ライフサイエンスコーパス: dione

1 oxybenzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione).

2 perazin-1-yl]-3-cyclohexyl-1H-pyrimidine-2,4-dione).

3 c aldehydes, aromatic amines, and butane-2,3-dione.

4 n 98.6% ee and 39% yield from cyclohexan-1,3-dione.

5 s and 3.6% overall yield from cyclohexan-1,3-dione.

6 the reaction product 1,4-androstadiene-3,17-dione.

7 generation of ruthenium(0) and the requisite dione.

8 approach to 1,7-dioxaspiro[4.4]non-2-ene-4,6-diones.

9 g to substituted chromeno[3,4-c]chromene-6,7-diones.

10 nation generating 6,7-dihaloisoquinoline-5,8-diones.

11 n-7-ones and 2-R-anthra[2,1-b]thiophene-6,11-diones.

12 ylates versus benzazine-3-ones/benzazine-2,3-diones.

13 rrangement to furnish 1,4-benzodiazepine-2,5-diones.

14 lium bromides and prochiral cyclopentene-1,3-diones.

15 by loss of alcohol to indeno[1,2-b]pyran-4,5-diones.

16 logenation reactions of 4,4'-bipyridine-2,2'-diones.

17 nones, 3-butyne-1,2-dione, and 4-pentene-2,3-diones.

18 yl)benzyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione].

19 lpiperazin-1-yl)-2-(1H-indol-3-yl)ethane-1,2-dione (1) were prepared and characterized to assess thei

20 1-phenyl-3-(3,5-dimethoxyphenyl)-propane-1,3-dione (1), a molecule with two methoxy groups in one of

21 , 7-acetamido-2-(8'-quinolinyl)quinoline-5,8-dione (11) and 7-amino-2-(2-pyridinyl)quinoline-5,8-dion

22 hthalic peranhydride (9), and benzofuran-2,3-dione (11) and also by matrix photolysis of 9, 11, and 2

23 yl)butyl)-4-methyl-1,2,4-tri azine-3,5(2H,4H)dione ((11)C-CUMI-101), a novel 5-HT(1A) agonist radiotr

24 cogenin) and 11alpha-hydroxypregn-4-ene-3,20-dione (11alpha-hydroxyprogesterone) were used as startin

25 thalen-1-ylmethyl)-1,2,4-triazine-3,5(2H,4H)-dione 11h was found to be selective over a number of tar

26 of 9, 11, and 2-diazocyclohepta-4,6-dien-1,3-dione (12).

27 (1-methylethenyl)-1H-2,3-benzoxazine-1,4(3H)-diones (16a-e).

28 13)C-labeled 1a to hepta-1,2,4,6-tetraen-1,7-dione (17a) by means of electrocyclic ring opening follo

29 e N-unsubstituted 1H-2,3-benzoxazine-1,4(3H)-diones (17a-e) at rates that were dependent on temperatu

30 ylmethylidene)dioxy]-19-norpreg n-4-ene-3,20-dione ((18)F-FFNP), as well the feasibility of imaging t

31 lin- 2-yl)ethyl)-4-isopropoxyisoindoline-1,3-dione ((18)F-MNI-654) and 2-(2-(3-(4-(2-fluoroethoxy)phe

32 lin-2-yl)ethy l)-4-isopropoxyisoindoline-1,3-dione ((18)F-MNI-659), with the goal of selecting the be

33 iallylated or 2,2-dipropargylated indane-1,3-diones 2 followed by stereoselective radical cyclization

34 amines were condensed with cholest-4-ene-3,6-dione (2) to give 3-arylimino steroids.

35 l-1H-pyrrol-3-yl)methylene)thiazolidine-2,4- dione (2), a thiazolidine-2,4-dione, was obtained from a

36 3-oxo-2-benzofuran-1(3H)-ylidene)pentane-2,4-dione (2).

37 eficient class of indeno[1,2-b]fluorene-6,12-dione, 2,2'-(indeno[1,2-b]fluorene-6,12-diylidene) dimal

38 11) and 7-amino-2-(2-pyridinyl)quinoline-5,8-dione (23), showed selective cytotoxicity toward the NQO

39 nitro-6-(4-nitrostyryl)pyrimidine-2,4(1H,3H)-dione (26), which has a K(i) of 3.7 microM vs M. tubercu

40 is(2-aminoethylamino)anthra[2,3-b]furan-5,10-dione (2a) binds to RG4s in the KRAS transcript under lo

41 -aminoethylamino)anthra[2,3-b]thiophene-5,10-dione (2b) repress translation in a dose-dependent manne

42 ylamine (SKA-31), 6,7-dichloro-1H-indole-2,3-dione 3-oxime (NS309), and 1-ethylbenzimidazolin-2-one (

43 a)2.1 than NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime), an unselective but hitherto the most pot

44 S309, SKS-11 (6-bromo-5-methyl-1H-indole-2,3-dione-3-oxime) and SKS-14 (7-fluoro-3-(hydroxyimino)indo

45 yl-2-bute n-1-yl)-2H-1-benzopyran-4,7(3H,8H)-dione; 3-[(2-O-beta-d-glucopyranosyl-beta-d-glucopyranos

46 exahydro-2H-pyrazinopyrrolo[2,3-b]indole-1,4-dione 39, which in turn is available in enantiomerically

47 n of thioamides 3 with 3-tosyloxypentane-2,4-dione 4 led to in situ formation of 5-acetylthiazole 5 w

48 Fluoroalkyl-substituted triazinane-2,4-diones 4 are obtained by the reaction of phenyl isocyana

49 5-bis(dimethylamino)napthalen-1-yl)furan-2,5-dione (4-maleicanhydridoproton sponge or "MAPS").

50 1-(4-hydroxyphenyl)-2-phenylpyrazolidine-3,5-dione (4-OH-OPB) killed both replicating and NR Mtb, inc

51 into the corresponding enantiomerically pure diones 4b, the absolute configuration of which was deter

52 lly pure N-Boc 9-azabicyclo[3.3.1]nonane-2,6-dione (4b), a potentially useful chiral building block,

53 T cell activation, 5-hydroxynaphthalene-1,4-dione (5HN).

54 pansion to quinazolino[4,5-b]quinazoline-6,8-dione 7 rather than, as previously believed, its isomer

55 ed lapacho quinones, naphtho[2,3-b]furan-4,9-dione (7), was modified in the search for novel agents a

56 ro[3H-indole-3,2'(1H)quinazoline]-2,4'(1H,3H)dione 8, which was also identified as an intermediate in

57 these, 8-hydroxynaphtho[2,3-b]thiophene-4,9-dione (8a), are described.

58 tro-6-(2-hydroxystyryl)pyrimidine-2,4(1H,3H)-dione (9) was identified as a novel inhibitor of Schizos

59 Benzo[a]pyrene-7,8-dione a representative PAH o-quinone is reduced back to

60 7-aminopyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione, a Janus-type nucleobase, has been synthesized and

61 ional heterocyclic moiety, imidazolidine-4,5-dione, a known pharmacophore.

62 ylcyclohexyl)methoxy]benzyl}thiazolidine-2,4-dione, a thiazolidinedione peroxisome proliferator-activ

63 5-phenylthiophene-3-yl-methylpyrimidi ne-2,4-dione (ACET), on altered behavioral phenotypes in the ge

64 violet-induced photochemistry of pentane-2,4-dione (acetylacetone, AcAc).

65 ue, containing 5-aminoquinazoline-2,4(1H,3H)-dione, acts as a Forster resonance energy transfer accep

66 ctedly, substrates such as 4-androstene-3,17-dione (ADD) and 4-BNC displayed strong substrate inhibit

67 reactions were investigated in azetidine-2,3-diones, affording the corresponding 3,3-disubstituted-be

68 roid (3alpha,5alpha)-3-hydroxypregnane-11,20-dione (alphaxalone) with regard to time of onset and rat

69 2-hexyldodecyl)-1,3-thieno[3,4-c]pyrrole-4,6-dione-alt-5,5-(2,5-bis(3-dod ecylthiophen-2-yl)thiophene

70 ed direct conversion to the isoquinoline-5,8-dione; alternatively, N-haloimides of cyanuric acid prov

71 ropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36) (3) is among the few RXR ligands known.

72 ted derivatives of 5alpha/beta-pregnane-3,20-dione, among which the 5beta-H-7alpha-benzoyloxy-11alpha

73 N-aryl, and N-hetereoaryl pyridopyrazine-1,6-diones, an important class of medicinally significant la

74 as pharmacological tools, a thiazolidine-2,4-dione analogue, 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl

75 s region with 6-cyano-7-nitroquinoxaline-2,3-dione and (2R)-amino-5-phosphonovaleric acid greatly red

76 1-alkyl 1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione and 2-alkyl 2H-naphtho[2,3-d][1,2,3]triazole-4,9-d

77 enzylaminomethylene)isoquinoline-1,3-(2H,4H)-dione and 4-[(pyridylmethyl)aminomethylene]isoquinoline-

78 3 (AKR1C3) converts Delta(4)-androstene-3,17-dione and 5alpha-androstane-3,17-dione to testosterone (

79 the formation of tricyclic hexahydroxanthene-dione and a diastereoselective bis-hydroxylation.

80 exahydro-2H-pyrazinopyrrolo[2,3-b]indole-1,4-dione and cinnabarinic acid fragments of these marine al

81 3,4-g]thieno[3,2-c]isoquinoline-5,11(4H,10H)-dione and fluorenedicyclopentathiophene dimalononitrile,

82 A new class of pyrazolo[3,4-c]pyridine-3,7-dione and pyrazolo[3,4-d]azepine-3,7-dione scaffolds was

83 g indirubin [(2Z)-2,3-biindole-2,3 (1'H,1'H)-dione and quercetin (2-(3,4dihydroxyphenyl)-3,5,7-trihyd

84 H2 activation with polyaromatic diones and B(C6F5)3 leads to radical formation in good y

85 activation-arylation of pyridopyrimidin-2,4-diones and barbituric acids, respectively, with boronic

86 lectrochemical synthesis of pyrazolidine-3,5-diones and benzoxazoles by N-N bond formation and C,O li

87 reaction of 1,3,5-trisubstituted pentane-1,5-diones and substituted pyrazoles afforded good yields of

88 Condensation of isatin (indole-2,3-dione) and 2-aminobenzamide led to the spirocyclic molec

89 certain compounds (e.g., 2-cyclopentene-1,4-dione) and a decrease in others (e.g., pyrrole).

90 ylpiperazin-1-yl)-1,4-dihydronaphthalene-1,4-dione) and idebenone, which show modest whole-cell activ

91 -hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) and its derivatives as ligands.

92 f tryptanthrin (indolo[2,1-b]quinazolin-6,12-dione) and nine derivatives on growth, survival, and mut

93 (4-bromobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione) and tandem conjugate reduction-selective monoredu

94 henyl)-furan-2-ylmethylene]-thiazolidine-2,4-dione) and TGX221(7-methyl-2-(4-morpholinyl)-9-[1-(pheny

95 10)-trien-17-yl]amino}hexyl)-1H-pyrrole-2,5- dione), and recovery from inhibition is prevented by wor

96 ne) dimalononitrile, bisindenofluorene-12,15-dione, and 2,2'-(bisindenofluorene-12,15-diylidene) dima

97 s, 2-methylthio-1H-1-indenones, 3-butyne-1,2-dione, and 4-pentene-2,3-diones.

98 nomethylene-1,3-indanedione, benzazepine-1,5-dione, and 9,10-anthraquinone derivatives via solvent co

99 alcohols, phenols, 2-hydroxynaphthalene-1,4-dione, and indoles allow the direct and efficient synthe

100 s of Meldrum's acid derivatives, pyrrole-2,3-diones, and pyrrole-2-carboxylic esters, producing the e

101 rin, a potent tetracyclic aminoquinoline-5,8-dione antitumor antibiotic that reached phase II clinica

102 Piperazine-2,5-diones are formed by Dieckmann cyclization (NaH, THF) of

103 2,3-dihydro-2-alkoxy-indeno[1,2-b]pyrano-4,5-diones are labile compounds since through an opening of

104 estane, 6-methylideneandrosta-1,4-diene-3,17-dione, are preeminent drugs for the treatment of estroge

105 he discovery of the 3-hydroxyquinazoline-2,4-dione as a useful scaffold to obtain potent inhibitors o

106 ort herein the discovery of isoquinoline-1,3-dione as a viable chemotype for selectively inhibiting T

107 ble to use cholesterol and 4-androstene-3,17-dione as primary carbon and energy sources.

108 The first use of vicinal diols, ketols, or diones as 22pi components in metal-catalyzed [2+2+2] cyc

109 The focused set of new pyrrolidine-2,5-diones as potential broad-spectrum hybrid anticonvulsant

110 2,2,2- trifluoroethyl)butyl]thiazolidine-2,4-dione} as the optimal agent, which exhibited high antitu

111 Modeling of the substrate 4-androstene-3,17-dione at the position of the product revealed its intera

112 romatase inhibitor 1,4,6-androstatriene-3,17-dione (ATD) or the androgen receptor blocker flutamide,

113 oxazolidin-2-one, 2-pyridone, pyrimidine-2,4-diones (AZT derivatives), or inosines to the electron-de

114 cator-deficient variants, benzo[a]pyrene-7,8-dione (B[a]P-7,8-dione) produced fewer DNA strand breaks

115 : 1-(2-benzoic acid)-(1H,3H)-quinazoline-2,4-dione (BaQD), 1-(2-benzoic acid)-(1H,3H)-quinazoline-2-o

116 cifically, a 5-methoxyquinazoline-2,4(1H,3H)-dione-based emissive uracil analogue was identified to b

117 ituted naphthalene-1,4-diols and naphtha-1,4-diones bearing a phosphonate group at the 2-position and

118 of 2-aryl perhydropyrrolo[3,4-c]pyrrole-1,3-diones bearing N-acyl substituents have been assessed wi

119 yl)butyl)-4-methyl-1,2,4-tr iazine-3,5(2H,4H)dione) binding in monkey cerebellum.

120 H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione (BIP-135), efficiently abolished the inhibitory ef

121 xy-1H-pyrrolo[2,3-b]pyridin-3- yl)ethane-1,2-dione (BMS-377806, 3) and 1-(4-benzoylpiperazin-1-yl)-2-

122 xy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane -1,2-dione (BMS-488043, 4).

123 yl-1H-pyrrolo[2,3-c]py ridin-3-yl)ethane-1,2-dione (BMS-585248, 12m) exhibited much improved in vitro

124 ibitors represented by the benzothiazole-4,7-dione, BN82685, block the second of two trans-esterifica

125 esponding 2-hydroxy-1,2-dihydroquinoline-3,4-diones, but was unable to inactivate the PQS precursor H

126 tion of the steroid Delta(5)-androstene-3,17-dione by the glutathione transferase A3-3 in mammals was

127 o)ethyl]amino}-5,8-dihydroxy-anthracene-9,10-dione] by reduction of the N-oxides to dimethylamino sub

128 ecylidene)-5-(2-hydroxyethyl)pyrrolidine-2,4-dione (C(12)-TA), derived from one of its quorum sensing

129 gands such as 6-cyano-7-nitroquinoxaline-2,3-dione can produce a full lobe closure, presumably with l

130 ing group in the chromeno[3,4-c]chromene-6,7-diones caused a significant red shift in both the absorp

131 Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therap

132 or antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) acted on RGCs to reduce On responses of gan

133 injection of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and (2R)-amino-5-phosphonovaleric acid (AP-

134 r antagonists 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and DL-2-amino-5-phosphonopentanoic acid (A

135 PA antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and the gap-junction blockers, carbenoxolon

136 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), a partial agonist at TARP-associated AMPAR

137 or antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), whereas this drug had no effect on FGM.

138 or antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 10 microM) abolished field population spiki

139 R antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 4 nmol) or the selective AMPAR antagonist,

140 yl)amino)ethylidene)-5-phenylcyclohexane-1,3-dione (compound 16c) with an IC50 = 0.09 +/- 0.01 muM in

141 unusual 3H-benzo[d]pyrrolo][1,3]oxazine-3,5-dione core.

142 at the C-6 position of the isoquinoline-1,3-dione core.

143 ural products containing a 1,4-oxazepane-2,5-dione-core are known.

144 and 3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-diones could be potential lead compounds for the develop

145 pounds, NQO1 protected against quinoline-5,8-dione cytotoxicity.

146 elling with 4-(3-azidopropyl)cyclohexane-1,3-dione (DAz-2) shows that Cys420 also forms a sulfenic ac

147 2b with diol dihydro-1k, alpha-ketol 1k, and dione dehydro-1k.

148 (3alpha,5alpha)-3-hydroxypregn-16-ene-11,20-dione (Delta(16)-alphaxalone) is explained by the steroi

149 ol-5-yl]-1,3-dipropyl-3,7-dihydro-purine-2,6-dione derivative 66: K(i) A(2B) = 9.4 nM, IC(50) hA(2B)

150 anded on a series of pyrido[2,1-f]purine-2,4-dione derivatives as human adenosine A3 receptor (hA3R)

151 and 3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-dione derivatives as potential antiosteoclastogenic agen

152 thyl)aminomethylene]isoquinoline-1,3-(2H,4H)-dione derivatives reported here represents a novel class

153 ormed on pyranopyrazole and pyranopyrimidine-dione derivatives to obtain spirocyclopropylpyrazolones

154 he resulting 3,3-difluoropyridine-2,4(1H,3H)-dione derivatives underwent palladium-catalyzed hydrogen

155 Subsequently, a series of thiazolidine-2,4-dione derivatives was synthesized.

156 A series of indeno[1,2-b]indole-9,10-dione derivatives were synthesized as human casein kinas

157 stituted 6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione derivatives were synthesized as inhibitors of D-am

158 drobenzo[e]indeno[2,1-b][1,4]diazepine-10,12-dione derivatives.

159 , enantioenriched spiro(indoline-pyrimidine)-diones derivatives.

160 concentrations of 3,4-dihydroxy-3-hexen-2,5-dione (DHHD) and 2,3-dihydro-3,5-dihydroxy-6-methyl-4(H)

161 droepiandrosterone, Delta(4)-androstene-3,17-dione, dihydrotestosterone, all P < .001; testosterone,

162 reaction of 1,3-di(pyridin-2-yl)propane-1,3-dione dioxime (dpdH2) with triangular [Mn(III)3O(O2CMe)(

163 en 3-phenyl-1,5-bis(pyridin-2-yl)pentane-1,5-dione dioxime (pdpdH(2)) and triangular [Mn(III)(3)O(O(2

164 and synthesis of a series of anthracene-9,10-dione dioxime series of compounds demonstrated potent in

165 honooxy)prop yl-1-(2-propynyl)-1H-purine-2,6-dione disodium salt hydrate), in modulating cocaine- and

166 l-1-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione displayed equal potency in the new assays, in agre

167 ) reaction provides 1,2,4-dithiazolidine-3,5-diones [dithiasuccinoyl (Dts)-amines] by the rapid react

168 2-dodecyl-6-methoxycyclohexa-2,5-diene- 1,4-dione (DMDD) remarkably inhibited the growth of human br

169 rized antagonist, 6,7-dinitroquinoxaline-2,3-dione (DNQX), acts as an efficient fluorescence energy t

170 eaction with chalcones to give 2-benzoyl-1,4-diones (double aroylation products), which, in turn, wer

171 study using 1,2-di(thiophen-2-yl)ethane-1,2-dione (DTED).

172 on-donating group, cyclopenta[c]thiophen-4,6-dione electron acceptor and various pi-linkers including

173 rotestosterone, and Delta(4)-androstene-3,17-dione elucidated the structural basis for this functiona

174 tension of the substrate scope to cyclic 1,3-dione equivalents, such as 2-cyanocyclohexanone (4), is

175 with 4-ferrocenylmethyl-1,2,4-triazoline-3,5-dione (FMTAD): once derivatized, the determination of 25

176 sis of a late-stage intermediate, the "Corey dione", from which DICA has been made previously.

177 ,4,5,6,7-heptafluro-8-hydroxyanthracene-9,10-dione) functionalizing the nanoparticle surface.

178 lyzed bond scission of pentafluorobutane-1,3-diones generates difluoroenolates that react with aldehy

179 t IBMX and other oxypurines containing a 2,6-dione group interfere with the binding of glutamate to t

180 by the antagonist 6,7-dinitroquinoxaline-2,3-dione had no effect in the PGE2-induced hyperalgesia in

181 2-alkyl 2H-naphtho[2,3-d][1,2,3]triazole-4,9-dione has been developed.

182 oazetidine-2-carbaldehydes and azetidine-2,3-diones has been described for the first time.

183 ration of highly functionalized beta-enamino diones has been developed.

184 trahydro-1H-pyrrolo[1,2-c]imidazol e-1,3(2H)-dione] has been characterized as a high-affinity and pot

185 rini reactions of tetramethylcyclobutane-1,3-dione have been performed in this work.

186 2-heptyl-2-hydroxy-1,2-dihydroquinoline-3,4-dione (HHQD).

187 a novel variant of 2-hydroxyisoquinoline-1,3-dione (HID) scaffold featuring a crucial C-6 benzyl or b

188 a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs).

189 ropanoate)-7abeta-methylhexahydro-1,5-indane-dione (HIP).

190 previously reported 3-hydroxypyrimidine-2,4-dione (HPD) core, we have designed and synthesized a new

191 reviously reported a 3-hydroxypyrimidine-2,4-dione (HPD) subtype that potently and selectively inhibi

192 tions of three novel 3-hydroxypyrimidine-2,4-dione (HPD) subtypes carefully designed to achieve selec

193 l and 1-alkyl 2,2,4,4,4-pentafluorobutan-1,3-dione hydrates has been used to produce a series of pent

194 iads based on the indeno[1,2-b]fluorene-6,12-dione (IF) scaffold.

195 ydroxypyruvaldehyde and 5-hydroxypentane-2,3-dione in barley and soy.

196 irradiation of N-methyl-1,2,4-triazoline-3,5-dione in the presence of substituted benzenes is capable

197 d 2,2,4-trihalo-5-hydroxy-4-cyclopentene-1,3-diones in drinking water.

198 Oxidation then affords bicyclic diones in good three-step yields.

199 uthenacyclopentadienes that engage transient diones in successive carbonyl addition.

200 shira cross-coupling reactions of cyclic 1,3-diones in the synthesis of beta-substituted cyclic enone

201 thin (3,3'-dihydroxy-beta,beta-carotene-4,4'-dione) in the blood-red flowers of Adonis aestivalis, an

202 Since previously identified diarylethane-1,2-dione inhibitors are decidedly hydrophobic, a modified d

203 novel C6-substituted androsta-1,4-diene-3,17-dione inhibitors have been designed.

204 C4 of the ribo and 2'-deoxy 3,3-difluoro-2,4-dione intermediates followed by deprotection gave the 3-

205 Wittig reagent at C4 of the 3,3-difluoro-2,4-dione intermediates gave exocyclic alkenes that underwen

206 prochiral 2,2-disubstituted cyclopentene-1,3-dione is catalyzed by a bifunctional tertiary aminourea

207 te derived from 2,2,7,7-tetramethyloctan-3,6-dione is characterized in the solid state by X-ray diffr

208 formation of 2-R-anthra[2,1-b]thiophene-6,11-diones is a new reactivity path.

209 ecedented reactivity of 3-aminoquinoline-2,4-diones is reported.

210 emestane (6-methyleneandrosta-1,4-diene-3,17-dione) is a synthetic steroidal inhibitor of the aromata

211 ydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione, is a polyphenolic compound naturally present in t

212 -hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] is a natural plant phenolic compound that possess

213 roline, and the cyclic ketones 1H-indole-2,3-dione (isatin), indenoquinoxaline-11-one and acenaphthen

214 utoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145), was synthesized and biologically character

215 of (E)-3-arylidene-1-phenyl-pyrrolidine-2,5-diones, l-proline, and the cyclic ketones 1H-indole-2,3-

216 ol condensation of 4-substituted heptane-2,6-diones leads to chiral cyclohexenones.

217 ), where phendione = 1,10-phenanthroline-5,6-dione, leads to DNA cleavage in an oxygen independent ma

218 reaction between the 1,10-phenanthroline-5,6-dione ligand and NADH.

219 ,6-pentachloro-6-hydroxy-cyclohexa-2-ene-1,4-dione may serve as a key branching point, with chloramin

220 lidene)dihydro-2-thioxopyrimidine-4,6(1H,5H)-dione (MDG 548), 3-((4-bromophenoxy)methyl)-N-(4-nitro-1

221 esferal decreased the formation of B[a]P-7,8-dione-mediated DNA strand breaks indicating that they we

222 he reaction of N-methyl-1,2,4-triazoline-3,5-dione (MeTAD) with acenaphthylene and indene leads not o

223 he reaction of N-methyl-1,2,4-triazoline-3,5-dione (MeTAD) with anisole in the presence of trifluoroa

224 4-methoxyphenyl)-4-morpholino-1H-pyrrole-2,5-dione, named RI-2 (referred to as compound 7a in this re

225 -6-nitro-7-sulfamoyl-benzo(f)quinoxaline-2,3-dione (NBQX) to block enhanced AMPA receptor glutamaterg

226 (naphthalene-1-yl)-1,2,4-thiadiazolidine-3,5-dione (NP12), lessens the magnitude of adverse myocardia

227 on of hydroxylated 5alpha/beta-pregnane-3,20-dione or 5beta-cholan-3-one precursors.

228 -(1,3-dihydroxyallylidene)-1H-indene-1,3(2H)-dione or by loss of alcohol to indeno[1,2-b]pyran-4,5-di

229 nyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3 H,6 H)-dione (or MDPD).

230 ne)-3-(1-methylcyclohexyl)-thiazolidin e-2,4-dione (OSU-CG12), that induces Sp1 degradation in a mann

231 ocarbons across the diol, hydroxyketone, and dione oxidation levels to form products of [4 + 2] cyclo

232 accessible from the diol, alpha-ketol or 1,2-dione oxidation levels with complete control of diastere

233 with a catalytic mechanism involving olefin-dione oxidative coupling to form an oxa-osmacyclopentane

234 ence of the dione product, phenanthrene-9,10-dione (P2), thought to arise from further oxidation of h

235 :4,5-b']dithiophene-thieno[3,4-c]pyrrole-4,6-dione) (PBDTTPD) polymers for bulk heterojunction (BHJ)

236 o[2,3-c:9,10-c']bis([1,2,5]thiadiazole)-6,13-dione (PBTDQ), with two peripheral thiadiazole rings was

237 The 6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione pharmacophore appears metabolically resistant to O

238 benzimidazole template and a quinoxaline-2,3-dione pharmacophore was modified to maintain GnRH antago

239 ing the redox active 1,10-phenanthroline-5,6-dione (phendione) ligand by electrochemical functionaliz

240 1R,5R)-6,6-dimethylbicyclo[3.1.1]heptane-2,3-dione ("PinDione").

241 3,4-g]thieno[3,2-c]isoq uinoline-5,11(4H,10H-dione) (PNSW); poly(4,10-bis(2-butyloctyl)-2-(5-(2-ethyl

242 ,4-g]thieno[3,2-c]isoquinoline-5,11(4H, 10H)-dione) (PNTPD); poly(5-(4,10-bis(2-butyloctyl)-5,11-diox

243 :4,5-b']dithiophene-thieno[3,4-c]pyrrole-4,6-dione polymers (PBDTTPD derivatives) was synthesized and

244 Structural changes to the quinoxaline-2,3-dione portion of the molecule resulted in several struct

245 -3,4]pyrr olo[1,2-a]quinoxaline-8,10-(7H,9H)-dione, PPQ-102, completely inhibited CFTR chloride curre

246 ariants, benzo[a]pyrene-7,8-dione (B[a]P-7,8-dione) produced fewer DNA strand breaks in AhR-deficient

247 o occurs as suggested by the presence of the dione product, phenanthrene-9,10-dione (P2), thought to

248 how that 2-pyridine-3-yl-methylene-indan-1,3-dione (PRT4165) is a potent inhibitor of PRC1-mediated H

249 17,21-Dimethyl-19-norpregna-4,9-dien-3,20-dione (R5020) progestin limited this effect and was coun

250 the ortho-quinone isomers (BP 7,8- and 9,10-diones, respectively), whereas TBI oxidation of the 1-,

251 s in separate rings (BP 1,6-, 3,6-, and 6,12-diones, respectively).

252 xystyryl)-7-methyl-3,7-dihydro-1H-purine-2,6-dione], respectively, in squirrel monkeys trained to int

253 Ms) that incorporates a pyridopiperazine-1,6-dione ring system.

254 roviding the dibenzo[b,f][1,4]-dioxocin-6,11-dione ring-system, which is otherwise difficult to prepa

255 tional equilibrium of 1,4-benzodiazepine-2,5-dione rings are discussed.

256 fused dihydro[1,3]dithiolo[4,5-c]pyrrole-4,6-dione rings interconnected by 3,5-diylidenethiomorpholin

257 yl)-4-(1-methyl-1H-indol-3-yl)1H-pyrrole-2,5-dione (SB216763) and linopirdine reduce PPI when directl

258 The tripyrrin-1,14-dione scaffold of urinary pigment uroerythrin coordinate

259 bitors are decidedly hydrophobic, a modified dione scaffold was designed and elaborated into a >300 m

260 ubstitutions of the indeno[1,2-b]indole-9,10-dione scaffold, potent CK2 inhibitors into selective ABC

261 ine-3,7-dione and pyrazolo[3,4-d]azepine-3,7-dione scaffolds was synthesized via a Michael addition a

262 ructure with bound product 4-androstene-3,17-dione showed that Ser-468 is in a position in which it c

263 MI-4a, a novel benzylidene-thiazolidine-2, 4-dione small molecule inhibitor of the Pim kinases, kills

264 iscovery of 1,3,8-triazaspiro[4.5]decane-2,4-diones (spirohydantoins) as a structural class of pan-in

265 1,3,8-Triazaspiro[4.5]decane-2,4-diones (spirohydantoins) were optimized as an advanced l

266 effective use of furan as a E-but-2-ene-1,4-dione surrogate, Nagao acetate aldol reaction, and Shiin

267 ion of the tricyclic naphtho[2,3-b]furan-4,9-dione system were synthesized and evaluated for their ab

268 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (TDZD-8) restored Schwann cell defects, effectivel

269 (4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione [TDZD-8]) or RNA interference-mediated knockdown o

270 elective inhibitors using similar indole-2,3-diones that exhibit differential inhibition of ALDH1A1,

271 phenanthro[1,10,9,8,o,p,q,r,a]per ylene-7,14-dione), the fluorescent, lipophilic pigment associated w

272 ndol-3-yl]-4-(1H-indol-3-yl)-1H-pyr role-2,5-dione), the PKCbeta-selective inhibitor Ruboxastaurin, a

273 eparation of chiral bicyclo[2.2.2]octane-2,5-dione, the precursor of useful chiral diene ligands, was

274 zol-2-ylthio)-6-tosylcyclohexa-2,5-diene-1,4-dione through a Michael-type addition of p-toluenesulfin

275 ostene-3,17-dione and 5alpha-androstane-3,17-dione to testosterone (T) and 5alpha-dihydrotestosterone

276 accessible 2-(2-bromobenzyl)cyclohexane-1,3-diones to provide the corresponding 2,3,4,9-tetrahydro-1

277 proved synthesis of thieno[3,4-c]pyrrole-4,6-dione (TPD) monomers, including Gewald thiophene ring fo

278 stituents on N-alkylthieno[3,4-c]pyrrole-4,6-dione (TPD)-based polymers and solar cell device perform

279 s are provided by a thieno[3,4-c]pyrrole-4,6-dione (TPD)-dithienosilole copolymer PTPDSi.

280 d more DNA single strand breaks in B[a]P-7,8-dione-treated Hepa cells and H358 cells than in its abse

281 e compound (z)-5-octylidenethiazolidine-2, 4-dione (TZD-C8) was a strong inhibitor of biofilm formati

282 3-triazole and 4-phenyl-1,2,4-triazoline-3,5-dione undergo a formal Diels-Alder reaction, which follo

283 ,6-pentachloro-6-hydroxy-cyclohexa-2-ene-1,4-dione via chlorophenol and chlorobenzoquinone intermedia

284 responding benzazine-3-ones or benzazine-2,3-diones via the 6-exo-trig process in compliance with Bal

285 The deleterious compound anthracene-9,10-dione was detected both in N2 and air atmospheres.

286 Benzo[a]pyrene-7,8-dione was reduced to benzo[a]pyrene-7,8-catechol by dith

287 -group, an N-unsubstituted 1,4-oxazepane-2,5-dione was synthesized.

288 ctionalized beta-lactams and pyrrolidine-2,5-diones was achieved through a sequential Ugi-4CR/cycliza

289 azolidine-2,4- dione (2), a thiazolidine-2,4-dione, was obtained from a high throughput screening of

290 imethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione} was previously developed in our lab as an antitum

291 dent DNA strand breaks mediated by B[a]P-7,8-dione were lower in AhR-deficient Hepa and AhR knockdown

292 hoxymethyl)-5-isopropylpyrimidine-2,4(1H,3H)-dione) were synthesized by reaction of 6-[(3,5-dimethylp

293 -5-nitrobenzylidene)-3-ethylthiazolidine-2,4-dione, were utilized to gain insight into the structure-

294 osphooxy)propyl-1-(2 propynil)-1H-purine-2,6-dione] were found previously to either decrease or incre

295 the steroid substrate 5alpha-androstane-3,17-dione, whereas wild-type M. tuberculosis H37Rv could.

296 2,2,4-tribromo-5-hydroxy-4-cyclopentene-1,3-dione, which is an analogue to several previously descri

297 ies of 7-amino- and 7-acetamidoquinoline-5,8-diones with aryl substituents at the 2-position were syn

298 pyrazolopyridin-2-ones, and pyridopyridazine diones with varying substitution patterns.

299 [2,3-a]dipyrido[3,2-h:2',3'-f]phenazine-5,18-dione), with lambdamax = 450 nm.

300 undred gram quantities of pyridopyrazine-1,6-diones without the use of specialized equipment.

301 system consisting of 1,10-phenanthroline-5,6-dione/ZnI2 that bypasses these constraints via an abiolo