ライフサイエンスコーパス: diphtheria toxin

1 ination of Foxp3+ Treg by treatment with Dx (diphtheria toxin).

2 variety of recombinant protein fragments of diphtheria toxin.

3 xpressing cells can be depleted by injecting diphtheria toxin.

4 IL-2 protein and as toxophore the truncated diphtheria toxin.

5 tly but selectively depleted by injection of diphtheria toxin.

6 y intracerebroventricular (ICV) injection of diphtheria toxin.

7 cific ablation of podocytes by administering diphtheria toxin.

8 nine; DCs were depleted by administration of diphtheria toxin.

9 e called diphthamide, which is the target of diphtheria toxin.

10 electively deplete pDCs by administration of diphtheria toxin.

11 nsive islet infiltration upon treatment with diphtheria toxin.

12 inooxy linkers bound to BSA or a recombinant diphtheria toxin.

13 D11c(+) cells was controlled by injection of diphtheria toxin.

14 immunity, only if Tregs were depleted using diphtheria toxin.

15 ma cells before depleting myeloid cells with diphtheria toxin.

16 s in activation of anthrax, pseudomonas, and diphtheria toxins.

17 genic mice were treated with intraperitoneal diphtheria toxin (5 ng/g b.wt.) in the presence or absen

18 nstrate that the fusion of Rad51 promoter to diphtheria toxin A (DTA) gene kills a variety of cancer

19 rprisingly, donor LC engraftment in Langerin-diphtheria toxin A (DTA) transgenic hosts was independen

20 ased in insulin-resistant uncoupling protein-diphtheria toxin A (UCP-DTA) transgenic mice, a murine m

21 have been ablated by targeted expression of diphtheria toxin A chain (DTA) under the control of the

22 the lethal factor amino-terminal domain and diphtheria toxin A chain expedited translocation.

23 oter/gene were used to express an attenuated diphtheria toxin A chain in transgenic mice.

24 that directs cone-specific expression of the diphtheria toxin A chain was used to ablate cone photore

25 T domain aids the membrane translocation of diphtheria toxin A chain.

26 off system is used to regulate expression of diphtheria toxin A chain.

27 on, utilizing temporally controlled targeted diphtheria toxin A expression, results in failure of neu

28 Interestingly, neutropenic lysozyme 2-diphtheria toxin A mice exhibited striking EG and amplif

29 s) via Cre-dependent viral expression of the diphtheria toxin A subunit (DT-A) in hemiparkinsonian tr

30 ression of the potent translation inhibitor, diphtheria toxin A subunit, from the Arabidopsis (Arabid

31 loped genetically modified mice that express diphtheria toxin A under control of a loxP-flanked stop

32 deficient in LCs by virtue of expression of diphtheria toxin A under the control of a BAC (bacterial

33 in mice for 25 d via neuronal expression of diphtheria toxin A-chain, producing both a neuroinflamma

34 ectories of the conformational transition of diphtheria toxin, a particularly challenging example, sh

35 ataxin-3-orexin, and doxycycline-controlled-diphtheria-toxin-A-orexin.

36 engineered human Langerin-DTR mice in which diphtheria toxin ablates LCs without affecting Langerin(

37 be specifically depleted from the brain upon diphtheria toxin administration.

38 The membrane-inserting T domain of diphtheria toxin aids the low-pH-triggered translocation

39 le we show that the translocation pathway of diphtheria toxin allows much larger molecules to be tran

40 splantation carrying a conditional allele of diphtheria toxin alpha subunit and cell-specific express

41 utively ablated because of expression of the diphtheria toxin alpha subunit within developing DCs.

42 selective ablation of PPARgamma(+) cells by diphtheria toxin also causes high bone mass due to decre

43 switch to tightly regulate the expression of diphtheria toxin and Cre recombinase, respectively.

44 ch are required for the cytotoxic effects of diphtheria toxin and exotoxin A.

45 (T) domain plays a key role in the action of diphtheria toxin and is responsible for transferring the

46 We found that diphtheria toxin and its nontoxic mutant, called CRM197,

47 tox (Ontak), a recombinant fusion protein of diphtheria toxin and ligand, IL-2, binds to the IL-2 rec

48 en shown to repress the transcription of the diphtheria toxin and other genes associated with ferrous

49 hMAb binds to the receptor-binding domain of diphtheria toxin and physically blocks the toxin from bi

50 thamide, which serves as the only target for diphtheria toxin and Pseudomonas aeruginosa exotoxin A.

51 teins that include the key virulence factors diphtheria toxin and the adhesive pili.

52 anthracis, toxin B of Clostridium difficile, diphtheria toxin, and exotoxin A of Pseudomonas aerugino

53 ng method to attach the catalytic subunit of diphtheria toxin as a toxic warhead to CTA1, thus conver

54 e used a transgenic mouse system that allows diphtheria toxin-based depletion of pericytes.

55 The delivery of the diphtheria toxin catalytic domain (DTA) from acidified e

56 The translocation of the diphtheria toxin catalytic domain from the lumen of earl

57 detrimental effects of anthrax lethal toxin, diphtheria toxin, cholera toxin, Pseudomonas aeruginosa

58 CD4+/CD25+ Tregs using the recombinant IL-2 diphtheria toxin conjugate DAB(389)IL-2 (also known as d

59 as their bovine serum albumin or recombinant diphtheria toxin conjugates.

60 ugars (OAg) of LPS to the nontoxic mutant of diphtheria toxin (CRM(197)).

61 etane grafting of the genetically detoxified diphtheria toxin CRM197 improves significantly the immun

62 Injection of diphtheria toxin deleted YFP(+) cells from Foxl1-Cre;Ros

63 fically depleted CD4(+)Foxp3(+) T cells in a diphtheria toxin-dependent manner.

64 Selective ablation of mitotic neurons using diphtheria toxin (DT) and a retrovirus vector encoding D

65 r 2 (eEF2) is the target of ADP ribosylating diphtheria toxin (DT) and Pseudomonas exotoxin A (PE).

66 tively sensitive to exogenously administered diphtheria toxin (DT) by targeted expression of the diph

67 In adult wild-type mice, administration of diphtheria toxin (DT) caused no significant hair cell lo

68 Diphtheria toxin (DT) contains separate domains for rece

69 However, diphtheria toxin (DT) crosses the blood-brain barrier, w

70 We have employed a hormone-inducible diphtheria toxin (DT) expression system in Saccharomyces

71 wild-type Tf, we showed enhanced delivery of diphtheria toxin (DT) from these mutants to a monolayer

72 Diphtheria toxin (DT) injection causes transient DC depl

73 y timed local (subconjunctival) injection of diphtheria toxin (DT) into mice that express high-affini

74 mouse models in which the administration of diphtheria toxin (DT) leads to specific depletion of reg

75 We generated mice in which administration of diphtheria toxin (DT) led to specific ablation of PYY-ex

76 We inserted diphtheria toxin (DT) receptor (DTR) cDNA into the 3' UT

77 a gene knock-in strategy inserting the human diphtheria toxin (DT) receptor (DTR) into the endogenous

78 hages in atherosclerosis, we developed CD11b-diphtheria toxin (DT) receptor (DTR) transgenic mice, wh

79 Hair cells express the human diphtheria toxin (DT) receptor behind the Pou4f3 promote

80 to the splenic marginal zone of naive CD11b-diphtheria toxin (DT) receptor bone marrow-chimeric mice

81 arance using a transgenic mouse model (CD11c-diphtheria toxin (DT) receptor GFP) that allows for thei

82 -Tg(.Itgax-DTR/EGFP.57)Lan/J) expressing the diphtheria toxin (DT) receptor on the CD11c promoter (DC

83 we used the DEREG mouse, which expresses the diphtheria toxin (DT) receptor under control of the Treg

84 used transgenic mice that express the human diphtheria toxin (DT) receptor under the control of the

85 HSV-1 infection was investigated using CD11c-diphtheria toxin (DT) receptor-green fluorescent protein

86 ned CBA/CaJ male mice, engineered to express diphtheria toxin (DT) receptors in hair cells, by system

87 acrophages was achieved by administration of diphtheria toxin (DT) to CD11b-DTR mice.

88 Administration of diphtheria toxin (DT) to these mice resulted in nearly c

89 Tg) mice but not in CLEC4C-DTR-Tg mice after diphtheria toxin (DT) treatment.

90 ic tyrosinase promoter, under the control of diphtheria toxin (DT), we eliminated and/or halted diffe

91 be the development and characterization of a diphtheria toxin (DT)-based antigen delivery system.

92 ction when engaged by physiological ligands, diphtheria toxin (DT)-C3d fusion protein and C3dg-strept

93 glycemia after induction of a more complete, diphtheria toxin (DT)-induced beta-cell loss, a situatio

94 Unexpectedly, OT-I cell injection into diphtheria toxin (DT)-treated beta(2)m --> K14-OVA x Lan

95 cTECs sensitive to the cytotoxic effects of diphtheria toxin (DT).

96 morphogenesis and maturation is disrupted by diphtheria toxin (DT).

97 can be selectively ablated by the action of diphtheria toxin (DT).

98 ecifically ablated from adult mice using the diphtheria toxin (DT)/DT-receptor system and the connexi

99 ynthetic antigen was conjugated to a mutated diphtheria toxin (DT, CRM197) with different copy number

100 lectively deplete human stromal cells (using diphtheria toxin, DT) without affecting mouse cancer cel

101 eration, we used Cre-activated expression of diphtheria toxin (DTA) in the Ascl3-expressing (Ascl3+)

102 ed with CRE-dependent AAV vectors expressing diphtheria toxin (DTA) to selectively ablate FC SST neur

103 Previous diphtheria toxin (DTA)-mediated ablation studies showed

104 sruption of the notochord and floor plate by diphtheria toxin (DTA)-mediated cell ablation did not di

105 addition to Stx, the phage-encoded exotoxin, diphtheria toxin (Dtx) expressed by Corynebacterium diph

106 in conjunction with mice expressing GFP and diphtheria toxin (DTx) receptor (DTR) under control of t

107 We have used CD11c-diphtheria toxin (DTx) receptor mice to deplete CD11c(+)

108 Some mice were given injections of diphtheria toxin during the recovery phase to delete Fox

109 esponse and type 2 diabetes mellitus (T2DM), diphtheria toxin-expressing (DT) mice that specifically

110 odon in the Rosa26(DTA/+) allele and induces diphtheria toxin fragment A (DTA) expression.

111 specific CreER allele to drive expression of diphtheria toxin fragment A (DTA).

112 Denileukin diftitox (DD), a diphtheria toxin fragment IL-2 fusion protein, is though

113 ral crest lineage using a Wnt1-Cre-activated diphtheria toxin fragment-A cell-killing system was empl

114 In vivo administration of LPS or an IL-2/diphtheria toxin fusion protein (Ontak) to chronically S

115 a rapid tool to confirm the presence of the diphtheria toxin gene (tox) in an isolate or specimen.

116 inducible Caspase-8 protein and an inducible diphtheria toxin gene, results in new neurons.

117 transformation method by the introduction of diphtheria toxin genes into the transformation vector as

118 riggered membrane insertion, the T domain of diphtheria toxin helps translocate the catalytic domain

119 d potent human neutralizing antibody against diphtheria toxin holds promise as a potential therapeuti

120 family includes ADP-ribosyltransferases with diphtheria toxin homology (ARTD).

121 The 18 human ADP-ribose transferases with diphtheria toxin homology include ARTD1/PARP1, a cancer

122 depletion by a brief course of interleukin-2 diphtheria toxin (IL-2DT) transiently reduced AML diseas

123 Transient expression of diphtheria toxin in beta cells of old mice resulted in i

124 pressing either tetanus toxin light chain or diphtheria toxin in gal4-defined neural circuits, we wer

125 ique hMAbs were tested for neutralization of diphtheria toxin in in vitro cytotoxicity assays with a

126 gerin(+) DCs were depleted by treatment with diphtheria toxin in Lang-DTREGFP knock-in mice.

127 Five days after administering diphtheria toxin in these adult mice, changes were obser

128 In these albumin-deficient rats, exposure to diphtheria toxin induced an increase in albumin GSC and

129 use, a model of hyperglycemia resulting from diphtheria toxin induced beta cell ablation.

130 ischemia/reperfusion (I/R) injury or a novel diphtheria toxin-induced (DT-induced) model of selective

131 state was perturbed by coronary ligation or diphtheria toxin-induced macrophage depletion in CD11b(D

132 microglia exert beneficial effects during a diphtheria toxin-induced neuronal lesion, but impede rec

133 11b promoter such that the administration of diphtheria toxin induces ablation of nearly 97% of resid

134 model, PMN(DTR) mice, in which injection of diphtheria toxin induces selective neutrophil ablation.

135 Within 2 weeks of diphtheria toxin injection, heterozygous Pmch(DTR/+) mic

136 In Corynebacterium diphtheriae, diphtheria toxin is encoded by the tox gene of some temp

137 In particular, the folded A chain of diphtheria toxin is readily translocated by that toxin b

138 Diphthamide, the target of diphtheria toxin, is a post-translationally modified his

139 Diphthamide, the target of diphtheria toxin, is a unique posttranslational modifica

140 Diphthamide, the target of diphtheria toxin, is a unique posttranslational modifica

141 sing a Rosa26 conditional allele, expressing diphtheria toxin, led to crypt loss.

142 ied as a potent but unselective inhibitor of diphtheria toxin-like ADP-ribosyltransferase 3 (ARTD3).

143 The diphtheria toxin-like ADP-ribosyltransferases (ARTDs) ar

144 Diphtheria toxin-mediated ablation of lysozyme M-positiv

145 o acutely and selectively eliminate them via diphtheria toxin-mediated ablation.

146 answer this question, we used Cre-dependent, diphtheria toxin-mediated cell ablation to selectively r

147 diabetes mellitus of the NOD mouse by using diphtheria toxin-mediated cell ablation.

148 Using a progressive, time-controllable, diphtheria toxin-mediated cell ablation/dysfunction tech

149 Using diphtheria toxin-mediated depletion models in mice, we s

150 Importantly, diphtheria toxin-mediated depletion of IL-7-producing st

151 In this study, an established model of diphtheria toxin-mediated depletion of resident pulmonar

152 Diphtheria toxin-mediated selective depletion of MCs or

153 Diphtheria toxin-mediated, acute ablation of hypothalami

154 nd that limited podocyte renewal occurs in a diphtheria toxin model of acute podocyte ablation.

155 and covalently linked to recombinant CRM197 diphtheria toxin mutant (CRM197) to produce CPS-CRM197.

156 hesized and attached via a chain linker to a diphtheria toxin mutant carrier protein.

157 Regions of both colicin Ia and diphtheria toxin N-terminal to the channel-forming domai

158 calizes to tumors in vivo and rVAR2 fused to diphtheria toxin or conjugated to hemiasterlin compounds

159 lls was assessed by selective depletion with diphtheria toxin or depleting anti-CD20 monoclonal antib

160 vidity of immunoglobulin (Ig) G specific for diphtheria toxin, pertussis toxin, filamentous hemagglut

161 Screens for sensitivity to a cholera-diphtheria toxin provide broad insights into the mechani

162 a fusion protein of interleukin 2 (IL-2) and diphtheria toxin, provides a means of targeting Treg cel

163 onate (sLC), inducible depletion using CD11b diphtheria toxin receptor (CD11b DTR) transgenic mice, a

164 pletion of this population in CD11B promoter-diphtheria toxin receptor (CD11B-DTR) transgenic mice ca

165 onstituted with bone marrow cells from CD11c-diphtheria toxin receptor (CD11c-DTR) and CCR5(-/-) or C

166 mouse strains that either express the human diphtheria toxin receptor (DTR) coupled to the CD11b pro

167 Cs from LNs based on their expression of the diphtheria toxin receptor (DTR) directed by the gene enc

168 Many such models rely on transgenic diphtheria toxin receptor (DTR) expression driven by DC-

169 e adult mouse utricle by inserting the human diphtheria toxin receptor (DTR) gene into the Pou4f3 gen

170 Lgr5-expressing cells in mice using a human diphtheria toxin receptor (DTR) gene knocked into the Lg

171 tance, using B6.Foxp3(DTR) mice that express diphtheria toxin receptor (DTR) in Foxp3(+) cells.

172 via transgenic expression of a high-affinity diphtheria toxin receptor (DTR) is a new and powerful ap

173 In these mice, the diphtheria toxin receptor (DTR) is expressed under contr

174 Conditional expression of diphtheria toxin receptor (DTR) is widely used for tissu

175 Murine Langerin-diphtheria toxin receptor (DTR) mice allow for the induc

176 We attempted to create a model that used diphtheria toxin receptor (DTR) to ablate specific cell

177 in vivo, we targeted expression of the human diphtheria toxin receptor (DTR) to the gene for MCH (Pmc

178 1c-enhanced green fluorescent protein (EGFP)-diphtheria toxin receptor (DTR) transgene was associated

179 used several murine models, including BDCA-2-diphtheria toxin receptor (DTR) transgenic and IFN-alpha

180 s were eliminated in newly generated SiglecH-diphtheria toxin receptor (DTR)-transgenic (Tg) mice but

181 Expression of the human diphtheria toxin receptor (hDTR) gene under the regulato

182 e induced limited podocyte depletion using a diphtheria toxin receptor (hDTR) transgenic rat.

183 nerated transgenic mice expressing the human diphtheria toxin receptor (hDTR, encoded by HBEGF) from

184 el transgenic mouse model in which the human diphtheria toxin receptor (huDTR) is selectively express

185 m1cre mice were bred to homozygous inducible diphtheria toxin receptor (iDTR) mice to generate mice e

186 using the human diphtheria receptor system (diphtheria toxin receptor [DTR]) expressed in Lysmd1-cre

187 cendants (Foxl1-Cre;Rosa(YFP/iDTR)-inducible diphtheria toxin receptor [iDTR] mice).

188 By using B6/Langerin-diphtheria toxin receptor chimeric mice and LC ablation,

189 We generated mice that express the diphtheria toxin receptor exclusively in podocytes, allo

190 Using CX3CR1(CreER) to drive diphtheria toxin receptor expression in microglia, we fo

191 To test this hypothesis, we used a diphtheria toxin receptor expression system to selective

192 nondiabetic mice conditionally expressing a diphtheria toxin receptor in mural cells.

193 ria toxin (DT) by targeted expression of the diphtheria toxin receptor in oligodendrocytes.

194 , a transgenic rat strain in which the human diphtheria toxin receptor is specifically expressed in p

195 Using Langerin-diphtheria toxin receptor mice and established mouse mod

196 organs (liver, spleen, and kidneys) in CD11c-diphtheria toxin receptor mice but not in wild-type mice

197 ished hepatic metastases in transgenic CD11b-diphtheria toxin receptor mice by intrasplenic injection

198 n, in either Mac1-deficient mice or in CD11b-diphtheria toxin receptor mice in which CD11b-positive c

199 etion of Treg during MCMV infection in Foxp3-diphtheria toxin receptor mice or in wild-type mice reca

200 epithelial debridement wound model and CD11c-diphtheria toxin receptor mice that express a CD11c prom

201 g monocytes only in CCR2 promoter-controlled diphtheria toxin receptor mice, whereas neutrophil numbe

202 otein (EGFP) knock-in mice and Langerin-EGFP-diphtheria toxin receptor mice--three dimensional rotati

203 CD11b/Gr1(mid) subset in a transgenic CD11b-diphtheria toxin receptor mouse model markedly reduced t

204 ectly test this hypothesis, we expressed the diphtheria toxin receptor specifically on either B lymph

205 e have generated a transgenic strain, Clec9A-diphtheria toxin receptor that allows us to ablate in vi

206 Therefore, the diphtheria toxin receptor transgene was specifically exp

207 apidly killing peptide-pulsed DCs carrying a diphtheria toxin receptor transgene with timed injection

208 depletion of dendritic cells (DCs) in CD11c-diphtheria toxin receptor transgenic mice followed by in

209 and reconstitution in CD11b promoter-driven diphtheria toxin receptor transgenic mice revealed that

210 phtheria toxin treatment of sensitized CD11c-diphtheria toxin receptor transgenic mice to deplete CD1

211 We generated diphtheria toxin receptor transgenic mice to selectively

212 We used CD11b-diphtheria toxin receptor transgenic mice to transiently

213 nduced acute lung injury, wild-type or CD11c-diphtheria toxin receptor transgenic mice were treated w

214 To test the involvement of DCs, CD11c-diphtheria toxin receptor transgenic mice were used to d

215 We also used a CD11c-diphtheria toxin receptor transgenic mouse model system

216 olerance was assessed by combining the CD11c-diphtheria toxin receptor transgenic system, in which DC

217 We used mice expressing Diphtheria toxin receptor under control of the Foxp3 pro

218 l macrophage ablation mice express the human diphtheria toxin receptor under the control of the CD11b

219 t C57BL/6-DEREG mice expressing a transgenic diphtheria toxin receptor under the Foxp3 promoter, tran

220 se line, using the Cre/loxP system, in which diphtheria toxin receptor was selectively expressed in m

221 Foxp3-GFP-DTR (human diphtheria toxin receptor) C57BL/6 mice allow eliminatio

222 tein, cluster of differentiation 11c (CD11c)/diphtheria toxin receptor, and IL-17 receptor A(-/-) mic

223 11c promoter driving expression of the human diphtheria toxin receptor, we found that selective deple

224 Exploiting a transgene encoding the human diphtheria toxin receptor, we punctually and specificall

225 or mice that express a CD11c promoter-driven diphtheria toxin receptor, we showed that DCs migrate al

226 We developed a diphtheria toxin receptor-based strategy to selectively

227 induced responses in CD11c promoter-directed diphtheria toxin receptor-expressing mice that were depl

228 r macrophages and in CD11b promoter-directed diphtheria toxin receptor-expressing mice that were depl

229 We used immunophenotyping techniques and diphtheria toxin receptor-expressing, chemokine receptor

230 the number of macrophages in mice following diphtheria toxin receptor-mediated cell ablation of panc

231 rgy induction to CD4 memory T cells, because diphtheria toxin receptor-transgenic mice that were cond

232 ith type II AEC-restricted expression of the diphtheria toxin receptor.

233 mice expressing the CCR2 promoter-controlled diphtheria toxin receptor.

234 y podocyte-specific transgenic expression of diphtheria toxin receptor.

235 ress both green fluorescence protein and the diphtheria toxin receptor.

236 ogenic insult using a conditional, inducible diphtheria-toxin receptor expression strategy in mice.

237 Diphtheria-toxin receptor expression was induced among g

238 nction, we eliminated DCS cells by using the diphtheria-toxin receptor gene knocked into the murine R

239 To confirm this, we used a CD11b-diphtheria toxin-receptor (DTR) transgenic mouse model.

240 ke reaction, we generated K14-OVA x Langerin-diphtheria-toxin-receptor (Langerin-DTR) Tg mice to allo

241 d a combinatorial viral technique to express diphtheria toxin receptors in specific neuron population

242 Using the diphtheria toxin-related fusion protein toxin DAB(389)IL

243 Upon activation of diphtheria toxin repressor (DtxR) by transition metals,

244 om Bacillus anthracis and is a member of the diphtheria toxin repressor (DtxR) family of proteins.

245 The diphtheria toxin repressor (DtxR) is a metal ion-activat

246 The diphtheria toxin repressor (DtxR) is an Fe(II)-activated

247 The metal-ion-activated diphtheria toxin repressor (DtxR) is responsible for the

248 a membrane-anchored metal ion permease and a diphtheria toxin repressor (DtxR)-like transcriptional r

249 The diphtheria toxin repressor contains an SH3-like domain t

250 rms substituted in domain IV confer dominant diphtheria toxin resistance, which correlates with an in

251 We found that a single injection of diphtheria toxin resulted in an initial peak of proteinu

252 Exposure of PdxCre;R26DTR mice to diphtheria toxin resulted in extensive ablation of acina

253 an langerin were used to drive expression of diphtheria toxin, resulting in absence of LC, suggest th

254 Diphtheria toxin robustly depleted circulating monocytes

255 ed to specific recognition of the A chain by diphtheria toxin's translocation pathway because the tra

256 velopment, including rituximab, epratuzumab, diphtheria toxin-single chain Fv (DC2219), belimumab, at

257 r nanoparticulate delivery of DNA encoding a diphtheria toxin suicide protein (DT-A).

258 Furthermore, using the diphtheria toxin system to selectively eliminate APCs th

259 Diphtheria toxin T domain aids the membrane translocatio

260 The diphtheria toxin T domain helps translocate the A chain

261 The diphtheria toxin T domain translocates the catalytic C d

262 effect on the pH-triggered insertion of the diphtheria toxin T-domain.

263 enzymatically inactive and nontoxic form of diphtheria toxin that contains a single amino acid subst

264 plasm (BPDCN) using an engineered version of diphtheria toxin that is targeted to malignant cells via

265 Its name refers to the target function for diphtheria toxin, the disease-causing agent that, throug

266 Thus, in contrast to diphtheria toxin, the formation of a membrane-competent

267 ring with a bacterial ADP-ribosyltransferase diphtheria toxin, the observed rate constant of sirtuin-

268 oyed at source by the targeted expression of diphtheria toxin, the remaining cells take over and the

269 izures were frequent, mice were treated with diphtheria toxin to ablate peri-insult generated newborn

270 on of CD11c(high) cells by administration of diphtheria toxin to CD11c.DOG mice.

271 We used diphtheria toxin to deplete DCs to study their functiona

272 ol of intracerebroventricular application of diphtheria toxin to efficiently ablate hypothalamic cell

273 d (TT) or the cross-reactive mutant (CRM) of diphtheria toxin to form detoxified LOS (dLOS)-TT, dLOS-

274 We used diphtheria toxin to kill all mouse postmitotic sensory n

275 We induced autonomous expression of diphtheria toxin to kill articular surface chondrocytes

276 In vivo targeting of diphtheria toxin to kill Tregs leads to a lower fraction

277 ontributes to lung fibrosis, we administered diphtheria toxin to transgenic mice with type II AEC-res

278 c mice that express an attenuated version of diphtheria toxin (Tox176) linked to a modified Pax6 prom

279 switching in several systems, including the diphtheria toxin translocation (T) domain, which is resp

280 cdB and the well-characterized alpha-helical diphtheria toxin translocation domain provide insights i

281 we constructed a gene encoding a portion of diphtheria toxin transmembrane helix 1, T1, which carrie

282 A single systemic diphtheria toxin treatment 2 d before HSV-1 corneal infe

283 In this study, we used diphtheria toxin treatment of sensitized CD11c-diphtheri

284 In chimeric CD11c-DTR mice, diphtheria toxin treatment results in enhanced neutrophi

285 either B lymphocytes or macrophages and used diphtheria toxin treatment to deplete these specific cel

286 e, using doxycycline-inducible expression of diphtheria toxin, triggers a significant compensatory pr

287 d to those conjugated to tetanus (TT) or the diphtheria toxin variant, CRM.

288 embrane insertion pathway of the T-domain of diphtheria toxin was studied using site-selective fluore

289 x (DD), a fusion protein comprising IL-2 and diphtheria toxin, was initially expected to enhance anti

290 ecifically ablated through administration of diphtheria toxin, we demonstrate that natural Tregs are

291 selectively ablated by minute injections of diphtheria toxin, we depleted renal inflammatory macroph

292 sing Tregs that can be depleted in vivo with diphtheria toxin, we show that injected cells are requir

293 protected cells from anthrax edema toxin and diphtheria toxin, which also require an acidic environme

294 ansport and also provided protection against diphtheria toxin, which enters the cytosol from early en

295 ndritic cells (dDCs) after administration of diphtheria toxin, which results in reduced CHS.

296 al switching is essential for functioning of diphtheria toxin, which undergoes a membrane insertion/t

297 X-expressing neurons after administration of diphtheria toxin while leaving the neural precursor pool

298 which DC can be depleted via treatment with diphtheria toxin, with a TCR-transgenic adoptive transfe

299 ono-ADP-ribosyltransferase proteins, such as diphtheria toxin, with the exception of a unique loop th

300 receptor transgene with timed injections of diphtheria toxin without altering the course of an accom