ライフサイエンスコーパス: diphenyleneiodonium

1 nhibition of NADPH oxidases with apocynin or diphenyleneiodonium.

2 d is abolished by the flavoenzyme inhibitor, diphenyleneiodonium.

3 ed completely when rats were pretreated with diphenyleneiodonium (1 mg/kg), an inhibitor of NADPH OX.

4 Remarkably, post-treatment with diphenyleneiodonium 10 months after lipopolysaccharide i

5 In contrast, diphenyleneiodonium (10 microm), an NADPH oxidase inhibi

6 At both sites, diphenyleneiodonium (10(-4) M) abolished staining.

7 ely abolished by the NADPH oxidase inhibitor diphenyleneiodonium (25-50 microM).

8 evented by vitamin E (an antioxidant) and by diphenyleneiodonium (a NADPH oxidase inhibitor).

9 in thiol oxidation states were suppressed by diphenyleneiodonium, a NADPH oxidase inhibitor.

10 Diphenyleneiodonium also suppressed indole analogue-medi

11 Diphenyleneiodonium, an inhibitor of flavin-containing e

12 oscillations were abolished by 10 micromol/L diphenyleneiodonium, an inhibitor of NAD(P)H oxidase (n=

13 Inhibitors of NADPH oxidase activity (diphenyleneiodonium and apocynin) blocked migration >65%

14 de dismutase, the NAD(P)H oxidase inhibitors diphenyleneiodonium and apocynin, or the protein kinase

15 knockdown and the pharmacological inhibitors diphenyleneiodonium and apocynin.

16 3K-Akt-forkhead signaling was insensitive to diphenyleneiodonium and AS-p47phox.

17 a(2+) release was blocked by catalase and by diphenyleneiodonium and was not observed in cells lackin

18 was inhibited by the NADPH oxidase inhibitor diphenyleneiodonium and was significantly attenuated in

19 P)H oxidase (10 micromol/L to 200 micromol/L diphenyleneiodonium) and xanthine oxidase (1 mmol/L allo

20 N-acetylcysteine, diphenyleneiodonium, and apocynin blocked norepinephrine

21 ffect inhibited by NADPH oxidase inhibitors, diphenyleneiodonium, and apocynin.

22 Moreover, both an NADPH oxidase inhibitor, diphenyleneiodonium, and NAPDH oxidase genetic deficienc

23 agonist, ABT-627, the flavoprotein inhibitor diphenyleneiodonium, and the NADPH oxidase inhibitor apo

24 inistration of the NAD(P)H oxidase inhibitor diphenyleneiodonium, apocynin, the protein kinase C (PKC

25 of apparent toxic side effects suggest that diphenyleneiodonium at ultra-low dose may be a promising

26 The flavin antagonist diphenyleneiodonium blocked light induction of gsa in bo

27 tivation, we found that N-acetylcysteine and diphenyleneiodonium both suppressed Erk activation in M-

28 6a2 and lacs2 mutants were hypersensitive to diphenyleneiodonium but could be reverted to wild-type P

29 synthesis, an effect that was antagonized by diphenyleneiodonium but not by other inhibitors of cellu

30 which was inhibited by superoxide dismutase, diphenyleneiodonium, chelerythrine, or removal of extrac

31 I activates the NADH/NADPH oxidase; however, diphenyleneiodonium chloride (10 micromol/L), an inhibit

32 EK inhibitor), SP600125 (JNK inhibitor), and diphenyleneiodonium chloride (an NADPH oxidase inhibitor

33 Importantly, in VHL-deficient cells, diphenyleneiodonium chloride (DPI), an inhibitor of Nox

34 abrogated by the respiratory burst inhibitor diphenyleneiodonium chloride (DPI), but infection of MDM

35 This effect was abolished by diphenyleneiodonium chloride (DPI), indicating a role fo

36 jections (approximately C(4)) of apocynin or diphenyleneiodonium chloride (DPI), two structurally and

37 reated with catalase (H(2)O(2) scavenger) or diphenyleneiodonium chloride (NADPH oxidase inhibitor) e

38 AT, NADPH oxidase inhibitors (apocynin and diphenyleneiodonium chloride [DPI]), and an inhibitor to

39 Neither N(G)-monomethyl-l-arginine nor diphenyleneiodonium chloride affected the induction of a

40 ratory chain complex I inhibitors, including diphenyleneiodonium chloride and rotenone.

41 d increase in IGF-1R mRNA was inhibitable by diphenyleneiodonium chloride but not by other inhibitors

42 substantially decreased by the RED inhibitor diphenyleneiodonium chloride or by the P450 inhibitor me

43 ble of driving the production of superoxide, diphenyleneiodonium chloride was an efficient inhibitor

44 An inhibitor of NADPH oxidase (diphenyleneiodonium chloride) blocked the PMA-mediated i

45 -overexpressing MCF-7 cells was inhibited by diphenyleneiodonium chloride, a general NADPH reductase

46 directly associated with ROS generation; (c) diphenyleneiodonium chloride, a ROS blocker, or BAX-inhi

47 lus (iron loading plus PMA) and inhibited by diphenyleneiodonium chloride, an inhibitor of NADPH oxid

48 Here we show that diphenyleneiodonium chloride, an inhibitor of Nox oxidas

49 e, the NADPH oxidase inhibitors apocynin and diphenyleneiodonium chloride, the superoxide scavenger t

50 t with lovastatin or NADPH oxidase inhibitor diphenyleneiodonium chloride.

51 , zileuton) but not a flavoenzyme inhibitor (diphenyleneiodonium) completely abrogated Ag-induced dic

52 The NADPH oxidase inhibitor, diphenyleneiodonium, decreased NBT reduction to 9+/-1 pm

53 responsible for ROS generation, as seen by a diphenyleneiodonium-dependent suppression of basal and a

54 r absence of BP autoantibodies, brefeldin A, diphenyleneiodonium, DNase or blocking F(ab')2 fragments

55 Inhibition of NADPH oxidase with diphenyleneiodonium (DPI) blocked both Nrf2 translocatio

56 The NADPH oxidase inhibitor diphenyleneiodonium (DPI) induced high levels of Pro acc

57 sue damage, we treated colonic explants with diphenyleneiodonium (DPI), a flavoenzyme inhibitor, or N

58 etylcysteine (NAC), a thiol antioxidant, and diphenyleneiodonium (DPI), a potent NADH/NADPH oxidase i

59 ing potent inhibition of the GTN response by diphenyleneiodonium (DPI), a widely used inhibitor of fl

60 ration on downstream insulin signaling using diphenyleneiodonium (DPI), an inhibitor of cellular NADP

61 treatment with the NADPH oxidase inhibitors, diphenyleneiodonium (DPI), and 4-(2-aminoethyl)-benzenes

62 Flavoenzyme inhibitor, diphenyleneiodonium (DPI), and antisense oligonucleotide

63 ced by treatment with NOX inhibitors such as diphenyleneiodonium (DPI), apocynin (APO) and VAS2870.

64 oncentrations of the flavoprotein inhibitor, diphenyleneiodonium (DPI), reduced nicotinamide adenine

65 lly inhibited by the NADPH oxidase inhibitor diphenyleneiodonium (DPI, 10 microm), by the farnesyltra

66 was abrogated by the NADPH oxidase inhibitor diphenyleneiodonium (DPI; 10 microM) and in AMs derived

67 OD) or NADPH oxidase inhibitors (apocynin or diphenyleneiodonium [DPI]).

68 flavoproteins and heme-containing proteins, diphenyleneiodonium, effectively inhibited phenazine red

69 Diphenyleneiodonium-elicited neuroprotection was associa

70 nucleotide phosphate oxidase activation with diphenyleneiodonium following hypoxia but before reoxyge

71 h such mutants, the NADPH oxidase inhibitor, diphenyleneiodonium, had no effect on VPA-induced transc

72 3 nmol/L), antimycin A (IC50=13 nmol/L), and diphenyleneiodonium (IC50=28 micromol/L).

73 ine dinucleotide phosphate oxidase inhibitor diphenyleneiodonium in both endotoxin (lipopolysaccharid

74 in, a dominant negative Ras, and myxothiazol/diphenyleneiodonium, indicating a mitochondrial origin f

75 The CPR flavin site inhibitor diphenyleneiodonium inhibited this NO2(-) generation, wh

76 Only flavin site XO inhibitors such as diphenyleneiodonium inhibited XO-mediated organic nitrat

77 For example, diphenyleneiodonium inhibits a variety of flavoenzymes,

78 ic complex, since the flavoprotein inhibitor diphenyleneiodonium not only blocked a productive respir

79 Diphenyleneiodonium, on the other hand, was a powerful i

80 NADPH oxidase 2 inhibition by diphenyleneiodonium or apocynin, or global reactive oxyg

81 al cell coculture; this was not inhibited by diphenyleneiodonium or by SOD plus catalase, but was inh

82 Inhibiting ROS synthesis with diphenyleneiodonium or ethylene perception with 1-methyl

83 ro treatment with the flavoprotein inhibitor diphenyleneiodonium or the angiotensin II type I recepto

84 ia was attenuated by myxothiazol, but not by diphenyleneiodonium or the nitric-oxide synthase inhibit

85 y the NADPH oxidase inhibitors, apocynin and diphenyleneiodonium, or the antioxidant, N-acetyl-L-cyst

86 The NAD(P)H oxidase inhibitor diphenyleneiodonium (P<0.01) abolished SVG-derived.O(2)(

87 In summary, infusion of ultra-low dose diphenyleneiodonium potently reduced microglia-mediated

88 of enzyme components (p47(phox) or rac1) or diphenyleneiodonium, prevented the pressure-induced gene

89 Diphenyleneiodonium, proposed to inhibit protox by inter

90 In superfused PA myocytes, diphenyleneiodonium, rotenone, and myxothiazol, which in

91 thelial cells possess a distinct cytoplasmic diphenyleneiodonium-sensitive NAD(P)H:paraquat oxidoredu

92 gulation of Nox4 enhanced both rotenone- and diphenyleneiodonium-sensitive O(2)(-) production in mito

93 Our data revealed that post-treatment with diphenyleneiodonium significantly attenuated progressive

94 primary cultured aortic VSMCs, catalase and diphenyleneiodonium significantly suppressed AVP- and an

95 rombin pretreatment could also be blocked by diphenyleneiodonium, suggesting that the NAD(P)H oxidase

96 The ability of diphenyleneiodonium to block the effects of nitrate, but

97 tion of iNOS with the flavoprotein inhibitor diphenyleneiodonium totally blocked these O-2 signals.

98 A pathophysiological evaluation of diphenyleneiodonium-treated mice, including assessment o

99 n of Nox2 by coadministration of apocynin or diphenyleneiodonium was associated with reduced fibrogen

100 her nitrite or nitrate was the active anion, diphenyleneiodonium was used to inhibit oxidation/reduct

101 n is inhibited by the flavoprotein inhibitor diphenyleneiodonium, whereas inhibitors of electron tran

102 rfused rat lungs, rotenone, myxothiazol, and diphenyleneiodonium, which inhibit mitochondria in the p