ライフサイエンスコーパス: dipeptidyl peptidase IV

1 complex with the cell membrane protein CD26/dipeptidyl peptidase IV.

2 gelatinase that is related to the ectoenzyme dipeptidyl peptidase IV.

3 xopeptidases prolylcarboxypeptidase and CD26/dipeptidyl peptidase IV.

4 lymphocytes in a process independent of CD26/dipeptidyl peptidase IV.

5 n in syngeneic Fischer 344 rats deficient in dipeptidyl peptidase IV.

6 r repopulation by histochemical staining for dipeptidyl peptidase IV.

7 ll surface multifunctional glycoprotein CD26/dipeptidyl peptidase IV.

8 curs bound to the membrane glycoprotein CD26/dipeptidyl peptidase IV.

9 in juvenile and senescent rats deficient in dipeptidyl-peptidase IV.

10 -glucosidase (37.8%), alpha-amylase (35.6%), dipeptidyl peptidase-IV (34.4%), reactive oxygen species

11 a leukocyte activation marker that possesses dipeptidyl peptidase IV activity but whose natural subst

12 ified as a soluble human plasma protein with dipeptidyl peptidase IV activity that is expressed and r

13 n known to bind adenosine deaminase and have dipeptidyl peptidase IV activity.

14 border membrane vesicles reveals that it has dipeptidyl peptidase IV activity.

15 hepatocyte colonies with strong canalicular dipeptidyl peptidase IV activity.

16 ity, indicating that the association between dipeptidyl peptidase IV and ADA did not require enzymati

17 atrophy and marked up-regulation of mucosal dipeptidyl peptidase IV and PepT1 messenger RNA.

18 tology and expression of brush border enzyme dipeptidyl peptidase IV and peptide transporter PepT1 me

19 s are a good source of natural inhibitors of dipeptidyl peptidase-IV and prolyl endopeptidase and cou

20 th expression of the brush border hydrolases dipeptidyl-peptidase IV and sucrase-isomaltase or with b

21 ent on degradation by neutral endopeptidase, dipeptidyl peptidase IV, and aminopeptidase P.

22 f, its mRNA, and the "NPY-converting enzyme" dipeptidyl peptidase IV (both protein and mRNA), which t

23 an unusual substrate specificity shared with dipeptidyl peptidase IV (CD26/DPPIV).

24 l specificity that is comparable to both the dipeptidyl-peptidase IV/CD26 and lactococcal x-prolyl di

25 Three groups of mutant F344 dipeptidyl peptidase IV-deficient (DPPIV(-)) rats were r

26 integrate into the liver parenchyma, we used dipeptidyl peptidase IV-deficient F344 rats as hosts.

27 sed transplanted hepatocytes as reporters in dipeptidyl peptidase IV-deficient F344 rats.

28 eficient rats, which allowed localization of dipeptidyl peptidase IV-deficient hepatocytes in normal

29 , we used transplanted cells as reporters in dipeptidyl peptidase IV-deficient mice.

30 hepatocytes were transplanted into syngeneic dipeptidyl peptidase IV-deficient rats followed by histo

31 Use of dipeptidyl peptidase IV-deficient rats should help furth

32 Dipeptidyl peptidase IV-deficient rats were used as reci

33 atase (ATPase) activity in normal but not in dipeptidyl peptidase IV-deficient rats, which allowed lo

34 F344 rat hepatocytes with or without DAR in dipeptidyl peptidase IV-deficient rats.

35 ter transplanting syngeneic hepatocytes into dipeptidyl peptidase IV-deficient rats.

36 t and proliferation of transplanted cells in dipeptidyl peptidase IV-deficient rats.

37 hepatocytes were transplanted into syngeneic dipeptidyl peptidase IV-deficient rats.

38 d Fischer 344 rat hepatocytes into syngeneic dipeptidyl peptidase IV-deficient rats.

39 Dipeptidyl-peptidase-IV-deficient female rats received B

40 both analogues were completely resistant to dipeptidyl peptidase IV degradation.

41 ts but does not inhibit close FAP homologues dipeptidyl peptidase IV, dipeptidyl peptidase 9, and pro

42 CD26 or dipeptidyl peptidase IV (DP IV) is expressed on various

43 Dipeptidyl peptidase IV (DP-IV) is a cell surface serine

44 Dipeptidyl peptidase IV (DP-IV), a member of the prolyl

45 s in T cell activation, was shown to possess dipeptidyl peptidase IV (DPP IV) activity.

46 6)PAL) and GIP(Lys(37)PAL) were resistant to dipeptidyl peptidase IV (DPP IV) degradation.

47 Dipeptidyl peptidase IV (DPP IV) expressed on rat lung c

48 Dipeptidyl peptidase IV (DPP IV) is a ubiquitous membran

49 Binding of plasminogen type II (Pg 2) to dipeptidyl peptidase IV (DPP IV) on the surface of the h

50 method to a variety of proteases, including dipeptidyl peptidase IV (DPP IV), dipeptidyl peptidase 8

51 ained lactam aminoboronic acid inhibitors of dipeptidyl peptidase IV (DPP IV; E.C. 3.4.14.5).

52 gorous steady state enzyme kinetic assay for dipeptidyl peptidase IV (DPP IV; E.C. 3.4.14.5).

53 e synthesized and evaluated as inhibitors of dipeptidyl peptidase IV (DPP-4) for the treatment of typ

54 novel aminopiperidine-fused imidazopyridine dipeptidyl peptidase IV (DPP-4) inhibitor 1 has been dev

55 ered as potent, selective, and orally active dipeptidyl peptidase IV (DPP-4) inhibitors by extensive

56 Dipeptidyl peptidase IV (DPP-IV) belongs to a family of

57 Dipeptidyl peptidase IV (DPP-IV) degrades the incretin h

58 e synthesized and evaluated as inhibitors of dipeptidyl peptidase IV (DPP-IV) for the treatment of ty

59 e synthesized and evaluated as inhibitors of dipeptidyl peptidase IV (DPP-IV) for the treatment of ty

60 Inhibition of dipeptidyl peptidase IV (DPP-IV) has been proposed recen

61 agon-like peptide-1 (GLP-1) degrading enzyme dipeptidyl peptidase IV (DPP-IV) have been shown to be e

62 Xanthine oxidase (XO) and dipeptidyl peptidase IV (DPP-IV) inhibition by amino aci

63 Dipeptidyl peptidase IV (DPP-IV) inhibition has the pote

64 acid linked l-cis-4,5-methanoprolinenitrile dipeptidyl peptidase IV (DPP-IV) inhibitors led to the i

65 tent angiotensin converting enzyme (ACE) and dipeptidyl peptidase IV (DPP-IV) inhibitory and oxygen r

66 Nine novel dipeptidyl peptidase IV (DPP-IV) inhibitory peptides (FL

67 ts (DOE) was used to optimise the release of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides dur

68 of 72 dietary proteins to act as a source of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides.

69 as no significant effect of pH regulation on dipeptidyl peptidase IV (DPP-IV) properties.

70 These peptides are known to act as preferred dipeptidyl peptidase IV (DPP-IV) substrates.

71 l screening was performed against the target dipeptidyl peptidase IV (DPP-IV) to identify good chemic

72 re deficient for the bile canalicular enzyme dipeptidyl peptidase IV (DPP-IV), cultured WB-F344 rat l

73 HSA), other components, such as the protease dipeptidyl peptidase IV (DPP-IV), possibly contribute to

74 N-terminal sequence-specific serine protease dipeptidyl peptidase IV (DPP-IV).

75 Dipeptidyl peptidase IV (DPP-IV; E.C. 3.4.14.5), a serin

76 uggest a variety of bioactivities, including dipeptidyl peptidase-IV (DPP-IV) and angiotensin convert

77 wever, its rapid degradation by enzymes like dipeptidyl peptidase-IV (DPP-IV) and neutral endopeptida

78 f GLP-1 is short due to rapid degradation by dipeptidyl peptidase-IV (DPP-IV) and renal clearance.

79 P-1 is short because of rapid degradation by dipeptidyl peptidase-IV (DPP-IV) and renal clearance.

80 Dipeptidyl peptidase-IV (DPP-IV) inhibitors are poised t

81 Dipeptidyl peptidase-IV (DPP-IV) is a serine protease in

82 P-1, due to its resistance to degradation by dipeptidyl peptidase-IV (DPP-IV).

83 n, expression of sucrase isomaltase (SI) and dipeptidyl-peptidase IV (DPP-IV), two well known intesti

84 ies to a single transmembrane protein, CD26 (dipeptidyl peptidase IV [DPP IV]) (monoreactive anti-DPP

85 Dipeptidyl peptidase IV (DPP4) deactivates glucose-regul

86 Dipeptidyl peptidase IV (DPP4) inhibitors are emerging a

87 Dipeptidyl peptidase IV (DPP4/CD26) and seprase/fibrobla

88 ing of the purified protein identified it as dipeptidyl peptidase IV (DPPIV) (EC ), which was confirm

89 Dipeptidyl peptidase IV (DPPIV) activity was quantified

90 , we treated Fischer 344 (F344) rats lacking dipeptidyl peptidase IV (DPPIV) activity with cyclophosp

91 (r) 110,000 surface-bound ectopeptidase with dipeptidyl peptidase IV (DPPIV) activity, has an array o

92 epatocytes can give rise to SHPCs, rats with dipeptidyl peptidase IV (DPPIV) chimeric livers, which h

93 expression of CD26, especially its intrinsic dipeptidyl peptidase IV (DPPIV) enzyme activity, results

94 study demonstrates that the 175-kDa form of dipeptidyl peptidase IV (DPPIV) found in normal human se

95 ine (C5-Pro-Pro) analogues was discovered as dipeptidyl peptidase IV (DPPIV) inhibitors as a potentia

96 Dipeptidyl peptidase IV (DPPIV) is a cell surface peptid

97 Dipeptidyl peptidase IV (DPPIV) is a serine protease wit

98 as evaluated by injecting cell isolates from dipeptidyl peptidase IV (DPPIV) positive (DPPIV+) Fische

99 Dipeptidyl peptidase IV (DPPIV), a cell surface serine p

100 ddresses the hypothesis that the activity of dipeptidyl peptidase IV (DPPIV), an enzyme that inactiva

101 expression of a cell transplantation marker, dipeptidyl peptidase IV (DPPIV), and GFP.

102 membrane-bound prolyl peptidases seprase and dipeptidyl peptidase IV (DPPIV), at invadopodia of migra

103 transplanted intrasplenically into syngeneic dipeptidyl peptidase IV (DPPIV)-deficient rats.

104 FAPalpha exhibits a dipeptidyl peptidase IV (DPPIV)-like fold, featuring an

105 g the protocol of injecting hepatocytes from dipeptidyl peptidase IV (DPPIV)-positive donors into ret

106 ffects of HIR on engraftment of transplanted dipeptidyl peptidase IV (DPPIV)-positive hepatocytes in

107 howed similarities to the 110-kDa subunit of dipeptidyl peptidase IV (DPPIV).

108 their ability to inhibit the serine protease dipeptidyl peptidase IV (DPPIV).

109 rotein (FAP) is a serine protease related to dipeptidyl peptidase IV (DPPIV).

110 ed structure of AprA has similarity to human dipeptidyl peptidase IV (DPPIV).

111 y inhibition of the closely related protease dipeptidyl peptidase IV (DPPIV).

112 proteins after enzymatic digestion, against dipeptidyl peptidase IV (DPPIV); an enzyme known to deac

113 ied throughout a 6-month period in syngeneic dipeptidyl peptidase IV (DPPIV-) mutant F344 rats.

114 Lung endothelial dipeptidyl peptidase IV (DPPIV/CD26) is a vascular addre

115 ate or propionate increased DBS, enhanced by dipeptidyl peptidase-IV (DPPIV) inhibition, at the same

116 Wild-type (dipeptidyl peptidase IV [DPPIV(+)]) embryonic day (ED) 1

117 Dipeptidyl peptidase IV (EC 3.4.14.5; DPP IV), also know

118 -Pro-naphthylamide in the presence of excess dipeptidyl-peptidase IV (EC 3.4.14.5).

119 h CD26 on T cell lines lacking either ADA or dipeptidyl peptidase IV enzymatic activity, indicating t

120 110-kDa cell surface glycoprotein, exhibits dipeptidyl peptidase IV enzyme activity and plays an imp

121 assays based on F344 recipient rats lacking dipeptidyl peptidase IV enzyme activity to identify tran

122 Markers for Y chromosome, dipeptidyl peptidase IV enzyme, and L21-6 antigen were u

123 ow cytometry and histochemical estimation of dipeptidyl-peptidase IV enzyme activity of donor cells i

124 ibited APCE with a K(i) of 54 microM but not dipeptidyl peptidase IV even at 2 mM.

125 lly marked hepatocytes (isolated from normal Dipeptidyl peptidase IV+ Fischer 344 rats) were delivere

126 5' upstream region (-448/-443) of the human dipeptidyl peptidase IV gene promoter containing a conse

127 Further, since dipeptidyl peptidase IV has an absolute requirement for

128 brush border Na(+)-H(+) exchanger NHE3 with dipeptidyl peptidase IV in the proximal tubule.

129 vivo, but this effect was only detected with dipeptidyl peptidase IV inhibition, while mucosal respon

130 ulocyte-colony stimulating factor (G-CSF), a dipeptidyl peptidase IV inhibitor (DPP-4i), and a proton

131 The dipeptidyl peptidase-IV inhibitor saxagliptin (Onglyza)

132 tivities and clinical variants, for example, dipeptidyl peptidase-IV inhibitor-associated noninflamma

133 in medicinal chemistry applications such as dipeptidyl peptidase IV inhibitors.

134 d 1-beta-fructofuranosyl nystose) are potent dipeptidyl peptidase-IV inhibitors as well as peroxisome

135 CD26, a T cell activation Ag, also known as dipeptidyl peptidase IV, is directly associated with ade

136 tal liver cells were transplanted into adult dipeptidyl peptidase IV knockout mice and differentiated

137 normal and retrorsine (Rs) treated syngeneic dipeptidyl peptidase IV mutant (DPPIV(-)) F344 rats.

138 cells) into the liver of retrorsine-treated Dipeptidyl peptidase IV- mutant Fischer 344 rats in conj

139 One week post-MMC treatment, dipeptidyl peptidase IV negative host rats were given a

140 ction of several serine proteases, including dipeptidyl peptidase-IV, neutrophil elastase, matrix met

141 rats into syngeneic recipients deficient in dipeptidyl peptidase IV or from transgenic hepatitis B s

142 vivo and mature into hepatocytes expressing dipeptidyl peptidase IV or fumarylacetoacetate hydrolase

143 These data strongly suggest that dipeptidyl peptidase IV plays a role in the inactivation

144 ntained large clusters of sinusoids lined by dipeptidyl peptidase IV positive endothelial cells coexp

145 newborn, or adult total liver isolates from dipeptidyl peptidase IV positive rats.

146 otransfection of USF expression vectors with dipeptidyl peptidase IV promoter constructs revealed tha

147 nd possible site of USF interaction with the dipeptidyl peptidase IV promoter was localized to the -1

148 Interestingly, the product of a dipeptidyl peptidase IV substrate inactivated bile canal

149 ogenic substrate, Ala-Pro-2naphthylamide, by dipeptidyl peptidase IV, whereas d-Pro2-endomorphin-2 wa

150 he substrate requirements of the proteinase, dipeptidyl peptidase IV which removes dipeptides from th

151 nzymatic activity of molecules such as CD26 (dipeptidyl-peptidase IV), which may act by metabolizing