ライフサイエンスコーパス: dioxolane

1 does not lead to benzoin but to a stable 1,3-dioxolane.

2 l muscarinic agonists oxotremorine-M and cis-dioxolane.

3 tions between the bilayers and the SS and RR dioxolanes.

4 rial activities and ADME profiles of the 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isoste

5 activated charcoal to form 5-substituted-1,3-dioxolane-2,4-diones in 90-100% yield.

6 The 1,3-dioxolane-2-phosphenium ion, 1,3-benzodioxole-2-phosphen

7 h is modeled on 3,5-dimethyl-5-hexadecyl-1,2-dioxolane-3-acetic acid (1a), an unnamed natural product

8 The first asymmetric synthesis of 1,2-dioxolane-3-acetic acids is reported.

9 II), the predominant reaction course for 1,2-dioxolane 3a was two-electron reduction.

10 hol, alpha,alpha,alpha',alpha'-tetraaryl-1,3-dioxolane-4,5-dimethanol (TADDOL), catalyzes the all-car

11 TADDOL=alpha,alpha,alpha,alpha-tetraaryl-1,3-dioxolane-4,5-dimethanol).

12 ne}succinate and (R)-2,2,5,5-tetramethyl-1,3-dioxolane-4-carbaldehyde, facile synthesis of (-)-epi-cl

13 ral primary alcohol (R)-(-)-2,2-dimethyl-1,3-dioxolane-4-methanol to the corresponding trichloromethy

14 d glycerol moiety, (S)-(+)-2, 2-dimethyl-1,3-dioxolane-4-methanol, allowed the selective crystallizat

15 metal surface with poly((N-2,2-dimethyl-1,3-dioxolane-4-methyl)-5-norbornene-exo-2,3-dicarboximide),

16 demethylation to produce corresponding (1,3-dioxolane-4-yl)-1,4-benzoquinones.

17 rmore, series of other isoprostanes, such as dioxolane A(2), D(2), E(2), etc., can be derived from th

18 ydroxy-9,11-dioxolane eicosatetraenoic acid (dioxolane A3, DXA3).

19 des with acetone to prepare 2,2-dimethyl-1,3-dioxolanes (acetonides) in good to excellent yields.

20 es a novel stereoselective photochemical 1,3-dioxolane addition to 5(S)-benzyloxymethyl-2(5H)-furanon

21 atic interactions between the oxygens in the dioxolane and adjacent carbonyls in the R,R-dioxolane-li

22 sis for the utilization of C-C bound ribose, dioxolane and dioxane moieties in the generation of impr

23 yl diazomalonate, competition exists between dioxolane and epoxide formation so that with p-anisaldeh

24 As dioxolane and oxathiolane nucleosides have exhibited pro

25 ive synthesis of a broad range of chiral 1,2-dioxolanes and 1,2-dioxanes, thereby facilitating biolog

26 gold(I)-catalyzed ring-opening of cyclic 1,3-dioxolanes and dioxanes by trimethylsilyl alkynes to set

27 ones or aldehydes into the corresponding 1,3-dioxolanes and the carboxyl group of benzoate ester into

28 ing 4-hydroperoxy-2-alkanols to 3-alkoxy-1,2-dioxolanes, and Lewis acid mediated homologation of the

29 e electron-donating groups 4-methoxy and 1,3-dioxolane are preferred at P2' phenyl ring, as compounds

30 ketones caged as 4-(2,5-dihydroxyphenyl)-1,3-dioxolanes are efficiently (Phi = 0.1-0.2) released in a

31 Replacing the S,S-dioxolane by an S,S-cyclopentane had no effects on the g

32 ose unit is rearranged into an unprecedented dioxolane (cis-bicyclo[3.3.0]-2',4',6'-trioxaoctan-3'bet

33 thia-CMP > beta-L-2',3'-dideoxy-CMP > beta-L-dioxolane-CMP.

34 Beta-L-(-)-dioxolane cytidine [(-)-OddC] is the first nucleoside an

35 well as L-nucleoside analogs such as beta-L-dioxolane-cytidine (L-OddC), beta-L-2',3'-dideoxy-3'-thi

36 beta-l-Dioxolane-cytidine (l-OddC, BCH-4556, Troxacitabine) is

37 Beta-L-dioxolane-cytidine (L-OddC, BCH-4556, Troxacitabine), a

38 beta-L-Dioxolane-cytidine (L-OddC, Troxacitabine, BCH-4556), a

39 at the in vivo therapeutic efficacy of l-1,3-dioxolane-cytidine against solid tumors may be improved

40 ctivity on matched, 3' mispaired, and beta-l-dioxolane-cytidine nicked DNA are 2.3, 61.2, and 98.8 mi

41 d, 3' mispaired, or nucleoside analog beta-l-dioxolane-cytidine terminated nicked DNA as well as for

42 l-1,3-Dioxolane-cytidine, a potent anticancer agent against le

43 antly improved antitumor activity over l-1,3-dioxolane-cytidine.

44 Sufficient amounts of synthetic 26-dioxolane dEpoB were produced using this sequence for an

45 D- and L-Oxathiolane and -dioxolane derivatives 13, 16, 20, 21, and 29-34 were pre

46 two of them, the linker was the conventional dioxolane described previously (SS and RR channels).

47 rs, however, proton affinities of gA and the dioxolane-dimer were significantly lower (K(D) of approx

48 oposes a dioxolane structure, 8-hydroxy-9,11-dioxolane eicosatetraenoic acid (dioxolane A3, DXA3).

49 yclic peroxides, bicyclic endoperoxides, and dioxolane-endoperoxides.

50 ting groups with traditional 1,3-dioxane/1,3-dioxolane for carbonyl compounds.

51 e Rh-catalyzed method for the preparation of dioxolanes from alpha-alkyl-alpha-diazoesters.

52 stage Noyori acetalization incorporated the dioxolane functionality.

53 were covalently linked with a novel modified dioxolane group containing a retinal attachment (ret-SS

54 The direct role of the dioxolane group on the gating and single-channel conduct

55 2,6-diaminopurine dioxolane), the prodrug of dioxolane guanosine (DXG), is currently in phase I/II cl

56 anscriptase-catalyzed viral DNA synthesis by dioxolane guanosine 5'-triphosphate (DXG-TP), 3'-azido-3

57 Consistent with previous data, both dioxolanes had very weak antimalarial properties.

58 unctional consequence of the flipping of the dioxolane inside the pore of the channel.

59 olanyluracil analogues was prepared from the dioxolane intermediates 2, and their anti-Epstein Barr v

60 lycosylation reaction of the oxathiolane and dioxolane intermediates with silylated uracil analogues

61 mical reactions by production of dioxane and dioxolane isomers, furfural and 5-hydroxymethylfurfural,

62 series can be further oxidized to form novel dioxolane-IsoP-like compounds, analogous to those genera

63 ), D(2), E(2), etc., can be derived from the dioxolane-isoprostane peroxides.

64 A novel class of peroxides (termed dioxolane-isoprostanes) having a bicyclic endoperoxide m

65 Nonperoxidic 1,3-dioxolane isosteres of 3 were inactive as were trioxolan

66 s seems to depend on the conformation of the dioxolane link between gA's.

67 In contrast, for the dioxolane linked gA dimers, E(a) values were strongly mo

68 us measurements obtained in the S,S- and R,R-dioxolane-linked as well as in native gA channels.

69 ayer used in this study, both the SS- and RR-dioxolane-linked channels opened in a mode of bursting a

70 dioxolane and adjacent carbonyls in the R,R-dioxolane-linked gA channel attenuate the rate of H(+) t

71 ), and in the SS- and RR-diastereoisomers of dioxolane-linked gA channels (SS and RR channels).

72 gA) and in the SS and RR diastereoisomers of dioxolane-linked gA channels in planar bilayers.

73 lyceride bilayers on proton transfer in both dioxolane-linked gA channels must relate to distinct int

74 d in two diastereoisomers (SS and RR) of the dioxolane-linked gA channels were measured in glycerylmo

75 ne are considerably larger than those in R,R-dioxolane-linked gA channels.

76 The RR dioxolane-linked gA dimer "inactivated" in GMO/decane bu

77 Dioxolane-linked gA dimers formed ion channels, selectiv

78 n A (gA) and in covalently linked SS- and RR-dioxolane-linked gA proteins.

79 onductance of different stereoisomers of the dioxolane-linked gramicidin A (gA) channels reconstitute

80 Two different stereoisomers of the dioxolane-linked gramicidin A (gA) channels were individ

81 uctance (g(H)) in single SS stereoisomers of dioxolane-linked gramicidin A (gA) channels were measure

82 The mobility of protons in a dioxolane-linked gramicidin A channel (D1) is comparable

83 (g(H)) in two different stereoisomers of the dioxolane-linked gramicidin A channel (the SS and RR dim

84 As in HCl, the presence of a retinal in the dioxolane linker did not affect the gating behavior of t

85 nd hydrophobic retinal group immobilizes the dioxolane linker in the bilayer core preventing its rota

86 arise from different chiralities within the dioxolane linker.

87 A novel series of benzo-1,3-dioxolane metharyl derivatives was synthesized and evalu

88 The 2,2-dimethyl-1,3-dioxolane moiety also served as a protected form of a di

89 ety characteristic of the isoprostanes and a dioxolane peroxide functionality in the same molecule wa

90 served and with p-nitrobenzaldehyde only 1,3-dioxolane products are formed.

91 mine- and iodine-substituted 16alpha,17alpha-dioxolane progestins, some of which, when appropriately

92 s, (4) the constitution of the 4,5-fused 1,3-dioxolane ring (2, 54, 55, 63-68, 76, 77, 80, 83a-r, 84-

93 sults showed that the replacement of the 1,3-dioxolane ring by a tetrahydrofuran, cyclopentanone, or

94 4) The dioxolane ring is probably responsible for the closing f

95 n as to the optimal configuration around the dioxolane ring of the ITZ scaffold.

96 holines via a tandem reductive vinyl dioxane/dioxolane ring opening and alkyliodide coupling process

97 (gA) molecules were covalently linked with a dioxolane ring.

98 iviral activity profile is the presence of a dioxolane ring.

99 nd 4, 5-fused (30-38, 43, 45-47, 52, 53) 1,3-dioxolane rings, (4) the constitution of the 4,5-fused 1

100 2-(1,1-Dimethylethyl)-2-(4-methylphenyl)[1,3]dioxolane (SAH51-641, 1) has previously been demonstrate

101 Detailed characterization proposes a dioxolane structure, 8-hydroxy-9,11-dioxolane eicosatetr

102 In the biphenyl and dioxolane systems, the reactions proceed with surprising

103 d cycloalkyl groups to the central benzo-1,3-dioxolane template were found to be potent and selective

104 talyzed cyclization of enynols, alpha-alkoxy dioxolane-tethered 1,3-enynes exclusively undergo bis-ox

105 Amdoxovir ((-)-beta-D-2,6-diaminopurine dioxolane), the prodrug of dioxolane guanosine (DXG), is

106 through selective 2-functionalization of 1,3-dioxolane through nickel and photoredox catalysis.

107 ort for the first time that 18 saponins with dioxolane-type (2 saponins) and acetal-type (16 saponins

108 lon-dihydroxy-beta-amino ester bears a trans-dioxolane unit, cyclization occurs upon attack of the al

109 silon-dihydroxy-beta-amino ester bears a cis-dioxolane unit, cyclization occurs upon attack of the be

110 ictated by the relative configuration of the dioxolane unit.

111 esters (beta-substituted with cis- and trans-dioxolane units) coupled with in situ enolate oxidation

112 The potency of L-dioxolane uracil nucleosides against EBV replication is

113 carbonyl compounds to the corresponding 1,3-dioxolane using ethylene glycol is also catalyzed by Bi(

114 ewis acid-mediated allylation to furnish 1,2-dioxolanes via attack of hydroperoxide on the intermedia

115 The 1,2-dioxolanes were either inactive or orders of magnitude l

116 Fourteen spiro- and dispiro-1,2-dioxolanes were synthesized by peroxycarbenium ion annul

117 th aromatic aldehydes gives tetrasubstituted dioxolanes with unusually high diastereoselectivity.