ライフサイエンスコーパス: direct involvement

1 These results unambiguously show the direct involvement and promoting role of water in CO oxi

2 Supporting its direct involvement, biochemical analysis shows that A2BP

3 learned with PolioPlus, such as the value of direct involvement by local Rotarians, the program for e

4 s lacking V(1) subunits E or G, suggesting a direct involvement for these subunits in interaction of

5 ls in NLRP3 inflammasome assembly, but their direct involvement has not been shown.

6 recruitment to the SNR47 gene, suggesting a direct involvement in 3' end formation.

7 used on identifying the residues that have a direct involvement in an enzymatic reaction, but these s

8 e self-antigen, raising the possibility of a direct involvement in antibody-mediated beta-cell dysfun

9 the 3' end of rgg, are necessary, either by direct involvement in binding or by indirectly affecting

10 not affect these interactions, suggesting no direct involvement in cargo loading/unloading.

11 f the high resolution WT structure, defining direct involvement in catalysis as well as in stabilizat

12 on of gK with virus-induced cell fusion, its direct involvement in cellular membrane fusion has been

13 ysical properties of cell membranes, but its direct involvement in cellular signaling has not been th

14 eric satellite DNA arrays rather than a more direct involvement in centromere structure.

15 Surprisingly, neither shows a direct involvement in chain association.

16 CBFbeta for wild-type AML1 function and its direct involvement in chromosomal translocation, we demo

17 esence of a marker allele, either because of direct involvement in disease etiology or because of LD

18 ge response system, although its exact role (direct involvement in DNA repair versus indirect, facili

19 nd/or its subunits have functions other than direct involvement in DNA repair.

20 served cysteine residues has suggested their direct involvement in hASBT function.

21 ng hotspot positions, and strongly support a direct involvement in hybrid infertility.

22 f total community), many of which had little direct involvement in metal or sulfate respiration.

23 recent studies have proposed that Myo2 has a direct involvement in mitochondria inheritance.

24 n the ubiquitin-proteasome system, but their direct involvement in muscle protein catabolism in cance

25 elial cells in injured muscle to suggest its direct involvement in muscle regeneration or angiogenesi

26 roles in metazoan embryonic development and direct involvement in numerous disease states.

27 meostasis after ovarian events, instead of a direct involvement in ovarian functions.

28 ically devoted to the ICU for the purpose of direct involvement in patient care.

29 chia coli L2, which has been implicated in a direct involvement in peptidyl transferase activity.

30 ep of transcription initiation factor IIIB's direct involvement in promoter opening.

31 ue and cancer in various organs, without any direct involvement in promoting fibroblast recruitment a

32 ng Kunitz and endostatin domains, suggesting direct involvement in protease inhibition and axonal mig

33 hts into the function of hTFIIIC and suggest direct involvement in recruitment of both TFIIIB and RNA

34 ymatic activity of Them2 suggests additional direct involvement in regulating hepatic nutrient homeos

35 To date, their direct involvement in retinal innate defense against bac

36 (PQBP1) is of particular interest due to its direct involvement in several X chromosome-linked intell

37 been linked to MAPK activation suggesting a direct involvement in signaling cascades.

38 tion in developing pollen, indicative of its direct involvement in specification of aperture position

39 s near the subunit interface rules out their direct involvement in subunit association but leaves ope

40 stem lost this resistance, demonstrating its direct involvement in survival under these conditions.

41 flexible nature of Glu165, which favors its direct involvement in the formation of the enediol inter

42 unctions, but there is little evidence for a direct involvement in the junctional permeability barrie

43 ugh 34 d after infection, nor do they have a direct involvement in the maintenance of HSV-1 latency.

44 ld interact directly with Msk, suggest their direct involvement in the nuclear import of MAD.

45 pathway initiated by exogenous FGF-1 by its direct involvement in the nuclear transport and signalin

46 bstrate specificity and strongly suggest its direct involvement in the recognition of and binding to

47 armaceutical industry drug target due to its direct involvement in the regulation of food intake and

48 t Fob1p is a nucleolar protein, suggesting a direct involvement in the replication fork block.

49 conformational change is unlikely to have a direct involvement in toxicity.

50 in/CTTN is considered a likely candidate for direct involvement in tumor progression because of its c

51 n, and intestinal colonization; however, its direct involvement in virulence has not been reported.

52 h strong aliphatic C-H bonds, indicating the direct involvement of 3 in the oxidation/chlorination re

53 These studies had strongly suggested direct involvement of a flexible paratope in the observe

54 ese data provide additional evidence for the direct involvement of a metal-coordinated sulfur nucleop

55 is is the first report that demonstrates the direct involvement of a regulatory protein (SarA) in con

56 study we provide the first evidence for the direct involvement of a specific NK killer receptor in p

57 simple technique support the contention of a direct involvement of a vitamin D-induced calcium-bindin

58 While the direct involvement of Abeta in AD has been well document

59 xt used optogenetic silencing to confirm the direct involvement of abGCs in context encoding and disc

60 Its biological effects may be due to direct involvement of ADM receptors, but also to activat

61 tor restored glycogen stores, confirming the direct involvement of Akt/GSK-3beta signaling.

62 Our findings demonstrate the direct involvement of an extracellular matrix protein as

63 ently bound to the ATF4 promoter, suggesting direct involvement of an mTORC1/c-MYC-driven signaling p

64 by light exposure raises the question of the direct involvement of AP-1 in mediating photoreceptor ce

65 Our findings indicate a direct involvement of aPKC in Hh signaling beyond its ro

66 These findings show direct involvement of Arps in the chromatin-remodeling p

67 ded a wealth of data that largely supports a direct involvement of astrocytes on diverse aspects of b

68 result provides a possible mechanism for the direct involvement of ATM in non-homologous end joining-

69 lding by Hsp90 is poorly understood, and the direct involvement of ATP has been particularly contenti

70 gns of antibody maturation are indicative of direct involvement of B cells in local inflammatory proc

71 These results suggest the direct involvement of B cells in tolerance to p1-102 epi

72 These findings support a direct involvement of basophils in inflammation as well

73 Direct involvement of C1INH in modulation of selectin-me

74 k of this current by nifedipine suggests the direct involvement of Ca(v)1.3 Ca(2+) channels in its ac

75 doptive transfer experiment, we assessed the direct involvement of CCR2 and CCR6 in the recruitment o

76 from lack of cell movement rather than from direct involvement of ciliary assembly pathway component

77 esults provide experimental evidence for the direct involvement of conditionally disordered regions i

78 identification and action planning; and the direct involvement of consultant obstetricians and anaes

79 o the most compelling pieces of evidence for direct involvement of cortical signals in perception com

80 Although there is robust evidence for the direct involvement of Cx26 in cochlear functions, the co

81 h Arg-122 at the active site of CN, implying direct involvement of CyPA-CsA in the regulation of CN c

82 nd individual human cathepsins demonstrate a direct involvement of cysteine cathepsin B (CtsB) and L

83 The direct involvement of Dbp3p in ribosomal biogenesis is s

84 rovide first experimental evidence showing a direct involvement of DeltaDNMT3B4 in regulating RASSF1A

85 Our findings provide evidence for the direct involvement of DNA Pol lambda in the repair of DS

86 studies of individual genes have revealed a direct involvement of epigenetic factors in alternative

87 These observations suggest a direct involvement of Era in the assembly and maturation

88 However, no evidence for direct involvement of FIS in tRNA1Leu expression has bee

89 Short range functions include: (a) direct involvement of five amino acids in Ca2+ binding w

90 an FK506 non-producing mutant demonstrating direct involvement of fkbA in the biosynthesis of FK506.

91 In this study we report on direct involvement of fluid shear stresses on the osteob

92 In addition, direct involvement of Fur in the regulation of DNA synth

93 ibited Raf-1 and ERK1 activity, indicating a direct involvement of G betagamma subunits in the signal

94 tion early after transplantation, suggesting direct involvement of gammadelta T cells in anti-CMV imm

95 neuron autonomous event facilitated without direct involvement of glial cells.

96 The direct involvement of Gq/11/phospholipase C signaling an

97 No evidence for direct involvement of GSH in the induction of assembly w

98 The direct involvement of GTP for the phosphorylation of Env

99 Direct involvement of His(229) in the reaction mechanism

100 nd three other lines of evidence support the direct involvement of HisZ in the transferase function.

101 e disequilibrium with a disease locus or the direct involvement of HLA alleles in RA.

102 aken together, these results demonstrate the direct involvement of hMR in HIV-1 infection of astrocyt

103 ts of Ad-HO-1 gene transfer, documenting the direct involvement of HO-1 in protection against I/R inj

104 ated with the functional complex, implying a direct involvement of Hsp90 in telomere length regulatio

105 These observations reveal a novel direct involvement of human PABP in the stabilization of

106 in cleavages have been observed in which the direct involvement of ICE-like proteases has been postul

107 PAC-IUBMB-IUPAB inter-union venture with the direct involvement of ICSU and CODATA.

108 The direct involvement of IGFBP-3 in cell growth inhibition

109 jection in atopic hosts does not require the direct involvement of infiltrating eosinophils.

110 lls bearing KDR CNGs, providing evidence for direct involvement of KDR.

111 The present study provides evidence for a direct involvement of kinase suppressor of Ras 2 (KSR2)

112 Here we report the direct involvement of KU80, a protein that binds dsT-DNA

113 ine (DA) release, while the possibility of a direct involvement of L-dopa itself in LID has been larg

114 r results present definitive evidence of the direct involvement of LCRs in 22q11 deletions and map bo

115 replication sequences may further suggest a direct involvement of left-end replication sequences in

116 Furthermore, direct involvement of lipid metabolism in the pathogenes

117 ing AUGC sequences of the viral RNA, without direct involvement of loop nucleotides.

118 , Brk may regulate other Dpp targets without direct involvement of Mad.

119 ed the cytotoxicity of ara-C, suggesting the direct involvement of MAPK as a downstream antiapoptotic

120 evidence for linkage disequilibrium and the direct involvement of markers DR4 Dw4, DR4 Dw14, and DR1

121 enzymes can affect O(2) reactivity without a direct involvement of metal cofactors.

122 radical cation decay is achieved through the direct involvement of methanol in the deprotonation of t

123 s on the latest progress made in the area of direct involvement of miRNAs in signaling, translocation

124 Direct involvement of mitochondrial ROS in intestinal tu

125 MLH1 gene was reintroduced, demonstrating a direct involvement of MMR proteins in sensitivity to the

126 -apo riboflavin-binding protein, we show the direct involvement of molecular oxygen and DNA base-drug

127 provides a means to oxidize proteins without direct involvement of more potent oxidants.

128 e results demonstrate for the first time the direct involvement of MOSC2 and CYB5B in the amidoxime r

129 However, controversies about the direct involvement of MSCs in tumor progression suggest

130 ese data, both in vitro and in vivo, suggest direct involvement of MSH2 in processing IdUrd in DNA.

131 thermore, recent studies have demonstrated a direct involvement of mTOR signaling in regulating HSF1-

132 ese abnormal characteristics, indicating the direct involvement of N-glycosylation events in these ph

133 To examine the direct involvement of NAD(P)H oxidases in Ang II-induced

134 These data provide new evidence for direct involvement of neurogenesis in the etiology of de

135 28 stimulation in T-cells, which implies the direct involvement of NFAT in mediating the CD28 stimula

136 lls and virus-infected cells, highlighting a direct involvement of NP1 in viral DNA replication at Or

137 ntly, this represents the first evidence for direct involvement of one two-component system in transc

138 hese results provide strong evidence for the direct involvement of organometallic Ni(III) species in

139 The direct involvement of p38 pathways in cardiac hypertroph

140 ality patient-centered care will require the direct involvement of patients and medical professionals

141 Direct involvement of PKC in the regulation of ODC by ox

142 , as shown by immunoprecipitation, indicated direct involvement of PKCs in Bad phosphorylation.

143 This study establishes a direct involvement of plasminogen in monocyte recruitmen

144 However, the direct involvement of poly ADP-ribosylation was also app

145 Demonstration of the direct involvement of primary tumor stroma in metastasis

146 ion across the channel, which occurs without direct involvement of protein hydrophilic residues.

147 These results are consistent with the direct involvement of proteoglycans in transfection.

148 To examine the possible direct involvement of PSA in the interactions between PC

149 e of adjacent subunits can be sensed without direct involvement of R-finger residues.

150 Our findings provide support for the direct involvement of RAG2 in DNA binding during all ste

151 The direct involvement of RAR beta in atRA-induced STAT1 gen

152 ay can be caused by two separate mechanisms: direct involvement of RDH8 and ABCA4 in cone chromophore

153 The direct involvement of reactive oxygen in the kinetically

154 experiments in the presence of 6-AHA reveal direct involvement of residues Tyr36, Trp62, Phe64, and

155 rom that used by mice, possibly reflecting a direct involvement of rodents and not humans in the para

156 ations via amino acid substitutions and/or a direct involvement of S6 C-termini in Na(+) channel gati

157 ATP and was abolished by BHQ, indicating the direct involvement of SERCA.

158 ence from human translocations regarding the direct involvement of SNRPN in the pathogenesis of PWS a

159 signal independently of Notch, indicating a direct involvement of somatic myosin activity in axis fo

160 We report here the molecular basis for the direct involvement of Spi-1 in HCMV activation of il1b.

161 r knowledge, this is the first report of the direct involvement of surface-expressed enolase in the p

162 e mutants leave open the question concerning direct involvement of T1 in gating.

163 he proteinase K treatment, demonstrating the direct involvement of T2SS in translocation of MtrC and

164 These findings, which suggest a direct involvement of tau in axonal transport, have impl

165 limits clonal burst (P = 0.0001) revealing a direct involvement of telomerase in T cell fate decision

166 Our results point to direct involvement of the AChR molecule in restricting r

167 vent formation of the fVIII.vWf complex, the direct involvement of the acidic region in this binding

168 Together, these results suggest a direct involvement of the alpha 5 subunit in the observe

169 compared with WT controls, corroborating the direct involvement of the alpha4-subunit in high-affinit

170 The direct involvement of the BMP/Smad pathway in this induc

171 o the rate accelerations with added bases is direct involvement of the buffer base in either atom-pro

172 interactions prevent processing, whereas the direct involvement of the C-terminal region in processin

173 This work reports the direct involvement of the ESCRT machinery in the life cy

174 of pathogens via the bloodstream can lead to direct involvement of the eye.

175 ts pivotal role in bitter taste sensation, a direct involvement of the G-protein subunit alpha-gustdu

176 primarily of carbohydrate, with probably no direct involvement of the gp120 polypeptide surface.

177 Direct involvement of the heparan sulphate glycosaminogl

178 ore protein during infection and support the direct involvement of the HLA-DRB1 gene in vaccine nonre

179 These findings reveal a direct involvement of the Ig light chain (IgL) in B cell

180 ely, these findings provide evidence for the direct involvement of the IL-2/IL-2R signaling pathway i

181 studies revealed that the answer is not the direct involvement of the Lewis base catalyst, but rathe

182 ith GHRPYam, the packing of which showed the direct involvement of the ligand tyrosines in antiparall

183 Direct involvement of the lower gastrointestinal tract c

184 catalysis-dependent changes, suggesting the direct involvement of the metal ion in catalysis.

185 These observations imply direct involvement of the mismatch repair system in the

186 These data suggest a direct involvement of the mutated amino acid in metal io

187 Direct involvement of the N-terminal domains in the bind

188 sent the first experimental evidence for the direct involvement of the NisB protein in the maturation

189 These properties are a result of the direct involvement of the nuclear localization sequences

190 es weakly with mutated proteins, exclude the direct involvement of the polyalanine tract in dimer for

191 lu781-->Lys substitution seemingly precludes direct involvement of the residue in the cation binding

192 A modification enzymes and the potential for direct involvement of the RNA substrate in controlling t

193 The measurements focus on the direct involvement of the sole W residue in the nucleic

194 roposed mechanism, these results support the direct involvement of the substrate in O(2) activation b

195 Direct involvement of the Sxl glycine-rich region in pro

196 cytochrome oxidase subunit IV, indicating a direct involvement of the TbTim17 in the import process.

197 A direct involvement of the TRN in SZ and BD has not been

198 The direct involvement of the two pathways was further estab

199 These findings offer strong evidence for the direct involvement of the type A domain in C3b binding,

200 ly with this deleterious phenomenon, but the direct involvement of these inflammatory cells has not b

201 Such activity losses are consistent with the direct involvement of these latter two residues in the p

202 d by clonally expanded T cells, suggesting a direct involvement of these lymphocytes in plaque disrup

203 nsPs, which suggested to us that there is a direct involvement of these proteins in promoter recogni

204 se joints, consistent with studies showing a direct involvement of this cytokine in CD28 gene transcr

205 ed cell invasion and migration, indicating a direct involvement of this enzyme in cell locomotion.

206 ion of E2Fs has thus been unclear; moreover, direct involvement of this gene in primary human tumorig

207 promoting ovarian tumors and thus supports a direct involvement of this gene in the commencement of o

208 ells in the absence of ligand, verifying the direct involvement of this polypeptide in the regulation

209 no evidence was obtained to demonstrate the direct involvement of this protein in cobamide biosynthe

210 ximal to the affected telomere, suggesting a direct involvement of this protein in telomere maintenan

211 In this study, we investigated the direct involvement of TLR2 and TLR4 in MAM binding and p

212 lls stably expressing mouse TLR9, suggesting direct involvement of TLR9 in the recognition of RpG mot

213 rounded by DiI-labeled TBMCs, suggesting the direct involvement of transplanted TBMCs in myocardial c

214 uctural and biochemical data demonstrate the direct involvement of two metal ions in catalysis, and s

215 The direct involvement of ubiquitylation in caspase activati

216 w audiences through two different approaches-direct involvement of undergraduates in discovering and

217 ese results provide further evidence for the direct involvement of v-Src in tyrosine phosphorylation

218 t the observed cell death is the result of a direct involvement of VEGFA in chondrocyte survival.

219 ion, nifedipine or Bay K 8644, excluding the direct involvement of voltage-gated Ca(2+) channels in I

220 Several of the novel associations implicate direct involvement of, or interaction with, genes previo

221 , we manipulated glycolysis and assessed its direct involvement on V-ATPase function.

222 chromosome 12q24.13, was cloned through its direct involvement with MYC and IGH in a three-way trans

223 LCH is broadly divided into two categories: direct involvement with the disease (e.g., lytic lesions

224 asmic tail of retina insulin receptor showed direct involvement with the p85 subunit of PI3K in vitro