ライフサイエンスコーパス: dioxane

1 entrations, suggesting selective pressure by dioxane.

2 mine (Pa-2), respectively, in 1:1 mesitylene/dioxane.

3 efficient at pH 5.5, but only by 30% for 1,4-dioxane.

4 ...O hydrogen bond with a ring oxygen of the dioxane.

5 xamined in varying concentrations of THF and dioxane.

6 units RPA14 and RPA32 was identified to bind dioxane.

7 um dimethylaminoborohydride (LAB) in THF and dioxane.

8 n the two solvents investigated, toluene and dioxane.

9 is evidence for solvation of the carbene by dioxane.

10 )()eq interaction is especially important in dioxane.

11 e and caffeine, from their suspension in 1,4-dioxane.

12 o, 1,3-dioxane can be distinguished from 1,4-dioxane.

13 ntaminated with chlorinated solvents and 1,4-dioxane.

14 om (4S,5S)-5-amino-2,2-dimethyl-4-phenyl-1,3-dioxane.

15 ional solvent-vapor penetration (SVP) of 1,4-dioxane.

16 radditive treatment effect for degrading 1,4-dioxane.

17 ate hydroxyl (HO*) radicals that degrade 1,4-dioxane.

18 to an array of stock solutions of single 1,3-dioxanes.

19 h Na(HMDS) to form new sodium ferrate base [(dioxane)0.5 NaFe(HMDS)3 ] (1) enables regioselective mon

20 -2,6-(C6H4-4-(t)Bu)2 (Terph-Li) with UI3(1,4-dioxane)1.5 led to the formation of the homoleptic urani

21 proposed for C-H bonds in cyclohexane, 1, 3-dioxane, 1,3-oxathiane, and 1,3-dithiane were studied co

22 n of unsaturated peroxyacetals furnishes 1,2-dioxanes, 1,2-dioxepanes, and 1,2-dioxacanes through 6-e

23 gonal protecting groups with traditional 1,3-dioxane/1,3-dioxolane for carbonyl compounds.

24 iven Fenton reaction completely degraded 1,4-dioxane (10 mM initial concentration) in 53 h with an op

25 romoalkenes is promoted by Pd(OAc)2 (10%) in dioxane (100 degrees C) to give cyclotrimers in 27-77% y

26 a(1)-AR) binding sites recognized by the 1,4-dioxanes 2-4 display reversed stereochemical requirement

27 m-oxo bond scission and formation of UI4(1,4-dioxane)2 with extrusion of hexamethyldisiloxane.

28 (6S)-3-Methylene-6-methyl-1,4-dioxane-2,5-dione was synthesized from L-lactide and use

29 ing a small percentage of spiro[6-methyl-1,4-dioxane-2,5-dione-3,2'-bicyclo[2.2.1]hept[5]ene] into po

30 the dienophile to prepare spiro[6-methyl-1,4-dioxane-2,5-dione-3,2'-bicyclo[2.2.1]hept[5]ene] via an

31 nd is low and calculated as 6.0 kcal/mol for dioxane 22a and 2.0 kcal/mol for the formation of cycloh

32 3-dioxane (TMD) and 2-ethyl-5,5-dimethyl-1,3-dioxane (2EDD) which impart a distinctive sickening or o

33 Two series of 1,4-dioxanes (4-11 and 12-19) were rationally designed and p

34 cis-2-tert-butyl-5-(tert-butylsulfonyl)-1,3-dioxane, (4) determination of enthalpic and entropic con

35 m's acid (5-(4-bromobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione) and tandem conjugate reduction-select

36 d (5-(4-methoxybenzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione).

37 In 1,4-dioxane, 8 decomposes to Ph2C=CPh2 via first-order kinet

38 boronic acid reacted at only 60 degrees C in dioxane (86% yield).

39 However, axial 5-phenyl-1,3-dioxane adopts a "parallel" conformation that allows an

40 They demonstrated a higher stability of the dioxane alpha-bromo anion with respect to alpha-eliminat

41 microbially driven Fenton degradation of 1,4-dioxane, an indication that conventional and microbially

42 n of cell viability after treatment with 1,4-dioxane and 5-fluorouracil, which proves that it can be

43 ltaG(double dagger)(298) by 4.2 kcal/mol for dioxane and 6.4 kcal/mol for cyclohexane derivatives tha

44 At sites where dioxane and chlorinated solvents were present, the media

45 Radicals derived from dioxane and diisopropyl ether by flash photolysis of DTB

46 esirable chemical reactions by production of dioxane and dioxolane isomers, furfural and 5-hydroxymet

47 -2-substituted pyrrolidines using 4 N HCl in dioxane and MeOH gave the corresponding enantiomers of 2

48 e involved in the aerobic degradation of 1,4-dioxane and other environmental contaminants.

49 hR partial agonist, were designed by opening dioxane and replacing hydroxyl carbon with nitrogen.

50 Treatment of LB with 2 equiv of GeCl(2).dioxane and SnCl(2) in toluene gives compounds [(LB)Ge(I

51 growth on the environmental contaminant 1,4-dioxane and the first member of the genus Pseudonocardia

52 cts, a connected trans-3,6-disubstituted-1,2-dioxane and trans-2,5-disubstituted-tetrahydrofuran ring

53 in the side-chain conformations between the dioxane and water structures are of the same magnitude a

54 were provided with lactate, Fe(III), and 1,4-dioxane and were exposed to alternating aerobic and anae

55 the efficient synthesis of alpha-acyloxy-1,4-dioxanes and 1,4-dithianes employing t-butyl peroxyester

56 atorial conformers of phenyl substituted 1,3-dioxanes and tetrahydropyrans are compared with those of

57 osobenzothiazoline (2a) in acetonitrile, 1,4-dioxane, and cyclohexane followed first-order kinetics.

58 s water, methanol, chloroform, acetonitrile, dioxane, and DMSO.

59 size, chemical function, and geometry of 1,4-dioxane, and hence, a noncovalent auxiliary interaction

60 ewis bases, such as tert-butyl methyl ether, dioxane, anisole, ethyl acetate, beta-chloroethyl ether,

61 Solutions of the Lewis acid B(C6F5)3 in 1,4-dioxane are found to effectively catalyze the hydrogenat

62 fferences of para-substituted 2,2-diaryl-1,3-dioxanes are linearly related to the Hammett sigma value

63 e to high yields under ambient conditions in dioxane as solvent and aqueous tert-butyl hydroperoxide

64 tions, only in the presence of K2CO3, in 1,4-dioxane as solvent and under microwave irradiation, and

65 s achieved using 30% of catalytic loading in dioxane at 10 degrees C.

66 ylphosphino-1,1'-binaphthyl] and AgSbF(6) in dioxane at 100 degrees C for 24 h led to isolation of 1-

67 % yield and 99% ee upon reaction with CuI in dioxane at 100 degrees C.

68 mol % of ethylenediamine as the catalyst in dioxane at 110 degrees C in the presence of K(3)PO(4) as

69 l)methane and 4,4'-biphenyldialdehyde in 1,4-dioxane at 120 degrees C to produce a highly porous 9-fo

70 ligand (DPEphos) and a base (LiOtBu) in 1,4-dioxane at 120 degrees C.

71 Sodium methoxide and (+)-23 in dioxane at 25 degrees C and at 0 degrees C yield (+)-ben

72 )2(o-biphenyl)]Cl (2) and AgOTf (5 mol %) in dioxane at 25 degrees C for 45 min led to isolation of b

73 or isolated C(60) nanoparticles dissolved in dioxane at 293 K and at 77 K.

74 ichiometric amount of CuCl(2) (2.2 equiv) in dioxane at 60 degrees C for 12 h formed 3-isobutyryl-2-i

75 NMR spectrum (delta = 127.8 ppm at pH 13 vs dioxane at 66.6 ppm) is comparable to those that have be

76 as now been determined at pH > 13 in aqueous dioxane at 70 degrees C.

77 the Air Force data set confirmed significant dioxane attenuation (131 out of 441 wells) at a similar

78 s established a positive correlation between dioxane attenuation and increasing concentrations of dis

79 was used to provide significant evidence of dioxane attenuation at field sites.

80 The magnitude and prevalence of dioxane attenuation documented here suggest that natural

81 Dioxane attenuation rates were positively correlated wit

82 oxidation, enhanced bioremediation) impacted dioxane attenuation.

83 These results indicated that the 1,4-dioxane backbone in the ligands having the general struc

84 - and dichloroborane adducts of dioxane from dioxane-BCl(3) and NaBH(4) in the presence of catalytic

85 al preference of a variety of 2,2-diaryl-1,3-dioxanes bearing remote substituents on the phenyl rings

86 le to the UV/H2O2 AOP for degradation of 1,4-dioxane, benzoate and carbamazepine across pH 5.5-8.3.

87 t 1,1-DCE was the strongest inhibitor of 1,4-dioxane biodegradation by bacterial pure cultures expose

88 d solvents and their mixtures on aerobic 1,4-dioxane biodegradation by Pseudonocardia dioxanivorans C

89 Inhibition of 1,4-dioxane biodegradation rates by chlorinated solvents was

90 5 mg L(-1) 1,1-DCE completely inhibited 1,4-dioxane biodegradation.

91 lts will have implications for selecting 1,4-dioxane bioremediation strategies at sites where chlorin

92 This characterization of the dioxane biosynthetic pathway sets the basis for the util

93 -borane adduct showed enhanced reactivity in dioxane but low reactivity in dichloromethane.

94 ed ring-opening of cyclic 1,3-dioxolanes and dioxanes by trimethylsilyl alkynes to set diol-derived p

95 Also, 1,3-dioxane can be distinguished from 1,4-dioxane.

96 luene together with solvents such as THF and dioxane can be heated way above their boiling point in s

97 Replacement of the (2,3-dihydro-benzo[1,4]dioxane)-carbonyl moiety of doxazosin with aryl-sulfonyl

98 C12,N13-bridged tetrahydrofuran, pyran, and dioxane compounds 10-13.

99 were primarily responsible for elevated 1,4-dioxane concentrations in the Cape Fear River watershed.

100 1,4-Dioxane concentrations ranged from <0.15 mug/L in nonimp

101 In WWTP effluent, 1,4-dioxane concentrations varied widely, with a range of 1.

102 p < 0.05) in source-zone samples with higher dioxane concentrations, suggesting selective pressure by

103 d by isotope dilution using mass-labeled 1,4-dioxane-d8 as internal standard.

104 Various cryptands based on 1,3-dioxane decorated 1,3,5-trisubstituted-benzene building

105 Dioxane decreases the observed rate of carbene reaction

106 oxygenase genes that are likely involved in dioxane degradation and suggests their usefulness as bio

107 The 1,4-dioxane degradation process was driven by pure cultures

108 oborated the vital role of monooxygenases in dioxane degradation.

109 ntial role in the initiation of 1,4-dioxane (dioxane) degradation.

110 to dioxane since 1980s revealed that various dioxane-degrading SDIMO genes were widespread, and PCR-D

111 A catalytic system involving DAPCy in dioxane demonstrates a temperature-dependent reactivity

112 A new d-erythrose 1,3-dioxane derivative was synthesized from d-glucose and fo

113 y, we linked an antiinflammatory moiety (1,3-dioxane derivative) to the key pharmacophoric moiety of

114 nted reaction is proposed to proceed via 1,2-dioxane derivatives, which decompose under formation of

115 The dioxane--dichloroborane adduct showed remarkable selecti

116 or position (C(2) or C(6)), and solvent (1,4-dioxane, dichloromethane, acetonitrile, methanol, and in

117 uch as tetrahydrofuran, tetrahydropyran, 1,4-dioxane, diethyl ether, tetrahydrothiophene, and 1,3-dit

118 heir potential role in the initiation of 1,4-dioxane (dioxane) degradation.

119 op appropriate management strategies for 1,4-dioxane (dioxane) due to its widespread occurrence and p

120 asmenylcholines via a tandem reductive vinyl dioxane/dioxolane ring opening and alkyliodide coupling

121 uptake and the surface area in the resulting dioxane-directed crystals.

122 Inclusion of dioxane directs the crystal packing for these cages away

123 d: a 3,5-bis-CF3 phenyl group at C(5) in 1,3-dioxane displays a pronounced preference for the axial o

124 probing of the conformational equilibria in dioxane, dithiane, and diselenane analogues by variable-

125 When 1,4-dioxane/DMF mixture was used as the common solvent and w

126 riate management strategies for 1,4-dioxane (dioxane) due to its widespread occurrence and perceived

127 Sodium methoxide in dioxane effects rearrangement-displacements of 14 (X = B

128 ct the conformational energy of a 5-aryl-1,3-dioxane: electron-withdrawing substituents decrease the

129 neration was influenced, and CH(3)CN and 1,4-dioxane emerged as the optimum solvents.

130 lly isomeric 2,2-diaryl-cis-4,6-dimethyl-1,3-dioxane epimers, X-ray crystallography, (1)H NOESY analy

131 Dioxane, ethyl acetate, and beta-chloroethyl ether form

132 cluding background groundwater with no known dioxane exposure history.

133 lyst conducted with a solution of ammonia in dioxane form primary arylamines from a variety of aryl e

134 selected oxygen-containing Lewis bases, only dioxane forms stable and reactive mono- and dichlorobora

135 ation of mono- and dichloroborane adducts of dioxane from dioxane-BCl(3) and NaBH(4) in the presence

136 Reaction of 4(*) with GeCl2.dioxane gives an anionic germanium(IV)-bis(dithiolene) c

137 B-induced dimeric capsule with entrapped 1,4-dioxane guest molecules.

138 L1 or L2 and the biphasic solvent system 1,4-dioxane/H(2)O.

139 e protease subtilisin Carlsberg in anhydrous dioxane has been determined to 2.6-A resolution.

140 show that an organic directing solvent, 1,4-dioxane, has a dominant effect on the lattice energy for

141 photostabilities in a selected solvent, 1,4-dioxane, have been investigated using a frequency double

142 used to manage some but not necessarily all dioxane-impacted sites.

143 The addition of a small amount of dioxane in CFCl(2)CF(2)Cl extends the lifetime of the ca

144 binding affinities have been identified for dioxane in CyP(6)Q[6] and adamantyl NH(3)(+) in CyP(7)Q[

145 ual solvents inhibited biodegradation of 1,4-dioxane in the following order: 1,1-dichloroethene (1,1-

146 n pure THF and with increasing the amount of dioxane in THF.

147 es with alkyl aldehydes provides the syn-1,3-dioxanes in a highly efficient and stereoselective manne

148 sulfonic acid in aqueous medium delivers 1,3-dioxanes in high yield.

149 ompounds such as ethyl pyruvate, furfural or dioxanes in higher concentration.

150 1,4-Dioxane is a likely human carcinogen, and an excess 10(-

151 roxylamine (NbzONH(2)) and sodium hydride in dioxane is a superior reagent combination for this purpo

152 1,4-dioxane is an emerging groundwater contaminant with sign

153 ttenuation or enhanced biodegradation of 1,4-dioxane is being considered for contaminated groundwater

154 The carcinogenic cyclic ether compound 1,4-dioxane is employed as a stabilizer of chlorinated indus

155 tric cyclopropanation of styrene by 8 in 1,4-dioxane is first-order in both copper carbene 8 and styr

156 nmental Protection Agency data show that 1,4-dioxane is frequently detected in U.S. drinking water de

157 f the persistent groundwater contaminant 1,4-dioxane is often hindered by the absence of dissolved ox

158 l groundwater treatments, remediation of 1,4-dioxane is often limited to costly ex situ UV-based adva

159 he reaction between AMS and 1 (80 degrees C, dioxane) is first order in both alkene and 1.

160 eries of anancomeric 2-tert-butyl-5-aryl-1,3-dioxane isomers demonstrates that remote substituents on

161 Individual members of the 1,3-dioxane library have activity in a variety of phenotypic

162 13 < 8 < 14 congruent with 19-21 and CCl4 < dioxane < MeCN < t-BuOH < MeCN:phosphate buffer (3:1 v/v

163 Dioxane mineralization ceased after 7 days and was resum

164 of solution hydrophobicity by means of water/dioxane mixtures yielded results similar to those for ca

165 ilization of C-C bound ribose, dioxolane and dioxane moieties in the generation of improved biologica

166 drate-like 4'-hydroxy-5'-hydroxymethyl-2',7'-dioxane moiety attached to the aglycone via a carbon-car

167 sugar-like 4'-hydroxy-5'-hydroxymethyl-2',7'-dioxane moiety attached via a carbon-carbon bond to the

168 Two of the bound dioxane molecules are in the active-site region, one in

169 The other five dioxane molecules are located on the surface of subtilis

170 The latter structure contains four 1,4-dioxane molecules from the crystallization solution, one

171 Seven enzyme-bound dioxane molecules have been detected, each potentially f

172 nding" domain of EthR is occupied by two 1,4-dioxane molecules, a component of the crystallisation bu

173 Accordingly, dioxane-monochloroborane should serve as a reagent of ch

174 The dioxane--monochloroborane adduct hydroborates representa

175 droboration of several terminal olefins with dioxane--monochloroborane were highly regioselective and

176 P production and down-regulation of both 1,4-dioxane monooxygenase (dxmB) and aldehyde dehydrogenase

177 2 (Cl)Ge:] 1 with sodium phosphaethynolate [(dioxane)n NaOCP].

178 been prepared, along with their adducts with dioxane Na[H(3)B-NRR'-BH(3)](diox)(x) where x = 0.5 or 1

179 d suggests their usefulness as biomarkers of dioxane natural attenuation.

180 The method was applied to investigate 1,4-dioxane occurrence and sources in the Cape Fear River wa

181 To support 1,4-dioxane occurrence investigations, source identification

182 quantum yield, or lifetime of 2AP in either dioxane or DMF.

183 tigated in binary mixtures of water with 1,4-dioxane or N,N-dimethylformamide (DMF).

184 In dioxane or THF solvent, LFP produces the corresponding e

185 sium hydroxide as base in a two-phase (water/dioxane or water/acetonitrile) process to provide modera

186 analytical method capable of quantifying 1,4-dioxane over a wide concentration range in a broad spect

187 ethylsilyloxymethyl-5-methylene-2-phenyl-1,3-dioxane, primary-selective phosphorylation, and cleavage

188 f a series of 4-substituted 2-iodomethyl-1,3-dioxanes proceeds rapidly and regioselectively to afford

189 Anancomeric 5-phenyl-1,3-dioxanes provide a unique opportunity to study factors t

190 solvent of low polarity (such as toluene or dioxane) provide especially high (> 80%) isolated yields

191 d by the reaction of 2 with Na(2)[Fe(CO)(4)].dioxane, represents an unusual "dual reduction" of the i

192 ults of photostability study in nonpolar 1,4-dioxane revealed the remarkable enhancement in stability

193 in tetrahydrofuran, acetonitrile (ACN), and dioxane reveals that isomers with similar molecular weig

194 rate that the phenyl prefers to lie over the dioxane ring in order to position an ortho-hydrogen to p

195 one-dimensional polymeric forms based on 1,4-dioxane rings in P2/c LiCO2, and the C(O(-))2 moieties i

196 lopropane 2a, containing two spiro-fused 1,3-dioxane rings, with MeLi gave only the methylation produ

197 acophore models and highlighted that the 1,4-dioxane scaffold is compatible with potent antagonist ac

198 ng the methyl group in position 6 of the 1,4-dioxane scaffold of the potent M(2)/M(3) muscarinic agon

199 and diastereospecific synthesis of a new 1,3-dioxane series of active analogues.

200 Microcosm assays with (14)C-labeled dioxane showed that the highest mineralization capacity

201 p) analysis of Arctic groundwater exposed to dioxane since 1980s revealed that various dioxane-degrad

202 orms undergo self-assembly in water or water/dioxane solution to give a variety of nanostructures.

203 m benzylate and sodium neopentoxide to NO in dioxane solution.

204 in glacial acetic acid (1Ea and 1Zc) and in dioxane solutions containing HCl, trifluoromethanesulfon

205 ino 2 isomers were determined in aqueous and dioxane solutions.

206 In dioxane solvent, however, iodomethane yields exclusively

207 lates and small amounts of nitromethane in a dioxane solvent, thereby reducing the hazards associated

208 edian value of all statistically significant dioxane source attenuation rates (equivalent half-life =

209 initial formation of dimeric 2,5-diamino-1,4-dioxane species, which were hydrolyzed in situ to the fi

210 The locations of the bound solvent in the dioxane structure are distinct from those in the structu

211 prevented lignin condensation by forming 1,3-dioxane structures with lignin side-chain hydroxyl group

212 In addition, a series of dioxane substitutions was designed and tested.

213 es C) in selected solvents, tetrahydrofuran, dioxane, tert-butyl methyl ether, n-pentane and dichloro

214 e quarterthiophene in a 2:1:1 mixture of 1,4-dioxane/tetrahydrofuran/toluene leads to self-assembly o

215 In dioxane, the K(trans/cis) values for AcProOMe, Ac-4R-Flp

216 For reactions of 14 with sodium methoxide in dioxane, the migratory aptitudes at 23 degrees C are p-C

217 broad range of chiral 1,2-dioxolanes and 1,2-dioxanes, thereby facilitating biological and medicinal

218 )][B(C(6)F(5))(4)] (3), [Mg(C(3)H(5))(2)(1,4-dioxane)(THF)] (2), [KMg(C(3)H(5))(3)(THF)] (6), and [MM

219 alodorous compounds were 2,5,5-trimethyl-1,3-dioxane (TMD) and 2-ethyl-5,5-dimethyl-1,3-dioxane (2EDD

220 expect an axial phenyl group at C(5) of 1,3-dioxane to adopt a conformation similar to that in axial

221 e, diyne 6 reacted with p-tolunitrile in 1,4-dioxane to give 7p and 7m (7:1 ratio) in 87% yield at a

222 ence of an imidazole/LiCl catalyst system in dioxane to provide the adducts possessing a syntheticall

223 -1) undergoes reaction with anhydrous HCl in dioxane to yield predominantly ( approximately 94%) a si

224 solvents, such as tert-butyl alcohol and 1,4-dioxane, to increase their solubility in the lyophilizat

225 ogy for in situ and ex situ treatment of 1,4-dioxane under a wide range of environmental conditions.

226 nc dust, and a catalytic amount of iodine in dioxane under high-intensity ultrasound (HIU) irradiatio

227 ified the D-ribose-5-phosphate origin of the dioxane unit and demonstrated that AlnA and AlnB are res

228 nsively investigated the biosynthesis of the dioxane unit through (13)C labeling studies, gene inacti

229 The role of the 1,3-dioxane units was targeted to ensure the preorganization

230 ncies of greater than 97% degradation of 1,4-dioxane, up to 4.6 times higher than noncatalyzed electr

231 Quantification of 1,4-dioxane was accomplished by isotope dilution using mass-

232 to prepare a PCL solvent based ink and 1, 4-dioxane was chosen with the consideration of both solubi

233 dioxanivorans CB1190 with 3.0 V applied, 1,4-dioxane was oxidized 2.5 times faster than in bioaugment

234 as tetrahydrofuran, tetrahydropyran, and 1,4-dioxane was studied.

235 upled to electrolysis, biodegradation of 1,4-dioxane was sustained even in the presence of the common

236 0-tetrahydrobenzo [a]pyrene (2) in water and dioxane-water mixtures have been determined over a pH ra

237 of reaction as a function of pH in water and dioxane-water solutions are reported.

238 he hydrolysis of cis-chlorohydrin 9 in 10:90 dioxane-water solutions yields the same ratio of tetrols

239 tion of sodium chloride concentration in 1:1 dioxane-water solutions.

240 trans chlorohydrins, have been determined in dioxane/water solutions.

241 l for GS-CH(2)Cl, range between 1 s(-1) (1:1 dioxane/water) and 64 s(-1) (1:10 dioxane/water).

242 s(-1) (1:1 dioxane/water) and 64 s(-1) (1:10 dioxane/water).

243 ligomeric silsesquioxane (FPOSS) cage in 1,4-dioxane/water.

244 yme (E) give a peak at 41.3 ppm (relative to dioxane) which represents the Cys42-sulfenic acid.

245 The reactions are also conducted in THF or dioxane, which greatly simplifies product isolation rela

246 Treatment of GeCl2(dioxane) with Li2(TPP)(OEt2)2 (TPP = tetraphenylporphyri

247 henyl)imidazol-2-ylidene (IPr)), towards [Na(dioxane)x ][PnCO] (Pn=P, As) is described.

248 nd Zn(II)(OEP); five-coordinate hosts, micro-dioxane)[Zn(II)(OEP)](2) and (py)Zn(II)(OEP); six-coordi