ライフサイエンスコーパス: direct action

1 ce of gabazine or tetrodotoxin, indicating a direct action.

2 ure levels are a key determinant of proposed direct actions.

3 rds themselves, rather than stored memories, directed action.

4 s for observation and execution of an object directed action.

5 ion and reprogramming of a naturalistic goal-directed action.

6 tion of the medial prefrontal cortex in goal-directed action.

7 te responses of neurons proximal to the goal-directed action.

8 cessing in the hippocampus may modulate goal-directed action.

9 standing the spatiotemporal dynamics of goal-directed action.

10 alizing touch in space is essential for goal-directed action.

11 his is true for perception, but not for goal-directed action.

12 action-outcome contingencies to control goal-directed action.

13 utcome (R-O) associations that underlie goal-directed action.

14 ent, but also joint attention and joint goal-directed action.

15 on is elaborated in terms of meaningful goal-directed actions.

16 cessing of number magnitudes and environment-directed actions.

17 ordinate reliable execution of flexible goal-directed actions.

18 coming more and DLS less engaged during goal-directed actions.

19 similar activity was observed for non-object directed actions.

20 ey roles in our normal and pathological goal-directed actions.

21 response is significantly greater for object directed actions.

22 g object directed and meaningless non-object directed actions.

23 microcircuits that ultimately influence goal-directed actions.

24 ific impairment in the ability to alter goal-directed actions.

25 erving spatial awareness and oculomotor goal-directed actions.

26 is likely due to their common role in object-directed actions.

27 mance of recently acquired instrumental goal-directed actions.

28 omponents of the MNS in understanding object-directed actions.

29 d the passive observation of particular goal-directed actions.

30 hat it may also have consequences for object-directed actions.

31 , leading to a conscious integration of goal-directed actions.

32 and the NAc core in the performance of goal-directed actions.

33 ns involved in the cognitive control of goal-directed actions.

34 vestigate the planning and execution of goal-directed actions.

35 nally driven inputs for the planning of goal-directed actions.

36 rons and stimulus-guided choice between goal-directed actions.

37 compute object locations for perception and directing actions.

38 ence unless the events are initiated by goal-directed actions [1].

39 suggests that the ACC selects extended goal-directed actions according to their learned costs and be

40 As expected, observing goal-directed actions activated a parietofrontal network know

41 A goal-directed action aiming at an incentive outcome, if repea

42 on and aortic osteogenic differentiation via direct actions and potentially via circulating OPN.

43 in relation to its role in controlling goal-directed action and reward-guided behaviors, yet very li

44 c activity disrupts the neural bases of goal-directed action and thus renders behavior habitual.

45 e and infer tool functions from others' goal-directed actions and demonstrations.

46 asks typically consist of a series of target-directed actions and often require choices about which t

47 has an established role in representing goal-directed actions and their outcomes, it is not known whe

48 was associated with observation of the goal-directed action, and a smaller part with the perception

49 abuse modulate learning of habitual and goal-directed actions, and can also modify long-term plastici

50 Goal-directed actions are sensitive to work-related response

51 t object directed and meaningless non-object directed actions are subserved by different neuronal net

52 Goal-directed actions are supported by orbitofronto-striatal

53 Epinephrine, which induces hyperalgesia by direct action at beta(2)-adrenergic receptors on primary

54 tnatal cortical neurons does not rely on its direct action at the cytosol/mitochondria but is exclusi

55 Zn(2+) and death of CA1 neurons, although a direct action at the time of the rise in Zn(2+) is unpro

56 upport the hypothesis that some GAs, through direct actions at TRP channels, increase postsurgical pa

57 alues and the subsequent choice between goal-directed actions based on those values.

58 der crowded conditions, whereas its plus end-directed action, being less space-hungry, is not.

59 ll survival and angiogenesis were not due to direct action but were instead a result of paracrine fac

60 n alter the excitability of GnRH neurons via direct action, but the intracellular signaling cascades

61 ovements, implying a functional role in goal-directed actions, but not necessarily more covert forms

62 assembly factors from importin beta, and 2) direct action by transportin binding and inhibiting asse

63 he representation or execution of externally directed actions contain only PV.

64 uption in the balance between flexible, goal-directed action control and habitual behavior.

65 ce in circuitry underlying habitual and goal-directed action control, which may represent a fundament

66 ty of OFC-DS terminals is necessary for goal-directed action control.

67 ion-making that allows for habitual and goal-directed action control.

68 ring engagement in non-self-referential goal-directed actions (default mode of brain function).

69 Goal-directed actions depend on our capacity to integrate the

70 was present in FGF23-null mice, indicating a direct action distinct from Klotho's known role as a cor

71 nflammation and display specific, epithelial-directed actions focused on mucosal homeostasis.

72 ciations, as well as the performance of goal-directed actions guided by previously acquired associati

73 ignment of reward or inventive value to goal-directed actions has been found to involve the basolater

74 s been implicated in the acquisition of goal-directed actions; however, no direct evidence of learnin

75 ted reduction of lipid synthesis by E2 via a direct action in islets, and PERalpha-/- mice were predi

76 part by neutralizing this effect, either by direct action in the growth cone or indirectly by transc

77 imulate glucose-dependent insulin release by direct action in the pancreas and to promote secretion o

78 To determine whether Cn exerts direct actions in osteoblasts, we generated mice lacking

79 ontrol processes are critical to select goal-directed actions in flexible environments.

80 ntribution of these sources of value to goal-directed actions in people with schizophrenia (SZ) (n =

81 to be necessary for the acquisition of goal-directed actions in rodents.

82 the performance of, and choice between, goal-directed actions in tests of outcome-specific Pavlovian-

83 re required to select among remembered, goal-directed actions in the same places; (ii) the same neuro

84 MaR1(n-3 DPA), each exerted potent leukocyte directed actions in vivo.

85 tion, and it tests whether knowledge of goal-directed actions, including an assumption that actors ma

86 blish that, in mice, the acquisition of goal-directed actions induced plasticity in both D1- and D2-S

87 D patients have difficulties performing goal-directed actions, instead exhibiting repetitive stimulus

88 s well established, but the mechanism of any direct action is mysterious because stathmin binds to mi

89 whether the involvement of the mPFC in goal-directed action is limited to the acquisition or to the

90 ability to shift between repetitive and goal-directed actions is a hallmark of cognitive control.

91 Choice between goal-directed actions is determined by the relative value of

92 ow that our capacity to infer rational, goal-directed action likely arose at least as far back as the

93 In addition to their DNA synthesis-directed actions many nucleoside analogs trigger apoptos

94 of proadipogenic factors in adipocytes, with direct action noted at the CAAT enhancer-binding protein

95 underlie the behavioral impairments in goal-directed action observed in schizophrenia.

96 articipants viewed (i) short films of object-directed actions (ODAs) which were either semantically m

97 lar change in relative gene expression is by direct action of a CSF can be confounded by endogenous m

98 behavior and provide functional evidence for direct action of a peripheral metabolic signal on VTA do

99 ected mice from tumors in vivo, suggesting a direct action of Ab on the tumor cells.

100 etion of PIP2 itself from the membrane, or a direct action of activated Galpha(q) on TASK channels.

101 contrast, inhibition of TRPM8 is caused by a direct action of activated Galphaq independent of the ph

102 We provide evidence for the direct action of Ago2 in mitochondrial translation by cr

103 Whether this involves a direct action of arachidonic acid on the channel protein

104 and Galpha(q)-coupled receptors requires the direct action of both Gbetagamma and Galpha(q) on PLCbet

105 mewhat controversial, favoring an immediate, direct action of calcium on ciliary beating and a second

106 retinohypothalamic projection, suggesting a direct action of cannabinoids on the retinohypothalamic

107 An in vitro assay confirms the direct action of caspase-8 cleavage on IRF-3.

108 NF-AT detected herein may form the basis of direct action of CsA on IL-22 expression by T cells, whi

109 lling is monitored and modulated through the direct action of DNA-repair factors.

110 Consistent with a direct action of doxorubicin, enhancement of nucleosome

111 ulture method of the mammary gland where the direct action of estrogens can be tested during embryoni

112 be a result of surface restructuring by the direct action of fluoride at the crystal surface.

113 These data provide support for the direct action of GABA on mechanisms of acetylcholine rel

114 This phenotype can be attributed to a direct action of galectin-8 on primary cultures of osteo

115 of a reduction in AMPAR expression or of the direct action of gamma-8.

116 hTRPC3-mediated calcium entry, suggesting a direct action of Gd3+ on hTRPC3 channels.

117 ong chain fatty acid levels but also through direct action of glucose on PPARalpha.

118 receptors represent a therapeutic target for direct action of GnRH analogues on certain proliferating

119 ial cell movement into the lung requires the direct action of hedgehog signaling.

120 HSPCs promote repair after stroke maybe via direct action of HSPC-derived MT-I and could therefore b

121 sites is thought to depend critically on the direct action of IFN-gamma on macrophages, this premise

122 LC migration is thought to require the direct action of IL-1beta and IL-18 on LC.

123 Direct action of IL-1beta is likely not the cause of the

124 ominantly by activated CD4 T cells, and that direct action of IL-21 on CD8 T cells was critical for t

125 A direct action of IL-23 on primary melanocytes, shown to

126 In contrast with studies suggesting that the direct action of inflammatory cytokines on muscle is suf

127 bolite within the MEP pathway rather than by direct action of IspE.

128 histochemistry to investigate the potential direct action of leptin on hypothalamic CART neurons and

129 take and body weight homeostasis require the direct action of leptin on hypothalamic proopiomelanocor

130 ulation of non-BM-derived cells, not through direct action of leptin on Th1 immunity.

131 opreventive effect of fish oil is due to the direct action of n-3 PUFA and not to a reduction in the

132 While the direct action of NIC on central neurons appears to be es

133 This direct action of norepinephrine in the POAH was tested i

134 ACV infection, we found that this reflects a direct action of OX40 expressed by CD8 T cells.

135 TRPM2 channel activation can occur through a direct action of oxidants on TRPM2 channels or indirectl

136 ls, but it is not known if this was due to a direct action of P-CREB on the CART gene promoter.

137 Furthermore, they provide evidence for the direct action of PEDF on photoreceptor and ganglion cell

138 The direct action of PFC on posterior regions can be directl

139 It is unclear whether this loss is due to direct action of phenylephrine on the ciliary muscle or

140 anges in channel activation rather than by a direct action of phosphorylation on the capsaicin bindin

141 t time that LT synthesis is inhibited by the direct action of protein kinase A (PKA) on 5-LO.

142 These data could be explained by a direct action of Rab3A on the fusion pore, or by Rab3A-d

143 n', has traditionally been attributed to the direct action of radially oriented diaphragmatic muscle

144 s in the otic vesicle are established by the direct action of Shh.

145 rgeting of transport machinery, suggesting a direct action of soluble alpha-synuclein on trafficking

146 Degradation appears to be the result of direct action of the APC, as the N-terminal domain is ub

147 es to the presence of Xf, rather than to the direct action of the bacterium.

148 tion of the annexin A2 (A2) gene through the direct action of the hypoxia-inducible factor-1 complex.

149 activities of IL-4 can be attributed to the direct action of this cytokine on myeloid effector cells

150 ic and pharmacological studies identifying a direct action of TSH on the skeleton.

151 nse to Chikungunya virus is dependent on the direct action of type I IFN on infected nonhematopoietic

152 We further demonstrated that direct action of type I IFN on NK cells, but not on dend

153 , our findings demonstrate the importance of direct action of type I IFNs on NK cells to mount effect

154 ral infection is critically dependent on the direct action of type I interferons (IFN-Is) on CD8 T ce

155 The mechanisms include the direct action of uric acid on smooth muscle and vascular

156 To determine whether direct actions of AT(1) receptors in epithelial cells of

157 These findings suggest that direct actions of AT1A receptors in VSMCs are essential

158 , indicating that they did not arise through direct actions of cADPR or Ca(2+) on the IP(3)R, but lik

159 porter Npt2a in alphaKL-null mice supporting direct actions of cKL in the absence of mKL.

160 in dopamine systems are well recognized, the direct actions of cocaine on serotonin systems also appe

161 GF acutely acts to increase L(p) through the direct actions of DAG, independently of PKC or arachidon

162 ciated heart injury may be attributed to the direct actions of fructose on cardiomyocytes.

163 lism in states of GH resistance results from direct actions of GH on lipid uptake and de novo lipogen

164 We propose that these direct actions of glucose on the arousal- and metabolism

165 Direct actions of increased bile acids on bile acid rece

166 ns and signaling pathways is a result of the direct actions of intact lycopene or its derivatives.

167 The results indicate direct actions of K(ATP) channel modulators within hair

168 illustrate the physiological significance of direct actions of leptin in a given peripheral tissue.

169 eatic beta-cells suggests the possibility of direct actions of leptin on insulin secretion.

170 rtas of hyperlipidemic mice, suggesting that direct actions of LXR ligands on vascular gene expressio

171 Our data reveal the direct actions of NRG1 signaling in ErbB4-expressing int

172 The direct actions of SCG10 on microtubules themselves and o

173 Some brain sexual dimorphisms, however, are direct actions of sex chromosome genes that are not medi

174 We trace this paradox to two direct actions of SHH: promoting quiescent-SC proliferat

175 lpha conjugate (mAb-IFN-alpha) could kill by direct actions of the monoclonal antibody (mAb) and IFN-

176 Here we investigated the direct actions of the proresolution mediator resolvin E1

177 an alteration in phenotype may occur by the direct actions of this trophic factor.

178 that IH after vascular injury is due to the direct actions of thrombin on mobilized VPs.

179 These enhancements were not due to the direct actions of TLR ligands on LCs, but mainly depende

180 It has proven difficult to show direct actions of UVA as a carcinogen in human cells.

181 ddressed this question by dissecting the RNA-directed actions of 8-Cl-Ado in MM cells.

182 nts or communicative gestures, as non-object directed actions of the upper limb are not well characte

183 manner and that Cdk5 suppresses ERKs through direct action on a novel site in MAP kinase/ERK kinase (

184 The effect of pioglitazone appears to be a direct action on beta cells, as islets from mice treated

185 k human IAPP-mediated beta-cell loss both by direct action on beta-cells and by decreasing insulin de

186 We investigated if CRF could also have a direct action on brain microvessel endothelial cells (BM

187 However, information about its direct action on cancer cells is limited.

188 rt disease and may act, at least in part, by direct action on cardiac fibroblasts and myocytes to alt

189 g Th2 responses during allergen challenge by direct action on CD4 T cells; however, these studies did

190 ffects of long-acting GLP1R agonists are via direct action on CNS GLP1R or the result of downstream a

191 this effect was due, at least in part, to a direct action on cyclin T1 in the absence of Tat.

192 n of reward circuitry is more complex than a direct action on DA neurotransmission.

193 TRPV4-mediated mechanism of sensitization by direct action on dissociated primary afferent neurons.

194 he PepT1 transport function probably through direct action on enterocytes.

195 gical improvements were most likely due to a direct action on EP4 receptors expressed on collecting d

196 mate fails to trigger GABA release through a direct action on GABAergic terminals under physiological

197 al activation may be accomplished by GLP-1's direct action on hypophysiotropic CRH neurons.

198 sses the NF-kappaB signaling pathway through direct action on IkappaB kinase (IKK).

199 Thus, leptin has a direct action on liver fibrogenesis by stimulating TIMP-

200 spinal cord, such effects may be mediated by direct action on microglial cells.

201 the steady-state catastrophe frequency by a direct action on microtubules, and furthermore, they ind

202 This could be due to a direct action on nerve fibers or via vascular mechanisms

203 These results reveal that STZ has a direct action on neurons and modulates the expression an

204 gh-density lipoprotein (HDL) cholesterol has direct action on numerous cell types that influence card

205 ediones result, at least in part, from their direct action on podocytes, similar to glucocorticoids.

206 duction, kisspeptin and GnIH, exert a strong direct action on POMC neurons.

207 transient, ruling out the possibility of its direct action on presynaptic Ca(2+) current.

208 d the evoked release of GABA, both through a direct action on presynaptic H(3) receptors (presumably

209 est that stathmin can promote catastrophe by direct action on protofilament structure and interaction

210 d that the inhibitor kills parasites through direct action on PSAC.

211 al GCs can mediate the stress effect through direct action on RFRP cells.

212 s to whether this suppression results from a direct action on sensory neurons and what are the cellul

213 Therefore, along with direct action on specific brain substrates, central effe

214 thymocyte progenitors, possibly through its direct action on TARPP.

215 RFX1 blocks TGFbeta2 expression through its direct action on TGFbeta2 transcription.

216 Consistent with a direct action on the clock mechanism, we show that CK2be

217 solated arteries showed that this occurs via direct action on the endothelium.

218 secretion was unaffected, arguing against a direct action on the exocytotic machinery.

219 increases inhibitory neurotransmission via a direct action on the GABA(A) receptor, the peak amplitud

220 ctions have always been assumed to be due to direct action on the heart since the larval heart was no

221 filling grade of Ca(2+) stores, suggesting a direct action on the IP(3)R.

222 as potent anti-diabetic drugs through their direct action on the nuclear receptor peroxisome prolife

223 ivert the cytolytic machinery, impairing its direct action on the plasma membrane.

224 o play an important role in anesthesia via a direct action on the receptor and an indirect action to

225 al axons and their postsynaptic targets by a direct action on the vesicle fusion machinery.

226 amo-pituitary-adrenal (HPA) axis function by direct action on these neurons, we examined the effects

227 s elusive whether RPL11 inactivates MDM2 via direct action on this zinc finger domain and what is the

228 ifferentiation of fungus-specific T cells by direct action on those cells, cooperation with non-T cel

229 In addition, plinabulin exerts a direct action on tumor cells, resulting in apoptosis.

230 to inhibit gastric transit was the result of direct action on vagovagal reflex circuitry in the dorsa

231 rus entry was demonstrated to be by both the direct action on virus particles and the interference on

232 e to energy homeostasis by regulating CBT by direct actions on AdipoR1 and R2 in the POA.

233 that the calcineurin effect was mediated by direct actions on astrocytes.

234 clast differentiation and bone remodeling by direct actions on bone, rescuing OPG production and rest

235 tral nervous system may arise, in part, from direct actions on catecholaminergic neurons in the peri-

236 BDZs) enhance GABA(A) receptor inhibition by direct actions on central BDZ receptors (CBRs).

237 Whether CRP has direct actions on endothelium and the mechanisms underly

238 ecific antibodies mediate protection through direct actions on fungal cells and through classical mec

239 ematopoietic stem cell proliferation by both direct actions on hematopoietic cells and through modula

240 l effects were mediated at least in part via direct actions on hepatocytes and were preserved in hepa

241 sm for inducing neoangiogenesis through both direct actions on local TrkB-expressing endothelial cell

242 ly as an end-stage effector cytokine through direct actions on macrophages.

243 promoting the M2 macrophage phenotype and by direct actions on muscle cells.

244 ase of IFN-gamma, although it can also exert direct actions on other inflammatory mediators.

245 entially promote lung cancer, either through direct actions on preneoplastic or neoplastic cells or t

246 t bacterial infections regulate pain through direct actions on sensory neurons, and specific receptor

247 ons of dec-RRLL-cmk represent the sum of its direct actions on SKI-1 and indirect actions on caspase-

248 morphine inhibited the hypocretin system by direct actions on the cell body that include reduced spi

249 H) activates the behavioral sequence through direct actions on the central nervous system.

250 ones (ETHs) initiate these behaviors through direct actions on the CNS.

251 hat the inflammatory response is mediated by direct actions on the dura and does not develop secondar

252 e and release of catecholamines and may have direct actions on the microvasculature.

253 r to have multiple beneficial effects, their direct actions on the myocardium have the potential to l

254 ing a predictor of coronary events, may have direct actions on the vessel wall in the evolution of at

255 iated vascular mineralization and in part to direct actions on the VSMC.

256 to induction of osteocyte apoptosis through direct actions on these cells.

257 discharge through a depolarization involving direct actions on TIDA neurons.

258 n suppress the progression of cancer through direct actions on tumor and endothelial cells.

259 through their own experience producing goal-directed action, or does some knowledge of others' actio

260 Stress promotes a shift from goal-directed action-outcome learning toward habitual stimulu

261 rdiac subtypes in the resultant populations: direct action potential phenotyping under current-clamp,

262 Contingency theories of goal-directed action propose that experienced disjunctions be

263 The performance of goal-directed actions relies on an animal's previous knowledg

264 ional basis of the visual processing of goal-directed actions remains largely unclear.

265 ion, manipulable objects activated an object-directed action representation system that includes left

266 s (13 females) whether the visuomotor object-directed action representation system that includes left

267 li specifically engage the visuomotor object-directed action representation system, in a constitutive

268 Adaptive goal-directed actions require the ability to quickly relearn

269 Goal-directed actions requiring prospective planning pervade

270 distractor triggers suppression during goal-directed action, resulting in enhanced efficiency and ac

271 To determine its direct actions, SAA was administered into murine lung, l

272 imulus, while the regions implicated in goal-directed action selection contained information about bo

273 and posterior cingulate cortices during goal-directed action selection in the training phase, whereas

274 An essential aspect of goal-directed action selection is differentiating between beh

275 between premature response impulses and goal-directed action selection is manipulated.

276 ng the neuroanatomy and neurobiology of goal-directed action selection on the one hand, and habit for

277 entral hippocampal trkB is essential to goal-directed action selection, countering habit-based behavi

278 In tasks involving goal-directed action selection, striatal neural activity has

279 t that striatal activity is involved in goal-directed action selection.

280 effect of distinct striatal pathways in goal-directed action selection.

281 the mOFC is a key regulator of "online" goal-directed action selection.

282 mental distinction between habitual and goal-directed action selection.

283 ccess to vision yet are able to perform goal-directed actions successfully.

284 information, while regions involved in goal-directed action, such as ventromedial and dorsolateral p

285 The characteristics of goal-directed actions tend to resemble those of previously ex

286 distractors produced less disruption in goal-directed action than weakly salient distractors.

287 and control of diastolic blood pressure are direct actions that should be taken to reduce the rate o

288 gorithm cannot explain many flexible or goal-directed actions that have been demonstrated behaviorall

289 RvE2 (1-10 nM) carries potent leukocyte-directed actions that include: 1) regulating chemotaxis

290 oth ethanol drinking and the shift from goal-directed action to habitual behavior.

291 operating in parallel with a system for more direct action-value learning.

292 In contrast, flexible goal-directed action was predicted by estimated tract strengt

293 In contrast, in a task requiring no goal-directed action, we found greater attentional interferen

294 Chemogenetic inhibition of OFC disrupts goal-directed actions, whereas optogenetic activation of OFC

295 work was preferentially active during object directed actions, whether observed or executed.

296 experienced or predicted value to guide goal-directed actions while undergoing functional magnetic re

297 cription-independent mechanism involving its direct action with a subset of Bcl-2 family member prote

298 s observed a series of movies depicting goal-directed actions, with the sequence controlled so that s

299 amines by low-dose psychostimulants involves direct action within the PFC, reflecting an intrinsic pr

300 ation between object directed and non-object directed actions within the human mirror system.