ライフサイエンスコーパス: direct regulation

1 EP gene promoter region in vitro, indicating direct regulation.

2 Direct regulation, altering the informational environmen

3 with low druggability have multiple positive direct regulations and positive feedback loops.

4 ns have proven to be effective tools for the directed regulation and modification of genes.

5 The main function of the sigma(E)-directed regulation appears to be to coordinate sigma(G)

6 his feedback loop is at least in part due to direct regulation, as assessed by in vivo and in vitro b

7 inS, supporting bioinformatic predictions of direct regulation at both promoters.

8 By contrast, few enzyme-encoding genes (direct regulation) but many ribosomal protein- and tRNA-

9 dermal explants culture system, suggesting a direct regulation by 1,25(OH)(2)D(3).

10 aining AGL15 binding sites as candidates for direct regulation by AGL15.

11 These genes respond transcriptionally to direct regulation by both the proneural proteins and the

12 BDCA-RNAIII promoter region, suggesting that direct regulation by CodY is unlikely to be the principa

13 Direct regulation by CovR was suggested by the presence

14 et of those genes, suggesting their possible direct regulation by Ctip2.

15 trameric but not dimeric GLUT1 is subject to direct regulation by cytosolic ATP and that this regulat

16 for some putative target genes support their direct regulation by Gli.

17 s rapidly induced upon sugar feeding through direct regulation by Mondo-Mlx.

18 ing and genomic sequences of Tead2 suggested direct regulation by MyoD, and consistent with this, Myo

19 Consistent with direct regulation by NMD, representative upregulated tra

20 teins identified were known to be subject to direct regulation by PrfA, the majority have not previou

21 a subset of these genes (n = 30), suggesting direct regulation by SigH.

22 ells at the animal pole, which are not under direct regulation by the Nodal pathway, behave normal in

23 estored regulation, confirming that there is direct regulation by the sRNA.

24 miR-122 bound HNF6 in vivo, confirming their direct regulation by this factor.

25 nalysis because such data cannot distinguish direct regulation by transcription factor binding from i

26 these genes, YDR492w and YOL002c, suggested direct regulation by Zap1p, whereas the expression of YO

27 rmination, and biological functions of miRNA-directed regulation have been reported for four of 15 kn

28 direct protein-protein contact and that this direct regulation is primarily responsible for the crypt

29 owing that gene expressions are often due to directed regulations, it is more meaningful to estimate

30 Direct regulation of 149 DEGs was suggested by strong pr

31 tes neuronal migration in the cortex through direct regulation of a second Rnd family member, Rnd3.

32 Small RNA regulatory circuits involve direct regulation of a small RNA by a TF and/or direct r

33 ect regulation of a small RNA by a TF and/or direct regulation of a TF by a small RNA and have been s

34 culum stress susceptibility, in part through direct regulation of activating transcription factor 4 (

35 thus reveals a critical role of a TLR in the direct regulation of adaptive immune response and pathog

36 gulation of B cell GC reactions that include direct regulation of AICDA and BCL6.

37 er P-AKT(T308), highlighting a prominent and direct regulation of AKT by mTORC2 in cancer cells.

38 poptotic response to HDAC inhibitors through direct regulation of APAF1.

39 We found no evidence for direct regulation of ARAP3's Rho GAP activity by PtdIns(

40 ion factor E2F-3 altered glutamine uptake by direct regulation of ASCT2 mRNA and protein expression,

41 ors during later development may involve the direct regulation of axon extension by target neurons.

42 s can be explained, at least in part, by the direct regulation of B-cell function.

43 The data suggest that direct regulation of beta-catenin-LEF/TCF signaling is o

44 and antagonizes canonical Wnt signaling via direct regulation of beta-catenin.

45 on of the erythroid lineage, associated with direct regulation of beta-globin expression.

46 f MDA-MB-231 cells is mediated by PLD2 under direct regulation of both JAK3 and the tyrosine kinase,

47 function, namely membrane translocation and direct regulation of Btk catalytic activity.

48 in-1-dependent transcription, likely through direct regulation of c-Jun activity.

49 tudies demonstrate a novel mechanism for the direct regulation of CD4(+) T cells by M. tuberculosis l

50 s involved in prostate cancer metastasis via direct regulation of CD44, a ubiquitous marker of PCa tu

51 tosis is mediated, at least in part, through direct regulation of Cdc25C.

52 mitosis is at least partly mediated through direct regulation of Cdc25C.

53 tes cellular proliferation and apoptosis via direct regulation of cellular gene expression.

54 re known to occur in vivo) and a pathway for direct regulation of cholesterol biosynthesis by bile ac

55 domain, providing support for a specific and direct regulation of CHT by APP through protein-protein

56 This direct regulation of CK2 by a cell surface receptor prov

57 ighting the importance of this interface for direct regulation of CLOCK:BMAL1 activity by CRY1.

58 The direct regulation of COL5A1 by miR-185 and miR-186 was c

59 However, direct regulation of collagen matrix by CRT has not been

60 Thus, direct regulation of complex I by mitochondrial MEF2D un

61 nd invasion and increases CAM-DR through the direct regulation of CXCR4 and FAK expression and FAK/PI

62 nd western blotting analyses, we confirm the direct regulation of CYGB by DeltaNp63alpha.

63 and gain-of-function studies further support direct regulation of dAP-2 by Hox proteins and suggest t

64 lterations in synaptic activity, rather than direct regulation of DCV release.

65 the Dll1 transcription start site suggesting direct regulation of Dll1 by GATA4.

66 eal a novel function of CRL4(Cdt2), i.e. the direct regulation of DNA polymerase delta, adding to its

67 Thus, E2A-HLF could transform cells by direct regulation of downstream target genes, acting thr

68 nents to the promoter, thus facilitating the direct regulation of E75A gene expression by JH.

69 We showed direct regulation of ENDOG by ERR-alpha and PGC1alpha (w

70 CPS also seems to provide a novel example of direct regulation of enzymatic activity in hormone biosy

71 Notch activity mediates CTL activity through direct regulation of EOMES, perforin, and granzyme B.

72 with many epithelial genes, suggesting that direct regulation of epithelial identity may be a conser

73 the intrinsic ligand, explaining the lack of direct regulation of ERG channels by cyclic nucleotides.

74 However, little evidence exists for direct regulation of extracellular diffusion by the ECM

75 gulation of the vicRKX operon or substantive direct regulation of fatty acid biosynthesis by VicR or

76 ese findings identify the first evidence for direct regulation of FLNa, implicating a mechanism where

77 is the first demonstration of GATA and RUNX direct regulation of Friend of GATA gene expression and

78 ansmission could be fully accounted for by a direct regulation of GABA release by kainate receptors l

79 Although direct regulation of GIRKs by the heterotrimeric G-prote

80 ted in response to JQ1 treatment, supporting direct regulation of GLI activity by BRD4.

81 through modulation of serum ADMA levels via direct regulation of hepatic DDAH1 gene expression.

82 ether this inhibitory action of GH is due to direct regulation of hepatic lipid metabolism.

83 owever, whether ERalpha is implicated in the direct regulation of HIF-1alpha and the role of HIF-1alp

84 In addition to the direct regulation of HLA-DRalpha, RTA can also indirectl

85 s, but whether these effects are mediated by direct regulation of host immunity or indirectly through

86 e the HSP-27 promoter, supporting a role for direct regulation of HSP-27 expression.

87 or the first time, specific miRNAs under the direct regulation of IGF-1 signaling in the estrogen rec

88 ogenic microRNAs (miRNAs) that are under the direct regulation of IGF-1 signaling.

89 n-dependent behavioral avoidance rather than direct regulation of innate immunity.

90 These findings indicate that direct regulation of IP3R by NADH is responsible for ele

91 tin immunoprecipitation and promoter assay a direct regulation of its transcription by RUNX1.

92 The direct regulation of key cell cycle regulators by the di

93 integration of environmental inputs and the direct regulation of key clock genes.

94 These results strongly support the direct regulation of Kv7 channels by PIP2 and its deplet

95 xpression of dAP-2 and provides evidence for direct regulation of leg segmentation by regional combin

96 oses the "default" cDC fate, in part through direct regulation of lineage-specific gene expression pr

97 Our study is the first to validate direct regulation of LOX and LOXL2 by the miR-200/ZEB1 a

98 ion of leukocytes; however, their intrinsic, direct regulation of lymphocyte fate remained unclear.

99 ChIP assays showed the direct regulation of miR-200b by CAGE.

100 rial abnormalities resulted from the loss of direct regulation of mitochondrial proteins by calpain-3

101 ly unappreciated mechanisms of Snai1 for the direct regulation of MMPs during EC development.

102 role of Cnn (or its related) proteins in the direct regulation of MT assembly and organization of non

103 knowledge, this is the first report to show direct regulation of MT1-MMP by HIF-2 and to provide a d

104 manner through a mechanism that includes the direct regulation of multiple effector T(H)17-associated

105 d protein kinase signaling pathway and/or by direct regulation of multiple metabolic pathways.

106 Our results provide evidence of direct regulation of Mxi1 by FOXO3a and imply an additio

107 In addition to a major role in the direct regulation of NAD homeostasis, some members of Nr

108 lay multiple roles in the CNS, including the direct regulation of neuronal and astrocytic functions.

109 These results identify a novel way for direct regulation of NF-kappaB activity in diverse cell

110 Our results report a direct regulation of Nurr1 by CREB after NMDAR stimulati

111 metabolic tissues, providing a framework for direct regulation of nutrient metabolism.

112 lation of eNOS at Ser-1177 is pivotal in the direct regulation of O(2)* and NO generation, altering b

113 ols ESC pluripotency and differentiation via direct regulation of Oct4 gene expression.

114 XA10 subsequently supports bone formation by direct regulation of osteoblast phenotypic genes.

115 (+/-)) increased bone resorption, suggesting direct regulation of osteoclast (OC) activity by the Hh

116 oblastic/osteoclastic cross-talk through the direct regulation of osteoprotegerin (OPG).

117 l to exhibit complementarity or evidence for direct regulation of other expressed sequences.

118 Direct regulation of other transcription factor genes li

119 part of the p53 transcriptional program and direct regulation of p53 target genes.

120 tic silenced tumor suppressor acting through direct regulation of p53 transcription and expression.

121 r findings establish a novel role for AP2 in direct regulation of PAR1 trafficking, a process critica

122 metabolism and suppresses metastasis through direct regulation of parallel acting transcriptional pro

123 Our results confirm the previously proposed direct regulation of Pax6 and further demonstrate that M

124 he self-renewal of muscle stem cells through direct regulation of Pax7.

125 IP(3) and membrane dynamics independently of direct regulation of PI3K activity and suggest that modu

126 In this study, we investigated the direct regulation of PLC-eta2 by Gbetagamma subunits of

127 Taken together, these findings reveal novel, direct regulation of PP2A activity by Galpha(12) and pot

128 These findings reveal direct regulation of PP2Ac polyubiquitination by a novel

129 s in effector tissues of this system enables direct regulation of processes (e.g. renal tubular Ca(2+

130 Direct regulation of programmed cell death may be an evo

131 responsive phosphorylation sites may reflect direct regulation of protein activity.

132 e that miR-132/212 controls cell survival by direct regulation of PTEN, FOXO3a and P300, which are al

133 ly binds the qseBC promoter, indicative of a direct regulation of qseBC gene transcription by PmrAB u

134 ration and differentiation, in part, through direct regulation of Rbl2 and Cdkn1a, whereas apical-bas

135 through the suppression of sRNA rsmZ via the direct regulation of RNase G in a biofilm-specific manne

136 n together, our results provide evidence for direct regulation of Runx2 by canonical WNT signaling an

137 ant effect on SR Ca(2+) leak rate mainly via direct regulation of RyR activity.

138 e [Ca]1/2 = 4.3 +/- 0.4 microM, suggesting a direct regulation of RyR1 function upon the calcium-depe

139 l where KLF2 regulates T cell trafficking by direct regulation of S1P(1) and CD62L and restrains spon

140 equentially control wing development through direct regulation of Ser expression in early, mid and la

141 However, the direct regulation of SHP expression may provide a basis

142 thylene biosynthesis and response, including direct regulation of soybean orthologs of At5g61590/MtSE

143 To define binding motifs that mediate direct regulation of splicing and polyadenylation by ESR

144 The underlying mechanism is likely the direct regulation of SR Ca2+ release channels by Casq2 r

145 cessary for VAT-Treg differentiation through direct regulation of ST2 and PPAR-gamma expression.

146 This role for HIF-1alpha demonstrates its direct regulation of survival and function in the inflam

147 out the role of M. tuberculosis molecules in direct regulation of T cell function.

148 mportant role of this innate receptor in the direct regulation of T-cell activation and survival duri

149 rovide the first molecular mechanism for the direct regulation of T-type Ca2+ channels by a protein k

150 including the hrpR promoter, suggesting the direct regulation of T3SS cascade genes by RhpR.

151 We validated the direct regulation of Tbx5 on Pcsk6 using immunohistochem

152 Direct regulation of the activity of RGS-RhoGEFs p115 or

153 sary for adult beta-cell replication through direct regulation of the beta-cell cycle.

154 This direct regulation of the BK channel identifies a previou

155 e metabolic response to pressure overload by direct regulation of the catalytic alpha subunit of AMPK

156 Reporter assays demonstrated direct regulation of the cdc34 3'-untranslated region by

157 rylation of TRPV1 in HEK cells, suggesting a direct regulation of the channel.

158 rojection may be specialized with respect to direct regulation of the circadian clock.

159 uronal differentiation and migration through direct regulation of the Dlx1/Dlx2 bigene cluster during

160 provide the first link between an miRNA and direct regulation of the ER stress response and reveal a

161 tivating its transcription, likely through a direct regulation of the expression of several ER chaper

162 ng canonical Wnt-signaling pathway under the direct regulation of the general protein quality control

163 he ChrAS system and provide evidence for the direct regulation of the hmuO and hrtAB promoters by Chr

164 essions caused by AP-1, suggesting this is a direct regulation of the hTERT promoter.

165 oprecipitation experiments suggested Notch-1 direct regulation of the IGF-1R promoter.

166 influences intestinal immune homeostasis via direct regulation of the IL-25-IL-23-IL-17 axis.

167 MEF2A controls this process through its direct regulation of the largest known mammalian microRN

168 es using GL3:GR and TTG1:GR fusions revealed direct regulation of the late biosynthetic genes only.

169 etoglutarate, which binds to PII, was due to direct regulation of the NRII-PII interaction and the ra

170 adaptors regulate proximal T cell signaling, direct regulation of the nuclear pore complex (NPC) has

171 NF4alpha is critical for urea homeostasis by direct regulation of the OTC gene in vivo.

172 functions and show the role of IRF-5 in the direct regulation of the plasma cell commitment factor B

173 gs uncover a function for the nucleus in the direct regulation of the protein synthesis machinery via

174 a genomic role, testosterone plays a role in direct regulation of the TRPM8 channel function.

175 These results demonstrate the direct regulation of the yggX gene by the redox-sensing

176 Although mitochondria contain sphingolipids, direct regulation of their levels in mitochondria or mit

177 d, here, we describe a role for BMP8B in the direct regulation of thermogenesis.

178 munoprecipitation (ChIP) analysis revealed a direct regulation of these genes by BrlR, with DNA bindi

179 rophoretic mobility shift assays, suggesting direct regulation of these genes by Cmr.

180 This finding is consistent with direct regulation of these genes by Crz1p.

181 The direct regulation of these genes by VqsM has been confir

182 However, direct regulation of these molecular components in media

183 phases of Earth's solar day, not through the direct regulation of these processes by light and darkne

184 of a newly discovered target, we demonstrate direct regulation of this target by RyhB.

185 rols human T-cell lineage commitment through direct regulation of three distinct processes: repressio

186 reprogramming of gene expression through the direct regulation of transcription factors or through th

187 H(2)O(2)-induced SOD-2 expression through a direct regulation of transcription mediated by activatin

188 ding proteins that has been involved in both direct regulation of transporter activity (inducer exclu

189 These data provide evidence for direct regulation of triglyceride turnover by a peripher

190 This is the first example of direct regulation of TRP channel function through tyrosi

191 uria in CasR-deficient mice, consistent with direct regulation of urinary calcium excretion by CasR i

192 Although there are limited examples of direct regulation of virulence factors, PASTA kinases ar

193 s a central role in bile acid conjugation by direct regulation of VLACSR and BAT in vivo.

194 tant molecular mediator of this Schwann cell-directed regulation of cancer cells in perineural invasi

195 These results demonstrate that miR164-directed regulation of CUC1 is necessary for normal embr

196 the design of transcription factors for the directed regulation of endogenous genes.

197 ides the basis for a mechanism of superoxide-directed regulation of eNOS, involving thiol oxidation,

198 RNA-directed regulation of epigenetic processes has recently

199 of the most powerful new approaches for the directed regulation of gene expression uses the phenomen

200 In addition to identifying a case of RNA-directed regulation of miRNA biogenesis, our study revea

201 we identify a developmental role for miR164-directed regulation of NAC-domain genes, which encode a

202 Thus, cGMP-directed regulation of PDE5 phosphorylation and the resu

203 t of editing levels, suggesting stronger cis-directed regulation of RNA editing for most sites, altho

204 providing auxiliary evidence for Wee kinase-directed regulation of the chromatin regulator Stonewall

205 se results reveal that a differential 5' UTR-directed regulation of translation can occur in coronavi

206 ed polymerase does not necessarily equate to direct regulation through pause release to productive el

207 han inhibiting other regulations, and adding direct regulations to a drug-target generally reduces it

208 To demonstrate direct regulation, we performed band shift and footprint