ライフサイエンスコーパス: dioxy

1 lpha,17alpha-[(R)-(1'-alpha-furylmethylidene)dioxy]-19-norpreg n-4-ene-3,20-dione ((18)F-FFNP), as we

2 arbonyl)amino-5-bromo-2,3-(dimethylmethylene)dioxy -4-hydroxymethylcyclopentane, was synthesized star

3 azinate (3), 2,3-dioxyquinoxalinate (4), 2,3-dioxy-5,6-dicyanopyrazinate (5), and cyanurate (6).

4 st 1-(4-amino-phenyl)-4-methyl-7,8-methylene-dioxy-5H-2, 3-benzodiazepine (GYKI 52466), but only mode

5 ormation and disappearance of a typical heme-dioxy catalytic intermediate.

6 igand mutations thus destabilize the ferrous-dioxy complex and uncouple the reduction of O2 from oxid

7 2) at a similar rate to generate the ferrous-dioxy complex.

8 wed by rapid O(2) binding yields the ferrous dioxy complex.

9 lexes to O2 does not give detectable ferrous-dioxy complexes and leads to the uncoupled reduction of

10 However, the rate of ferrous-dioxy decay (12 s(-1)) was equivalent to the rate of H(4

11 The rate of heme-dioxy decay matched the rates of H4B radical formation a

12 dihydrobiopterin-containing iNOSoxy, ferrous-dioxy decay was much slower and was not associated with

13 kinetic and quantitative links among ferrous-dioxy disappearance, H(4)B oxidation, and Arg hydroxylat

14 synthesis and establish that (1) the ferrous-dioxy enzyme reacts quantitatively with NOHA but not wit

15 NOS, the beginning ferrous enzyme, a ferrous-dioxy (Fe(II)O(2)) intermediate, Fe(III)NO, and an endin

16 lowing electron transfer to the heme ferrous-dioxy (Fe(II)O(2)) species during catalysis.

17 Optical spectra of the ferric, ferrous, heme-dioxy, ferrous-NO, ferric-NO, and ferrous-CO forms of ea

18 nitric-oxide synthesis, we followed ferrous-dioxy heme (Fe(II)O(2)) formation and disappearance, H(4

19 coupled to disappearance of an initial heme-dioxy intermediate and to Arg hydroxylation in a single

20 cally coupled to the disappearance of a heme-dioxy intermediate and to Arg hydroxylation.

21 lavoprotein domain and reduction of the heme-dioxy intermediate by H(4)B).

22 A ferrous-dioxy intermediate formed quickly (53 s(-1)) and then de

23 In the presence of Arg, the heme-dioxy intermediate in 5-methyl-H(4)B-bound iNOSoxy react

24 There was a buildup of a heme-dioxy intermediate in eNOSoxy and nNOSoxy followed by a

25 The buildup of the ferrous-dioxy intermediate preceded both H(4)B radical formation

26 s kinetically linked to conversion of a heme-dioxy intermediate to a heme-NO product complex.

27 y H(4)B transfers an electron to the ferrous-dioxy intermediate to enable the formation of a heme-bas

28 hat H4B first provides an electron to a heme-dioxy intermediate, and then the H4B radical receives an

29 on transfer between H(4)B and an enzyme heme-dioxy intermediate, and this in turn alters the kinetics

30 hereby H4B transfers an electron to the heme-dioxy intermediate.

31 d markedly slower reactivities of their heme-dioxy intermediate.

32 hase of a hemicarcerand with four butane-1,4-dioxy linker groups (5) in C(6)D(5)CD(3) at 77 K yields

33 rand with deuterated spanners and butane-1,4-dioxy linker groups (d(48)-5).

34 the biosynthetic reaction, implicate ferrous-dioxy nNOS as a critical reactant in that step, and elim

35 (3) The 5-methyl group influences heme-dioxy reduction by altering the electronic properties of

36 (2) Faster heme-dioxy reduction increases the efficiency of Arg hydroxyl

37 conclude the following: (1) The rate of heme-dioxy reduction is linked to pterin radical formation an

38 methyl-3,3'-di-tert-butyl-1,1'-biphenyl-2,2'-dioxy [(S)-BIPHEN] as a chiral auxiliary and screened in

39 o ferrous eNOS generated a transient ferrous dioxy species (Soret peak at 427 nm) whose formation and

40 ly with the disappearance of the enzyme heme-dioxy species and with the formation of a tetrahydrobiop

41 pecies that forms upon reduction of the heme-dioxy species by H4B.

42 ctivity toward substrate, but decreases heme-dioxy stability and lowers the driving force for heme re

43 ctivities from 20:1 to 82:1 favoring the 1,3-dioxy-substituted products have been achieved using Me2S

44 lkyl and the 10,11-methylene- (or ethylene-) dioxy substitutions.

45 with perovskites grown on poly(3,4-ethylene dioxy thiophene) polystyrene sulfonate.