ライフサイエンスコーパス: diphosphate

1 tro to the active antiviral metabolite, PMEG diphosphate.

2 d, ThDP is modified to thiamine 2-thiazolone diphosphate.

3 om isopentenyl diphosphate and dimethylallyl diphosphate.

4 configuration to generate linear polyprenyl diphosphate.

5 e for biosynthesis of the precursor farnesyl diphosphate.

6 ate and (E)-4-mercapto-3-methylbut-2-en-1-yl diphosphate.

7 is of phytyl-diphosphate from geranylgeranyl-diphosphate.

8 on interacts with HMBPP, specifically at the diphosphate.

9 scuss newly elucidated roles of guanosine 5'-diphosphate 3'-diphosphate (ppGpp) in transcription elon

10 light transmittance aggregometry (adenosine diphosphate 5 and 20 mumol/l and arachidonic acid), and

11 the stringent response alarmone guanosine 3'-diphosphate 5'-diphosphate (ppGpp) rise after a shift fr

12 by either enzyme, with the exception of 1,6-diphosphate 6.

13 ce the biologically inactive 6-thioguanosine diphosphate (6-TGDP)-Rac1 adduct, RhoGEF (Rho-specific G

14 allyl diphosphate (DMAPP) to form lavandulyl diphosphate, a precursor to the fragrance lavandulol.

15 ists (collagen-related peptide, adenosine 5'-diphosphate, A23187, thrombin, or U46619).

16 onsecutive condensation reactions of allylic diphosphate acceptor with isopentenyl diphosphate (IPP)

17 However, both reactions employ diphosphate-activated donors and each proceed via cation

18 Nucleotide (ATP, adenosine diphosphate, adenosine monophosphate) and nucleoside (ad

19 hosphate (ATP) and its precursors, adenosine diphosphate (ADP) and adenosine monophosphate (AMP), usi

20 Adenosine diphosphate (ADP) enhances platelet activation by virtua

21 e the adenosine triphosphate (ATP)/adenosine diphosphate (ADP) metabolite ratio which strongly correl

22 tion, as does either inhibiting adenosine 5'-diphosphate (ADP) P2Y12receptors or reducing integrin-de

23 or that operates downstream of the adenosine diphosphate (ADP) receptor, P2Y12, a target of antithrom

24 e (HPS) as a model to show that adenosine 5'-diphosphate (ADP) released by dense granules serves as a

25 h agonist doses or supplemental adenosine 5'-diphosphate (ADP) restored normal alpha granule secretio

26 r P2Y1 (P2Y1 R) is activated by adenosine 5'-diphosphate (ADP) to induce platelet activation and ther

27 P) and its first five catabolites: adenosine diphosphate (ADP), adenosine monophosphate (AMP), inosin

28 ding adenosine triphosphate (ATP), adenosine diphosphate (ADP), and adenosine monophosphate (AMP); an

29 s ATP and is strongly inhibited by adenosine diphosphate (ADP), we asked how Hsp104 functions at the

30 trate that ATP-bound Rok1, but not adenosine diphosphate (ADP)-bound Rok1, stabilizes Rrp5 binding to

31 icroscopy (cryo-EM) structures for adenosine diphosphate (ADP)-bound, full-length, hexameric wild-typ

32 romoted a greater inhibition of adenosine 5'-diphosphate (ADP)-induced Ca(2+) release in washed plate

33 Adenosine diphosphate (ADP)-induced platelet reactivity was assess

34 nd robust synthesis of polymers of adenosine diphosphate (ADP)-ribose (PAR) chains, primarily catalyz

35 V macro domain as a more efficient adenosine diphosphate (ADP)-ribose binding module than macro domai

36 Poly[adenosine diphosphate (ADP)-ribose] polymerases (PARPs) are a fami

37 Protein adenosine diphosphate (ADP)-ribosylation is a physiologically and

38 An adenosine diphosphate (ADP)-ribosyltransferase that causes actin c

39 tion of subthreshold amounts of adenosine 5'-diphosphate (ADP).

40 ciated with main power stroke) and adenosine diphosphate (ADP, release associated with minor mechanic

41 Niraparib is an oral poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) 1/2 inhibito

42 tors (adenosine triphosphate [ATP]/adenosine diphosphate [ADP]/adenosine monophosphate [AMP], nicotin

43 the galactan is constructed from uridine 5'-diphosphate-alpha-d-galactofuranose (UDP-Galf), which is

44 Median concentration of TFV-diphosphate also decreased significantly in cervical tis

45 tes, farnesyl diphosphate and geranylgeranyl diphosphate, also reduced endometrial cellular inflammat

46 Bis-O-diphosphate analogues 3-OPP/OPP, 4-OPP/OPP, and 5-OPP/OP

47 inhibitors (E)-4-amino-3-methylbut-2-en-1-yl diphosphate and (E)-4-mercapto-3-methylbut-2-en-1-yl dip

48 Nucleoside analogs such as gemcitabine diphosphate and clofarabine nucleotides target the large

49 r two universal building blocks, isopentenyl diphosphate and dimethylallyl diphosphate, was thought t

50 sis of farnesyl diphosphate from isopentenyl diphosphate and dimethylallyl diphosphate.

51 nctional diterpene synthases for ent-copalyl diphosphate and ent-kaurene biosynthesis is similar to o

52 uced aggregation in response to adenosine 5'-diphosphate and epinephrine, but variable aggregation de

53 d mevalonate pathway-intermediates, farnesyl diphosphate and geranylgeranyl diphosphate, also reduced

54 Both S-thiolo-dimethylallyl diphosphate and S-thiolo-isopentenyl diphosphate bind in

55 d SrKS1, SrCPS2 synthesized labda-13-en-8-ol diphosphate and successively catalyzed the formation of

56 urinergic receptors activated by adenosine 5-diphosphate and UDP-sugars, respectively-were upregulate

57 is critical for the synthesis of polyprenol diphosphates and cellular function.

58 rprisingly, can instead hydrolyze nucleoside diphosphates and triphosphates, which may play a role in

59 Soluble apyrase reduced renal ATP, adenosine diphosphate, and adenosine monophosphate, but not adenos

60 phosphatidylserine, phosphatidylinositol 4,5-diphosphate, and phosphatidylinositol 3,4,5-triphosphate

61 addition to anticoagulation and an adenosine diphosphate-antagonist an adjunct therapy with vasodilat

62 Compared with the use of 3,6-fluorescein diphosphate as a signal reporter in an ALP-linked immuno

63 ylgeranyl diphosphate (GGPP) and isopentenyl diphosphate as substrates.

64 th proton abstraction being achieved using a diphosphate-Asn-Ser relay.

65 ylallyl diphosphate and S-thiolo-isopentenyl diphosphate bind intact to S2, but are cleaved to (thio)

66 The phosphate and diphosphate binding of the generated channels was studie

67 ion, identifying dysregulated geranylgeranyl diphosphate biosynthesis as a potential disease mechanis

68 drugs targeting the inactive or guanosine 5'-diphosphate-bound conformation are not expected to be ef

69 te, monostarch monophosphate, and monostarch diphosphate, but significantly increased distarch monoph

70 santhemol in addition to trans-chrysanthemyl diphosphate, but the enzymes responsible for the convers

71 locus from the chloroplast genome, ribulose diphosphate carboxylase.

72 where glycans are completed on undecaprenyl diphosphate carriers at the cytosol:membrane interface,

73 ylcholine (PC) biosynthesis via the cytidine diphosphate (CDP)-choline pathway at the expense of beta

74 nt-CPP) synthase SdCPS1, and the clerodienyl diphosphate (CLPP) synthase SdCPS2.

75 We found that chloroquine diphosphate (CLQ), an antimalarial drug, inhibits Burkho

76 NA/dATP and HBV-RT/DNA-RNA/TFV-DP (tenofovir diphosphate) complexes with the native hybrid DNA-RNA su

77 ish sauce yields higher erythrocyte thiamine diphosphate concentrations (eTDP) among lactating women

78 Tenofovir diphosphate concentrations in dried blood spots were sta

79 ng-term adherence, as evidenced by tenofovir diphosphate concentrations in dried blood spots.

80 whereas no differences in intracellular TFV diphosphate concentrations were observed.

81 immune sensor RIG-I distinguishes 5' tri- or diphosphate containing viral double-stranded (ds) RNA fr

82 clases that produce the intermediate copalyl diphosphate (CPP), along with the more surprising findin

83 s the "irregular" monoterpenes chrysanthemyl diphosphate (CPP), lavandulyl diphosphate (LPP), and tra

84 ultimers and the closure time with adenosine diphosphate (CT-ADP), a point-of-care measure of hemosta

85 cking conserved motifs required for farnesyl diphosphate cyclase activity.

86 The final enzyme in this pathway, mevalonate diphosphate decarboxylase (MDD), acts on mevalonate diph

87 nal and structural studies on the mevalonate diphosphate decarboxylase from E. faecalis (MDDEF).

88 termediate alpha,beta-dihydroxyethylthiamine diphosphate (DHEThDP) within the enzymatic active site.

89 PS-c subfamily were characterized as copalyl diphosphate (diterpene) synthases, and those belonging t

90 he primary isoprene substrate, dimethylallyl diphosphate (DMADP), which can mask the effects of oscil

91 phosphate (IDP) and its isomer dimethylallyl diphosphate (DMADP).

92 opentenyl diphosphate (IPP) to dimethylallyl diphosphate (DMAPP) and then to geranyl diphosphate (GPP

93 pentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) to form geranyl diphosphate (GPP) an

94 ndensation of two molecules of dimethylallyl diphosphate (DMAPP) to form lavandulyl diphosphate, a pr

95 S pairs, tenofovir (TFV) hair levels and TFV diphosphate (DP) in DBS were strongly correlated (Spearm

96 e (7-deaza-G), and 7-methylguanosine (m(7)G) diphosphates efficiently accepted pRNA, resulting in the

97 f polyketide phenol nucleophiles and terpene diphosphate electrophiles.

98 inhibitor (adenosine 5'-alpha,beta-methylene-diphosphate) enhanced the microbicidal M1 subset predomi

99 iterpene synthases (diTPSs), the ent-copalyl diphosphate (ent-CPP) synthase SdCPS1, and the clerodien

100 The metal complex binds diphosphate esters over other anionic groups, such as mo

101 tential and adenosine triphosphate/adenosine diphosphate failed to reach a new steady state following

102 ering RNA showed that inhibition of farnesyl-diphosphate farnesyl transferase (squalene synthase), bu

103 GDP synthase (GGDPS) that condenses farnesyl diphosphate (FDP) and isopentenyl pyrophosphate.

104 from its natural substrate (2E,6E)-farnesyl diphosphate (FDP).

105 A 5'-diphosphate form of antiviral ribavirin weakly inhibited

106 sizes the "regular" sesquiterpenoid farnesyl diphosphate (FPP) by coupling isopentenyl diphosphate (I

107 PP) and between IPP and GPP to give farnesyl diphosphate (FPP).

108 orophyll, not on de novo synthesis of phytyl-diphosphate from geranylgeranyl-diphosphate.

109 se (FPS) catalyzes the synthesis of farnesyl diphosphate from isopentenyl diphosphate and dimethylall

110 resulted into identification of guanosine 5'-diphosphate (GDP) as a promising hepcidin-binding agent.

111 n K-Ras or the G12X mutants and guanosine 5'-diphosphate (GDP) or GDPnP (a stable GTP analogue) were

112 that in solution, farnesylated guanosine 5'-diphosphate (GDP)-bound K-Ras4B is predominantly autoinh

113 De novo synthesis of guanosine diphosphate (GDP)-fucose, a substrate for fucosylglycans

114 ROUND & AIMS: De novo synthesis of guanosine diphosphate (GDP)-fucose, a substrate for fucosylglycans

115 ear C25 isoprenoid precursor geranylfarnesyl diphosphate (GFPP) defines sesterterpene scaffolds.

116 eranylgeranylation reactions, geranylgeranyl diphosphate (GGDP), is the product of the enzyme GGDP sy

117 ly 55 carbons in length using geranylgeranyl diphosphate (GGPP) and isopentenyl diphosphate as substr

118 current study identifies C20 geranylgeranyl diphosphate (GGPP) as a precursor for lycopaoctaene bios

119 production of monoterpene and geranylgeranyl diphosphate (GGPP) diversities, and plant morphology by

120 in the plant cell derive from geranylgeranyl diphosphate (GGPP) synthesized by GGPP synthase (GGPPS)

121 ically active conformation of geranylgeranyl diphosphate (GGPP).

122 O-GlcNAcylation requires uridine diphosphate-GlcNAc, a precursor responsive to nutrient s

123 ted activity towards quercetin and adenosine diphosphate glucose (ADPG), kaempferol and UDPG, quercet

124 ukat/Kg protein toward phloretin and uridine diphosphate glucose (UDPG) at an optimal temperature of

125 catalysing the biosynthesis of undecaprenyl-diphosphate-glucose, the first step in the assembly of c

126 Uridine diphosphate glucunosyltransferases (UGTs) metabolize 15%

127 We used rs6742078 located in the uridine diphosphate-glucuronosyltransferase locus as an instrume

128 hylallyl diphosphate (DMAPP) to form geranyl diphosphate (GPP) and between IPP and GPP to give farnes

129 yzing the irreversible conversion of geranyl diphosphate (GPP) to geraniol.

130 MoeN5 catalyzes the reaction of geranyl diphosphate (GPP) with the cis-farnesyl group in phospho

131 llyl diphosphate (DMAPP) and then to geranyl diphosphate (GPP).

132 With the formation of labda-7,13E-dienyl diphosphate, GrTPS2 adds an additional function to the p

133 te N-acetylhexosamine (UDP-HexNAc)]/[uridine diphosphate hexose (UDP-hexose)] ratio exhibited dramati

134 an-Akt inhibitor MK2206 increased uridine-5'-diphosphate-hexose cell content which was suppressed by

135 bstrate, (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate (HMBPP) and to the inhibitors (E)-4-amino-3-

136 analog of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP) bound to BTN3A1 with intermediate af

137 occurring (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP) or a synthetic cell-permeable prodru

138 s, such as (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP), are ligands of the internal domain

139 Recently, the nucleoside diphosphate hydrolase NUDT15 has received attention on t

140 ived from the 5C building blocks isopentenyl diphosphate (IDP) and its isomer dimethylallyl diphospha

141 ; thiamin, thiamin monophosphate and thiamin diphosphate in bovine milk.

142 repeatedly high concentrations of tenofovir diphosphate in dried blood spots.

143 adherence, and measured levels of tenofovir diphosphate in dried blood spots; and (3) examine patter

144 e with the homoallylic substrate isopentenyl diphosphate in other prenyltransferases.

145 on of mevalonate 5-phosphate to mevalonate 5-diphosphate in the mevalonate pathway.

146 '-diphosphate trisodium salt and MRS2365 (5'-diphosphates) in some signaling events, such as extracel

147 bind intact to S2, but are cleaved to (thio)diphosphate, in S1.

148 Ras into inactive Ras is bound to guanosine diphosphate, inactivating Ras.

149 Dictyostelium discoideum converted farnesyl diphosphate into (2S,3R,6S,9S)-(-)-protoillud-7-ene and

150 diTPS PxaTPS8, which converts geranylgeranyl diphosphate into a previously unknown 5,7-fused bicyclic

151 e I and type II TSs initiate cyclization via diphosphate ionization and protonation, respectively, an

152 ein levels by 9-fold and reduced isopentenyl diphosphate (IPP) accumulation by 4-fold.

153 ain elongation reactions between isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP)

154 llylic diphosphate acceptor with isopentenyl diphosphate (IPP) in the cis (Z) configuration to genera

155 the carbon-carbon double bond in isopentenyl diphosphate (IPP) in the primary building reactions in t

156 yl diphosphate (FPP) by coupling isopentenyl diphosphate (IPP) to dimethylallyl diphosphate (DMAPP) a

157 The mevalonate pathway produces isopentenyl diphosphate (IPP), a building block for polyisoprenoid s

158 cycle predominant formation of (-)-kolavenyl diphosphate is observed.

159 Thiamine diphosphate is required as a cofactor in at least five l

160 the product of 11,1-cyclization of farnesyl diphosphate, is the product of the first committed step

161 lipids but does not transport a glycosylated diphosphate isoprenoid lipid.

162 the deregulation of mitochondrial nucleoside diphosphate kinase (NDPK) together with defects in mitoc

163 ver of the multifunctional enzyme nucleoside diphosphate kinase A (NDPK-A) that controls cell prolife

164 in the ndk or dcd genes, encoding nucleoside diphosphate kinase and dCTP deaminase, respectively, had

165 ylates the catalytic histidine on nucleoside diphosphate kinase B (NDPK-B).

166 ncreatic Zn(2+) (hZnT8WT) induced nucleoside diphosphate kinase B, and Zn(2+) reduction (hZnT8RW) ind

167 cells, an effect regulated by the nucleoside diphosphate kinase ndk-1.

168 58) in the cytoplasmic region, by nucleoside diphosphate kinase-B (NDPK-B).

169 Nucleoside diphosphate kinases (NDKs) play a central role in divers

170 Nucleoside diphosphate kinases (NDPKs) are enriched at the plasma m

171 Nucleoside-diphosphate-kinases (NDKs) are leaderless, multifunction

172 scular inorganic phosphate, H(+) , adenosine diphosphate, lactate and phosphocreatine depletion was 5

173 Tenofovir diphosphate levels consistent with a high degree of anti

174 asurements on intact lithium/silver vanadium diphosphate (Li/Ag2VP2O8) electrochemical cells demonstr

175 e useful for the preparation of undecaprenol diphosphate-linked glycans and glycopeptides with site-s

176 es that catalyze the formation of polyprenol diphosphate-linked glycans via phosphosugar transfer fro

177 lycans from membrane-associated undecaprenol diphosphate-linked substrates to proteins in the bacteri

178 chrysanthemyl diphosphate (CPP), lavandulyl diphosphate (LPP), and trace quantities of maconelliyl d

179 lation intermediate, C2-alpha-lactyl-thiamin diphosphate (LThDP), which has subsequent decarboxylatio

180 played reductions in PMM activity, guanosine diphosphate mannose, lipid-linked oligosaccharide precur

181 res performed on children: (99m)Tc-methylene diphosphate (MDP) bone scans, (99m)Tc-mercaptoacetyltrig

182 the condensation of geranyl- or isopentenyl-diphosphate moieties by geranyltranstransferases.

183 s confirmed residues involved in binding the diphosphate moiety of GGPP and identified DxxxxE as a po

184 e (LPP), and trace quantities of maconelliyl diphosphate (MPP) from two molecules of DMAPP, and coupl

185 hate decarboxylase (MDD), acts on mevalonate diphosphate (MVAPP) to produce IPP while consuming ATP.

186 cose and glutamine are precursors of uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), a substrat

187 ed, whereas the distribution of the [uridine diphosphate N-acetylhexosamine (UDP-HexNAc)]/[uridine di

188 ies indicated thatlymphostatin binds uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) but not UDP

189 synthetic pathway (HBP), to increase uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc).

190 We hypothesized that nicotinamide adenosine diphosphate oxidase 2 (Nox2) plays an important role in

191 Nicotinamide adenosine diphosphate oxidase 2 knockout was also associated with

192 f radial access and novel platelet adenosine diphosphate P2Y12 receptor inhibitors.

193 t of some compounds related with the geranyl-diphosphate pathway (neryl and geranyl acetates) and som

194 e possible targets: YubA, YubB (undecaprenyl diphosphate phosphatase (UPPP)), and YubD.

195 inner membrane, thereby uncoupling adenosine diphosphate phosphorylation from nutrient oxidation.

196 absence of l-alpha-phosphatidylinositol 4,5-diphosphate (PIP2).

197 to reduced isoprene substrate dimethylallyl diphosphate pool size.

198 cidated roles of guanosine 5'-diphosphate 3'-diphosphate (ppGpp) in transcription elongation that cou

199 esponse alarmone guanosine 3'-diphosphate 5'-diphosphate (ppGpp) rise after a shift from light to dar

200 of the disease, early treatment of adenosine diphosphate receptor antagonists at presentation, older

201 Guidelines recommend the use of adenosine diphosphate receptor inhibitor (ADPri) therapy for 1 yea

202 ting to guide choice and dosing of adenosine diphosphate receptor inhibitor (ADPri) therapy in routin

203 used data from the Treatment With Adenosine Diphosphate Receptor Inhibitors-Longitudinal Assessment

204 sing TRANSLATE-ACS (Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment

205 RANSLATE-ACS study (Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment

206 nts enrolled in the Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment

207 33 hospitals in the Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment

208 The Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment

209 Cangrelor is a potent intravenous adenosine diphosphate-receptor antagonist that in the CHAMPION tri

210 ability of rapidly-acting platelet adenosine diphosphate-receptor antagonists, the need for routine g

211 for catalysis and is proposed to facilitate diphosphate release in S1, while the P1 phosphate in S2

212 uginosa show a specificity for phosphate and diphosphate, respectively.

213 fluid and its intracellular metabolite (TFV diphosphate) revealed that TDF PrEP efficacy was best de

214 It metabolizes NAD(+) to adenosine diphosphate ribose (ADPR) and cyclic ADPR, regulating se

215 ng messengers, including cyclic adenosine 5'-diphosphate ribose (cADPR), and CD38 knockout studies ha

216 is, analogues based on the cyclic inosine 5'-diphosphate ribose (cIDPR) template were synthesised.

217 ding to the crystal structure of adenosine-5-diphosphate-ribose (ADP-ribose) in complex with non-phos

218 itrotyrosine (marker of RNS), poly(adenosine diphosphate-ribose) (PAR, marker of PARP activation) and

219 s (RNS) and the activation of poly(adenosine diphosphate-ribose) polymerase (PARP).

220 ective clinical trial of the poly-(adenosine diphosphate-ribose) polymerase inhibitor olaparib in mCR

221 pendent kinase inhibitors and poly(adenosine diphosphate-ribose) polymerase inhibitors.

222 nts it from inhibiting PARP1 [poly(adenosine diphosphate-ribose) polymerase], a critical DNA repair p

223 al substrate for sirtuins and poly(adenosine diphosphate-ribose) polymerases (PARPs), which are NAD(+

224 ymes such as the sirtuins and poly(adenosine diphosphate-ribose) polymerases.

225 race (FTT) depicts activated poly (adenosine diphosphate-ribose)polymerase (PARP) expression and is f

226 The poly(adenosine diphosphate-ribose)polymerase (PARP) family of enzymes i

227 he phosphorylated state with the adenosine-5-diphosphate-ribosylarginine (ADP-RA) complex (51.56%) th

228 with and regulates the activity of adenosine diphosphate ribosylation factor 6 (ARF6), a small G prot

229 Furthermore, we identified the adenosine diphosphate ribosylation factor-1 GTPase to be required

230 on to endocytosis and show that adenosine 5'-diphosphate-ribosylation factor 6 (Arf6) plays a key rol

231 omology, the phosphate-specific OprP and the diphosphate-specific OprO pores show structural differen

232 uble mutations interchange the phosphate and diphosphate specificities of OprP and OprO.

233 gly, LOS uses alternative C15 and C20 prenyl diphosphate substrates to produce combinatorial hybrid h

234 regulate RR specificity among its nucleoside diphosphate substrates.

235 Small isoprenoid diphosphates, such as (E)-4-hydroxy-3-methyl-but-2-enyl

236 via phosphosugar transfer from a nucleotide diphosphate-sugar to a polyprenol phosphate.

237 yclic 7,13 double bond in labda-7,13E-dienyl diphosphate suggest that GrTPS2 catalyzes the first comm

238 Chrysanthemyl diphosphate synthase (CDS), the first enzyme involved in

239 hosphate synthase (FPPase) and chrysanthemyl diphosphate synthase (CPPase) from Artemisia tridentata

240 RP) and c.124A>G, p.K42E in dehydrodolichol diphosphate synthase (DHDDS) (33%).

241 The amino acid sequences of farnesyl diphosphate synthase (FPPase) and chrysanthemyl diphosph

242 Farnesyl diphosphate synthase (FPS) catalyzes the synthesis of fa

243 , in transgenic tobacco by elevating geranyl diphosphate synthase (GPS) activity.

244 -to-middle" monoterpene synthase, lavandulyl diphosphate synthase (LPPS).

245 ur RNA sequencing analysis uncovered copalyl diphosphate synthase (SrCPS) and kaurene synthase1 (SrKS

246 fied nine divergent putative trans-isoprenyl diphosphate synthase (trans-IDS) transcripts.

247 everal compounds also inhibited undecaprenyl diphosphate synthase (UPPS) with IC50 values of 100-500

248 bacterial cis-prenyl synthase, undecaprenyl diphosphate synthase (UPPS), and contains an allylic sit

249 homo-dimeric bacterial enzyme, undecaprenyl diphosphate synthase (UPPS), has been structurally and m

250 nthase (SlDXS), Arabidopsis thaliana geranyl diphosphate synthase 1 (AtGPS) and Mentha x piperita ger

251 targeted overexpression of an avian farnesyl diphosphate synthase along with two versions of botryoco

252 Farnesyl diphosphate synthase catalyzes the sequential chain elon

253 te pathway were overexpressed, and a geranyl diphosphate synthase from the plant Abies grandis was ex

254 s to pitavastatin is potentiated by farnesyl diphosphate synthase inhibitors or geranylgeraniol trans

255 ensis CB00739 was verified as an ent-copalyl diphosphate synthase involved in the biosynthesis of pla

256 hase 1 (AtGPS) and Mentha x piperita geranyl diphosphate synthase small subunit (MpGPS.SSU) on produc

257 Both UPPP as well as undecaprenyl diphosphate synthase were inhibited by compound 1.

258 ent competitive inhibitors of avian farnesyl diphosphate synthase with KI = 1.0 +/- 0.12 muM, KI = 0.

259 ing of NgBR (Nus1) and hCIT (dehydrodolichol diphosphate synthase) subunits, and this composition has

260 ion revealed the target was the undecaprenyl diphosphate synthase, an enzyme that catalyzes the synth

261 e as inhibitors of the enzyme geranylgeranyl diphosphate synthase, and their activity can be highly s

262 e homodimeric bacterial enzyme, undecaprenyl diphosphate synthase, generates 11 isoprene units and ha

263 ddle" prenyltransferase, isosesquilavandulyl diphosphate synthase, involved in biosynthesis of the me

264 ntly, we discovered that unlike undecaprenyl diphosphate synthase, mammalian cis-PT is a heteromer co

265 y-3-methylglutaryl-CoA reductase or farnesyl diphosphate synthase, reduced endometrial organ and cell

266 DMAP can also competitively inhibit farnesyl diphosphate synthase.

267 e long-chain trans-polyisoprene via farnesyl diphosphate synthases (FPSs).

268 hosphate (MEP) pathway genes, geranylgeranyl diphosphate synthases 3 (GGPPS3) and GGPPS4.

269 the catalytic base group in the ent-copalyl diphosphate synthases found in all seed plants for gibbe

270 (e.g. cis-farnesyl, decaprenyl, undecaprenyl diphosphate synthases), the large, hydrophobic side chai

271 (TAF) on HIV infection and intracellular TFV-diphosphate (TFV-DP) concentrations in blood and genital

272 MVC, TFV, and TFV diphosphate (TFV-DP) concentrations in colorectal tissue

273 Tenofovir diphosphate (TFV-DP) concentrations in peripheral blood

274 Tenofovir-diphosphate (TFV-DP) in red blood cells was used to cate

275 lated inversely with intracellular tenofovir diphosphate (TFV-DP), which was detected in 53% of those

276 itabine, their active metabolites (tenofovir diphosphate [TFVdp] and emtricitabine triphosphate [FTCt

277 ow that when these herbicides bind, thiamine diphosphate (ThDP) is modified.

278 To synthesize the cofactor thiamin diphosphate (ThDP), plants must first hydrolyze thiamin

279 S is unique among the superfamily of thiamin diphosphate (ThDP)-dependent enzymes in stabilizing the

280 In response to adenosine 5'-diphosphate, the P2Y1 receptor (P2Y1R) facilitates plate

281 enofovir that efficiently delivers tenofovir diphosphate to lymphoid cells following oral administrat

282 f the ubiquitous terpenoid precursor geranyl diphosphate to the iridoid loganic acid.

283 A biosynthesis is the conversion of farnesyl diphosphate to trichodiene (TD), a volatile organic comp

284 at catalyzes the conversion of nucleoside 5'-diphosphates to deoxynucleotides (dNDPs).

285 ro, HpRppH converts RNA 5'-triphosphates and diphosphates to monophosphates.

286 the hydrocarbon moiety of allylic isoprenoid diphosphates to the carbon-carbon double bond in isopent

287 lular application of guanosine 5'-[beta-thio]diphosphate trilithium salt and guanosine 5'-[gamma-thio

288 onse curves of both 2-methylthioadenosine 5'-diphosphate trisodium salt and MRS2365 (5'-diphosphates)

289 reversible conversion of sucrose and uridine diphosphate (UDP) into fructose and UDP-glucose, is a ke

290 ily transformed in cells into the uridine 5'-diphosphate (UDP)-activated form, it was not incorporate

291 rase MurU catalyzes the synthesis of uridine diphosphate (UDP)-MurNAc, a crucial precursor of the bac

292 Unnatural uridine diphosphate (UDP)-sugar donors, UDP-4-deoxy-4-fluoro-N-a

293 P2Y2 (UTP/ATP) and P2Y6 [ADP/UTP/uridine 5'-diphosphate (UDP)] have been shown to have profibrotic e

294 e agonists ADP and 2-methylthio-adenosine-5'-diphosphate, was reduced.

295 s, isopentenyl diphosphate and dimethylallyl diphosphate, was thought to proceed exclusively by way o

296 (e.g., adenosine triphosphate and adenosine diphosphate) were readily degraded into a mono-organopho

297 t to conserved Ser, comes close to the HMBPP diphosphate, whereas double mutation of nonconserved res

298 a coli, and demonstrated to cyclize farnesyl diphosphate, yielding beta-selinene as the dominant prod

299 otein extracts, but only when (Z,E)-farnesyl diphosphate [(Z,E)-FPP] was offered as a substrate.

300 ing (E,E)-FPP, whereas PsIDS3 produced neryl diphosphate, (Z,Z)-FPP, and (Z,E)-FPP.