ライフサイエンスコーパス: dioxygenase

1 ally, this involves TET1, a 5-methylcytosine dioxygenase.

2 tryptophan-catalyzing enzyme indoleamine 2,3-dioxygenase.

3 scribe this enzyme as a 3-mercaptopropionate dioxygenase.

4 fied enzyme sample revealed that it too is a dioxygenase.

5 cinate dioxygenase, and 3-mercaptopropionate dioxygenase.

6 doleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase.

7 e by an Fe(II)/alpha-ketoglutarate-dependent dioxygenase.

8 uted tryptophan analogues by indoleamine 2,3-dioxygenase.

9 he enzyme is designated as mercaptosuccinate dioxygenase.

10 -nitrocatechol-bound homoprotocatechuate 2,3-dioxygenase.

11 gh not in vivo) inhibitor of indoleamine 2,3-dioxygenase.

12 oxyglutarate affect 2-oxoglutarate-dependent dioxygenases.

13 nd electronic differences with cofactor-free dioxygenases.

14 tarate (D2-HG) disrupting alpha-KG-dependent dioxygenases.

15 a member of a nonheme lipoxygenase family of dioxygenases.

16 xidation reactions through monoxygenases and dioxygenases.

17 serving as a cofactor for TET methylcytosine dioxygenases.

18 ggests an ancient developmental role for Tet dioxygenases.

19 haracteristic of an Fe(II)/alphaKG-dependent dioxygenases.

20 pression of its biosynthetic enzyme cysteine dioxygenase 1 (CDO1).

21 Human indoleamine 2,3-dioxygenase 1 (hIDO1) is an attractive cancer immunother

22 Since the discovery of indoleamine 2,3-dioxygenase 1 (IDO1) as an attractive target for antican

23 etroviral ISGs indicate that indoleamine 2,3-dioxygenase 1 (IDO1) can inhibit retroviral replication

24 -gamma-mediated induction of indoleamine 2,3-dioxygenase 1 (IDO1) enzyme activity with subsequent act

25 yptophan catabolizing enzyme indoleamine 2,3 dioxygenase 1 (IDO1) in splenic macrophages (MPhi).

26 Indoleamine 2,3-dioxygenase 1 (IDO1) is a key regulatory enzyme that sup

27 Indoleamine 2,3-dioxygenase 1 (IDO1) is a single chain oxidoreductase th

28 Indoleamine 2,3-dioxygenase 1 (IDO1), promoting immune escape of tumors,

29 binding protein 1 (YB-1) and methylcytosine dioxygenase 1 (Tet1), bind to BDNF chromatin in naive bu

30 x) or gp91(phox)) or indoleamine-pyrrole 2,3-dioxygenase 1 with or without angiotensin (Ang) II infus

31 programmed cell death 1, and indolamine 2,3-dioxygenase 1), corresponding to higher frequency of som

32 m (CsNCED1, 9-cis-neoxanthin epoxycarotenoid dioxygenase 1, and CsCYP707A) rendering a significant ho

33 irus (HIV) infection-induced indoleamine 2,3-dioxygenase-1 (IDO) expression in activated monocytes an

34 Indoleamine 2,3 dioxygenase-1 (IDO-1) is an enzyme in the kynurenine pat

35 Small-molecule inhibitors of indoleamine 2,3-dioxygenase-1 (IDO1) are emerging at the vanguard of exp

36 ethyltransferase3A (DNMT3A-CD) or Ten-Eleven Dioxygenase-1 (TET1-CD) for loci-specific alteration of

37 el of messenger RNA encoding indoleamine 2,3-dioxygenase-1 was significantly increased.

38 The contribution of Tet methylcytosine dioxygenase 2 (TET2) and nuclear factor kappaB to DNA de

39 nsferase 3 Beta (DNMT3B), Tet methylcytosine dioxygenase 2 (TET2), and Thymine DNA glycosylase (TDG)

40 PLOD2 (procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2) hydroxylates lysine residues in collagen

41 The carotenoid cleavage dioxygenase 2, a new member of the CCD family, catalyzes

42 level of a probable 2-oxoglutarate-dependent dioxygenase 2-ODD2, involved in gibberellin biosynthesis

43 ls of messenger RNAs encoding tryptophan 2,3-dioxygenase-2 and solute carrier family 6 member 19 (als

44 droxylase (F6'H), a 2-oxoglutarate dependent dioxygenase (2OGD), catalyzes a pivotal step in the bios

45 biosynthetic genes NINE-CIS-EPOXYCAROTENOID DIOXYGENASE 3 (NCED3) and ALDEHYDE OXIDASE 3 (AAO3) are

46 shoot branching-related CAROTENOID CLEAVAGE DIOXYGENASE 8 gene was found to be significantly downreg

47 entification of a putative mercaptosuccinate dioxygenase, a cysteine dioxygenase homologue, possibly

48 pounds in E. polonica, initiated by catechol dioxygenase action, are important to the infection, grow

49 Increased indoleamine 2,3-dioxygenase activity and consequent induction of immunos

50 lfide bridge both defines the kinetics of NO dioxygenase activity and regulates appearance of the fre

51 ation in Tet that specifically abolishes the dioxygenase activity causes similar morphological and mo

52 obacterium tuberculosis displays a potent NO dioxygenase activity despite lacking a reductase domain.

53 utilization of O2 by CCOs and indicate that dioxygenase activity is a feature common among double bo

54 We directly demonstrate that PCO dioxygenase activity produces Cys-sulfinic acid at the N

55 formations, there a few examples of apparent dioxygenase activity where both oxygen atoms are donated

56 Using sequence alignment to infer cysteine dioxygenase activity, a cysteine dioxygenase homologue f

57 in HmpA, which has aerobic nitric oxide (NO) dioxygenase activity.

58 ing rapid concomitant loss of methylcytosine dioxygenase activity.

59 rtion lines with 50% to 99% decreased sulfur dioxygenase activity.

60 oxygenated products, identified a novel 10S-dioxygenase activity.

61 unctions have been put forward, including NO dioxygenase activity.

62 Like other iron/2-oxoglutarate-dependent dioxygenases, AlkB employs a two-step mechanism in which

63 nd reduced mRNA expression of indolamine 2,3-dioxygenase, an immunosuppressive factor.

64 te dioxygenases (YRWH), appears to be a heme dioxygenase ancestor.

65 ABA biosynthetic gene 9-cis-epoxycarotenoid dioxygenase and dampening expression of ABA 8'-hydroxyla

66 TET1 is a 5-methylcytosine dioxygenase and its DNA demethylating activity has been

67 levels of CD163, CD206, and indoleamine 2,3-dioxygenase and secrete immunosuppressive (interleukin [

68 ent process and catalyzed by indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase.

69 we make a direct comparison with iron-based dioxygenases and explain the mechanistic and electronic

70 e, cysteamine dioxygenase, mercaptosuccinate dioxygenase, and 3-mercaptopropionate dioxygenase.

71 nase, a hydroxylating nonheme-iron-dependent dioxygenase, and an ABM family monooxygenase for oxidati

72 mediated by DC expression of indoleamine 2,3-dioxygenase, and was confirmed in IDO-KO mouse model.

73 ises soluble Fe(2+)/2-oxoglutarate-dependent dioxygenases, and FNSII enzymes are oxygen- and NADPH-de

74 s the activity of multiple alphaKG-dependent dioxygenases, and results in alterations in cell differe

75 een structurally characterized for intradiol dioxygenases, and they validate four decades of spectros

76 r-promoting genes, including indoleamine 2,3-dioxygenase; and attenuation of these changes by blockad

77 Acireductone dioxygenase (ARD) from the methionine salvage pathway (M

78 Using toluene dioxygenase as biocatalyst, enantiopure cis-dihydrodiol

79 enome encodes for more than 60 2KG-dependent dioxygenases, assigning their individual functions remai

80 s, Fe(II)- and alpha-ketoglutarate-dependent dioxygenases, base excision glycosylases, and sequence-s

81 oxidatively cleaved by beta-carotene 15,15'-dioxygenase (BCO1) at the central 15-15' double bond to

82 ember of this family, the beta-carotene 9,10-dioxygenase (BCO2), converts xanthophylls to rosafluene

83 We focused on beta,beta-carotene-9',10'-dioxygenase (BCO2, also known as BCDO2), the only known

84 idase and (1H)-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase, both cofactor-independent enzymes that surm

85 on, we identified a 2-oxoglutarate-dependent dioxygenase (BX13) that catalyzes the conversion of DIMB

86 Inhibition of 3-hydroxyanthranilate 3,4-dioxygenase by 6-chloro-dl-tryptophan prevented both inc

87 e inhibitor of alpha-ketoglutarate-dependent dioxygenases' by Xu and colleagues, published in Cancer

88 the Ten-eleven translocation (TET) family of dioxygenases can lead to demethylation.

89 entified in E. polonica that encode catechol dioxygenases carrying out these reactions.

90 Dioxygenases catalyze a diverse range of biological reac

91 Dioxygenases catalyze a diverse range of chemical reacti

92 TET-family dioxygenases catalyze conversion of 5-methylcytosine (5m

93 The Tet 5-methylcytosine dioxygenases catalyze DNA demethylation by producing 5-h

94 The TET dioxygenases catalyze iterative oxidation of 5mC, leadin

95 ommon reaction mechanism for indoleamine 2,3-dioxygenase-catalyzed oxidation of tryptophan and other

96 and HPPD1, encoding 4-hydroxyphenylpyruvate dioxygenase catalyzing the committed step of plastoquino

97 carotenoids catalyzed by carotenoid cleavage dioxygenase (CCD).

98 ires the activity of the carotenoid cleavage dioxygenase CCD4.

99 Carotenoid cleavage dioxygenases (CCDs) are non-heme iron-containing enzymes

100 utant lines deficient in carotenoid cleavage dioxygenases (CCDs), we identified CCD4 as being mainly

101 n mammals, the non-heme iron enzyme cysteine dioxygenase (CDO) helps regulate Cys levels through conv

102 mately tied to the function of both cysteine dioxygenases (CDOs) and nitrile hydratases (NHases), and

103 The ten-eleven translocation (Tet) dioxygenases convert 5mC to 5hmC, 5fC and 5caC in three

104 This family of enzymes includes cysteine dioxygenase, cysteamine dioxygenase, mercaptosuccinate d

105 synthesis pathway have been identified: 4,5-dioxygenase (DODA) that catalyzes the formation of betal

106 nism is well characterized and the catalytic dioxygenase domain is highly conserved, the function of

107 minal P450 domain fused to a heme peroxidase/dioxygenase domain was discovered in Saprolegnia declina

108 mplexity insert between the two parts of the dioxygenase domains) is only poorly understood.

109 t CRL4(VprBP) is a critical regulator of TET dioxygenases during development and in tumor suppression

110 the alpha-ketoglutarate (alphaKG)-dependent dioxygenase Egln1, which senses oxygen and regulates the

111 ide synthase enzymes as compared to cysteine dioxygenase enzymes and present pathways for both reacti

112 More than 60 years after these dioxygenase enzymes were first isolated, the mechanism o

113 eviously showed that two CAROTENOID CLEAVAGE DIOXYGENASE enzymes, CCD1 and CCD4, are the primary medi

114 restricting the activity of prolyl hydroxyl dioxygenase enzymes, which hydroxylate HIF-1alpha and HI

115 ) by the ten-eleven translocation (TET) 5-mC dioxygenase enzymes.

116 umulation of CD11c cells and indoleamine 2,3-dioxygenase expression.

117 ctor was highly correlated with naringenin 3-dioxygenase (F3H) and dihydroflavonol-4-reductase (DFR)

118 are members of the 2-oxoglutarate-dependent dioxygenase family and comprise three isoenzymes in huma

119 the Fe (II)- and oxoglutarate-dependent AlkB dioxygenase family and is linked to both obesity and int

120 en eleven translocation (Tet) methylcytosine dioxygenase family members, and the roles of Tet protein

121 r of the Fe(II) and 2-oxoglutarate-dependent dioxygenase family, and we show that mutation of the ami

122 by members of Ten-Eleven-Translocation (TET) dioxygenase family, was not observed to undergo any alte

123 of the Fe(II)/alpha-ketoglutarate-dependent dioxygenase family.

124 ning, we identified 2-oxoglutarate-dependent dioxygenase Feruloyl-CoA 6'-Hydroxylase1 (F6'H1) to be e

125 he function of the Arabidopsis thaliana gene DIOXYGENASE FOR AUXIN OXIDATION 1 (AtDAO1).

126 Here, we show that DIOXYGENASE FOR AUXIN OXIDATION 1 (DAO1) catalyzes forma

127 clude oxidation by Arabidopsis thaliana gene DIOXYGENASE FOR AUXIN OXIDATION 1/2 (AtDAO1/2) and conju

128 5-methylcytosine (5mC) by Tet methylcytosine dioxygenases, for which Fe(II) is an essential cofactor.

129 rmation allowed us to generate a strain--the dioxygenase fr9P(-) mutant--that accumulates only the ca

130 The prediction identified biphenyl dioxygenase from Paraburkholderia xenovorans LB400 as th

131 activity of the iron-dependent gentisate 1,2-dioxygenase from Pseudaminobacter salicylatoxidans expre

132 of a related enzyme, hydroxyethylphosphonate dioxygenase from Streptomyces albus (SaHEPD), and find t

133 7 genes [e.g., alpha-ketoglutarate dependent dioxygenase (FTO), interleukin 6 (IL6), insulin receptor

134 PU demethylated products; a distinct aniline dioxygenase gene cluster adoQTA1A2BR, which has a broad

135 enine pathway, 3-hydroxyanthranilic acid 3,4-dioxygenase (HAAO) and kynureninase (KYNU).

136 te is conserved in 3-hydroxyanthranilate 3,4-dioxygenase (HAO), from single cellular sources but not

137 indicating that members of this subfamily of dioxygenases have a general function in demethylating nu

138 eme iron oxygenases: hydroxyethylphosphonate dioxygenase (HEPD) and methylphosphonate synthase (MPnS)

139 2-Hydroxyethylphosphonate dioxygenase (HEPD) and methylphosphonate synthase (MPnS)

140 nistic analysis of 2-hydroxyethylphosphonate dioxygenase (HEPD), which cleaves the C1-C2 bond of its

141 GmHGO1 encodes a homogentisate dioxygenase (HGO), which catalyzes the committed enzymat

142 TET2, a methylcytosine dioxygenase highly expressed in these cells and frequent

143 Bacterial (1H)-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase (HOD) belongs to a class of oxygenases able

144 Bacterial 1-H-3-hydroxy-4-oxoquinaldine-2,4-dioxygenase (HOD) catalyzes the spin-forbidden transfer

145 er cysteine dioxygenase activity, a cysteine dioxygenase homologue from Pseudomonas aeruginosa (p3MDO

146 ve mercaptosuccinate dioxygenase, a cysteine dioxygenase homologue, possibly representing the key enz

147 ological function of 4-hydroxyphenylpyruvate dioxygenase (HPPD), as well as on the development and ap

148 R) 4 signaling, can regulate indoleamine 2,3-dioxygenase (IDO) activity, favoring TH2 responses.

149 ppression through the enzyme indoleamine 2,3-dioxygenase (IDO) and subsequent production of kynurenin

150 phan caused by expression of indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) r

151 The enzyme indoleamine-2,3-dioxygenase (IDO) catalyses degradation of the essential

152 Additionally, indoleamine 2,3-dioxygenase (IDO) expression was only modestly increased

153 han (trp) metabolism through indoleamine 2.3-dioxygenase (IDO) has been previously proposed to predic

154 Indoleamine 2,3-dioxygenase (IDO) has immunoregulatory roles associated

155 an immunomodulatory enzyme, indoleamine 2,3-dioxygenase (IDO) in dermal fibroblasts generates a tryp

156 ugate of PEG with NLG919, an indoleamine 2,3-dioxygenase (IDO) inhibitor currently used for reversing

157 hemotherapeutics, radiation, indoleamine 2,3-dioxygenase (IDO) inhibitors, inhibitors of T cell check

158 Indoleamine 2, 3-dioxygenase (IDO) is an immunoregulatory enzyme that bre

159 Indoleamine 2,3-dioxygenase (IDO) is the enzyme that catalyzes the degra

160 Indoleamine 2,3-dioxygenase (IDO) is the first and rate-limiting enzyme

161 ing in the immunosuppressive indoleamine 2,3-dioxygenase (IDO) pathway.

162 an 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) play a central role in tryptophan meta

163 ophan (Trp) catabolic enzyme indoleamine 2,3-dioxygenase (IDO) represent a vanguard of new immunometa

164 stigated the relationship of indoleamine 2,3-dioxygenase (IDO) systemic activity on clinical outcomes

165 tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) were analyzed using flow cytometry and

166 -specific local induction of indoleamine 2,3-dioxygenase (IDO), a tryptophan catabolic enzyme previou

167 s expressed higher levels of indoleamine 2,3-dioxygenase (IDO), an enzyme associated with tolerance i

168 is induced the expression of indoleamine 2,3-dioxygenase (IDO), an enzyme involved in tryptophan cata

169 Expression of indoleamine-2,3-dioxygenase (IDO), an immunosuppressive enzyme in human

170 RTs) through the activity of indoleamine 2,3-dioxygenase (IDO), an intracellular enzyme that converts

171 pecific inhibitor of indoleamine-pyrrole 2,3-dioxygenase (IDO), but not by NSC-398, a specific inhibi

172 otherapy agent that inhibits indoleamine 2,3-dioxygenase (IDO), encapsulated in the nMOF channels to

173 Indoleamine 2,3-dioxygenase (IDO), which degrades tryptophan (Trp) to ky

174 dysfunction with circulating indoleamine 2,3-dioxygenase (IDO)-dependent tryptophan metabolites (TMs)

175 n products produced from the indoleamine 2,3-dioxygenase (IDO)-mediated kynurenine pathway and are pr

176 yptophan-metabolizing enzyme indoleamine 2,3-dioxygenase (IDO).

177 egulatory mechanisms such as indoleamine 2,3 dioxygenase (IDO).

178 IL-4, IL-10, CD274/PD-L1 and indoleamine 2,3 dioxygenase (IDO).

179 the immunoregulatory enzyme indoleamine-2,3-dioxygenase (IDO).

180 partly via the production of indoleamine 2,3-dioxygenase (IDO).

181 via induction of the enzyme indoleamine-2,3-dioxygenase (IDO).

182 yptophan catabolizing enzyme indoleamine-2,3-dioxygenase (IDO).

183 expression of PD-L1; Tim-3; indoleamine 2, 3-dioxygenase (IDO); and interleukin 10.

184 catabolizing enzymes such as indoleamine 2,3-dioxygenase (IDO-1) to induce an immunosuppressive envir

185 Indoleamine 2,3-dioxygenase (IDO1) is a tryptophan (Trp)-catabolizing en

186 n three enzymes in this pathway: indoleamine dioxygenase (IDO1), kynurenine monooxygenase (KMO), and

187 o sulfinosuccinate by this mercaptosuccinate dioxygenase; (ii) sulfinosuccinate is spontaneously desu

188 Knockdown of the sulfur dioxygenase impaired embryo development and produced phe

189 ed the expression of indoleamine-pyrrole 2,3-dioxygenase in parallel with increased expression of int

190 mechanisms of catalysis, the roles of these dioxygenases in post-translational protein modification

191 roles of the ten-eleven translocation (Tet) dioxygenases in the modification of methylated bases (5m

192 echanisms, and the roles of the AlkB-related dioxygenases in the repair of damaged DNA and RNA.

193 ts of the alpha-ketoglutarate/iron-dependent dioxygenases in this eighth Thematic Series on Metals in

194 ion of D2HG inhibits many alpha-KG-dependent dioxygenases, including histone demethylases, to cause b

195 By the same reasoning, dioxygenase inhibition by FQ was predicted to stabilize

196 conditions, a broad-spectrum 2-oxoglutarate dioxygenase inhibitor is a better mimic of the overall t

197 he reaction mechanism of protocatechuate 3,4-dioxygenase is investigated here using the alternative s

198 of Fe(II)- and alpha-ketoglutarate-dependent dioxygenases is a class of ubiquitous direct reversal DN

199 cause aromatic dioxygenation by nonheme iron dioxygenases is frequently the initial step of biodegrad

200 The family of ten-eleven translocation (Tet) dioxygenases is widely distributed across the eukaryotic

201 The action of the oxidase (LSD1) and a dioxygenase (JMJD2A) in the presence of Fe++ elicits an

202 uced enzymatic activity without altering the dioxygenase labeling pattern.

203 and a novel C-terminal hydroxyphenylpyruvate dioxygenase-like domain.

204 The trends exclude multiple dioxygenase mechanisms as well as the proposal that init

205 the ten-eleven translocation (TET) family of dioxygenase-mediated DNA demethylation requires new meth

206 ersed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to 5-hydroxymethyl

207 es includes cysteine dioxygenase, cysteamine dioxygenase, mercaptosuccinate dioxygenase, and 3-mercap

208 a co-factor of Fe2(+) and alpha-KG-dependent dioxygenases, mimics TET2 restoration by enhancing 5-hyd

209 mes, namely, nitrobenzene and 2-nitrotoluene dioxygenase (NBDO and 2NTDO) to elucidate the enzyme- an

210 ated that induction of 9-cis-epoxycarotenoid dioxygenase (NCED), a rate-limiting ABA biosynthesis gen

211 ic studies of an Fe(2+)-containing extradiol dioxygenase, no evidence for a superoxo or peroxo interm

212 ibit reactivity related to both nitric oxide dioxygenase (NOD) and nitrite reductase (NiR) activity.

213 diate in the catalytic cycle of nitric oxide dioxygenase (NOD) enzymes, which facilitate a .NO homeos

214 The identity of the specific nitric oxide dioxygenase (NOD) that serves as the main in vivo regula

215 r NO. detoxification systems are Hmp, an NO. dioxygenase (NOD), and NorV, an NO. reductase (NOR).

216 he oxygenation of unsaturated fatty acids by dioxygenases occurs in all kingdoms of life and produces

217 Dioxygenases of the TET (Ten-Eleven Translocation) famil

218 ted Ten-Eleven Translocation (TET) family of dioxygenases on 5mC, our studies also suggest the abilit

219 TET-family dioxygenases oxidize 5-methylcytosine (5mC) in DNA, and

220 The ten-eleven translocation (TET) dioxygenases oxidize 5mC into oxidized methylcytosines (

221 led water and (18)O2 revealed an unambiguous dioxygenase pattern of O2 incorporation into the reactio

222 :quinone oxidoreductase (SQR) and persulfide dioxygenase (PDO) genes.

223 s sulfide quinone oxidoreductase, persulfide dioxygenase (PDO), rhodanese, and sulfite oxidase and co

224 gulated by prolyl-4-hydroxylase domain (PHD) dioxygenases PHD1, PHD2, and PHD3, which function as cel

225 PIV3, including IFITM1, IDO (indoleamine 2,3-dioxygenase), PKR (protein kinase, RNA activated), and v

226 Indoleamine 2,3-dioxygenase plays a key role in local tryptophan metabol

227 en eleven translocation (TET) methylcytosine dioxygenase, predominantly TET1 in HCC cells, is a direc

228 intermediates from the intra- and extradiol dioxygenases provides a rationale for site specificity o

229 , OdaA and OdaI have predicted hydratase and dioxygenase reductase activities, respectively.

230 The TET2 DNA dioxygenase regulates cell identity and suppresses tumor

231 mpact characterization of human ALKBH family dioxygenases related to prostate cancer.

232 of the protein and a catalytically inactive dioxygenase-related N-terminal domain, which is importan

233 lographic comparison with mammalian cysteine dioxygenase shows that the overall active site geometry

234 o groups of LD-associated proteins, caleosin/dioxygenase/steroleosin and LD/oil body-associated prote

235 aining iron(II) and 2-oxoglutarate-dependent dioxygenase superfamily and is evolutionarily well conse

236 imilar to that found in other members of the dioxygenase superfamily.

237 of the Trp catabolic enzymes tryptophan 2,3-dioxygenase (TDO) and IDO2 may also safely broaden effic

238 Tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO)

239 ed and used to identify novel tryptophan 2,3-dioxygenase (TDO) inhibitors.

240 ine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) resulted in ATF4-dependent upregulatio

241 ine-3-monooxygenase (KMO) and tryptophan-2,3-dioxygenase (TDO).

242 xpress high levels of AHR and tryptophan-2,3-dioxygenase (TDO); representative ER(-)/PR(-)/Her2(-) ce

243 Trp and Arg catabolism (IDO1, IDO2, Trp 2,3-dioxygenase [TDO], arginase [ARG] 1, ARG2, inducible NO

244 abolism, including the enzyme tryptophan 2,3-dioxygenase (TDO2), in an NF-kappaB-dependent manner.

245 ted by ibuprofen was neuronal tryptophan 2,3-dioxygenase (Tdo2), which encodes an enzyme that metabol

246 icle, we demonstrate that the methylcytosine dioxygenase ten-eleven translocation (TET)2 regulates CD

247 DNA methylcytosine dioxygenase Ten-eleven translocation 1 (TET1) is a criti

248 in metastatic tumours in the methylcytosine dioxygenase ten-eleven translocation 2 (TET2), which is

249 Here we examined a possible role for the DNA dioxygenase, ten-eleven translocation protein 1 (TET1),

250 a site predicted to govern the mono- versus dioxygenase tendency of CCOs, greatly reduced enzymatic

251 s (stage I) followed by a Tet methylcytosine dioxygenase (Tet)-dependent decrease in methylated cytos

252 The methylcytosine dioxygenase TET1 ('ten-eleven translocation 1') is an im

253 nistically, Lin28A recruits 5-methylcytosine-dioxygenase Tet1 to genomic binding sites to orchestrate

254 Here, we reveal the methylcytosine dioxygenases TET1 and TET2 as active regulators of CTCF-

255 H2S maintained expression of methylcytosine dioxygenases Tet1 and Tet2 by sulfhydrating nuclear tran

256 The Ten-Eleven translocation dioxygenases (TET1, 2, and 3) have been found to oxidize

257 /EBPalpha also induces the expression of the dioxygenase Tet2 and promotes its translocation to the n

258 on of 5-methylcytosine by the methylcytosine dioxygenase Tet2 regulates cytokine production in Th cel

259 s of ten-eleven translocation methylcytosine dioxygenase (TET2)-mediated 5-hydroxymethylcytosine (5-h

260 TET2 is a dioxygenase that catalyses multiple steps of 5-methylcyt

261 duct, ArsI, is an Fe(II)-dependent extradiol dioxygenase that cleaves the carbon-arsenic (C-As) bond

262 enzymes, including an oxoglutarate-dependent dioxygenase that closes the core cyclohexane ring of the

263 lpha-ketoglutarate-dependent non-heme Fe(II) dioxygenase that forged the azetidine ring on the okaram

264 anslocation-2 (Tet2) is a DNA methylcytosine dioxygenase that functions as a tumor suppressor in hema

265 rohydroquinone, demonstrating that ArsI is a dioxygenase that incorporates one oxygen atom from dioxy

266 I is a microbial non-heme, ferrous-dependent dioxygenase that transforms toxic methylarsenite [MAs(II

267 own to inhibit alpha-ketoglutarate-dependent dioxygenases that are involved in DNA and histone demeth

268 iron alpha-ketoglutarate (alphaKG)-dependent dioxygenases that catalyze Hyp formation.

269 series of iron and 2-oxoglutarate-dependent dioxygenases that catalyze post-translational hydroxylat

270 cofactor for Ten-eleven translocation (TET) dioxygenases that catalyze the oxidation of 5-methylcyto

271 alpha-ketoglutarate- and iron(II)-dependent dioxygenases that hydroxylate four sp(3) carbons; one fl

272 amily of 2-oxoglutarate and Fe(II)-dependent dioxygenases that mediates homeostatic responses to oxyg

273 ery of ten-eleven-translocation (TET) family dioxygenases that oxidize 5mC to 5-hydroxymethylcytosine

274 inhibition of alpha-ketoglutarate-dependent dioxygenases that require iron as a co-factor.

275 e Fe(II)- and 2-oxoglutarate (2OG)-dependent dioxygenases that successively oxidize 5-methylcytosine

276 O1 is currently classified as 2-nitropropane dioxygenase, the previous name for nitronate monooxygena

277 The Nostoc linoleate 10S-dioxygenase, the sequence of which contains the signatur

278 ma signaling and mediated by indoleamine 2,3-dioxygenase to a constitutive mechanism that relied upon

279 in part by reducing the function of Tet2, a dioxygenase tumour suppressor.

280 Previously, we have shown that cysteine dioxygenase type 1 (Cdo1) promoted adipogenesis of prima

281 Mechanistic studies provide evidence for a dioxygenase-type C-C bond cleavage reaction pathway invo

282 Intradiol aromatic ring-cleaving dioxygenases use an active site, nonheme Fe(3+) to activ

283 is reaction is catalyzed by Fe(II)-dependent dioxygenases using the essential metabolite 2-ketoglutar

284 Indoleamine 2,3-dioxygenase was expressed on background accessory cells.

285 Therefore, the putative mercaptosuccinate dioxygenase was heterologously expressed, purified, and

286 ater expression of 3-hydroxyanthranilate 3,4-dioxygenase was identified as a potential contributor to

287 ture structure of an extradiol ring-cleaving dioxygenase was solved by utilizing the improved operati

288 luorescens ATCC 17483 containing naphthalene dioxygenases was associated with moderate carbon isotope

289 tion, expression of IL-2 and indoleamine 2,3-dioxygenase were evident in TLR4 compared with WT allogr

290 ncoding for transporters, an integrase and a dioxygenase were involved in BAC biotransformation.

291 actions catalyzed by 4-hydroxyphenylpyruvate dioxygenase were studied with the QM/MM method ONIOM(B3L

292 Three dioxygenases were examined in HEK293 cells treated with

293 tB shows structural similarities to cysteine dioxygenase which transfers two oxygen atoms to the thio

294 th cell populations, unlike indoleamine 2, 3-dioxygenase which was only produced following IFN-gamma

295 These included IDO1 and tryptophan 2,3-dioxygenase, which catalyze the rate-limiting step in th

296 mediated by the host enzyme indoleamine 2,3-dioxygenase, which converts l-tryptophan to N-formylkynu

297 Stomata of plants expressing bacterial NO dioxygenase, which prevents NO accumulation, did not clo

298 (AhR) and the hepatic enzyme tryptophan 2,3-dioxygenase, which provided an activating ligand to the

299 apid (>100 turnovers/s) reaction of the heme dioxygenase with oleic and linoleic acids.

300 ence of cyclooxygenases and fungal linoleate dioxygenases (YRWH), appears to be a heme dioxygenase an