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1 and AMOT family members control YAP through direct binding.
2 onjugated Sepharose 4B beads confirmed their direct binding.
3 7 inhibits processing of these pri-miRNAs by direct binding.
4 kinase 3 (FLT3) is transactivated by SYK via direct binding.
5 ated AmpR dimer regulates ampC expression by direct binding.
6 r either by physicochemical properties or by direct binding.
7 This is through disruption of CD22-CD11b direct binding.
8 ppress WOX1 and PRS expression, also through direct binding.
9 emoreceptor that mediates QACs taxis through direct binding.
10 nucleotide-binding protein 1 (HINT1) through direct binding.
11 entify 3E10 as a novel inhibitor of RAD51 by direct binding, accounting for its ability to suppress H
12 e, the Nan-EKLF protein accomplishes this by direct binding and aberrant activation of genes encoding
13 may induce kidney tissue remodeling through direct binding and activation of the renal EGF receptor.
14 at COUP-TFII confers atrial identity through direct binding and by modulating expression of a broad s
15 ted HLA-DRalpha at the protein level through direct binding and degradation through the proteasome pa
16 ncHIFCAR forms a complex with HIF-1alpha via direct binding and facilitates the recruitment of HIF-1a
17 c inhibitory function of LECT2 in HCC by the direct binding and inactivation of MET, opening a potent
19 , Esrrb sustains the stemness of TS cells by direct binding and regulation of TS cell-specific transc
22 lex elicited approximately 100-fold lower V3-directed binding and neutralization titers than those ob
24 creatic EVs limit IAPP amyloid formation via direct binding as a tissue-specific control mechanism.
25 We have reported previously on a powerful direct binding assay called fluorescent labels in kinase
26 cessful development of a fluorescence-based, direct binding assay for the detection of type II and II
30 ur study, combining electrophysiological and direct binding assays, demonstrates that hEAG1 channels
31 proteins, this work is the first to utilize direct binding assays, X-ray crystallography, and modeli
33 rapid phosphorylation of STAT4, resulting in direct binding at the granzyme B promoter within 2 h of
35 nthase activity in AD pathology results from direct binding between Abeta and ATP synthase and inhibi
36 ) mapping to the ATPase domain cause loss of direct binding between BAF and PRC1 that occurs independ
38 eraction by coimmunoprecipitation and showed direct binding between dAmph-SH3 domain and dNedd4Lo N-t
40 n of MCT transport activity by CAII requires direct binding between histidine 64 in CAII and a cluste
45 e plasmon resonance (SPR) experiments showed direct binding between recombinant hCD98 and EPEC/C. rod
46 tion reveals that, surprisingly, there is no direct binding between the adsorbed CO2/CH4 molecules an
47 et al. and Chen et al. provide evidence for direct binding between the cytoplasmic tails of receptor
48 ind to PI(3,5)P2 on lipid arrays, suggesting direct binding between the lipid and the membrane sector
49 ndeed, this observation is supported by both direct binding, crossreactivity, and inhibition studies.
57 In vivo, 5: maintained high, alphavbeta6-directed binding in the paired DX3purobeta6-DX3puro mode
58 irst time, the experimental observation of a direct binding interaction between adsorbed CH4 molecule
61 ruggability is mainly studied by focusing on direct binding interactions between a drug and its targe
64 e M-CSFM variants with mutations both in the direct binding interface and distant from the binding si
67 culated from binding plots and compared with direct binding measurements using ultracentrifugation as
70 by substantial conformational changes, with direct binding mediated by the carboxy termini of Dam1p
71 the drugs tested here may block infection by direct binding near these critical sites for virus entry
76 scence lifetime imaging experiments revealed direct binding of AVR-Pia and AVR1-CO39 to RGA5-A, provi
78 w that arterial Dll4 expression requires the direct binding of both the RBPJ/Notch intracellular doma
82 smon resonance analysis we were able to show direct binding of CADA to the SP of hCD4 and identify th
83 S2R+ cells, our data revealed an unexpected direct binding of Corkscrew, the drosophila ortholog of
89 hroughout the chondrocyte genome, reflecting direct binding of each factor to the same enhancers and
91 d PRDM1 (BLIMP-1) transcription results from direct binding of EBNA3A and EBNA3C to regulatory elemen
96 ifier potassium (GIRK) channels are gated by direct binding of G protein beta-gamma subunits (Gbetaga
99 ation and luciferase reporter assay revealed direct binding of HIF-1alpha to a transcriptionally acti
100 production in human tissue explants through direct binding of HIF-2alpha to a specific site in the m
101 o indicate that the ARC gene is regulated by direct binding of HIF1 to a hypoxia response element (HR
104 nd CD24 was transcriptionally upregulated by direct binding of HOXA5 to their promoter sequences as d
106 et in vitro and in vivo by demonstrating (i) direct binding of HuR to WEE1's mRNA (a discrete 56-bp r
108 changes in filopodium dynamics by increasing direct binding of its receptor, Robo, to members of the
109 trophoretic mobility shift assays revealed a direct binding of KLF9 to the putative KLF binding motif
112 ndent RNA structural alterations can promote direct binding of m6A-modified RNAs to low-complexity re
113 sion changes could be explained by predicted direct binding of miRNAs to corresponding mRNAs, suggest
115 ift assay (EMSA) was used to demonstrate the direct binding of MYB46 to the promoter of CSLA9 in vitr
117 on and luciferase reporter assays revealed a direct binding of NANOG to a transcriptionally active si
120 noprecipitation and TOPflash assays revealed direct binding of Nog to Wnts to functionally prevent Wn
121 Gga adaptors facilitate TGN-PVC transport by direct binding of noncanonical phosphoregulated Gga-bind
124 itation-qPCR (ChIP-qPCR), we did not observe direct binding of p53 to MIR182, MIR203, MIR222, and MIR
125 ctivates NFkappaB signalling, leading to the direct binding of p65 to the promoter of Beclin 1 and to
127 old relative to an empty vector control, and direct binding of Pdx-1 to the proximal SERCA2 promoter
128 ify an innate recognition system by NaD1 for direct binding of PIP2 that permeabilizes cells via a no
132 mice carrying Smad4 conditional deletion and direct binding of pSmad1/5/8 to the Hcn4 regulatory regi
134 B counteract genome-destabilizing effects of direct binding of RAD51 to dsDNA in human tumor cells.
135 cell cycle independent, and instead reflects direct binding of Rb to pluripotency genes, including So
138 rt for the first time, to our knowledge, the direct binding of resistin to Toll-like receptor (TLR) 4
139 atom-bound motif RS(*)Au(0)S(*)R or involves direct binding of RS(*) to face-centered-cubic or hexago
140 11/12 (the Tup-family corepressors) suppress direct binding of Rst2 to UAS2, but this suppression is
141 n blot to identify the receptors involved in direct binding of RSV and pneumococci, the effects of wh
143 previously not linked to PRC2, we confirmed direct binding of Scm and PRC2 using recombinant protein
145 nd biochemical data support a model in which direct binding of Slit to Dscam1 enhances the interactio
146 Mullerian duct epithelial cells (MDECs) via direct binding of SMADs on the highly conserved 5' seque
147 atin immunoprecipitation analyses showed the direct binding of Snail to the VE-cadherin promoter.
149 ng intrinsic or acquired drug resistance via direct binding of STAT3 in IGF2 P3 and P4 promoters.
153 s with the active telomerase complex through direct binding of TERC and regulates Cajal body localiza
155 l interaction between MCT4 and CAII requires direct binding of the enzyme to the acidic cluster (431)
156 e glucose signal transducer protein Mth1 via direct binding of the EVH1 domain of the Psy2 regulatory
157 inations of subunits (GIRK1-4), activated by direct binding of the Gbetagamma subunit of Gi/o protein
158 tion inhibits TRPM3 channel activity through direct binding of the Gbetagamma subunit to the channel.
159 vo protein-mapping techniques to demonstrate direct binding of the heterologous Nhp6A protein at a La
162 Early RA treatment prevents this switch by direct binding of the RA receptor at the GLI3 promoter.
164 maging of the isolated protein confirmed the direct binding of the sigma-1 receptor to hERG monomers,
165 ls stably expressing TRPM8 further confirmed direct binding of the steroid hormone, testosterone, to
166 ereby beta3 integrin activation involves the direct binding of the talin head domain to the switch re
167 agging using this engineered ligase requires direct binding of the target and, thus, provides a usefu
170 se of SPR, NMR, and fluorescence assays, the direct binding of three of the identified fragments to A
171 ly 9,400 human recombinant proteins revealed direct binding of TINCR RNA to the staufen1 (STAU1) prot
178 DNA affinity precipitation demonstrated direct binding of ZBP-89 to the mouse Tph1 promoter, whi
180 c properties of its carbonyl oxygen atoms, a directed binding of the substrate to the template is pos
181 addition, we found that miR-128 through BMI1 direct binding on the PTEN promoter affected PTEN expres
182 l Mean Force, we showed that Arg is prone to direct binding onto the NP surface, while Lys needs to o
183 ment of the bound label-antibody fraction in direct binding or sandwich-assay type approaches with va
187 the branched actin regulator cortactin as a direct binding partner of phosphatidylinositol 3,5-bisph
188 rotein component of caveolar membranes, is a direct binding partner of Sirt1, as shown by the binding
191 the 19S assembly chaperones dp27 and dS5b as direct binding partners of the proteasome regulator PI31
192 TCP1 subunit 6A (CCT6A) as an inhibitor and direct binding protein of SMAD2 and found that CCT6A sup
193 h a fluorescent dye for visualization of the direct-binding protein targets of curcumin in situ.
195 evidence of allosteric coupling between the direct binding site and the NBD1:CL4 interface, thus ena
205 ional activity of HOX proteins through their direct binding, the functional importance of their inter
206 nformations of these binding pockets include direct binding through desolvated ion bridges in the GpC
207 PUM1/2 rather promote FOXP1 expression by a direct binding to 2 canonical PUM responsive elements pr
209 most conotoxin channel blockers function by direct binding to a channel and disrupting its normal io
210 ivity by preventing processing of miR-22 via direct binding to a conserved ERalpha-binding element wi
211 ls a mode of Avr protein recognition through direct binding to a novel, non-LRR interaction domain.
212 ptional repressor and regulated IFN-beta via direct binding to a previously unidentified specific reg
214 ating seed oil biosynthesis was fulfilled by direct binding to a RY (CATGCA) cis-regulatory element i
216 chanical link at the Muller cell membrane by direct binding to actin and a transmembrane protein comp
218 ibution of Na(+),K(+)-ATPase is modulated by direct binding to Akt substrate of 160 kD (AS160), a Rab
221 t ZNF24 represses VEGF transcription through direct binding to an 11-bp fragment of the VEGF proximal
222 ress by the NF-E2-related factor 2 (NRF2) by direct binding to an antioxidant response element in the
223 l-1H-pyrazole-3-ca rboxamide (AM251) through direct binding to and destabilization of ERRalpha protei
225 nts is governed by myosin XI members through direct binding to AtDCP1 rather than through an adapter
226 bridges in the GpC steps in B-DNA and A-RNA; direct binding to backbone oxygens; binding of Mg[(H2O)6
227 olyubiquitination of alpha4, indicating that direct binding to Bbox1 was necessary for the polyubiqui
228 role in activation of AP-1 target genes via direct binding to c-Jun at the target promoters, leading
230 lved in the different CDCs to preferentially direct binding to cholesterol in different lipid environ
232 limits the duration of IRE1alpha activity by direct binding to cysteine 148 in the lumenal domain of
234 transcription of thousands of genes through direct binding to DNA response elements, physically asso
236 of GAP activity of ELMOD1-3 proteins as its direct binding to either ELMOD1 or ELMOD2 resulted in lo
241 at miR-24 inhibits Jab1/CSN5 translation via direct binding to its 3' untranslated region (3'UTR) and
245 that this in turn reduces miR-23b levels by direct binding to its promoter, releasing the pro-invasi
246 ession, a homolog of plant CONSTANS (CO), by direct binding to its promoter, while it reduces the exp
247 ic cells through two independent mechanisms: direct binding to L1 RNA and regulation of a cellular fa
248 Pil1, generates these invaginations through direct binding to lipids including phosphoinositides.
250 is unclear, as current models indicate that direct binding to minichromosome maintenance (MCM) plays
252 etalloproteinase 3 (MMP3) expression without direct binding to MMP3 promoter and increased the 5-hydr
259 one protein function and are a result of its direct binding to polysomes, complex formation with cell
262 poE influences sAbeta metabolism not through direct binding to sAbeta in solution but through its act
263 telomerase recruitment to telomeres requires direct binding to single-stranded DNA, unlike the indire
265 reactions, including the hapten hypothesis, direct binding to T-cell receptors (the pharmacologic in
266 evels through pleiotropic effects, including direct binding to the 3' untranslated region of VWF and
269 a novel mechanism of BAX inhibition through direct binding to the BAX N-terminal activation site.
272 a mechanism of metabolite transport in which direct binding to the charged form exerts selectivity wh
273 by multiple divergent Cas9 orthologs through direct binding to the conserved HNH catalytic domain of
274 orts the chemotherapeutic drug cisplatin via direct binding to the ectodomain, we demonstrate that th
275 y mediated by Scl and Nkx2.5, likely through direct binding to the etv2 promoter, and cis-regulatory
277 ens or wounding to induce innate immunity by direct binding to the membrane-localized leucine-rich re
278 tor signaling in smooth muscle cells through direct binding to the N-terminal region of myocardin.
279 that Cdk1 phosphorylates Ska3 to promote its direct binding to the Ndc80 complex (Ndc80C), a core out
280 lls by the plant defensin NaD1 that acts via direct binding to the plasma membrane phospholipid phosp
285 chanism of Dyn2 action in these contexts via direct binding to the Rac1 guanine nucleotide exchange f
286 main are associated with altered patterns of direct binding to the RAD51C, RAD51 and BRCA2 HR protein
294 boundary biocatalysis that involves remotely directed binding to and engulfing insoluble substrates,
296 of three different Mg(2+) binding modes: 1) direct binding via N7 coordination, 2) direct binding vi
297 s: 1) direct binding via N7 coordination, 2) direct binding via O6 coordination, and 3) binding via h
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