ライフサイエンスコーパス: dipeptide

1 and nonbiased exit of one of the products (a dipeptide).

2 ately the same distance apart as in a normal dipeptide.

3 -permeable and free in solution, to form the dipeptide.

4 in patients receiving intravenous glutamine dipeptide.

5 inding of the penta- rather than that of the dipeptide.

6 -Val while low response was achieved for the dipeptide.

7 hydroxylation of the proline residue in the dipeptide.

8 he three distinct oxygen environments of the dipeptide.

9 n enabled the stereoselective synthesis of a dipeptide.

10 leucine dipeptide; (g) L-leucyl-L-isoleucine dipeptide.

11 ate interatomic distances in a fully labeled dipeptide.

12 t, which catalyses the formation of a second dipeptide.

13 h polymerization and binding by the PRn poly-dipeptide.

14 of the free energy landscape of the alanine dipeptide.

15 f the six divalent ions with amino acids and dipeptides.

16 across the entire series of amino acids and dipeptides.

17 adily switched from 0% to 100% in Xaa-PsiPro dipeptides.

18 tive to this puromycin analogue to recognize dipeptides.

19 zed by two highly conserved tyrosine-leucine dipeptides.

20 urable structures for C-domain inhibition in dipeptides.

21 sion of the C9BAC transgene and the poly(GP) dipeptides.

22 nd oil as well as to analyze amino acids and dipeptides.

23 ways and with lower levels of gamma-glutamyl dipeptides.

24 positively associated with 5 gamma-glutamyl dipeptides.

25 nd/or RAN translation into potentially toxic dipeptides.

26 lt of the phosphorylation of several Ser-Pro dipeptides.

27 p (n = 75) received PN containing alanyl-GLN dipeptide (0.5 g/kg/d), proportionally replacing AA in P

28 Single-crystal XRD analysis of the dipeptide 1 showed parallel beta-sheet arrangement along

29 The crystals of dipeptide 1, upon heating at 85 degrees C, underwent cry

30 le efficiently with alpha-amino acids 21a-e, dipeptides 22a-c, aminoxyacetic acid 23a, depsidipeptide

31 A protein containing both thiolated dipeptide 4 and a 7-methoxycoumarin fluorophore was foun

32 han-, tyrosine- and phenylalanine-containing dipeptides, 50-80% of the total ACE-inhibiting potential

33 rbon sources and incorporates them mainly as dipeptides, a wide variety of dipeptide production proce

34 faced the molecular recognition of a target dipeptide (Ac-EY-OH) mimicking a biologically relevant s

35 pH-switching properties of the new family of dipeptide-acetylene conjugates where pH-gated light-acti

36 lpP1P2 complex requires binding of N-blocked dipeptide activators.

37 rks of hepatotoxicity such as gamma-glutamyl dipeptides, acylcarnitines, and proline derivatives.

38 Dipeptides adopt one of two intramolecular-hydrogen bond

39 In the solid state, the dipeptide adopted a fully extended conformation featurin

40 eld for lauroyl glycine and less than 5% for dipeptide after 96h of synthesis, at 45 degrees C and ac

41 lalanine tert-butyl ester, and the resulting dipeptide after ester cleavage was linked to (3S)-methyl

42 taste papillae (HBO) cells with five arginyl dipeptides: Ala-Arg (AR), Arg-Ala (RA), Arg-Pro (RP), Ar

43 The unnatural phosphinic dipeptide analogs exhibited a high affinity for monozinc

44 (2) and Phe-Gly (3)), as well as a thiolated dipeptide analogue (4) and a fluorescent oxazole (5) hav

45 ng and that interaction between the PRn poly-dipeptide and LC domains is polymer-dependent.

46 nhibitor binding to the Escherichia coli PTR dipeptide and tripeptide permease A (DtpA), which shows

47 of all the predicted MS/MS spectra from 400 dipeptides and 8000 tripeptides was created, and a searc

48 in the range of 0-200muM for the individual dipeptides and in the range of 0-100muM for each dipepti

49 lowed by coupling with various amino esters, dipeptides and nucleophiles provided taurine N- and O-co

50 Some leucine dipeptides and the triple-leucine tripeptide were among

51 s driven by the H bonds formed both to other dipeptides and to the guests, permitting the observed st

52 Small peptides, such as dipeptides and tripeptides, are naturally present in man

53 toward other zwitterionic compounds, such as dipeptides and tripeptides, has been successfully develo

54 id metabolism, 1 (prolylhydroxyproline) is a dipeptide, and 1 (erythritol) is a sugar alcohol.

55 cis lethal toxin, Toxoplasma gondii, muramyl dipeptide, and host intracellular ATP depletion.

56 A dozen amino acids, 10 glycine-containing dipeptides, and 3 glycine-containing diketopiperazines w

57 alyzed the archived samples for amino acids, dipeptides, and diketopiperazines by liquid chromatograp

58 butyrate-related metabolites, gamma-glutamyl dipeptides, and lysophosphatidylcholines, which are cons

59 and Tap chemoreceptors, which sense sugars, dipeptides, and pyrimidines.

60 energy trends for twenty amino acids, their dipeptides, and their interactions with the divalent cat

61 ne adopts cis-conformation in simple amides, dipeptides, and tripeptides whereas its carbamate-protec

62 N-Acyl dipeptides are also hydrolyzed under typical cleavage co

63 Hence, tryptophan containing dipeptides are interesting ingredients for functional fo

64 of neurotoxicity associated with these poly-dipeptides are not clear.

65 These results suggest that the N-chlorinated dipeptides are produced by chlorination.

66 nine instead of histidine, yet the resulting dipeptides are virtually absent from muscle or brain, su

67 Trp and Trp-containing dipeptides (Arg-Trp, Trp-Val, Val-Trp, Lys-Trp and Ile-T

68 chloride without base gave the corresponding dipeptides as a single diastereomer (6 examples).

69 demonstrate the feasibility of incorporating dipeptides as a single ribosomal event, and illustrate t

70 e report the identification of N-chlorinated dipeptides as chlorination products in drinking water us

71 This study has identified N-chlorinated dipeptides as new disinfection byproducts in drinking wa

72 This loop further contains an (872)GG(873) dipeptide, as well as two aromatic residues ((871)W and

73 (RE), and Glu-Arg (ER); and two non-arginyl dipeptides: Asp-Asp (DD) and Glu-Asp (ED).

74 pha-chymotrypsin and driven by hydrolysis of dipeptide aspartyl-phenylalanine-methyl ester (the sweet

75 e to tune the aspect ratio of populations of dipeptide assemblies.

76 icate that carnosine, a histidine containing dipeptide available through the diet, is an effective sc

77 of an additional activating factor (e.g. the dipeptide benzyloxycarbonyl-leucyl-leucine in vitro) to

78 thase prevented the accumulation of abnormal dipeptides (beta-alanyl-lysine, beta-alanyl-ornithine, g

79 The cage hosts were assayed for dipeptide binding using competition ESI-MS experiments a

80 The PRn poly-dipeptide binds to polymeric forms of the phenylalanine:

81 The newly formed dipeptide binds to vesicle membranes, which imparts enha

82 vities that cleave the proline-phenylalanine dipeptide bond in Ang II.

83 ted WT mice received the NOD2 ligand muramyl dipeptide, both hyperglycemia and the proinflammatory im

84 he model [2]-catenane is self-assembled from dipeptide building blocks and contains an extensive netw

85 s that expression of the arginine-containing dipeptides, but not alanine-containing dipeptides, produ

86 lecular dynamical systems, including alanine dipeptide, carbon nanotube, and benzene rings.

87 use it is the rate-limiting precursor of the dipeptide carnosine (beta-alanyl-l-histidine) in muscle.

88 been synthesized from Zn(2+) and the natural dipeptide carnosine (beta-alanyl-L-histidine).

89 ntitate two biologically important histidine dipeptides, carnosine and anserine, using capacitively c

90 consists of fatty-acid vesicles containing a dipeptide catalyst, which catalyses the formation of a s

91 ed in vitro data, revealing that each of the dipeptides caused toxicity, with poly GA being the most

92 modulate protein function through N-terminal dipeptide cleavage and inhibition of these enzymes has b

93 can are mediated by detection of its muramyl dipeptide component in the cytosol by NOD2, we report he

94 bly building block (naphthalenediimide (NDI)-dipeptide conjugate) by enzymatic condensation of NDI-fu

95 g a formamidinylated, N-hydroxylated Gly-Gln dipeptide conjugated to 6'-amino-pseudouridine.

96 Dipeptide conjugates with coprostanol and estradiol were

97 Here we describe a simple and robust FLFL-dipeptide construct to which a meso-tetraphenylporphyrin

98 Peptides, as short as dipeptides, contain all the molecular information needed

99 A designed beta-sheet-forming l-Ala-l-Val dipeptide containing azide and alkyne at its termini (N3

100 Interestingly, external supply of dipeptides containing BCAAs and ARO AAs rescues cell pro

101 Four model compounds and four dipeptides containing N-aminoazetidinecarboxylic acid (A

102 report a MOF that consists of glycyl-serine dipeptides coordinated to metal centres, and has a struc

103 PNTs have been made from Fmoc dipeptides, cyclic peptides, and lock-washer helical bun

104 The tricyclic acetonide of the dipeptide d-Hot horizontal lineTap is resistant to TFA a

105 ndent D,D-peptidases VanX and VanY acting on dipeptide (D-Ala-D-Ala) or pentapeptide (UDP-MurNac-L-Al

106 ry bile acids, glucose, free fatty acids and dipeptides decrease, whereas those of primary bile acids

107 Alanyl-glutamine (AQ) is a highly soluble dipeptide derivative of glutamine.

108 us works demonstrated that PriSM formed by a dipeptide derivative selectively inhibiting the growth o

109 a-diamino esters to afford the corresponding dipeptide derivatives in good yields.

110 formed under PTC to obtain C60-amino acid or dipeptide derivatives in yields up to 80% by P-C bond fo

111 We have prepared water-soluble phosphate and dipeptide derivatives of the KATP channel opener cromaka

112 hen the o-boronato-phosphonium amino acid or dipeptide derivatives were mixed with fluoride, the corr

113 Therefore, in this study, a Trp-containing dipeptide derived from a computer-aided simulation of pe

114 Although acting preferentially on basic dipeptides derived from beta-alanine or gamma-aminobutyr

115 Zn(2+) is required for hydrolysis of muramyl dipeptide, disulfide oxidation is not required for activ

116 ing intravenous supplementation of glutamine dipeptide during major abdominal surgery.

117 structures of isolated amino acids and their dipeptides emerge as lowest-energy conformers.

118 The toxic proline:arginine (PRn) poly-dipeptide encoded by the (GGGGCC)n repeat expansion in t

119 e intracellular targets of the toxic PR poly-dipeptide encoded by the repeat sequences expanded in th

120 ed, which employs lactic acid (Lact) and the dipeptide ester (Nalpha-Ac)-Ser(Ala)- as linkers for dil

121 unsymmetrical urea A and carboxy-imidazolyl-dipeptide ester B intermediates.

122 oporin domains rich in phenylalanine-glycine dipeptides (FG domains) fills the nuclear pore.

123 This dipeptide forms the central motif of the Abeta peptides,

124 The aminopeptidase DPP9 removes dipeptides from N-termini of substrates having a proline

125 of function, toxicity by the expanded RNA or dipeptides from non-ATG-initiated translation are respon

126 d Lys-gingipains cooperatively liberate most dipeptides from nutrient oligopeptides.

127 expressed in mammalians, releases X-Pro/Ala dipeptides from the N-terminus of peptides.

128 plus L-isoleucine; (f) L-isoleucyl-L-leucine dipeptide; (g) L-leucyl-L-isoleucine dipeptide.

129 ducers included adenine, guanosine, arginine dipeptides, gamma-D-Glu-Gly, methylamine, and others.

130 iomeric excess of mixed monolayers of chiral dipeptides gave rise to continuous changes in the orient

131 We synthesized a dipeptide gelator decorated with azide and alkyne at its

132 tuted and N-unsubstituted alpha-amino acids, dipeptide Gly-Gly, and also benzylamine were used as the

133 The four incorporated species included two dipeptides (Gly-Phe (2) and Phe-Gly (3)), as well as a t

134 ity towards the lipoaminoacid instead of the dipeptide glycylglycine and synthesis yield were evaluat

135 -tetrahydropyranyl-4-carboxylic acid derived dipeptide GSK-2793660, which is currently in clinical tr

136 ization of a tetrahydro-beta-carboline-based dipeptide has been developed to prepare new indole-fused

137 tathione and its constituting aminoacids and dipeptides have been used as ligands.

138 d for the preparation of triazole-containing dipeptides having the structural motives typical of turn

139 hat Ca(2+) unloading from proteins, histidyl dipeptides (HDPs; e.g., carnosine), and ATP can underlie

140 systems, namely atomic clusters and alanine dipeptide, highlighting the connections to broken ergodi

141 rationally designed and the lead, phosphinic dipeptide hPhePpsi[CH2]Phe, was modified in a single pos

142 altered steady-state kinetic parameters for dipeptide hydrolysis and remodeled S1 subsite specificit

143 to pronase treatment yielding the alkylated dipeptide hydroxyethylthioethyl-CysPro (HETE-CP) derived

144 Third, an Arg-Asp dipeptide immediately preceding the ZF helix, conserved

145 emphasize the importance of the Gly25-Ser26 dipeptide in organizing Abeta42 monomer structure and th

146 cy and efficiency on the examples of alanine dipeptide in vacuum and C-terminal beta-hairpin of prote

147 enable sensitive detection of N-chlorinated dipeptides in authentic water, we developed a high-perfo

148 nd widespread production of RNA foci and RAN dipeptides in C9-BACexp mice, behavioral abnormalities a

149 er Arg-Ser repeat along with several Ser-Pro dipeptides in the C-terminus of the RS domain.

150 RPK1 phosphorylates serine residues of SR/RS dipeptides in the hinge region of the HPV1 E2 protein in

151 The limit of detections (LOD) for the dipeptides in the mixture were 0.10muM for carnosine and

152 fly models and found that the arginine-rich dipeptides, in particular Proline-Arginine (PR), are pot

153 ates heightened ITCH(-/-) macrophage muramyl dipeptide-induced responses.

154 etter inhibitory activities than traditional dipeptide inhibitors.

155 yl) ether C-terminal capping group mimicking dipeptide interactions was probed through ring substitut

156 e were shown to support the incorporation of dipeptides into proteins.

157 We show that the Ala-Thr dipeptide is necessary for normal Ci-MRF function, and t

158 de proves a modular binding mode, where each dipeptide is recognized by one internal repeat.

159 eviously reported synthesis of ketomethylene dipeptide isosteres to allow for the preparation of deri

160 t of crystal structures containing the NmAPN dipeptide ligand were used to verify and to confirm the

161 DNA interaction with novel arginine-arginine dipeptide ligands were explored to promote binding and r

162 2 also acted at lower rates on some "classic dipeptides" like alpha-alanyl-lysine and alpha-lysyl-lys

163 Introduction of a labile dipeptide linker at the N terminus of a T-cell epitope i

164 induced TNF-alpha can be affected by muramyl dipeptide (MDP) in a biphasic concentration-dependent ma

165 esponse to the presence of bacterial muramyl dipeptide (MDP) in the host cell cytoplasm, thereby indu

166 uce an unusual, glycolylated form of muramyl dipeptide (MDP) that is more potent and efficacious at i

167 t, ApoE(-/-) mice injected i.p. with Muramyl DiPeptide (MDP) to stimulate NOD2 and given an oral gava

168 Here we investigated the effects of muramyl dipeptide (MDP), a bacterial cell wall component that ac

169 r, induces autophagy on detection of muramyl dipeptide (MDP), a component of microbial cell walls.

170 ycobacterial cell wall component and muramyl dipeptide (MDP), a peptidoglycan derivative respectively

171 nts, such as the NOD2 cognate ligand muramyl dipeptide (MDP), and are selectively required for NOD2 r

172 h receptor, NOD2, via recognition of muramyl dipeptide (MDP), triggers a distinct network of innate i

173 in response to i.p. and intravitreal muramyl dipeptide (MDP).

174 igand MurNAcTri(DAP) and NOD2 ligand muramyl dipeptide [MDP]) but not bacterial Toll-like receptor (T

175 R132H) expression increased the abundance of dipeptide metabolites, depleted key tricarboxylic acid c

176 ns models of ALS, suggesting that the (PR)50 dipeptide might engage similar toxicity mechanisms as ot

177 A new semirigid dipeptide mimetic was prepared on multigram scale, in go

178 here plus stereochemical constraint model of dipeptide mimetics to enumerate the side-chain dihedral

179 Here, we employed a dipeptide model of oxidized PTP1B to investigate the nuc

180 Furthermore, cysteine-proline dipeptide motifs in BACH1 that mediate heme-dependent de

181 reveal that the pathways altered by the poly-dipeptides-mRNA complexes are potential therapeutic targ

182 bserved in the reactions of CumO(*) with the dipeptides N-BocProGlyOH and N-BocGlyGlyOH.

183 ids, FMOC-l-leucine and FMOC-l-valine, and a dipeptide, N-acetyl-l-valyl-l-leucine (N-Ac-VL), were st

184 ow the formation of tryptophan-phenylalanine dipeptide nanoparticles (DNPs) that can shift the peptid

185 o polycrystalline specimens of two different dipeptide nanotubes: l-Ala-l-Val and its retro-analog l-

186 porting the hypothesis that RNA foci and RAN dipeptides occur presymptomatically and are not sufficie

187 cement of the C-terminal Leu(13)-Met(14)-NH2 dipeptide of SB3 by Sta(13)-Leu(14)-NH2, the novel GRPR

188 onstrate for the first time that the Ala/Thr dipeptide of the basic domain of an invertebrate MRF beh

189 ceptor, sialic acid, by supplying a critical dipeptide on their projecting, heavy-chain third complem

190 hesis or prolonged standing in solution when dipeptides or longer peptides are acylated on the N-term

191 od stimulation with the NOD2 ligand, muramyl dipeptide, or B. pseudomallei.

192 mycin derivative in this study contained the dipeptide p-methoxyphenylalanylglycine, implying the abi

193 to digest a small, synthetic tetrasaccharide dipeptide PG fragment into the cognate 1,6-anhydromuramy

194 ree amino acids (Met, Leu and Trp) and eight dipeptides (Phe-Leu, Trp-Val, His-Leu, Glu-Lys, Ala-Leu,

195 We designed novel dipeptide (phenylalanine-alpha,beta-dehydrophenylalanine

196 cognition of the central peptide bond in the dipeptide, potentially enabling the incorporation of a b

197 n of the diene system, we easily converted a dipeptide precursor into the desired C6-functionalized a

198 cally label chlamydial PG using d-amino acid dipeptide probes and click chemistry.

199 ining dipeptides, but not alanine-containing dipeptides, produces toxic phenotypes in multiple cellul

200 rystal structure of Rv3717 in complex with a dipeptide product shows that, compared with previously c

201 them mainly as dipeptides, a wide variety of dipeptide production processes mediated by dipeptidyl-pe

202 ructures of N-domain ACE in complex with the dipeptide products of Ac-SDKP cleavage were obtained and

203 rting that either C9orf72 transcripts or RAN dipeptides promote nucleolar dysfunction.

204 f this repeat gives rise to several distinct dipeptide protein species that could play pathological r

205 uniformly (13)C,(15)N and 70% (17)O-labeled dipeptide prove the attainability of (17)O as a probe fo

206 The dipeptide receptor exhibited 29% of virtual-experimental

207 ded transcripts, as well as their translated dipeptide repeat (DPR) products, and also mitigated dege

208 Ectopic expression of the dipeptide repeat (DPR) protein (GR)80 in iPSC-derived co

209 Dipeptide repeat (DPR) proteins are toxic in various mod

210 -ATG-dependent translation, generating toxic dipeptide repeat (DPR) proteins thought to contribute to

211 n in neuronal tissues and RAN translation of dipeptide repeat (DPR) proteins, as observed in patients

212 he characteristic pathological finding is of dipeptide repeat (DPR) proteins, formed by unconventiona

213 etion of TDP-43 (chi(2) P = 0.75) or poly-GA dipeptide repeat protein inclusions (chi(2) P = 0.46).

214 At autopsy, widespread RNA foci and dipeptide repeat protein inclusions were observed, but T

215 urgical resection tissue contained RNA foci, dipeptide repeat protein inclusions, and loss of nuclear

216 and in vivo models to dissect repeat RNA and dipeptide repeat protein toxicity.

217 anslation and formation of potentially toxic dipeptide repeat protein.

218 ion of G4C2 RNA can result in five different dipeptide repeat proteins (DPR: poly GA, poly GP, poly G

219 Dipeptide repeat proteins (DPRs) produced by unconventio

220 expansion is translated into five different dipeptide repeat proteins (DPRs) that accumulate within

221 tional translation of these repeats produces dipeptide repeat proteins (DPRs) that may cause neurodeg

222 these expansions are translated to form five dipeptide repeat proteins (DRPs).

223 is driven by the repeat RNA itself and/or by dipeptide repeat proteins generated by repeat-associated

224 TG dependent translation gives rise to toxic dipeptide repeat proteins that form inclusions in patien

225 Expression of repeat transcripts and dipeptide repeat proteins trigger multiple mechanisms of

226 Expression of individual dipeptide repeat proteins with a non-GGGGCC RNA sequence

227 y(Gly-Pro), poly(Gly-Ala), and poly(Gly-Arg) dipeptide repeat proteins, as well as TDP-43 pathology.

228 ranuclear RNA foci and poly(glycine-proline) dipeptide repeat proteins.

229 d repeats promoted neurodegeneration through dipeptide repeat proteins.

230 through the production of toxic aggregating dipeptide repeat proteins.

231 gical C9ORF72 transcripts, the production of dipeptide-repeat proteins and alleviates neurotoxicity i

232 ), in which the accumulation of RNA foci and dipeptide-repeat proteins are expected to modify RNA met

233 level-dependent accumulation of RNA foci and dipeptide-repeat proteins synthesized by AUG-independent

234 roduced sustained reductions in RNA foci and dipeptide-repeat proteins, and ameliorated behavioral de

235 n addition to possible RNA toxicity, several dipeptide repeats (DPRs) are translated through repeat-a

236 Moreover, arginine-rich dipeptide repeats (DPRs) derived from C9orf72 hexanucleo

237 Arginine-glutamic acid dipeptide repeats (RERE) is located in the proximal 1p36

238 ranslation (RAN translation) into pathologic dipeptide repeats in patient brains, a process that is t

239 diated expression of C9orf72-related RNA and dipeptide repeats in the mouse central nervous system in

240 ranslation (RAN translation) into pathologic dipeptide repeats, as well as any oligonucleotide repeat

241 e data suggest that toxicity of the PRn poly-dipeptide results in part from its ability to lock the F

242 he pentapeptide and 56%, 57% and 45% for the dipeptide, riboflavin and tryptophan respectively, howev

243 o identify and quantify for the first time a dipeptide S-conjugate to 3MH, the gammaGluCys-3MH, in Sa

244 Several catalytic anions bearing a pseudo-dipeptide scaffold, in combination with a biotinylated i

245 The incorporation of isoacyl dipeptide segments into both A and B chains greatly impr

246 Once internalized, these dipeptide species activate amino-acid signalling via a p

247 Our results demonstrate that dipeptide species support CML stem cell maintenance by a

248 ulate significantly higher levels of certain dipeptide species than normal HSCs.

249 s and tailored affinities by the assembly of dipeptide-specific modules based on armadillo repeats.

250 RF4 under either 55 unstimulated and muramyl dipeptide-stimulated conditions.

251 ng to the model, a hydrophobic C-terminal LM dipeptide submotif acts as an anchor to establish initia

252 m covalent adducts with histidine-containing dipeptides such as carnosine and anserine, which are pre

253 or the first time that tryptophan-containing dipeptides such as Ile-Trp or Val-Trp, which were recent

254 itored fish metabolites include amino acids, dipeptides, sugars, vitamins, biogenic amines, as well a

255 usly demonstrated the formation of the [cage.dipeptide] supramolecular complexes and rendered quantit

256 ocols for the preparation of various Xaa-Gly dipeptide surrogates in the form of Xaa-psi[triazole]-F2

257 An example of catalytic dipeptide synthesis is reported.

258 The catalysed dipeptide synthesis proceeds with higher efficiency in v

259 d puromycin reactivity but no differences in dipeptide synthesis rates when compared with the beta-ly

260 he mechanism by which Val-boroPro, a boronic dipeptide that inhibits post-proline cleaving enzymes, m

261 ction, we designed an unnatural d-amino acid dipeptide that is metabolically incorporated into Lipid

262 We identified N,C-capped dipeptides that are selective for the Mycobacterium tube

263 To this end, we have investigated dipeptides that bind to the F pocket of class I molecule

264 being glucosinolates, phenylpropanoids, and dipeptides, the latter of which is not yet explored in r

265 alent interactions with successive substrate dipeptides through two distinct classes of side chain bi

266 uses an invariant 'cross-subunit' Gly-cisPro dipeptide to capture the chiral centre of incoming D-ami

267 Here, inspired by the ability of aromatic dipeptides to form ordered nanostructures with unique ph

268 s, drugs, single amino acids, peptides (from dipeptides to hexapeptides), and proteins.

269 genyl (cycloSal) phosphodiester moiety, into dipeptides to investigate the inhibitory effect on SH2 d

270 ee facility, were given antibiotics, muramyl dipeptide (to stimulate NOD2), or dextran sodium sulfate

271 ers a mechanistic interpretation of PRn poly-dipeptide toxicity in the context of a prominent form of

272 ds to the accumulation of five types of poly-dipeptides translated from the GGGGCC hexanucleotide rep

273 port ATP-binding protein (NikE), periplasmic dipeptide transport protein (DppA), and outer membrane p

274 First, three model dipeptides, tyrosylglycine (Tyr-Gly), tyrosylalanine (Ty

275 by the presence of a repeating alpha,epsilon-dipeptide unit have been prepared and characterized by (

276 tides such that each repeat interacts with a dipeptide unit within the stretched target peptide.

277 eins containing the catabody-sensitive Abeta dipeptide unit.

278 Importantly, pharmacological inhibition of dipeptide uptake inhibits CML stem cell activity in vivo

279 s their binding abilities toward N-protected dipeptides using a combination of different techniques (

280 red by mechanochemistry from amino esters or dipeptides, via a 1,1'-carbonyldiimidazole-mediated one-

281 nd orally bioavailable SP(1-7) mimetics, the dipeptide was chosen as a lead compound.

282 PN supplemented with GLN dipeptide was safe, but did not alter clinical outcomes

283 se IV (DPP-IV) inhibition by amino acids and dipeptides was studied.

284 hese effects, a series of end-capped Thr-Pro dipeptides was synthesized, tracking the sequential post

285 cted in the raw water, but the N-chlorinated dipeptides were at background levels.

286 The dipeptides were clearly detected in the raw water, but t

287 di-Cl-Tyr-Ala along with their corresponding dipeptides were detected in authentic tap water samples.

288 d solid phase extraction (C18 matrix), three dipeptides were identified.

289 and (GR)50-green fluorescent protein tagged dipeptides were present in the nucleus and nuclear local

290 These identified N-chlorinated dipeptides were synthesized and found to be stable in wa

291 ptides and in the range of 0-100muM for each dipeptide when both were present as a mixture.

292 d repeat-associated non-ATG (RAN) translated dipeptides, which were suppressed by antisense oligonucl

293 ation of the neighboring ACBC residue in the dipeptides: while the trans-ACBC derivatives prefer the

294 that drugs altering the interactions of this dipeptide with neighboring side-chain atoms or with the

295 Other dipeptides with a hydrophobic second amino acid show sim

296 wed a remarkable selectivity for N-protected dipeptides with an aromatic amino acid at the carboxylic

297 aborately complemented DPP7 in liberation of dipeptides with hydrophobic P1 residues.

298 y expressed cytosolic enzyme that hydrolyzes dipeptides with proline or hydroxyproline at the carboxy

299 the pentapeptides Thr-Gly-Ala-X-Met into the dipeptides X-Met (X = Phe, AMPhe).

300 f tyrosine-containing peptides, ranging from dipeptides (YG, pYG, and sYG) over tripeptides (GYR, GpY