogenase (DMGDH) (E.C. number 1.5.9

20 n acyl-CoA dehydrogenase, was incubated with dimethylglycine dehydrogenase and electron transferring

21 thylation reactions conducted by the enzymes dimethylglycine dehydrogenase and sarcosine dehydrogenas

22 formaldehyde by sarcosine dehydrogenase and dimethylglycine dehydrogenase from their respective subs

23 ectron transferring flavoprotein and porcine dimethylglycine dehydrogenase or sarcosine dehydrogenase

24 ( approximately 35% identity) with rat liver dimethylglycine dehydrogenase, a sarcosine dehydrogenase

25 ly related to the mitochondrial flavoprotein dimethylglycine dehydrogenase, which functions in cholin

26 nity constants of 2.0 and 5.0 microm for the dimethylglycine dehydrogenase-electron transferring flav

27 ionization-mass spectrometry signal for the dimethylglycine dehydrogenase.electron transferring flav

28 genases have the ability to compete with the dimethylglycine dehydrogenase/sarcosine dehydrogenase fa

29 betaine (Bet) to homocysteine (Hcy) to form dimethylglycine (DMG) and methionine (Met).

30 ave suggested possible protective effects of dimethylglycine (DMG) on glucose metabolism.

31 and gbcB (PA5411), were capable of growth on dimethylglycine (DMG), a catabolic product of GB, but no

32 the reduction in betaine and the increase in dimethylglycine during pregnancy and strengthens the ass

33 folate status affects choline, betaine, and dimethylglycine during pregnancy.

34 solubility and oral bioavailability, the N,N-dimethylglycine ester 40 was prepared.

35 e I clinical trials as the water-soluble N,N-dimethylglycine ester prodrug 40 (CEP-7055).

36 e analyzed for plasma free choline, betaine, dimethylglycine, folate, vitamin B-12, total homocystein

37 GW and with lower plasma betaine and higher dimethylglycine from 24 to 27 GW, for the rest of pregna

38 nal choline intake also led to a doubling of dimethylglycine in cord plasma (P = 0.002).

39 ed by 34.8% (1.0%) throughout pregnancy, and dimethylglycine increased by 39.7% (2.7%) between 24-27

40 hioacetate [(CH(3))(2)S(+)CH(2)CO(2)(-)] and dimethylglycine (K(d) = 20.5 and 17.4 mM, respectively)

41 igher levels of trimethylamine-N-oxide, N,N'-dimethylglycine, m-hydroxyphenylpropionic acid, N-acetyl

42 ine N-methyltransferase (GSMT) and sarcosine dimethylglycine N-methyltransferase.

43 hose observed with sarcosine analogues (N,N'-dimethylglycine, N-benzylglycine).

44 Here we report crystal structures of dimethylglycine oxidase (DMGO) from the bacterium Arthro

45 Dimethylglycine oxidase (DMGO) is a covalent flavoenzyme

46 ehydrogenase active site of the bifunctional dimethylglycine oxidase (DMGO) of Arthrobacter globiform

47 However, in contrast to dimethylglycine oxidase and T-protein, the YgfZ family l

48 alphaB) is similar to the C-terminal half of dimethylglycine oxidase and the T-protein of the glycine

49 The covalent flavin in dimethylglycine oxidase is identified as an alphaN1-hist

50 ructure is very similar to that of bacterial dimethylglycine oxidase, an enzyme of the glycine betain

51 f a proton from the substrate amine group of dimethylglycine prior to C-H bond breakage and FAD reduc

52 0.0001), betaine (r = 0.58, P < 0.0001), and dimethylglycine (r = 0.30, P < 0.0001) in maternal blood

53 Flavin oxidation of dithionite- and dimethylglycine-reduced enzyme by O2 occurs in a single

54 d plasma concentrations of choline, betaine, dimethylglycine, retinol, essential fatty acids, methion

55 0.001) but lower concentrations of betaine, dimethylglycine, sarcosine, and methionine (13-55%; P <

56 GbdR regulon includes the genes encoding GB, dimethylglycine, sarcosine, glycine, and serine cataboli

57 nal region binds FAD covalently and oxidizes dimethylglycine to a labile iminium intermediate.

58 ved in the metabolism of choline, converting dimethylglycine to sarcosine.

59 e, folinic acid, methyl-B(12), thymidine, or dimethylglycine to the cultured trisomy 21 lymphoblastoi

60 hat catalyzes the oxidative demethylation of dimethylglycine to yield sarcosine, formaldehyde, and hy

61 ethionine (SAM), homocysteine, cysteine, and dimethylglycine were also assessed monthly.

62 Plasma free choline, betaine, and dimethylglycine were lower in women at 36 wk of gestatio

63 MR spectroscopy, revealed that his levels of dimethylglycine were much higher than control values.

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