ライフサイエンスコーパス: direct interaction

1 he mPPCs disassemble Abeta fibrils through a direct interaction.

2 suggesting that pTRS1 inhibits PKR through a direct interaction.

3 remained unclear if this effect is due to a direct interaction.

4 plasma membrane in the cytosol, indicating a direct interaction.

5 and seeds the aggregation of VEGFR2 through direct interaction.

6 ation (CUE) domain in SMARCAD1 mediate their direct interaction.

7 helicase activities of RECQL4 through their direct interaction.

8 nocopy each other exactly, consistent with a direct interaction.

9 Magnaporthe oryzae effector AVR-Pia through direct interaction.

10 iRNAs cannot be explained based on predicted direct interactions.

11 thought to be repressed by PER2 and CRY1 via direct interactions.

12 its the function of the COP1-SPA1 complex by direct interactions.

13 ice arrangement through metal-organic linker-directed interactions.

14 The resulting network comprises 41 direct interactions among all 13 sigma factors.

15 ein-protein interaction analysis showed that direct interactions among genetic products were signific

16 Direct interactions among pancreatic beta-cells via cell

17 cess, but it does not appear to be caused by direct interactions among viral proteins.

18 fluorescence test showed that TP-alpha have direct interaction and appear glucagon with a significan

19 e presence of p42 to accelerate AML, and the direct interaction and degradation of C/EBPalpha p42 is

20 uble iron-scavenging siderophores or through direct interaction and extraction from host proteins.

21 ity complex which is optimized by modulating direct interactions as well as dynamics, while toleratin

22 micelle size, but cardiolipin stabilizes by direct interactions as well.

23 ture C-terminal domain (MCD), suggesting the direct interaction between AC domain and the MCD is requ

24 ur graphene wrapped approach circumvents the direct interaction between Ag array and the analytes, th

25 riatal cholinergic dysfunction, induced by a direct interaction between alpha-syn and GluN2D-expressi

26 In this study, we identified a novel direct interaction between APP and the alpha2A-adrenergi

27 in adhesions did not require Cas binding, a direct interaction between BCAR3 and Cas was necessary f

28 Isothermal titration calorimetry showed a direct interaction between calcium cations and both FPs.

29 ytes and pulldown experiments to analyze the direct interaction between carbonic anhydrase II (CAII)

30 on assays and FRET experiments, we uncover a direct interaction between CaVbeta and actin filaments.

31 Our results reveal a direct interaction between CD200L(+) endothelial cells a

32 This prevented the direct interaction between CD8(+) T cells and beta-cells

33 anism that is not dependent on a substantial direct interaction between CDC37 and HSP90, but neverthe

34 These findings provide evidence of a direct interaction between Cdk9 and its inhibitor, Hexim

35 and one-hybrid assays, we find evidence for direct interaction between DAF-3 and the lag-2 promoter.

36 mass spectrometry data, indicates a possible direct interaction between DCT and CAV1.

37 We demonstrate a direct interaction between DEP and airway C-fiber affere

38 In this study we demonstrate a direct interaction between dysferlin and the SNARE prote

39 was obtained in yeast 2-hybrid assays for a direct interaction between either UVR8 or HY5 and severa

40 n and ELISA-style binding assays confirmed a direct interaction between EMILIN-1 and fibulin-4.

41 ysis following SCI revealed CD200L-dependent direct interaction between endothelial and local CD200R(

42 IL6R, and LDLR as modifiers of MMP9, with a direct interaction between ERG and MMP9.

43 port the biochemical characterization of the direct interaction between FGF2 and Tec kinase as well a

44 Here we show that a similar direct interaction between Galpha13 and the cytoplasmic

45 tly reported that GPCR activation promotes a direct interaction between Galphaq and protein kinase C

46 on, adding to previous findings indicating a direct interaction between gL and gB in EBV membrane fus

47 uantitative interaction proteomics reveals a direct interaction between GlcNAcylated nucleosomes and

48 quivalent to that of HAdV-5, indicating that direct interaction between HAdV-5 and CAR is not require

49 Mechanistically, we have identified a direct interaction between Hippo and oestrogen receptor-

50 se results are consistent with a model where direct interaction between HmpF and the T4P system activ

51 A direct interaction between indole-3-carbinol and the aux

52 o analysis with pure proteins demonstrated a direct interaction between IQGAP1 and YAP.

53 Binding assays revealed direct interaction between Kar1 and C-terminal Sfi1 frag

54 two-hybrid analysis showed no evidence of a direct interaction between kinesin-1 and AC141 or VP39,

55 The combined results indicate that the direct interaction between L1 and Reelin as well as the

56 SBED-biotin-transfer provided evidence for a direct interaction between MIF and CXCR7.

57 The occurrence of direct interaction between milk bioactive peptides, Ile-

58 components of the ERMES complex establish a direct interaction between mitochondria and peroxisomes

59 rd-facing conformations presumably through a direct interaction between Na(+) and transmembrane helic

60 ng to the molecular mechanisms mediating the direct interaction between Nedd4 (WW1-3 domains) and Cx4

61 Here we demonstrate that direct interaction between P. gingivalis and S. cristatu

62 We have previously shown that the direct interaction between p50 and BCL-3 is required for

63 These findings indicate that a direct interaction between PGC-1alpha and Tug1 modulates

64 t behavioral evidence to our knowledge for a direct interaction between polarized light and the light

65 Clear evidence for a direct interaction between purified human Na,K-ATPase an

66 ts that signal integration occurs through 1) direct interaction between receptors, 2) regulation of e

67 This direct interaction between RNA polymerase and ribosomes

68 We confirmed the recently postulated direct interaction between RPS15 and MDM2/MDMX and trans

69 These findings suggest that direct interaction between S1 and M1 may contribute to t

70 In particular, direct interaction between SHP2 and c-SRC was revealed b

71 first time, binding of VWF to C1q and thus a direct interaction between starter molecules of hemostas

72 2 kinase activity, which was supported by a direct interaction between STIM1 and Rictor, a specific

73 Kinase activation in vivo could result from direct interaction between Stt7 and the b6f complex or l

74 Evidence for a direct interaction between SWCNTs and CYP3A4 was also pr

75 biolayer interferometry and NMR indicated a direct interaction between the alphaMI domain, the major

76 Here we identify a direct interaction between the catalytic domain of Auror

77 T cell migration relied on a direct interaction between the CD95 domain called calciu

78 We also study different forms of direct interaction between the cells, and show that ener

79 ce) spectroscopy and simulation, show that a direct interaction between the cobalamin cobalt and the

80 y, in the absence of beta-chains, we found a direct interaction between the cytoplasmic domain of ATP

81 ow open-state dependent rearrangement of the direct interaction between the eag domain and CNBHD, whi

82 botronic logic operations, which realize the direct interaction between the external environment and

83 HJURP is recruited to centromeres through a direct interaction between the HJURP centromere targetin

84 ion complex early in infection, suggesting a direct interaction between the incoming viral particles

85 ear magnetic resonance (NMR) data rule out a direct interaction between the NDSM and the K65 residue

86 xcitation of ultrafast magnetization require direct interaction between the photons of the optical pu

87 Moreover, photo-cross-linking suggested a direct interaction between the PTEN C-tail and a segment

88 We were unable to find a direct interaction between the receptor and c-Cbl, raisi

89 -crystal structure bound to DNA, revealing a direct interaction between the two factors and induced D

90 of which express NPS receptors, suggesting a direct interaction between the two systems.

91 s, we identified the regions involved in the direct interaction between the yeast CAF-1 subunits, and

92 iradicaloids, i.e., biradicals stabilized by direct interaction between their radical centers, which

93 ion of C/EBPalpha p42 requires site-specific direct interaction between TRIB2 and C/EBPalpha p42 for

94 Previous studies have demonstrated that the direct interaction between TRN-SR2 and HIV integrase pre

95 We demonstrate that a direct interaction between Ubp10 and the Sir2/4 sub-comp

96 These findings implicate direct interactions between Bregs and Tregs to facilitat

97 Thus, there is no barrier preventing direct interactions between chromosomal DNA and the plas

98 Mechanistically, we uncover novel direct interactions between endogenous GPR124 and the Rh

99 nce approaches, we systematically tested for direct interactions between hERG1a and hERG1b subunits.

100 anism of repeat recognition for RIP involves direct interactions between homologous double-stranded D

101 Demonstrating direct interactions between host and virus proteins duri

102 city is at least to some extent dependent on direct interactions between ILs and the biomembrane.

103 Akt-membrane binding is mediated by direct interactions between its pleckstrin homology doma

104 ings, and one order of magnitude higher than direct interactions between multiple lambs.

105 mulate additional non-native species even if direct interactions between non-natives species are nega

106 We suggest that direct interactions between PilA and PilS in the inner m

107 Hence, for the first time, we uncover direct interactions between plastic nanoparticles and br

108 ins rare, and further questions remain about direct interactions between predators that could prevent

109 Direct interactions between proteins are essential for t

110 Coupling is thought to involve direct interactions between RNA polymerase (RNAP) and th

111 Proximity ligation assay revealed direct interactions between SNAP-25 and Gbetagamma subun

112 Direct interactions between the 2 proteins have been als

113 e membranes, a current hypothesis postulates direct interactions between the Na,K-ATPase and Src kina

114 y agglomerates at the ice surface, driven by direct interactions between the organic molecules.

115 hypothesis that this protection results from direct interactions between the preconditioning dose of

116 tetherin, this antagonism is carried out via direct interactions between the transmembrane domains (T

117 Previously, we reported extensive and direct interactions between TLR and Siglec families of p

118 ce that these functions are mediated through direct interactions between two key nodes of a posited "

119 ase activity of a UvrD dimer is promoted via direct interactions between UvrD subunits that affect th

120 Such a secretional division dictates directed interactions between the systemic circulation (

121 s reveal that MFN2 suppresses mTORC2 through direct interaction by binding its domain HR1.

122 The network structure corresponding to direct interactions can be fully uncovered.

123 substantial performance gains in estimating direct interactions compared to correlation analysis on

124 abilizing DNA binding to the octamer through direct interactions, core structural rearrangements, and

125 methods have been successfully used to infer direct interactions from biological datasets such as gen

126 GRN from gene expression data to distinguish direct interactions from indirect associations.

127 relationships discriminate the evidence for direct interactions from indirect interactions more prec

128 howed similar group membership patterns, but direct interactions involving touch occurred at a rate t

129 Release of this direct interaction is ATP dependent, consistent with a t

130 This direct interaction is mediated by the newly identified P

131 This direct interaction is required for the synergy between t

132 This direct interaction is strongly enhanced under phosphoryl

133 A system-level identification of drug-target direct interactions is vital to drug repositioning and d

134 This direct interaction might contribute to the pathogenic me

135 The profound and direct interaction observed between oxytocin and ethanol

136 Based on these results, we hypothesized that direct interactions occur between the NTD and the CTD.

137 Direct interaction of BIG1 N-terminal sequence with beta

138 Here, we study the direct interaction of Ca(2+) with phosphatidylinositol 4

139 The direct interaction of CaM with DR5 is localized at DR5 d

140 This is enabled by the direct interaction of CD81 with the deoxynucleoside trip

141 Yeast two-hybrid assays established a direct interaction of Cep170 with AKAP350A.

142 nt of LEC to a subset of snRNA genes through direct interaction of EAF and the N-terminal domain (NTD

143 However, coherent phonon excitation by direct interaction of electromagnetic radiation and nucl

144 Furthermore, we confirmed the direct interaction of FMRP with one candidate, RhoC, by

145 inhibition can also be mediated through the direct interaction of Gbetagamma subunits with the solub

146 mSIRK to induce DA efflux, consistent with a direct interaction of Gbetagamma with the transporter.

147 Moreover, we detected no direct interaction of HIF-2alpha with YAP1.

148 ed nuclear magnetic resonance (NMR) revealed direct interaction of I942 and I178 with EPAC1 and EPAC2

149 ponse in tumors may partially originate from direct interaction of immunogenic ncRNAs expressed in ca

150 Direct interaction of Kindlin-2 with beta- and gamma-cat

151 Reporter assays indicated that direct interaction of miR-124 with the 3'-untranslated r

152 PCR) and immunoblot experiments demonstrated direct interaction of miR-217 with kallikrein 7 (KLK7),

153 tary approaches were used to demonstrate the direct interaction of MKK3 with MYC in vitro and in vivo

154 Our previous studies have shown that the direct interaction of netrin receptor DCC and DSCAM with

155 chanism of NM2-membrane association includes direct interaction of NM2s with membrane lipids and indi

156 The direct interaction of NT-7-16 with purified tubulin was

157 n the partial pressure of O2 indicative of a direct interaction of O2 with molecular CO adsorbed on t

158 acid sphingomyelinase activity rather than a direct interaction of oxPLs with nanoplatform constituen

159 fluorescence anisotropy assay, we tested the direct interaction of several such polysaccharides with

160 own of GAB2 and Far-Western blots proved the direct interaction of SHP2 with p85, independent of adap

161 The direct interaction of Skap2 with the Wiskott-Aldrich syn

162 and XPF, which is recruited to telomeres via direct interaction of SLX4 with TRF2.

163 d that this effect probably occurs through a direct interaction of spermine with NspS, as purified Ns

164 genous TDP-43 in cells, allowing to assume a direct interaction of TDP-43 with zinc ions.

165 link between ABA and JA signaling through a direct interaction of the ABA receptor PYL6 (RCAR9) with

166 We observe direct interaction of the bacterial cells with Al NPs an

167 these approaches, little is known about the direct interaction of the bacterium with a complex host

168 This mitotic function is mediated by direct interaction of the central domain of ARHGEF17 wit

169 24-hydroxylase inhibition but rather from a direct interaction of the compounds at the level of Smo.

170 ntracellularly, therefore do not require the direct interaction of the cytotoxin with the organelle,

171 ributed to axon demyelination resulting from direct interaction of the M. leprae-specific phenolic gl

172 In this study, we report a direct interaction of the oncogenic RNA binding protein

173 The direct interaction of the OvCa cells with mesothelial ce

174 olves reduced phosphorylation of SMADs and a direct interaction of the receptors with SMAD3 and SMAD4

175 and stable association events depend on the direct interaction of the telomerase protein TERT with t

176 Notably, direct interaction of the two receptors via their cystei

177 of 43S ribosomal complexes does not require direct interaction of their eIF3 constituent with the IR

178 ines and lipid mediators can influence ILC2, direct interaction of these cells with the microenvironm

179 Yeast two-hybrid experiments confirmed the direct interaction of these transcription factors.

180 eplication and show evidence that supports a direct interaction of TOE1 with the viral specific trans

181 This mechanism involves the direct interaction of two different types of conserved m

182 Biochemical analyses demonstrated direct interaction of vimentin and ERK, which promoted E

183 We characterized direct interactions of a whole nonenveloped virus (simia

184 rt of cytosolic cargos, based on short-lived direct interactions of cargo with a highly processive an

185 ia both translation-dependent mechanisms and direct interactions of FMRP with a number of ion channel

186 In present study, we showed a direct interactions of p38, ERK or IkappaBalpha with MKP

187 Pull-down experiments demonstrated direct interactions of PilM with PilB and PilT.

188 scopy maps and, for the first time, show the direct interactions of the p53 C-terminal with DNA.

189 transfer (FRET) assays, we now show the PBM directs interaction of p14 with GTP-Rab11.

190 focus on predicting indirect interactions or direct interactions on a small scale.

191 dyl complexes are analysed considering their direct interaction or not with DNA as the cause of cell

192 blets for outer arm assembly, either through direct interactions or indirectly, perhaps by modifying

193 ANXA2 with PS-ASO is not dependent on their direct interactions or mediated by ANXA2 partner protein

194 amily of Plasmodium surface proteins, as its direct interaction partner.

195 family of merozoite surface proteins, as the direct interaction partner.

196 icipate in their crossreactivity or in their direct interaction, representing promising diagnostic an

197 +) regulation of PC2 is actually mediated by direct interaction(s) with structural elements of the ac

198 In the current work, we have looked for direct interactions utilizing purified recombinant Na,K-

199 pus egg extracts to show that TopBP1 makes a direct interaction, via its BRCT2 domain, with RPA-coate

200 etween PvTRAg38 and basigin was confirmed by direct interaction where basigin was specifically recogn

201 r one phase) just balances the effect of the direct interactions, which cause it to prefer the other.

202 t modulating a transition metal center via a direct interaction with a Lewis acidic support can be a

203 This direct interaction with actin suggests a new role of SPA

204 llular architecture in podocytes through its direct interaction with actin.

205 to the termination of lipid peroxidation by direct interaction with active groups of these lipids an

206 soluble cellular fraction, likely because of direct interaction with aggregated Abeta in the IL-10-ex

207 TRIB2 suppression is exerted via direct interaction with AKT a key signalling protein in

208 Stimulation of ATR activity requires direct interaction with an ATR activation domain (AAD)-c

209 RET represses the proapoptotic genes through direct interaction with and phosphorylation-dependent in

210 ells by efficient intracellular trafficking, direct interaction with AR, reduction of nuclear AR leve

211 uman antigen R (HuR) stabilizes mRNA through direct interaction with AREs on 3'-UTR.

212 ojuvelin (HJV) regulates iron homeostasis by direct interaction with bone morphogenetic protein (BMP)

213 primed" PIDD relocates to kinetochores via a direct interaction with BubR1.

214 conformational changes in C4b rather than a direct interaction with C5.

215 ondrial detergent-resistant microdomains via direct interaction with cardiolipin and inhibits MAVS pr

216 egulatory effect of the MR was mediated by a direct interaction with CD45 on the T cell, inhibiting i

217 revealed that C9b activates this pathway via direct interaction with cellular inhibitor of apoptosis

218 g apoptosis and autophagy, which involve its direct interaction with cellular proteins and thus requi

219 tion on endothelial cells not only through a direct interaction with chemokines but also by binding a

220 s, whereas SP-C does not seem to establish a direct interaction with cholesterol that could increase

221 Inactivation of AMT1;2 by direct interaction with CIPK23 requires kinase activity

222 h positive regulation on BRCA1 expression by direct interaction with E2F1.

223 alleviates bleomycin-induced lung injury via direct interaction with extracellular histones.

224 e ability of myosin to translocate actin via direct interaction with F-actin and myosin II and by act

225 .e. its direct interaction with PKA, and its direct interaction with GSK3beta are required for the re

226 ugh which the TOP2 CTD regulates the CPC via direct interaction with Haspin at mitotic centromeres.

227 an equally distant gene further upstream, by direct interaction with HIF.

228 be inactivated by substantially reducing its direct interaction with HSP90.

229 iR-210 regulated GPD1L protein level through direct interaction with its mRNA three prime untranslate

230 ibodies elicited by HCV proteins or by their direct interaction with M3R.

231 ochondria from oxidant injury likely through direct interaction with mitochondria.

232 mesolimbic dopaminergic sensitization, via a direct interaction with mTOR/p70S6 kinase signaling with

233 t CotE enables binding of spores to mucus by direct interaction with mucin and contributes to its deg

234 ulate auxin-responsive genes in vivo through direct interaction with MYB77 and MYB44.

235 in 14-5 oligomer (95 kDa) was found to be in direct interaction with Na,K-ATPase.

236 th purified recombinant proteins showed that direct interaction with Norbin increases the basal, PIP3

237 he PFV CBS is essential and sufficient for a direct interaction with nucleosomes and present a crysta

238 We reveal a direct interaction with PABP that is sufficient to promo

239 ing IL-7-stimuated JAK/STAT5 signaling via a direct interaction with phosphorylated JAK3.

240 at both the AKAP function of GSKIP, i.e. its direct interaction with PKA, and its direct interaction

241 ZFHX3 regulates transcription via direct interaction with predicted AT motifs in target ge

242 We tested a model in which direct interaction with protein partners protects Isu fr

243 A/piRNA-L may play a regulatory role through direct interaction with proteins in physiological and pa

244 ependent transcription termination through a direct interaction with Rho.

245 RNA signals that modulate transcription via direct interaction with RNA polymerase (RNAP), we deep s

246 in-independent proteasome substrate, and the direct interaction with Rpn8 C terminus mediates its pro

247 Like Dut80alpha, DutNM1 forms a direct interaction with SaPIbov1 Stl both in vivo and in

248 sion-are incorporated into COPII vesicles by direct interaction with Sec24.

249 l adaptor, is targeted by Salmonella through direct interaction with SifA.

250 o the centriole during interphase depends on direct interaction with Spd2.

251 Highly reactive calcium ions form a direct interaction with starch to alter considerably its

252 Evidence is now provided of a direct interaction with Stt7 on the stromal side of the

253 egulation by miR-339-3p, functioning through direct interaction with the 3' untranslated region of MC

254 iation by RNA polymerase II (RNA pol II) via direct interaction with the basal transcription/DNA repa

255 otyrosine-binding domain of IRS-1 mediates a direct interaction with the C-terminal tail of IQGAP1.

256 he central spindle and the midbody through a direct interaction with the centralspindlin component MK

257 strate that confinement at the nanoscale and direct interaction with the charged interfaces produce a

258 bstantial, and specific potency gain through direct interaction with the enzyme and/or effects on the

259 s the farnesylated PDE6alpha subunit through direct interaction with the farnesyl moiety, mutations c

260 eurotrophin receptor oligomerization through direct interaction with the first cysteine-rich domain o

261 modified by the addition of lipids allowing direct interaction with the hydrophobic core of membrane

262 g checkpoint effector kinase Rad53 through a direct interaction with the INO80 chromatin remodeling c

263 DRM1, is recruited to the proteasome through direct interaction with the large scaffolding protein RP

264 d by the archaeal proteasome, by virtue of a direct interaction with the modifier.

265 he observed defects cannot be explained by a direct interaction with the mutated residue, and thus th

266 1 replication but not Sabin-2 or Sabin-3 via direct interaction with the PV 5'UTR.

267 ein kinase (AMPK) metabolic sensor through a direct interaction with the regulatory autoinhibitory do

268 ms a cellular complex with NF-kappaB through direct interaction with the Rel homology domain of RelA.

269 y region 3 membrane protein RIDalpha via its direct interaction with the sterol-binding protein ORP1L

270 We determined that recruitment depended on a direct interaction with the synaptic protein Munc13, bec

271 17, but not TH1 and TH2, differentiation via direct interaction with the T cell.

272 taM in regulation of gene expression through direct interaction with the transcriptional co-regulator

273 form of the endosomal Rab5 small GTPase via direct interaction with the viral replication protein.

274 r be generated in situ at the M star through direct interaction with the white dwarf's magnetosphere.

275 vel URAT1 binding assay provides support for direct interaction with these amino acids; thus, current

276 ry, which we demonstrate to be mediated by a direct interaction with Tic110.

277 BDNF)-dependent biological responses through direct interaction with TrkB receptors.

278 and hydrophilic nicotine molecule showed no direct interactions with Abeta, nor did it affect Abeta

279 In addition, proposed individual direct interactions with active zone proteins are insuff

280 ate the cell's unfolded protein response via direct interactions with amyloidogenic proteins.

281 16 target the Snf1 (AMPK) kinase complex via direct interactions with both the core enzymatic subunit

282 s involved in the immune response, including direct interactions with chromatin, RNA and proteins.

283 These results demonstrate that, through direct interactions with F-actin and EndoB2, CPG2 physic

284 binds chromatin in a multivalent fashion via direct interactions with H3K4me2/3 and DNA, and indirect

285 ell understood, especially in the context of direct interactions with HCMV-infected cells.

286 nd other signaling pathways via antagonistic direct interactions with key transcription factors.

287 We introduce matter , an R package for direct interactions with larger-than-memory datasets, st

288 mi1 in iCM reprogramming is mediated through direct interactions with regulatory regions of cardiogen

289 osin II and by activating RhoA signaling via direct interactions with RhoA-specific guanine nucleotid

290 ic immunosuppressive effects in vivo through direct interactions with T cells, either inducing T regu

291 nein from soma to axon terminal is driven by direct interactions with the anterograde motor kinesin-1

292 rol coupling and abundance of CaV2.1 through direct interactions with the CaV2.1 alpha1 subunit C-ter

293 s to either the axon or the dendrite through direct interactions with the clathrin-associated adaptor

294 ed the direction of gliding motility through direct interactions with the gliding motor.

295 dominantly inhibited by cholesterol through direct interactions with the transmembrane domain.

296 sis by up-regulating VEGF expression through direct interactions with the VEGF gene and the Sp1 trans

297 A) regulates HIV-1 viral infectivity through direct interactions with the viral capsid, by an unknown

298 pendent of membrane composition and involves direct interactions with transmembrane and periplasmic s

299 lates the level of hippocampal activation by directed interactions with the ventral midline thalamus.

300 umber of putative motifs that, if capable of direct interaction, would interact with cytosolic host c