ライフサイエンスコーパス: direct

1 However, poor scaling often renders direct ab initio calculations intractable for large or c

2 residual EOC after cyto-reduction by gaining direct access into the peritoneal cavity, enabling eleva

3 This allows direct access to pathological and control human brain ti

4 We show here that direct actin binding, via the inner centromere protein (

5 alent in the renal transplant population but direct acting antiviral agents (DAA) provide an effectiv

6 ed the cost-effectiveness of two alternative direct-acting antiviral (DAA) treatment policies in a re

7 nse after treatment with regimens containing direct-acting antiviral agents (DAAs) have limited retre

8 operating in parallel with a system for more direct action-value learning.

9 s (13 females) whether the visuomotor object-directed action representation system that includes left

10 entral hippocampal trkB is essential to goal-directed action selection, countering habit-based behavi

11 porter Npt2a in alphaKL-null mice supporting direct actions of cKL in the absence of mKL.

12 fter the biotic disturbance, rather than the direct activity of any specific pathogen.

13 beige adipogenesis in obesity that required direct adhesive interactions between macrophages and adi

14 Emerging treatment concepts use drugs directed against KIT and other relevant targets in neopl

15 ice after treatment with a blocking antibody directed against PD-1.

16 whether benralizumab, a monoclonal antibody directed against the alpha subunit of the interleukin-5

17 Bevacizumab, a monoclonal antibody directed against VEGF, improves outcomes when added to p

18 f CO2 with distributed, humidity-swing-based direct air capture (HS-DAC).

19 hway and key transcriptional regulators that direct AM-specific gene expression have been established

20 chain reaction (PCR) assays that facilitate direct analysis of a single infecting genome in a steril

21 early thymocyte development often precludes direct analysis of potential roles during later developm

22 By direct analysis of water purification membranes using am

23 subjects were positive by using the combined direct and enriched toxigenic culture method (reference

24 e conserved RNA helicase Aquarius/EMB-4 as a direct and essential link between small RNA pathways and

25 equation modelling to test the importance of direct and indirect (via floral resources) climate effec

26 enetic instability and DNA repair defects by direct and indirect assays in 12 breast cancer cell line

27 onfirmation of the event and to mitigate the direct and indirect damages to public health and resourc

28 We used a mathematical model to predict the direct and indirect effectiveness of PCV by analyzing se

29 We found that frost had species-specific direct and indirect effects.

30 en these regions are complicated by multiple direct and indirect hippocampal-prefrontal connections.

31 We aimed at evaluating overall outcomes, direct and putative indirect effects of CMV, possible im

32 ding to GAGs in the extracellular matrix can direct and regulate vaspin interaction with target prote

33 ctors (Teffs; CD4(+)CD25(-)FOXP3(-)) and the direct antiproliferative effects of AzaC on allogeneic T

34 r after inclusion (with interferon then with direct antiviral agents) and underwent an ultrasound exa

35 Palladium-catalyzed direct arylation of 4-(2-bromophenyl)-2-methylthiazole p

36 As compared to direct assays of plasma or leukocytes, the EV detection

37 this Perspective, we present new approaches directed at the design of efficient entry inhibitors to

38 However, the mechanisms that direct atrial versus ventricular specification remain la

39 In addition, the 10-lipid mixture had direct bactericidal effects against Staphylococcus aureu

40 single-layer tungsten disulfides (WS2) is a direct band gap semiconductor with a gap of 2.1 eV featu

41 Direct band-gap semiconductors play the central role in

42 ces action-outcome memory, resulting in goal-directed behavior in mice that would otherwise express s

43 sis has suggested that core deficits in goal-directed behavior in obsessive-compulsive disorder (OCD)

44 also to FA nutrient signals to modulate food-directed behavior.

45 ndent RNA structural alterations can promote direct binding of m6A-modified RNAs to low-complexity re

46 TCP1 subunit 6A (CCT6A) as an inhibitor and direct binding protein of SMAD2 and found that CCT6A sup

47 of three different Mg(2+) binding modes: 1) direct binding via N7 coordination, 2) direct binding vi

48 s: 1) direct binding via N7 coordination, 2) direct binding via O6 coordination, and 3) binding via h

49 1d bound to nonantigenic lipids, followed by direct biochemical analysis of the lipid antigens trappe

50 iated with the euphotic zone rather than its direct biosynthesis by primary producers.

51 rapid, 'inside-out' electrical signaling to direct blood flow to active brain regions.

52 Ps) and proteins in aqueous solutions can be directed by modifying the salt concentration.

53 ctive for accelerating C(sp(3))-H activation directed by weakly coordinating auxiliaries, which provi

54 oach to catechols, employing an oxyacetamide-directed C-H hydroxylation on phenols.

55 d micromolar level H2O2 during just 1 min of direct CAP treatment on these cells.

56 With CPG-directed care, intra-abdominal abscess rate decreased fr

57 In black-grass, while no direct causative link was established linking viral infe

58 nd hepatic diseases for which obesity is the direct cause (eg, nonalcoholic fatty liver disease) or i

59 seen but without the identification of their direct causes (5,6) .

60 shift thoughts between high-level internally directed cognitive states, when thinking about the self,

61 the Scc2/4 cohesin loading complex, thereby directing cohesin loading to centromeres.

62 A direct comparison of bulk and surface spectral functions

63 ch CECs may be effectively preserved through direct conjugation, a previously overlooked risk.

64 ontact resistance which mainly resulted from direct contact between the lower MoS2 layers and electro

65 47.6% (229 of 481) had high level exposure (direct contact with a corpse, body fluids, or a case wit

66 uman syncytiotrophoblasts, cells that lie in direct contact with maternal blood, and show that these

67 a shared responsibility, but available male-directed contraceptive methods are either not easily rev

68 as to subcortical nuclei that are under the direct control of corticofugal projections.

69 le option and has functional advantages over direct control.

70 Sprague Dawley rats (3-4 months) revealed a direct correlation between serum E2 levels and pLTF expr

71 namic structural probes enabled us to derive direct correspondence between the atomic-level structura

72 due contact prediction are based entirely on Direct Coupling Analysis (DCA) of correlated mutations i

73 enhancers transcribed in breast cancer cells direct critical gene regulatory networks that promote pa

74 These Hall effects direct current around the FIs, concentrating magnetic fl

75 simultaneous M-cell spikes generated through direct current injection were not sufficient to generate

76 isted motor imagery (MI-BCI) or transcranial direct current stimulation (tDCS) has been used in strok

77 KEY POINTS: Applications of transcranial direct current stimulation to modulate human neuroplasti

78 es and that they mediate graft rejection via direct cytotoxicity and priming of alloreactive T cells.

79 al tight junction strands, this is the first direct demonstration of the ability of ZO-1 to stabilize

80 low, the technique can be broadly applied to direct detection of any fluorescent target, including nu

81 applications of molecular technology is the direct detection of specific resistance mechanisms that

82 tes with a high number density, which allows direct detection of the Criegee intermediate via various

83 development of aptamer-based biosensors and direct detection strategies.

84 y field-of-view are offered by counting mode direct detection, showing promise for efficient spectrum

85 Our main results are (1) direct determination of N; (2) demonstration that deltaN

86 a of the adsorbent, which was used for their direct determination.

87 olecular architecture similar to that of the direct developing hemichordate Saccoglossus kowalevskii.

88 in vitro environment and growth factors can direct differentiation of human pluripotent stem cells i

89 provide or deliver cues to retain stemness, direct differentiation, promote reprogramming, manipulat

90 rotein (BMP) family reiteratively signals to direct disparate cellular fates throughout embryogenesis

91 This 3' UTR heterogeneity directs distinct temporal patterns of translational acti

92 ignaling pathways, and the effects of betaAR-directed drugs.

93 racteristic fingerprint is also confirmed by direct dynamics simulations for ethyl as residue and att

94 Muscle-restricted Cas9 expression enables direct editing of the mutation, multi-exon deletion or c

95 complex binds RNA in vitro, consistent with direct EF-RNA interaction.

96 d to poverty before age 7 years had a larger direct effect (difference in cognitive function z score)

97 T cells and monocytes for sex, we detected a direct effect of these intrinsic factors for the majorit

98 However, vaccine efficacy and direct effectiveness estimates have varied, with differe

99 lt to quantify, hindering the attribution of direct effects of exposure on severe health outcomes.

100 Yet little is known regarding the direct effects of IL-4 on keratinocyte function.

101 We examined the neuronally directed effects of the retinoid X receptor agonist bexa

102 t the electrode acted effectively due to the direct electron exchange between heme of ADH and modifie

103 Here we report direct electron-microscopic observations of deposition g

104 ar vibrations that can promote, suppress and direct electronic processes.

105 We investigated direct emissions of primary organic aerosol (POA) and ph

106 contribute to their abundance either through direct emissions or surface reactions.

107 rocess for wastewater treatment that enables direct energy recovery from nitrogen (N) in three steps:

108 controlled for fragment loss, which enabled direct estimation of the fraction of accessible DHSs wit

109 an oncogene in different human cancers, but direct evidence for its role in tumorigenesis has been l

110 wy bodies and other alpha-synucleinopathies, direct evidence for the precise synaptic localization ha

111 icted to be present in the human genome, but direct evidence for their biological function is scarce.

112 In this study, we present direct evidence for water dissociation equilibrium on ru

113 Altogether, our study provides direct evidence that endogenous Rspo2 and Rspo3 chromoso

114 Chinese residential coal combustion provides direct evidence that intensive coal combustion could con

115 in libraries, and should enable the in vitro directed evolution of proteins with designer single-mole

116 e engineering of a cytochrome P450 enzyme by directed evolution to catalyze metal-oxo-mediated anti-M

117 sually carried out by rational design and/or directed evolution.

118 in the MOB where 5-HT2A receptors mediate a direct excitatory action.

119 tes and their internal dynamics have escaped direct experimental observation.

120 To date, however, there has been no direct experimental probe of these dark excitons.

121 rystallographically characterized, hindering direct experimental validation of the offline hypothesis

122 cortex, we were able to selectively inhibit directed exploration while leaving random exploration in

123 s while other mammals contain PFOS from both direct exposure and precursor degradation.

124 In parallel, direct exposure to the HIV-related proteins Tat or gp120

125 ed in a predictable variation of the address-directed flux of a redox analyte, ferrocenedimethanol (F

126 y of this new concept is demonstrated in the direct functionalization of enaminone precursors, such a

127 design and application of a reagent for the direct functionalization of pyridines.

128 xperiences and enables bacteria to use it to direct future behaviors.

129 ree of freedom that corresponds with the two direct-gap valleys of the band structure, which can be o

130 the directness of factors in initiating PIWI-directed gene silencing, we employed a Piwi-interacting

131 in hepatocytes and thus the outcome of liver-directed gene therapy using AAV vectors and showed in a

132 on and exhibit increased levels of sigma(F) -directed gene transcription.

133 e pathway, creating an alternative route for directing glucose into the pentose phosphate pathway tha

134 We report the Pd(II)-catalyzed, bidentate directing group (BDG)-assisted arylation and successive

135 loying an internally oxidizing O-N bond as a directing group.

136 chelation-assisted removable vicinal diamine directing groups was developed.

137 aterally to form lateral heterojunctions via direct growth.

138 ctively a "reaction in the beaker", avoiding direct handling of highly toxic fluorine gas.

139 hade works by physically shielding skin from direct harmful UV rays; however, skin may still remain e

140 we report an electrochemical method for the direct, highly sensitive detection of dsDNA based on the

141 the bidirectional histone3-histone4 promoter direct HLB formation in Drosophila In addition, the CLAM

142 are specific to eutherian mammals because no direct homologs exist at the syntenic genomic locus in m

143 Results also suggest that direct human modification of streams through actions suc

144 a propofol derivative, meta-azipropofol, for direct identification of binding sites in mouse TRPA1.

145 We report here the direct identification of the blaOXA48 gene, which codes

146 iton propagation length are demonstrated via direct imaging of polaritonic standing waves by means of

147 ces, it can be greater than that achieved by direct immunization.

148 linical implications of positive or negative direct immunofluorescence biopsies (DIF) in patients wit

149 However, the direct impact of antibiotic resistance in the severity a

150 gh a TBK1-binding domain (TBD), there was no direct impact of the TBD on viral replication or virulen

151 multifactorial hypothesis that has potential direct implications on the epidemiology and management o

152 of plasma jet treatments (both indirect and direct) in dividing human cells.

153 epresent a possible neuronal mechanism for a direct influence of the respiratory cycle on memory func

154 n of GABAA receptors was responsible for the direct inhibition of light-evoked spike responses, the s

155 cobacterial compounds; however, evidence for direct inhibition of MmpL3 activity is also lacking.

156 gulating the rho pathway rather than through direct inhibition of myosin.

157 s with 22 picometre precision can be used as direct input for DFT calculations of material properties

158 Although both types of neurons receive direct input from entorhinal cortex onto their distal de

159 smic swarm (April 1, 1984) due to a SE-to-NW directed input from the high-attenuation domain, possibl

160 In this study, we identified a novel direct interaction between APP and the alpha2A-adrenergi

161 The combined results indicate that the direct interaction between L1 and Reelin as well as the

162 This direct interaction between RNA polymerase and ribosomes

163 Here, we study the direct interaction of Ca(2+) with phosphatidylinositol 4

164 This direct interaction with actin suggests a new role of SPA

165 ation (CUE) domain in SMARCAD1 mediate their direct interaction.

166 Coupling is thought to involve direct interactions between RNA polymerase (RNAP) and th

167 ase activity of a UvrD dimer is promoted via direct interactions between UvrD subunits that affect th

168 ipitation experiments established DGCR8 as a direct interactor of Tcf7l1 mRNA, a core component of th

169 cupies the SV2-binding site on HCA1, causing direct interference of HCA1 interaction with both the N-

170 We hypothesized that direct intraoperative valve sizing results in smaller ao

171 fects of depolarizations act in synergy with direct ischaemic effects of haemorrhage as mechanisms of

172 or CDK4 activation, we proposed that proline-directed kinases might specifically initiate the activat

173 tems may be feasible alternative to standard direct laryngoscopy approach.

174 intubation, video laryngoscopy compared with direct laryngoscopy did not improve first-pass orotrache

175 minimal use of intermediary steps as well as direct, late stage C-7 hydroxylation provides both natur

176 ganglia circuits are thought to mediate goal-directed learning by a process of outcome evaluation to

177 acrine TNF-alpha-TNFR1 signaling rather than direct ligand sensing, suggesting a form of quorum sensi

178 I interferon (IFN-I) in lupus, suggesting a direct link between reduced CD11b activity and the chron

179 ring that drives bacterial cell division by directing local cell wall synthesis.

180 An enantioselective direct Mannich-type reaction catalyzed by a sterically f

181 Here, we report the direct measurement of the energy spectra of electrons em

182 Direct measurements of circadian enzyme activities in mo

183 Here, we present direct measurements of phase transitions in single bilay

184 Using direct measurements of spatially resolved surface stress

185 Using direct measurements of sympathetic nerve activity and ph

186 However, direct measures of spontaneous neuronal activity and fun

187 , we report the synthesis of four surfactant-directed mesoporous silica nanoparticle structures, incl

188 humic-rich lake waters, were analyzed by the direct method presented here and in comparison with the

189 ased, knowledge-based, and experimental data-directed modeling for RNA structures and explore the new

190 wever, the functional necessity of minus-end-directed movement along actin is unclear as the underlyi

191 ant of MYO6, MYO6+, which undergoes plus-end-directed movement while retaining physiological cargo in

192 Therefore, we suggest that the directed movements are a response to the physical arrang

193 e polymers in the substrate and refer to the directed movements as polymertropism.

194 data and a catalytic model supported by site-directed mutagenesis allows full comparison with dicot C

195 relocated by pressure was validated by site-directed mutagenesis and by inhibition by small peptides

196 acids, which can be altered readily by site-directed mutagenesis and expressed in vitro and in vivo,

197 Site-directed mutagenesis and gene rescue studies show that A

198 By site-directed mutagenesis and structure-guided analyses, we d

199 cysteines within the mature peptide and site-directed mutagenesis experiments demonstrated that the f

200 spectroscopy, heme quantification, and site-directed mutagenesis of histidine residues, we demonstra

201 Furthermore, we show by site-directed mutagenesis that tyrosine (Y382-384) within the

202 Site-directed mutagenesis was performed by partial gene synth

203 its implications for heme transfer via site-directed mutagenesis, resonance Raman (RR), hydrogen-deu

204 ected patients (n = 168), together with site-directed mutagenesis, revealed Nef position 9 as a subty

205 ysis of transposase proteins containing site-directed mutations revealed the importance of the conser

206 rmation published in peer-review journals on direct N2O emissions from agricultural systems in tropic

207 lcifying herbivores, which can overwhelm any direct negative effects.

208 to functionalize aryl methyl ethers through direct nucleophilic substitution of aryl C-OMe bond has

209 Direct O2 utilization suffers from intrinsic challenges

210 from 37% to 48% during the study period, and direct OAC use increased from 5% to 30%.

211 Furthermore, concurrent validity of the direct observation checklist is demonstrated by statisti

212 tion are detailed; the results demonstrate a direct observation of enzymatic activity in solution by

213 strate this extreme localization of BISER by direct observation of nano-scale coherent x-ray sources

214 Direct observation of nanoparticles in the early stages

215 se, the activation reaction was too fast for direct observation of the intermediates, but they could

216 For clinical quality, we used data from direct observations of care to calculate providers' adhe

217 vibrational normal modes resulted in either Direct or Delayed reaction, depending on the vibrational

218 or the redox transformation via catalytic or direct oxidation pathways.

219 nique, this method is a visually controlled, direct patch-clamp technique similar to conventional pat

220 composition, abnormalities of which form the direct, pathophysiologic substrate for SCD.

221 In particular, direct pathway (dopamine D1 receptor-containing; D1R-) s

222 nduces a tonic inhibition of transmission at direct pathway synapses and D1-mediated activation of mo

223 athway would lead to sustained activation of direct-pathway T cells, arguably persisting for the life

224 In addition, we observed direct physical interactions between Blm and two telomer

225 ional regulator of cell fate and establish a direct, previously unappreciated link between alternativ

226 s efficient multifunctional reagents for the direct primary amination and hydroxylation of structural

227 show that both habit-like attention and goal-directed processes occur in the same learning episode at

228 Our recent study showed that CRBN, a direct protein target for the teratogenic and antitumor

229 However, direct quantification via western blots indicates that t

230 mRNA, and destabilizes target mRNAs through direct recruitment of the CCR4-NOT deadenylase complex.

231 A copper-mediated picolinamide directed regioselective cross-coupling of naphthylamines

232 Our findings identify PABPC1 as a direct regulator of cardiac hypertrophy and define a new

233 mutations in specific sets of genes, but the direct relationship of such mutations to leukemogenesis,

234 A direct relationship was found between depth, risk and se

235 Direct releases of CO2 from litter layer only accounted

236 indromic repeats/CRISPR-associated) homology-directed repair gene-editing.

237 tescibacteria LexA-binding motif has unusual direct-repeat structure, and comparative analyses reveal

238 NA packaging (pac) site containing two 21-bp direct repeats and a major terminase cleavage site in th

239 y, only environmentally driven, but not self-directed, repetitive behaviors were exacerbated in lesio

240 123 (21.9%) R1 (</=1 mm) and 326 (58.1%) R1 (direct) resections.

241 monstrated that neutrophil recruitment was a direct response to increased epithelial HIF-2alpha signa

242 ve ratings of surprised faces, and with more direct response trajectories toward negative ratings (i.

243 Despite increasing interest in goal-directed, restricted-volume fluid administration for maj

244 n factors are infrequent, casting doubt on a direct role for E2Fs in driving cancer.

245 These data uncover a direct role for RANK in lung cancer and may explain why

246 lamines, and hence, are not likely to have a direct role in adipocyte metabolism or adaptive thermoge

247 Many ALS/FTD linked genes play a direct role in autophagy/lysosomal degradation, one of t

248 presence of adenine, projection of the SHAPE-directed sampling correctly identified the on-conformati

249 rrelations, we performed genetic analyses by direct sequencing and multiplex ligation-dependent probe

250 equences to coarse-grained beads enables the direct simulation of trajectories for the co-translation

251 The results showcase the ability to direct solution conformation of polymers through monomer

252 perties of ligand binding: we observe both a direct stabilizing effect of ligand-protein interactions

253 llustrate how distinct signalling mechanisms direct stress-dependent versus homeostatic regeneration,

254 These results define direct structural roles for yeast CAF-1 subunits and unc

255 ptical counterparts, our findings imply that direct subarcsecond localizations may be the only way to

256 eral orders of magnitude from shady woods to direct sunlight.

257 An unprecedented solvent-directed "switch" both in helical pattern and handedness

258 The direct synthesis of aryl(2,4,6-trimethoxyphenyl)iodonium

259 In this work, a one-pot solution method for direct synthesis of interconnected ultrafine amorphous N

260 Unfortunately, the B lymphocyte-directed T1D interventions tested to date failed to halt

261 We identified Hhex as a direct target of RUNX1 and FLT3-ITD stimulation and conf

262 er reasons why germ plasm might be neither a direct target of selection nor causally linked to accele

263 ide GABP-binding site analyses identify GABP direct targets encoding proteins involved in cellular re

264 ch pathway, Notch1, Notch2, and Jagged 1, as direct targets of miR-34a.

265 To determine direct targets, we performed a chromatin immunoprecipita

266 rotection was found to be a novel pathway of direct TGF-beta-dependent Treg-cell suppression of mast

267 arch impact is an essential exercise to help direct the allocation of limited research resources, to

268 es, the T or B cell receptor repertoire, and direct the design of a personalized therapeutic.

269 how that SecA is necessary and sufficient to direct the targeting and translocation of RodZ to the ba

270 l type, indicating the genes are involved in directing the cell differentiation to that particular ce

271 dicates that lncRNAs play important roles in directing the development of diverse immune cells and co

272 Cytokines play a critical role in directing the discrete and gradual transcriptional chang

273 rowing understanding of the role of DAMPs in directing the immune response to transplantation has sug

274 attains the poststroke conformation without directing the lever arm forward; and second, the lever a

275 The latter also crucially directs the molecular packing in the solid.

276 ctories, we discover that the potential that directs the rotating lever arm toward the poststroke con

277 tent inhibitors could lead to promising host-directed therapeutic adjuvants for tuberculosis treatmen

278 n macrophages and indicates a potential host-directed therapeutic target to limit the damaging inflam

279 tically enhanced anti-tumour effects of EGFR-directed therapies including erlotinib.

280 10b may serve as a potential target for host-directed therapy aimed at manipulating host immunity aga

281 ith mortality differences between early goal-directed therapy and control included Acute Physiology a

282 athways are potential novel targets for host directed therapy in CNS TB.

283 get gene expression through an intrinsic and direct threshold-based readout of their mobility gradien

284 CI is directed to PDs through its interaction with P3N-PIPO.

285 les in the gray-matter, limited research was directed to the functional organization of the white-mat

286 on outgrowth and that time of axon outgrowth directs topographic mapping without affecting hox5 expre

287 We show that hox5 expression directs topographic mapping without affecting time of ax

288 ollows CEA intrinsic organization, or a more direct topography involving bed nucleus vs central nucle

289 Wound healing is a biological process directed towards restoration of tissue that has suffered

290 were positive for toxigenic C. difficile by direct toxigenic culture, and 141 of 682 subjects were p

291 e, a hallmark of cell polarization to ensure directed trafficking of promigratory factors.

292 we discovered that DLX1 and DLX2 function as direct transcriptional activators of Brn3b expression.

293 treatment via a multistep process including direct tumor cell lysis, induction of cytotoxic or apopt

294 r transport rate constants along with having direct tumoricidal effects.

295 ific assays, enhancing its applicability for direct use in CITES enforcement for distinguishing it fr

296 Direct visualization at 1873 K of 0% to 8% molten FeAl d

297 iological conditions, this new method allows direct visualization of heterogeneous ion transport of b

298 Direct visualization of the entire anastomosis was impro

299 of Tajima's D and Fay and Wu's H depend in a direct way on a peculiar measure of tree balance, which

300 Here we develop an animal model utilizing direct ZIKV inoculation into the uterine wall of pregnan