ライフサイエンスコーパス: dinucleotide

1 enine dinucleotide), and FAD (flavin adenine dinucleotide).

2 s harboring a hemi- and fully methylated CpG dinucleotide.

3 as the reduced form of nicotinamide adenine dinucleotide.

4 n of Mbd1, which recognizes unmethylated CpG dinucleotides.

5 n binding to methylated and unmethylated CpG dinucleotides.

6 d selectively to RNA sequences containing CG dinucleotides.

7 on and hydroxymethylation predictions in CpG dinucleotides.

8 a common theme across all the complementary dinucleotides.

9 methylation in many of the cytosine-guanine dinucleotides.

10 he decay of miRNAs that contain CA and/or UA dinucleotides.

11 is, lower than expected numbers of 5'-CG-3' dinucleotides.

12 f symmetrical 5-methylcytosines in CpG (mCG) dinucleotides.

13 and 7 879 142 differentially methylated CpG dinucleotides.

14 overy-stage cytosine-phosphate-guanine (CpG) dinucleotides, 13 replicated after Bonferroni correction

15 The cyclic dinucleotide 2',3'-cGAMP can bind the adaptor protein ST

16 owing treatment with the noncanonical cyclic dinucleotide 2',3'-cGAMP, suggesting that the STING path

17 ydroxymethylation occurs predominantly in CA dinucleotides (5hmCA) and it accumulates in regions flan

18 photoproduct as efficiently as the dithymine dinucleotide (74% and 66% at the 5'- and 3'-end, respect

19 f participants (n = 194), methylation at CpG dinucleotides across the genome was measured in peripher

20 ase, which generates STING-activating cyclic dinucleotides after binding cytosolic DNA species.

21 s cellular levels as both high levels of the dinucleotide and its absence result in a number of detri

22 or efficient initiation from GTP to form the dinucleotide and subsequent intermediates leading to hig

23 alysis revealed increased methylation of CpG dinucleotides and differential transcription factor bind

24 ons exhibit higher mutation rates due to CpG dinucleotides and show signatures of transcription-coupl

25 rically methylated and hydroxymethylated CpA dinucleotides and that this alternative binding selectiv

26 6mA occurred symmetrically at ApT dinucleotides and was concentrated in dense methylated a

27 nosyl methionine), NAD (nicotinamide adenine dinucleotide), and FAD (flavin adenine dinucleotide).

28 etween FCGR3A and FCGR3B are enriched at CpG dinucleotides, and mutation of variant CpGs reversed cel

29 However, with dinucleotide Ap4A as an agonist, BPTU suppressed the Ema

30 s unexpected sequence bias suggests that CpG dinucleotides are intrinsically more mutation prone.

31 CpG dinucleotides are the main mutational hot-spot in most c

32 cal mechanism that uses nicotinamide adenine dinucleotide as a cofactor.

33 f d-lactate to pyruvate using flavin adenine dinucleotide as a cofactor; knowledge of its function in

34 In the presence of beta-nicotinamide adenine dinucleotide as cofactor, and ethanol as fuel, the feasi

35 rylating nicotinamide/nicotinic acid adenine dinucleotide at the adenosine 3'-hydroxyl group.

36 t bind the polypyrimidine tract (PPT) and AG dinucleotides at the 3' splice site (3'ss).

37 for the strict conservation of the GU and AG dinucleotides at the 5' and 3' ends of introns and provi

38 Artificially increasing CpG/UpA dinucleotides attenuates viruses through an entirely unk

39 o K-tuple nucleotide composition and mode of dinucleotide-based auto-cross covariance into an ensembl

40 BK1/IRF3 signaling axis involves both cyclic-dinucleotide binding and its translocation from the ER t

41 n a hydrophobic pocket between an N-terminal dinucleotide binding domain and a smaller C-terminal dom

42 AD(+) (oxidized form of nicotinamide adenine dinucleotide) binding domains that regulate protein-prot

43 that the sequence of the key flavin adenine dinucleotide-binding domain is split into at least two p

44 The DUF consists of a Rossmann dinucleotide-binding fold fused to a three-stranded beta

45 rate-limiting enzyme in nicotinamide adenine dinucleotide biosynthesis.

46 h converts MoCo to bis-molybdopterin guanine dinucleotide (bis-MGD), a form of the cofactor that is r

47 Blue light using flavin adenine dinucleotide (BLUF) proteins are essential for the light

48 nosine triphosphate and nicotinamide adenine dinucleotide, both pathways converging in the formation

49 d by the polyketide DIF-1 or by the cyclical dinucleotide c-di-GMP.

50 ighting new mutation-promoting motifs at ApT dinucleotide, CAAT and TACG sequences.

51 We report the synthesis of novel mono- and dinucleotide cap analogues containing dihalogenmethylene

52 yclase capable of switching the major cyclic dinucleotide (CDN) produced based on ATP-to-GTP ratios.

53 e cytosol by cGAS, which produces the cyclic dinucleotide (CDN) second messenger cGAMP to activate th

54 e to cytosolic DNA via 2',3' cGAMP, a cyclic dinucleotide (CDN) second messenger containing mixed 2'-

55 ng adjuvant target due to its role in cyclic dinucleotide (CDN)-driven anti-viral immunity; however,

56 Detection of cyclic dinucleotides (cdNs) by the STING pathway potently trigg

57 Bacterial and host cyclic dinucleotides (cdNs) mediate cytosolic immune responses

58 NG and is an innate immune sensor for cyclic dinucleotides (CDNs) playing a critical role in infectio

59 tes cGAS, while STING is activated by cyclic dinucleotides (cdNs) produced by cGAS or from bacterial

60 electron transfer between the flavin adenine dinucleotide cofactor and tryptophan residues leads to t

61 The dinucleotide composition of HIV-1, and perhaps other RNA

62 that the antiviral protein ZAP recognizes CG dinucleotide composition to differentiate self from non-

63 ii) reverse complement kmer and (iii) pseudo dinucleotide composition.

64 well-studied, asymmetric methylation in any dinucleotide context has received less attention.

65 Both TLR9 and its ligand, the dinucleotide CpG, were present as cargo in IRAP(+) endos

66 of methylation of cytosine-phosphate-guanine dinucleotide (CpG) sites in relation to alcohol intake i

67 ome-wide DNA methylation at cytosine-guanine dinucleotides (CpGs) in whole blood from 2306 individual

68 Modification of cytosine-guanine dinucleotides (CpGs) is a key part of mammalian epigenet

69 from Geobacter sulfurreducens showed it is a dinucleotide cyclase capable of switching the major cycl

70 variation; although, how this differs by CpG dinucleotide density and genic location of the DNAm site

71 nt, the latter distinguished by increased CG dinucleotide density and polycomb-mediated repression, m

72 ChIP-seq data for vertebrates, which capture dinucleotide dependencies within TF binding sites.

73 of the NAD(+) (oxidized nicotinamide adenine dinucleotide)-dependent deacetylase Sir2.

74 Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase, and its dysregulatio

75 dent IDH1 and IDH2, and nicotinamide adenine dinucleotide-dependent IDH3) contribute to regulating th

76 genome analysis indicates unusually low CpG dinucleotide depletion in KYAV compared to other ledante

77 While the density of GG dinucleotides determines the initial crosslinking of cis

78 n and synthesis of an ITPA-specific chimeric dinucleotide (DIAL) that replaces the pyrophosphate leav

79 s led to the unexpected findings that the AU dinucleotide dictates the optimal binding of cap-binding

80 derivatives, namely, cyclic nucleotides and dinucleotides, dinucleoside 5',5'-polyphosphates, sugar

81 ylation of specific cytosine residues in CpG dinucleotides during mammalian development.

82 ts such as cGMP-AMP (cGAMP) and other cyclic dinucleotides elicit potent immune and antitumor respons

83 cription initiation, and cap-independent ApG dinucleotide extension in vitro, indicating that the PB2

84 he riboflavin (RF) cofactors, flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN), are

85 ct precursor of the cofactors flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN), the

86 Flavin-adenine dinucleotide (FAD) dependent glucose dehydrogenase (GDH)

87 )H domain with respect to the flavin adenine dinucleotide (FAD) domain that precludes binding of the

88 enine dinucleotide (NADH), and flavin denine dinucleotide (FAD) in fresh brain samples of a mouse mod

89 ease in the cellular level of flavin adenine dinucleotide (FAD), a metabolic cofactor of LSD1, causin

90 l structures of the catalytic flavin adenine dinucleotide (FAD)- and heme-binding domains of Cylindro

91 ide (phosphate) (NAD(P)H) and flavin adenine dinucleotide (FAD).

92 sidue Cys108 and its cofactor flavin adenine dinucleotide(FAD), and prompts VVD switching from Dark s

93 that taking into account position-dependent dinucleotide features improved the design of effective s

94 HCCs, is demethylated in liver tumors at CpG dinucleotides flanking the NF-kappaB-binding sequence, s

95 calcium content and in nicotinamide adenine dinucleotide fluorescence following pacing and 2) increa

96 l survival by enhancing nicotinamide adenine dinucleotide flux in injured neurons.

97 o(MGD)2 complex (MGD = molybdopterin guanine dinucleotide) for oxygen atom transfer (OAT).

98 Increasing CpG dinucleotide frequencies represents a generic and potent

99 all DNA viruses suppress genomic CpG and UpA dinucleotide frequencies, apparently mimicking host mRNA

100 ognition of methylated/hydroxymethylated CpA dinucleotides functions as an epigenetic switch redistri

101 zebrafish, with the exception of a GG or GA dinucleotide genomic match at the 5' end of the sgRNA.

102 glycerol-dehydrogenase/nicotinamide-adenine-dinucleotide (GlDH-NAD(+)) apoenzyme-coenzyme molecular

103 nine dinucleotide phosphate , flavin adenine dinucleotide , glutathione disulfide/glutathione).

104 of STING by intratumoral injection of cyclic dinucleotide GMP-AMP (cGAMP), potently enhanced antitumo

105 Codon-optimized RSV F containing fewer CpG dinucleotides had higher F expression, replicated more e

106 of DNA at cytosine-phosphate diester-guanine dinucleotides, histone modifications, microRNA interacti

107 ed DNA, which is the most frequently mutated dinucleotide in breast, head/neck, lung, bladder, cervic

108 trate that a nonsynonymous mutation at a CpG dinucleotide in the beta(A)-globin gene is responsible f

109 ormation of the proposed imidazolium-bridged dinucleotide in the expected pH-dependent manner.

110 nts to identify and validate a set of 67 CpG dinucleotides in 51 CpG islands that undergo age-related

111 etermining the pattern of methylation at CpG dinucleotides in a cell remains an essential component o

112 HSATII) is enriched in motifs containing CpG dinucleotides in AU-rich contexts that most of the human

113 sidering the expanding role played by cyclic dinucleotides in bacteria, we investigated whether the a

114 plasmic RNA depletion, and was exerted by CG dinucleotides in both translated and non-translated exon

115 us (IAV) with maximised frequencies of these dinucleotides in segment 5 showed comparable attenuation

116 The majority of CpG dinucleotides in the human genome are methylated at cyto

117 ferases DNMT3a/3b adding methyl groups to CG dinucleotides in the hypomethylated genome of early embr

118 re, it was also shown that GNA nucleotide or dinucleotide incorporation increases resistance against

119 The formation of an imidazolium-bridged dinucleotide intermediate provides a mechanistic interpr

120 th each other to form an imidazolium-bridged dinucleotide intermediate, which then binds to the templ

121 To explore this conundrum, we varied this AU dinucleotide into all possible permutations and analyzed

122 a structural interpretation as to why the AU dinucleotide is conserved during evolution.

123 The 3'-splice site AG dinucleotide is recognized through non-Watson-Crick pair

124 Gene body methylation at CG dinucleotides is a widely conserved feature of methylate

125 at the distribution of 5hmC in CG and non-CG dinucleotides is distinct and that it reflects the bindi

126 of all combinations of DNA sequences at the dinucleotide level and calculated these properties for d

127 bunit, upon HBx expression demethylate a CpG dinucleotide located adjacent to NF-kappaB/RelA half-sit

128 ccompanied this pattern, particularly at CpG dinucleotides located within binding or flanking regions

129 The single and dinucleotide loops in these structures show a high degre

130 S. aureus, leading us to speculate that this dinucleotide may have a regulatory role under certain co

131 nomic variants that create novel splice site dinucleotides may produce splice junction RNA-seq reads

132 es in the genome by binding to methylated CA dinucleotides (mCA) within transcribed regions of these

133 ressive association of DNA methylation at CG dinucleotides (mCG), mCH accumulates on Xi in domains wi

134 MBD1 binds to methylated cytosine-guanine dinucleotides (mCGs) within the sequence of sh-dsDNA.

135 associated with reduced nicotinamide adenine dinucleotide metabolism and altered citric acid cycle ac

136 formation in the first exon promoted by CpG dinucleotide methylation as a regulator of hTERT express

137 els of 3 metabolites, nicotinic acid adenine dinucleotide, methylnicotinamide, and N1-methyl-4-pyrido

138 incorporated into mRNA, the CCl2-substituted dinucleotide most efficiently promoted cap-dependent tra

139 des containing unmethylated cytidyl guanosyl dinucleotide motifs (CpG ODN) are TLR9 ligands with attr

140 (unmethylated deoxycytidylyl-deoxyguanosine dinucleotide) motifs activate endosomal TLR9.

141 he pyridinium ring of nicotinic acid adenine dinucleotide (NaAD) and cleaves the phosphoanhydride bon

142 We also report that nicotinic acid adenine dinucleotide (NAAD), which was not thought to be en rout

143 ed within the substrate/cofactor [alpha/beta dinucleotide NAD(P)H] binding fold is a functionally def

144 y liver, lowers hepatic nicotinamide adenine dinucleotide (NAD(+) ) levels driving reductions in hepa

145 tions: oxidized/reduced nicotinamide adenine dinucleotide (NAD(+) and NADH) and nicotinamide adenine

146 ed and reduced forms of nicotinamide adenine dinucleotide (NAD(+) and NADH), oxidized and reduced for

147 ving rapid breakdown of nicotinamide adenine dinucleotide (NAD(+)) after injury.

148 in the biosynthesis of nicotinamide adenine dinucleotide (NAD(+)) and its derivatives in all organis

149 ADH and its cofactor nicotinamide adenine dinucleotide (NAD(+)) are immobilized onto the OECT with

150 rmediate using oxidized nicotinamide adenine dinucleotide (NAD(+)) as the H(-) source, however, could

151 can also carry a 5' end nicotinamide adenine dinucleotide (NAD(+)) cap that, in contrast to the m(7)G

152 evere, neuron-specific, nicotinamide adenine dinucleotide (NAD(+)) depletion.

153 The reduction of nicotinamide adenine dinucleotide (NAD(+)) generating a maximum current densi

154 Nicotinamide adenine dinucleotide (NAD(+)) is an essential substrate for sirt

155 dative stress response, nicotinamide adenine dinucleotide (NAD(+)) is emerging as a metabolic target

156 om the oxidized form of nicotinamide adenine dinucleotide (NAD(+)) onto substrate proteins.

157 Nicotinamide adenine dinucleotide (NAD(+)) participates in intracellular and

158 Nicotinamide adenine dinucleotide (NAD(+)) participates in redox reactions an

159 e recently described 5' nicotinamide-adenine dinucleotide (NAD(+)) RNA in bacteria.

160 ribosyltransferases use nicotinamide adenine dinucleotide (NAD(+)) to modify target proteins with ADP

161 the amount of oxidized nicotinamide adenine dinucleotide (NAD(+)) to that of its reduced form (NADH)

162 cellular production of nicotinamide adenine dinucleotide (NAD(+)) via nicotinamide phosphoribosyltra

163 s the activation of the nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase sirtuin 1 (S

164 irtuin (SIRT) family of nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylases.

165 c pathways regulated by nicotinamide adenine dinucleotide (NAD(+)).

166 via increased levels of nicotinamide adenine dinucleotide (NAD(+)).

167 Retinal levels of nicotinamide adenine dinucleotide (NAD(+), a key molecule in energy and redox

168 om injury by regulating nicotinamide adenine dinucleotide (NAD) biosynthesis.

169 edominantly altered the nicotinamide adenine dinucleotide (NAD) cofactor pathway and the inflammation

170 cursor of the universal nicotinamide adenine dinucleotide (NAD) cofactor.

171 n, the concentration of nicotinamide adenine dinucleotide (NAD) falls, at least in part due to metabo

172 The nicotinamide adenine dinucleotide (NAD) glycohydrolase CD38, which is express

173 Nicotinamide adenine dinucleotide (NAD) is produced via de novo biosynthesis

174 Nicotinamide adenine dinucleotide (NAD) is synthesized de novo from tryptopha

175 AIMS: The mitochondrial nicotinamide adenine dinucleotide (NAD) kinase (NADK2, also called MNADK) cat

176 boosting intracellular nicotinamide adenine dinucleotide (NAD) levels, thus preventing or ameliorati

177 rom the C4 grasses with nicotinamide adenine dinucleotide (NAD) phosphate malic enzyme (NADP-ME) and

178 adduct of glutamate and nicotinamide adenine dinucleotide (NAD), fragments of NAD detected in the sam

179 ere, we report that the nicotinamide adenine dinucleotide (NAD)-dependent deacetylase SIRT1 acts as a

180 ), one of the mammalian nicotinamide adenine dinucleotide (NAD)-dependent lysine deacylases, catalyze

181 ne monophosphate [AMP], nicotinamide adenine dinucleotide /NAD, nicotinamide adenine dinucleotide pho

182 ction by downregulating nicotinamide adenine dinucleotide(+) (NAD(+))/reduced form of nicotinamide ad

183 chemical species (beta-nicotinamide adenine dinucleotide (NADH) and H2O2) acting as coreactants for

184 -lactate, using reduced nicotinamide adenine dinucleotide (NADH) as the cofactor.

185 Reduced nicotinamide adenine dinucleotide (NADH) can generate a ruthenium-hydride int

186 at the reduced cofactor nicotinamide adenine dinucleotide (NADH) is a possible hydride source inside

187 Nicotinamide Adenine Dinucleotide (NADH) is an important coenzyme in the huma

188 of tryptophan, reduced nicotinamide adenine dinucleotide (NADH), and flavin denine dinucleotide (FAD

189 rescence, attributed to nicotinamide adenine dinucleotide (NADH), was induced by two-photon laser exc

190 for the development of nicotinamide adenine dinucleotide (NADH)-based biosensors.

191 as the reduced form of nicotinamide adenine dinucleotide (NADH).

192 trix Ca(2+) and reduced nicotinamide adenine dinucleotide (NADH).

193 duced/oxidized ratio of nicotinamide adenine dinucleotide (NADH/NAD(+) ratio) and protein acetylation

194 (ROS) by the phagocyte nicotinamide adenine dinucleotide (NADPH) oxidase in patients with chronic gr

195 eplication in mutants with increased CpG/UpA dinucleotides occurred immediately after viral entry, wi

196 The deleterious effect of CG dinucleotides on HIV-1 replication was cumulative, assoc

197 Sixteen CpG dinucleotides on P2Y12 promoter were tested.

198 We performed bisulfite sequencing on 23 CpG dinucleotides on the transgene across three generations

199 dividual motifs composed of mononucleotides, dinucleotides or higher including hexamers.

200 d seamless assembly of short DNA blocks with dinucleotide overhangs through a simple ligation process

201 tion could be facilitated by starting with a dinucleotide (pGG).

202 rRxo1, 3'-NADP and 3'-nicotinic acid adenine dinucleotide phosphate (3'-NAADP), are substantially dif

203 Nicotinic acid adenine dinucleotide phosphate (NAADP) and cyclic ADP-ribose (cA

204 Nicotinic acid adenine dinucleotide phosphate (NAADP) is a Ca(2+) releasing int

205 Nicotinic acid adenine dinucleotide phosphate (NAADP) potently releases Ca(2+)

206 Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) stimulates calcium releas

207 Nicotinic acid adenine dinucleotide phosphate (NAADP), the most potent Ca(2+) m

208 the possible role of nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated Ca(2+) release f

209 ed and reduced forms of nicotinamide adenine dinucleotide phosphate (NADP(+) and NADPH), and adenosin

210 e (NAD(+) and NADH) and nicotinamide adenine dinucleotide phosphate (NADP(+) and NADPH); coenzymes of

211 Nicotinamide adenine dinucleotide phosphate (NADP) is a critical cofactor dur

212 and the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) as co-factor.

213 sis and regeneration of nicotinamide adenine dinucleotide phosphate (NADPH) in p53-deficient cancer c

214 Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is essential for biosynth

215 that antibiotics rescue nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (Nox2)-deficien

216 nerated through reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation becaus

217 reduced (hydrogenated) nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity in vivo.

218 The leukocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase generates reactiv

219 ating integrin-mediated nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-2 (NOX-2) express

220 Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases produce ROS loca

221 regulated expression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, antioxidant enz

222 emia linked to impaired nicotinamide adenine dinucleotide phosphate (NADPH) production and imbalanced

223 inucleotide phosphate / nicotinamide adenine dinucleotide phosphate , flavin adenine dinucleotide , g

224 nine dinucleotide /NAD, nicotinamide adenine dinucleotide phosphate / nicotinamide adenine dinucleoti

225 se II), which decreases nicotinamide adenine dinucleotide phosphate hydrogen synthesis, thereby, redu

226 Defects in phagocytic nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) function cause c

227 whereas the transfer of nicotinamide adenine dinucleotide phosphate oxidase 2-deficient MDSCs did not

228 GD) is due to defective nicotinamide adenine dinucleotide phosphate oxidase activity and characterize

229 ly decreases myocardial nicotinamide adenine dinucleotide phosphate oxidase activity via endocrine or

230 n suppresses myocardial nicotinamide adenine dinucleotide phosphate oxidase activity, by preventing A

231 hormonal activation of (nicotinamide adenine dinucleotide phosphate oxidase dependent) oxidative stre

232 etic deficiency of gp91 nicotinamide adenine dinucleotide phosphate oxidase subunit-2 prevented upreg

233 Adult rats; wild-type/nicotinamide adenine dinucleotide phosphate oxidase subunit-2-deficient mice;

234 vity is associated with nicotinamide adenine dinucleotide phosphate oxidase subunit-2-mediated upregu

235 activate transmembrane nicotinamide adenine dinucleotide phosphate oxidase type 2 to produce reactiv

236 The NOX (nicotinamide adenine dinucleotide phosphate oxidase) family includes seven un

237 d to reduced myocardial nicotinamide adenine dinucleotide phosphate oxidase-derived O2 (-), whereas c

238 Nicotinamide dinucleotide phosphate oxidases (NOX) control various ce

239 such as Rho kinase and nicotinamide adenine dinucleotide phosphate oxidases are also inhibited.

240 brane transporters, the Nicotinamide adenine dinucleotide phosphate reduced form (NADPH) oxidase comp

241 te the possible role of nicotinamide adenine dinucleotide phosphate reduced form oxidases (NOXs) in M

242 NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) oxidase, xanthine oxidase, the m

243 NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) oxidase-dependent killing and, i

244 nosine triphosphate and nicotinamide adenine dinucleotide phosphate, and have become attractive bioca

245 idizing glutathione and nicotinamide adenine dinucleotide phosphate, and significantly down-regulatin

246 ase channels gated by nicotinic acid adenine dinucleotide phosphate, as also as intracellular Na(+) c

247 e to associate with the nicotinamide adenine dinucleotide phosphate, reduced oxidase RESPIRATORY BURS

248 adenine nucleotide and nicotinamide adenine dinucleotide phosphate, respectively) serving as both a

249 The three IDH isoforms (nicotinamide adenine dinucleotide phosphate-dependent IDH1 and IDH2, and nico

250 lcholinesterase (AChE), nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d), glutamic ac

251 cell therapy decreased nicotinamide adenine dinucleotide phosphate-oxidase 2 and inducible nitric ox

252 vity, cellular oxidized nicotinamide adenine dinucleotide phosphate/NADPH levels, phagocytic reactive

253 fluorescence of reduced nicotinamide adenine dinucleotide (phosphate) (NAD(P)H) and flavin adenine di

254 autofluorescent reduced nicotinamide adenine dinucleotide (phosphate), NAD(P)H, has been previously e

255 methylation occurs nearly exclusively on CpG dinucleotides, plants genomes harbor DNA methylation als

256 actions, including simple mononucleotide and dinucleotide position weight matrix models.

257 As via endonucleolytic cleavage at CA and UA dinucleotides, preferentially at scissile bonds located

258 ce-derived features, such as sparse profile, dinucleotide profile, position weight matrix profile, Ma

259 demonstrated that frequencies of CpG and UpA dinucleotides profoundly influence the replication abili

260 dinucleotide synthetase cGAS and the cyclic dinucleotide receptor STING.

261 tron microscopy, and 3) nicotinamide adenine dinucleotide redox potential and adenosine triphosphate/

262 lymerase, and thylakoid nicotinamide adenine dinucleotide (reduced) and cytochrome b6/f complexes, we

263 ause of increased NADH (nicotinamide adenine dinucleotide, reduced form) and acetyl-CoA levels.

264 Length polymorphisms in the number of GT dinucleotide repeats in the HO-1 gene (HMOX1) promoter i

265 e polypyrimidine tract (Py-tract) and the AG-dinucleotide, respectively.

266 and also attained increased cytosine guanine dinucleotide responsiveness.

267 Activation of the cyclic dinucleotide sensor stimulator of interferon (IFN) genes

268 3A regulation in human NK cells in which CpG dinucleotide sequences and concurrent DNA methylation co

269 r dodecamers containing a substantial set of dinucleotide sequences provides new, consistent correlat

270 We show that the periodic occurrences of dinucleotide sequences relative to nucleosome dyads can

271 ere compared to that of their mutants, their dinucleotide shuffles, and their reverse complement sequ

272 of rs12041331, an intronic cytosine guanine dinucleotide-single-nucleotide polymorphism (CpG-SNP), i

273 restrict the DNA methylation analysis to CpG dinucleotide sites, which can be limiting in many biolog

274 structing candidate chains in representative dinucleotide steps and refining the models against SAXS

275 es are seen in the base stacking of pairs in dinucleotide steps, arising from energetically favorable

276 esponse to the presence of DNA and/or cyclic dinucleotides, STING translocates from the endoplasmic r

277 All possible single and tandem dinucleotide substitutions were surveyed.

278 This pressure may have driven CG dinucleotide suppression in HIV-1 and other RNA viruses

279 activation of the recently discovered cyclic dinucleotide synthetase cGAS and the cyclic dinucleotide

280 small deletion, a 12 kb PTEN deletion, and a dinucleotide TERT promoter substitution.

281 cyclic GMP-AMP synthase synthesizes a cyclic dinucleotide that initiates an inflammatory cellular res

282 that degrades extracellular bacterial cyclic dinucleotides, thereby promoting virulence.

283 ive measurement of DNAme at up to 50% of CpG dinucleotides throughout the mouse genome.

284 s that GGDEF enzymes make alternative cyclic dinucleotides to cdiG and expands the role of this widel

285 Then we move to larger systems, from dinucleotides to single- and double-stranded oligonucleo

286 xonuclease activity that precisely excises a dinucleotide using an intrinsic 'tape-measure'.

287 to predict the methylation state of DNA CpG dinucleotides using features inferred from three-dimensi

288 n of the DNA sensor molecule STING by cyclic dinucleotides was shown to stimulate infection-related i

289 pleted of A/T and enriched in G/C-containing dinucleotides, whereas MNase-sensitive nucleosomes form

290 enzymes is energized by nicotinamide adenine dinucleotide, which activates ubiquitin by the formation

291 avin mononucleotide (FMN) and flavin adenine dinucleotide, which are essential coenzymes in all free-

292 ic GMP-AMP synthase (cGAS) produces a cyclic dinucleotide, which leads to the upregulation of inflamm

293 ic unmethylated deoxycytidine-deoxyguanosine dinucleotides, which mimic bacterial DNA, induced hemoph

294 + and NADP+) and reduced (NADH) nicotinamide dinucleotides, which therapy decreased generally.

295 We describe novel STING-activating cyclic dinucleotides whose constituent nucleosides are adenosin

296 methylation of cytosine at the specific CpG dinucleotides will participate in quartet formation, cau

297 PMR1 preferentially cleaves between UG dinucleotides within a consensus YUGR element when prese

298 d twelve physical-chemical properties of the dinucleotides within DNA into PseDNC to formulate given

299 encing analysis of CpG rich regions, and CpG dinucleotides within the 5' regulatory regions, confirme

300 restingly, methylation of only six of 98 CpG dinucleotides within the EphA5 promoter blocks its trans