ライフサイエンスコーパス: diminution

1 its a large (>10,000-fold) specific activity diminution.

2 ucleation resulting in actin filament length diminution.

3 y of DNA cleavage, albeit without a dramatic diminution.

4 ly 1.0 mA resulted in sustained excitability diminution.

5 of the UCS alone were included to assess UCR diminution.

6 EFV was limited (-27+/-11%) compared to VAF diminution (-40+/-19%).

7 its reappearance in grade 3 cancers, and its diminution/absence in grade 4/5 neoplasms.

8 double stem-loop insertions as well as loop diminutions affecting RNA structural elements that are o

9 ng in the hematopoietic system that include: diminution and decreased competence of the adaptive immu

10 s in diverse species, but the function(s) of diminution and the specificity of sequence loss remain l

11 R4 and MR-2 does not result in PML-RARalpha diminution and the tested gene expressions.

12 I at HS2 and within cHS4, accompanied by its diminution at the gene promoter.

13 found to play an integral role in either the diminution (compressibility) or retention (incompressibi

14 This diminution correlated with a significant decrease in the

15 Here, we report that this diminution correlates with alterations in the gut microb

16 patocytes, and the effects persisted without diminution for 10 days.

17 d against other antigens; the basis for this diminution has not been elucidated fully.

18 Appearance of ectropion uveae showed diminution in 15 tumors (43%); newly present corectopia

19 marrow-derived macrophages revealed a marked diminution in a proinflammatory M1 phenotype due to decr

20 active site glutamate, E241Q, showed a large diminution in activity with ametryn, no detectable activ

21 ionyl specificity as predicted and displayed diminution in activity, but the decreases in activity we

22 , no quantitative examination of microtubule diminution in AD and its relationship with PHFs has been

23 Diminution in allantoic cell number and proliferation wa

24 3.8%, which correlated with a corresponding diminution in apical GLUT2 levels: the SGLT1 component a

25 Thus the decades-long, controlled diminution in athletic performance, should not be seen a

26 ividuals during the breeding season, and any diminution in attractiveness could compromise reproducti

27 ituximab therapy is associated with variable diminution in B cell numbers.

28 f platelet activation resulted in a profound diminution in both experimental and spontaneous metastas

29 the dominant negative forms of Rab27b caused diminution in both numbers and length of dendrites of me

30 infers that an individual has a significant diminution in brain volume.

31 NA and cannot account entirely for the large diminution in burst amplitudes.

32 Diminution in bypass efficiencies was also observed for

33 ndritic cells (DCs), which correlates with a diminution in CD103(+) DC numbers in the lamina propria.

34 SP caused a diminution in CD4(+) T cell surface expression of the HI

35 rus subgenomic messages, whereas no dramatic diminution in cellular translation was observed.

36 Further, no diminution in cellular viability, as measured by 3-(4,5-

37 between the 2 groups, reflecting the greater diminution in coronary flow reserve in group 2 dogs (LAD

38 base-stacking perturbation occurs and little diminution in current flow is observed.

39 plain the hydrophobic force and its reported diminution in deaerated water.

40 terial growth is controlled, and there is no diminution in either the number of IFN-gamma-producing A

41 studies revealed that there is no detectable diminution in functional opioid receptors in spinal tiss

42 A3G catalytic activity was required for the diminution in G-to-C mutagenesis.

43 methylation cycle, but we did not detect any diminution in global DNA methylation, in contrast to emb

44 No further diminution in gluconeogenic flux to G6P occurred over th

45 ated decline in drug metabolism as well as a diminution in growth hormone secretion.

46 re than 100 population doublings without any diminution in growth potential.

47 es 36, 120, 153, and 155 are modest (<8-fold diminution in k(cat)).

48 hosphate, is characterized by a >42,000-fold diminution in k(cat), indicating the critical involvemen

49 Minimal decreases in T cells and a partial diminution in macrophages were observed.

50 to normal tissues generally reveals a strong diminution in mitochondrial content and in oxidative pho

51 pulations could respond, indicating that the diminution in naive ABLE cell responses was not due to l

52 These events were associated with a marked diminution in nuclear factor kappaB (NF-kappaB)/DNA bind

53 old oocytes to NO resulted in a significant diminution in OMD and ZP dissolution time, whereas spont

54 Contrary to an anticipated diminution in pathology, CD14(-/-) mice exhibited more s

55 ion over extended periods and did not show a diminution in performance in any of the matrices.

56 cytic phagocyte survival (8-fold), a drastic diminution in peritoneal bacteria counts, and a 50-70% r

57 lts in a milder loss of microtubule mass and diminution in process length.

58 prevented p27 stabilization and blocked the diminution in proliferative potential that normally acco

59 tive increase in thromboxane, coupled with a diminution in prostacyclin in infarcted heart muscle, ca

60 hypotheses are advanced to explain both the diminution in rates with increased surface coverage and

61 time reduction then recovery suggesting that diminution in receptor proteins contributes to the phago

62 Tyr(168) to phenylalanine resulted in a 30% diminution in RGS16 GAP activity but completely eliminat

63 is some increase in gynecologic symptoms and diminution in sexual pleasure, survivors tended to have

64 In scanning electron microscope analysis, diminution in silicone was observed.

65 ot doubling in size at 1 month, at least 50% diminution in size at 3 months, and complete reepithelia

66 mycin therapy was associated with more rapid diminution in size of infected lymph nodes.

67 for ASO, delay of repair is associated with diminution in size of PV, which may subsequently reduce

68 se processes for stem cells can be profound: diminution in stem cell pools, or, because of altered ge

69 ary-adrenocortical (HPA) axis is marked by a diminution in stress responsiveness early in the postnat

70 rization of mammalian BiP and a coincidental diminution in substrate binding, pointing to the relativ

71 ar copper concentration resulted in a marked diminution in the abundance of this protein.

72 the activity of the p38 stress kinase and a diminution in the activity of the antiapoptotic Akt/PKB

73 der these conditions, there is a progressive diminution in the capacity to produce IL-2, TNF-alpha, a

74 cuity and RNFL thickness also showed greater diminution in the contralateral eye (P = .040 and P = .0

75 evels of Bcl-2, Bcl-x(L), and survivin and a diminution in the degree to which these anti-apoptotic p

76 R deposition may be the direct result of the diminution in the distant chaperoning capacity of the li

77 audate putamen was decreased, representing a diminution in the dopamine storage pool.

78 e activity that can be explained by a marked diminution in the expression of the catalytic subunit DN

79 antibacterial activity of the AgNPs through diminution in the extent of nanoparticle aggregation.

80 and stenting has been achieved with a marked diminution in the incidence of restenosis.

81 dThd as substrate, apart from Y21E (350-fold diminution in the k(cat)/K(m)).

82 he prostate is associated with a significant diminution in the level of a key regulator of prostate c

83 m survival of the CD4-deficient group and no diminution in the level of persistent virus shedding and

84 Diminution in the nematode Ascaris suum occurs during ea

85 Fibrinogen deficiency resulted in a dramatic diminution in the number of colonic adenomas formed foll

86 tion of SPG11-NPCs resulted in a significant diminution in the number of neural cells.

87 nd spermatids of the null mice showed marked diminution in the size of chromatoid bodies.

88 receptor interaction conferred a concomitant diminution in their abilities to promote membrane fusion

89 n substantial loss of microtubule mass and a diminution in total process length.

90 These results demonstrate that the diminution in TUNEL staining by alpha-MSH is through alp

91 This marked diminution in VlsE lower forms paralleled the clearance

92 We propose that diminution is a mechanism of germline gene regulation th

93 This diminution is not a sampling artifact.

94 Chromatin diminution is the programmed elimination of specific DNA

95 onse to M. tuberculosis infection, and their diminution may promote the intracellular survival of M.

96 This diminution might have occurred decades ago, but could be

97 m iodide as a source of free iodide led to a diminution of (99m)Tc-pertechnetate uptake in both mouse

98 Recent reports have shown a marked diminution of 15-PGDH expression in colorectal carcinoma

99 ed on both a non-significant enhancement and diminution of 2-back and 0-back performance, respectivel

100 CS relative to sham stimulation, with a mean diminution of 31% (SD=14; d=1.58, 95% CI=0.76-2.40).

101 of 4.1R in mouse red cells leads to a large diminution of actin accompanied by extensive loss of cyt

102 low 30 amino acids resulted in a significant diminution of activity.

103 psychological growth over time had a greater diminution of ADHD severity and impairment.

104 resent self-assembly processes guided by the diminution of adhesive-free energy as cells tend to maxi

105 A previously undescribed diminution of afferent neuronal voltage-dependent potass

106 aired group, higher CR was associated with a diminution of age-related alterations in CSF biomarkers

107 ng, DC10s to OVA-asthmatic mice, significant diminution of airway hyperresponsiveness (AHR) was first

108 a), impeded tumorigenesis with a concomitant diminution of Akt phosphorylation.

109 o PrPSc conversion is thought to involve the diminution of alpha-helical domains accompanied by the i

110 Diminution of AMPK signaling in vivo correlates with inc

111 e of adrenal-transplanted rats, suggesting a diminution of anterograde axoplasmic transport by adrena

112 n the defensin genes expression suggesting a diminution of antibacterial functions of epithelial cell

113 at VP through elevation of ROS anabolism and diminution of antioxidant detoxification.

114 These data indicate that diminution of AP endonuclease has a significant effect o

115 To directly test whether a genetic diminution of AP endonuclease results in increased spont

116 First, it led to a diminution of approximately 2-fold in the proportion of

117 complex I activity and increased ROS but no diminution of ATP production.

118 8) resulted in the loss of virulence and the diminution of avirulence activity of AvrPtoB(1-307), whe

119 effect of treatment indicated a progressive diminution of benefit with increasing CAC.

120 n heart failure, a condition associated with diminution of beta-adrenergic receptor (beta-AR) respons

121 xation of secondary structure, manifested as diminution of beta-sheet content in conjunction with a d

122 of CDPK1 is also associated with significant diminution of both rhizobial and mycorrhizal symbiotic c

123 Glu-235, His-269, or Asp-320 resulted in the diminution of catalytic activity by two to six orders of

124 robial sepsis following adoptive transfer or diminution of CD71(+) erythroid splenocytes under these

125 Diminution of CDC6 level in mouse zygotes by two differe

126 Furthermore, overall diminution of cellular RNA synthesis is also observed in

127 he mobilization of storage compounds and the diminution of cellular stress resistance.

128 No diminution of cellular uptake is observed under metaboli

129 hancing dynamin-dependent endocytosis, (2) a diminution of channel open probability (P(o)) that occur

130 n infected macrophages resulted in a gradual diminution of chlamydial antigens, although some of thes

131 ve studies were done using mice with genetic diminution of circulating FII.

132 As, and competition experiments in which the diminution of cleavage was measured following admixture

133 e adverse effects of unchecked elongation or diminution of coding ends during V(D)J recombination, th

134 y specimens of women with striae also show a diminution of collagen.

135 titative way, and also a lower percentage of diminution of colour.

136 growth accompanied by fibrosis and eventual diminution of contractility, which results from down-reg

137 inhibition of CRP surface binding and, thus, diminution of CRP-mediated complement deposition.

138 s involving integrins, and the elevation and diminution of cytoplasmic signalling molecules.

139 yltransferase (DNMT) activity and the forced diminution of DNMT-1, DNMT-3a, and DNMT-3b by siRNA targ

140 ar factor (NF)-kappaB activity, resulting in diminution of downstream inhibitors of TNF signaling.

141 creased degeneration of outer hair cells and diminution of DPOAE amplitudes but no difference in dege

142 crease in vascular permeability accompanying diminution of dysplastic microvasculature by the antiang

143 A/CIN85 complex by Alix was reflected in its diminution of EGFR internalization.

144 s the aggregation of voids in the system and diminution of elastic properties.

145 2% yield) and shorter reaction times with no diminution of enantioselectivity (91-98% ee).

146 15 residues (IN 273) resulted in incremental diminution of enzymatic function and infectivity and tha

147 -IL5(OXA) EoE mice resulted in a significant diminution of epithelial eosinophilia in addition to bas

148 expressing either wild-type or mutant EGFR, diminution of expression of both L858R and EGFR delL747-

149 the venous marker EphB4 receptor (ephb4) and diminution of expression of the arterial marker ephrin-B

150 which the pathogen avoids detection through diminution of extracellular receptors and attenuation of

151 This was followed by a diminution of far-red fluorescence emission from the cor

152 evering protein cofilin, and a corresponding diminution of filamentous actin.

153 It is widely thought that diminution of first-phase insulin release is the earlies

154 g diminish with increasing pressure, and the diminution of flow at high pressure can be compensated b

155 in vitro, and one compound induced a slight diminution of food intake in a rodent model of obesity.

156 This model predicts that a selective loss or diminution of function of the vmPFC would result in heig

157 These effects lead to the diminution of GABAergic synapses and are correlated with

158 , the VNS-treated rats showed no appreciable diminution of GAD cells rostral to the contralateral epi

159 er, MyD88 deficiency resulted in spontaneous diminution of graft infiltrating effector cells, includi

160 Attenuation was not associated with any diminution of growth in serum or ability to utilize seru

161 rowth plate, may partially contribute to the diminution of growth in these animals.

162 s expected; however, these mutants showed no diminution of H2O2 excretion, suggesting that H2O2 is pr

163 d that CSC mediated dose- and time-dependent diminution of H4K16Ac and H4K20Me3, while increasing rel

164 5(+)CD4(+) T reg cells may contribute to the diminution of HIV-specific T cell immune responses in vi

165 hese results demonstrate that the absence or diminution of humoral immune responses by itself is insu

166 reversal produced by transient ASO-mediated diminution of huntingtin synthesis.

167 These changes combine to result in a diminution of immune responsiveness in the elderly.

168 ing this enzyme led to tightly corresponding diminution of in vivo tyrosine hydroxylase activity that

169 y in interleukin (IL)-12p40 lead to a marked diminution of inflammation in both the colon and the liv

170 Diminution of inflammatory Th1 and Th17 associated cytok

171 In control studies, no diminution of insulin signaling to the mitogen-activated

172 hey can be viewed as being reflective of the diminution of integrative physiological prowess that occ

173 ependent regression of MRTs with correlative diminution of intratumoral trimethylation levels of lysi

174 on in primary macrophages also resulted in a diminution of invasive capacity.

175 on in IR-induced G2/M arrest and concomitant diminution of IR-induced activation of ataxia telangiect

176 ting this charge to other sites results in a diminution of its effectiveness that appears to depend o

177 ylalanine or alanine results in a 10(3)-fold diminution of k(cat) and suppression of the overall kine

178 as reduced by KAI1/CD82, consistent with the diminution of lamellipodia and actin cortical network; w

179 Contrary to the diminution of LC migration in PAF receptor-deficient mic

180 ne whether pain resolution is accompanied by diminution of lesions in patients with knee OA.

181 nical benefits were associated with a marked diminution of levels of circulating inflammatory cytokin

182 evidenced by a greater survival index and a diminution of liver enzymes (ALT and AST).

183 can significantly increase lifespan, without diminution of locomotor vigor, resistance to stress, or

184 ugh augmentation of type I IFN signaling and diminution of lung immunopathology.

185 Diminution of lymphoid tissue reversed pulmonary hyperte

186 pancreatic carcinogenesis and a significant diminution of MDSCs compared with KC mice at comparable

187 aB to activate a target promoter, as well as diminution of MHC-I transcription and cell surface expre

188 Diminution of MICU1 or MCU reduced mitochondrial Ca(2+)

189 n increase in granulocytic progenitors and a diminution of monocytic progenitors.

190 of glutamate to cultures results in a rapid diminution of movement and also an alteration from elong

191 In addition to a significant diminution of naive T-cell numbers, we found impaired de

192 They measure a similar diminution of nasal epithelial Ca(2+)-activated Cl(-) se

193 They measure a similar diminution of nasal epithelial Ca2+-activated Cl- secret

194 xylate C6 13C peak moves upfield, indicating diminution of negative charge, and broadens, indicating

195 the presence of FtsY, YlxM caused an overall diminution of net GTPase activity.

196 administration of calcineurin inhibitors and diminution of NETs production.

197 h of their neuronal progeny accounts for the diminution of neurons in older mutant embryos.

198 Diminution of NTAL expression by silencing RNA oligonucl

199 Withdrawal of signal leads to diminution of nuclear TFII-I, suggesting that the signal

200 The diminution of O-GlcNAc levels occurred synchronously wit

201 ks on their spectratypes, suggesting loss or diminution of overrepresented clonal T-cell populations.

202 revealed that AA produces an ilPFC-mediated diminution of pavlovian reactions that extends beyond th

203 20; and a cdh1-null mutant, we show that the diminution of Pds1p and Clb2p brought on by Tax is media

204 Exposure to SEMA3F-conditioned medium led to diminution of phospho-ERK1/2 in four of eight lung cance

205 rous fern pelleae rufa, however, progressive diminution of phosphoglucoisomerase activities encoded b

206 gregation of C60 in water and the consequent diminution of photoactivity present a significant challe

207 ugmented the inspiratory drive potential and diminution of PIP(2) reduced it; sensitivity to flufenam

208 The progressive diminution of plasticity with age is linked to the emerg

209 We have investigated whether this diminution of polarity results in an epithelial-to-mesen

210 ng decline in synaptic vesicle numbers and a diminution of presynaptic density size.

211 There was a significant diminution of probe activation following pretreatment wi

212 -deficient Schwann cells display a transient diminution of proliferative capacity.

213 Adaptation, defined as the diminution of receptor signaling in the presence of cont

214 cline in thymic activity in RA may lead to a diminution of regulatory T cells and loss of their negat

215 longed elevation of intracellular Ca(2+) and diminution of releasable synaptic vesicles.

216 (butylene adipate) (PBA) indicated that some diminution of response occurred during the analysis of t

217 o had undergone SLT 360 degrees (SLT 1) with diminution of response over time followed by repeat SLT

218 RIN4 reduction causes diminution of RPM1.

219 electronically excited DA manifests a 3-fold diminution of S(1)-->S(0) oscillator strength on a 2-20

220 We found that diminution of SERCA2 function by pharmacological inhibit

221 After 3 h, there is a maximal diminution of sGC mRNA expression (sGC alpha(1) 10% and

222 avioral state were characterized by dramatic diminution of sleep postures and exploring activity and

223 r cluster assembly leads to a Dun1-dependent diminution of Sml1 protein levels.

224 Diminution of sodium currents, largely NaV1.7, was recap

225 Selective diminution of SRP subunits by RNA interference resulted

226 We found a striking diminution of STAT6 phosphorylation in differentiated WT

227 Thus, diminution of steric crowding around the N-nitroso moiet

228 natural products correlates with substantial diminution of sterol synthesis, identifying HMG-CoA synt

229 Immunodomination, or diminution of subdominant epitope-specific responses by

230 ls induced by changes in reward; the loss or diminution of such teaching signals would result in slow

231 We also show that diminution of sumoylation does not affect Yku70 protein

232 Moreover, diminution of surface beta APP is profound at axonal ter

233 kine release and receptor expression, and by diminution of T cell activation, proliferation and apopt

234 t high viral loads result in the progressive diminution of T cell effector functions and subsequent p

235 We conclude that in the absence or gross diminution of TBs, mean PNJ gap width increases signific

236 particular, age-associated telomere damage, diminution of telomere 'capping' function and associated

237 in tissue volume that was associated with a diminution of tensile integrity.

238 duals than in middle age individuals, with a diminution of that effect in suicide completers, who pre

239 for the third patient, indicate progressive diminution of the areas of improved vision.

240 rebral angiogenesis, resulting in a profound diminution of the brain microvasculature without comprom

241 TSP-1 has shown elongation of the stalk and diminution of the C-terminal globule.

242 le via maintenance of the lipogenic pool but diminution of the carnitine palmitoyltransferase 1 inhib

243 A significant diminution of the coupled activities was also observed w

244 vacuum over a ca. 5 A band with progressive diminution of the density and hydrogen bonding.

245 ree patients underwent systemic therapy with diminution of the deposits and improvement in vision in

246 owing infection indicates also that temporal diminution of the dominant antigen OspC is impaired in l

247 rimethoprim mediated concentration-dependent diminution of the emission observed at 450 nm for DHFR I

248 een a role for the proteasome and a possible diminution of the free ubiquitin pool, we expressed a ch

249 Finally, we have shown that diminution of the glycosyltransferase activity of I-bran

250 e rats, there is a loss of GnRH pulses and a diminution of the GnRH surge.

251 HOM setup, offering some explanation for the diminution of the HOM visibility observed in many experi

252 are repeatedly injected in the skin, with a diminution of the inflammatory response occurring after

253 wever, we show that there is no quantitative diminution of the initial phase of antitumor activity in

254 responses are associated with a facilitated diminution of the leukemogenic PML-RARalpha protein and

255 fferentiate in culture, resulting in a rapid diminution of the multipotent cell population and their

256 ginates from both reduction of cell size and diminution of the number of cells and correlates with im

257 onal antibody provided further evidence that diminution of the Oag content occurred in situ during le

258 inotropic infusion resulted in a significant diminution of the peripheral eosinophilia and the EM bef

259 troducing positive feedback loops results in diminution of the probability distribution complexity.

260 eria causing plant diseases that result in a diminution of the quantity and quality of food produced

261 of the mPOA may be attributable in part to a diminution of the reinforcing effects of vaginocervical

262 erozoic-Cambrian boundary, signals the final diminution of the reservoir, a process that was likely i

263 Diminution of the Th1 response in infected WSX-1(-/-) mi

264 nscious expectations of the UCS, conditioned diminution of the UCR can be expressed independent of le

265 Greater diminution of the UCR was observed to the UCS when it fo

266 Our findings demonstrate conditioned diminution of the unconditioned SCR.

267 ctron microscopy and was demonstrated by the diminution of the voltammetric signals for 5-HIAA as wel

268 thioredoxin reductase (TR), concomitant with diminution of their cellular contents.

269 Nevertheless, there was a progressive diminution of their effector activities as their capacit

270 Diminution of these Abeta1-42 effects in primary culture

271 hment of the aquifer, leading to substantial diminution of this resource and rapid subsidence of the

272 le in 3- to 4-week-old mice, but a threefold diminution of thymic T cells became evident by 6 to 8 we

273 derived human DCs (mhDCs) demonstrate marked diminution of TLR3 and TLR4 mRNA expression compared wit

274 ate increased with time, whereas there was a diminution of total glutathione during this period.

275 e potential for preservation of activity and diminution of toxicity with alternative sequences and sc

276 d in the formation of the active metabolite, diminution of tumor vasculature, and hemorrhagic necrosi

277 Diminution of UbcH10 expression significantly inhibited

278 nfiltrating F4/80-positive macrophages and a diminution of vessel density, but not with obvious diffe

279 iew of a 66 year old male who presented with diminution of vision in right eye 17 days after uneventf

280 tended fixation and there is a corresponding diminution of visual sensitivity at nontarget locations.

281 geldanamycin over 24 hours, whereas partial diminution of wild-type EGFR required a minimum of 200 n

282 posure to 1 micromol/L geldanamycin, whereas diminution of wild-type EGFR was less substantial and se

283 dominant negative DMRTF mutant also causes a diminution of wing interveins, whereas overexpression of

284 lytic activity of human ANG, resulted in the diminution of xenograft tumoral growth through the inhib

285 grow under restricted water regimes without diminution of yield would minimize drought-related losse

286 nd promoter mutations lead to dysregulation (diminution) of Chga in brainstem cardiovascular control

287 analysis showed reproducible enrichment (or diminution) of particular TCR clonotypes across all chal

288 The diminution or elimination of signals due to nonphosphory

289 durably increased hemoglobin levels without diminution over 40 weeks.

290 er at 1 day post-injury, followed by gradual diminution over time.

291 we mechanistically demonstrate that miR-204 diminution promotes RUNX2 up-regulation and that sustain

292 However, diminution rather than total elimination of tipDC traffi

293 sophila cells it results in centriole length diminution that is overcome by codepletion of Klp10A to

294 Urea denaturation showed a diminution to the stability of the ALDH1 mutants.

295 sustained AP discharge in NGNs, and that its diminution underlies the decreased AP discharge of vagot

296 However, conditioned UCR diminution was also observed independent of differential

297 nt with this prediction whole body carnitine diminution was identified as a common feature of insulin

298 evels in the remainder, suggesting that such diminutions were triggering the overall synaptic patholo

299 omerase activity, demonstrates a significant diminution with age but a marked response to injury, and

300 support the following disease sequence: ONL diminution with INL thickening; amalgamation of residual