ライフサイエンスコーパス: directed

1 entified an essential role for the ubiquitin-directed AAA-ATPase, p97, in the clearance of damaged ly

2 led head and antennae and strong posteriorly directed abdominal setae.

3 s (13 females) whether the visuomotor object-directed action representation system that includes left

4 entral hippocampal trkB is essential to goal-directed action selection, countering habit-based behavi

5 action-outcome contingencies to control goal-directed action.

6 The directed activation of carbon-hydrogen bonds (C-H) is im

7 The presence of specific IgE directed against CCDs was investigated by bromelain IgE

8 We show that EGFR Abs directed against clinically relevant epitopes can be con

9 ned as a 4-fold increase in immunoglobulin G directed against Cryptosporidium gp15 and/or Cp23 antige

10 is a first-in-class antibody-drug conjugate directed against delta-like protein 3 (DLL3), a novel ta

11 tivity of CMLD-2, a small-molecule inhibitor directed against HuR, using non-small cell lung cancer (

12 Emerging treatment concepts use drugs directed against KIT and other relevant targets in neopl

13 Antibodies directed against M. leprae PGL-I represent a useful biom

14 ice after treatment with a blocking antibody directed against PD-1.

15 plasma IgE from DOCK8-deficient patients is directed against staple food antigens but not house dust

16 whether benralizumab, a monoclonal antibody directed against the alpha subunit of the interleukin-5

17 ografts with a pretargeted RIT (PRIT) system directed against the CD20 antigen.

18 ruses elicited an Igkappa-biased Ab response directed against the HA globular head and stem regions.

19 B significantly enhanced CAR T-cell efficacy directed against the Her2 antigen in two different estab

20 biomarker for therapeutic response to agents directed against the signal-regulatory protein CD47 and

21 develop Abs also called antidrug Abs (ADA), directed against these anti-TNF-alpha Abs after just a f

22 iRGD-targeted nanoparticles delivered siRNA directed against TNFalpha in a receptor-specific fashion

23 safe and effective live attenuated vaccines directed against VEEV and perhaps other closely related

24 Bevacizumab, a monoclonal antibody directed against VEGF, improves outcomes when added to p

25 ed less to the lysosomes, suggestive of FcRn-directed albumin salvage from lysosomal degradation.

26 agment union exploiting a Micalizio alkoxide-directed alkyne-alkene coupling tactic.

27 of cardiovascular disease prevention must be directed also to the family environment of the developin

28 y the mutagenic compounds, we applied effect-directed analysis (EDA) utilizing novel analytical and b

29 ructure analysis revealed a dual active site-directed and allosteric inhibition mode of this compound

30 roughout the embryo, but how cells move in a directed and collective manner has remained unclear.

31 mechanisms by computationally modeling goal-directed and habitual behavior as model-based and model-

32 An afucosylated Fc form (Pr20M) directed antibody-dependent cellular cytotoxicity agains

33 Finally, we develop a GPC2-directed antibody-drug conjugate that is potently cytoto

34 rovide the foundation for a materials-growth-directed approach aimed at realizing the loss control ne

35 This suggests that in addition to pTyr-directed associations, secondary interactions between th

36 targeted therapeutic and imaging strategies directed at aberrant signaling pathways in pancreatic tu

37 been associated with the presence of T cells directed at cancer neoantigens, a class of HLA-bound pep

38 ns is possible, but future efforts should be directed at determining what factors predict when withdr

39 ue to be a focus of public health strategies directed at S. pneumoniae.

40 this Perspective, we present new approaches directed at the design of efficient entry inhibitors to

41 opened up the potential for targeted therapy directed at the specific disease-causing abnormality.

42 the possibility that therapies specifically directed at these autoimmune processes could have therap

43 r a tendency toward prejudice in our society directed at those with skin disease.

44 ly polarized QD sources can be polarized and directed at will.

45 quality of life by impacting such spectrally directed auditory attention, its neurobiological bases a

46 Memory can inform goal-directed behavior by linking current opportunities to pa

47 Human prefrontal cortex supports goal-directed behavior by representing abstract information a

48 ces action-outcome memory, resulting in goal-directed behavior in mice that would otherwise express s

49 sis has suggested that core deficits in goal-directed behavior in obsessive-compulsive disorder (OCD)

50 also to FA nutrient signals to modulate food-directed behavior.

51 es an essential aspect of attention and goal-directed behavior.

52 general value signals in vmPFC to guide goal-directed behavior.

53 elease and is a canonical gatekeeper of goal-directed behavior.

54 Analysis of temperature-directed behaviors elicited by persistent PKC-2 activati

55 Goal-directed behaviour outside of spatial navigation similar

56 ly, transient and chronic reductions of goal-directed behaviours.

57 lity, which suggests that there is no cancer-directed benefit; therefore, there is no basis to prescr

58 Peptide-directed binding uses few synthetic transformations, req

59 Site-directed biopsies revealed enriched MIF and VEGF at the

60 is a complex mixture of diffusive behaviors (directed, Brownian, anomalous, or confined).

61 ll condensation at hair follicles is locally directed by an epidermal prepattern.

62 Ps) and proteins in aqueous solutions can be directed by modifying the salt concentration.

63 pendent place field assembly distribution is directed by tegmental dopaminergic activity.

64 ctive for accelerating C(sp(3))-H activation directed by weakly coordinating auxiliaries, which provi

65 in situ conversion of alcohols to imidates, directed C-H amination, and hydrolysis to NH2).

66 ries of Cp*Co(III)- and Cp*Rh(III)-catalyzed directed C-H bond functionalizations with diazo-compound

67 that binds to palladium and accelerates non-directed C-H functionalization with arene as the limitin

68 oach to catechols, employing an oxyacetamide-directed C-H hydroxylation on phenols.

69 ecular oxyacylation of alkenes via quinoline-directed C-O bond activation.

70 used autologous T cells that express a CD19-directed CAR (CTL019) to treat patients with diffuse lar

71 with preferences for provider roles-oncology-directed care versus primary care provider (PCP)-directe

72 With CPG-directed care, intra-abdominal abscess rate decreased fr

73 preferring oncology-directed care-versus PCP-directed care-for their general preventive care (black o

74 isplayed greater odds of preferring oncology-directed care-versus PCP-directed care-for their general

75 cted care versus primary care provider (PCP)-directed care-were assessed by using multivariable logis

76 s differs from cell activation and signaling-directed (CASD) reprogramming to cardiac progenitors.

77 ion lineages via the construction of entropy directed cell trajectories.

78 We have therefore created the first BRD9-directed chemical degraders, through iterative design an

79 or additional strategy to conventional tumor-directed chemotherapy.

80 This suggests Earth-directed CMEs are less like billiard balls and more like

81 shift thoughts between high-level internally directed cognitive states, when thinking about the self,

82 itioning into a set of subnetworks, revealed directed connections at distinct frequencies of interact

83 a shared responsibility, but available male-directed contraceptive methods are either not easily rev

84 g COG complex-dependent fusion of retrograde-directed COPI vesicles.

85 r JQ1 preferentially inhibits super-enhancer-directed cotranscriptional pri-miRNA processing.

86 2 + 2] cycloaddition and subsequent template-directed cyclization via Yamamoto coupling.

87 recruitment of the CCR4-NOT complex and TTP-directed decay of an mRNA containing an AU-rich element

88 to be rewarded is a critical aspect of goal-directed decision making.

89 nformation in order to make appropriate goal-directed decisions.

90 Such directed deflections can be triggered by a lateralized s

91 ld facilitate the study of gene function and directed differentiation in human stem cells.

92 yocyte formation from hPSCs and their use in directed differentiation of cardiac sub-lineages.

93 protocol that provides a common platform for directed differentiation of cardiomyocytes and endotheli

94 matopoietic stem cells, we perform morphogen-directed differentiation of human pluripotent stem cells

95 These findings identify Gata6-directed differentiation of NC to SMCs as an essential m

96 an half of the loci that are targeted by RNA-directed DNA methylation (RdDM).

97 teps: 5'-dRP lyase gap trimming and template-directed DNA synthesis.

98 ignaling pathways, and the effects of betaAR-directed drugs.

99 fellows performed and documented their goal-directed echocardiogram as normal or abnormal for right

100 hy was performed on schedule unless the goal-directed echocardiogram showed critical findings.

101 We examined the neuronally directed effects of the retinoid X receptor agonist bexa

102 Our study shows how sterically directed electrostatic interactions may assemble stable

103 Directed epitope rearrangements combined with a knowledg

104 ncrease affinity are typically identified by directed evolution involving combinatorial libraries.

105 in libraries, and should enable the in vitro directed evolution of proteins with designer single-mole

106 nstrate our approach using as an example the directed evolution of the bacteriophage lambda cI TF aga

107 e engineering of a cytochrome P450 enzyme by directed evolution to catalyze metal-oxo-mediated anti-M

108 sually carried out by rational design and/or directed evolution.

109 he metal system, so that the reaction can be directed exclusively toward C-H or C-F bonds or yield a

110 cortex, we were able to selectively inhibit directed exploration while leaving random exploration in

111 tegies to solve the explore-exploit dilemma: directed exploration, driven by information seeking, and

112 Cardiomyocyte-directed expression of the inhibitory CREM isoform CREM-

113 In an ERP for colorectal surgery, staff-directed facilitation of early mobilization increased ou

114 uld be to create and test interventions in a directed fashion.

115 ed in a predictable variation of the address-directed flux of a redox analyte, ferrocenedimethanol (F

116 Specifically, we apply directed forces to drive the GroEL conformational change

117 Directed functional connectivity paths (eg, region A inf

118 Directed functional connectivity paths within a depressi

119 To establish CRISPR-directed gene editing in N. vitripennis, we targeted a c

120 the directness of factors in initiating PIWI-directed gene silencing, we employed a Piwi-interacting

121 in hepatocytes and thus the outcome of liver-directed gene therapy using AAV vectors and showed in a

122 gative feedback loop that inhibits sigma(F) -directed gene transcription.

123 on and exhibit increased levels of sigma(F) -directed gene transcription.

124 On the basis of a directed genetic screen we find that vision plays a key

125 The introduction of Cas9-directed genome editing has expanded adoption of this ap

126 les site-specific gene insertion by homology-directed genome editing.

127 ARTS integrates target directed genome mining methods, antibiotic gene cluster

128 racterized signatures associated with gluten directed immune activity and identified gluten-induced T

129 mains can act as a potent guide RNA sequence-directed inducer or repressor of gene expression in mamm

130 smic swarm (April 1, 1984) due to a SE-to-NW directed input from the high-attenuation domain, possibl

131 in, imipenem or ciprofloxacin) by Transposon Directed Insertion-site Sequencing (TraDIS).

132 creen for essential genes using a transposon-directed insertional sequencing (TraDIS) approach.

133 nd from that same tip an electrospray can be directed into a mass spectrometer.

134 P32-directed intraperitoneal targeting of other anticancer a

135 or CDK4 activation, we proposed that proline-directed kinases might specifically initiate the activat

136 es, i.e., at sites phosphorylated by proline-directed kinases, which represent 40% of all sites in th

137 ganglia circuits are thought to mediate goal-directed learning by a process of outcome evaluation to

138 albumin with high FcRn-binding affinity was directed less to the lysosomes, suggestive of FcRn-direc

139 ecules designed according to the multitarget-directed ligand paradigm to exert combined activity at h

140 nd INCh2, and discuss the potential of a non-directed mass-screening approach for mAb production agai

141 ure development and implementation of person-directed mealtime care programs and dining environment a

142 polymerases in employing a protein-template-directed mechanism of DNA synthesis opposite undamaged a

143 00 mg twice daily]) in addition to guideline-directed medical therapy.

144 , we report the synthesis of four surfactant-directed mesoporous silica nanoparticle structures, incl

145 Using directed microbial culture techniques, we discovered Clo

146 Cytoplasmic dynein is an enormous minus end-directed microtubule motor.

147 utants result from a decrease in animal pole-directed migration and are independent of endoderm.

148 Directed migration by contact guidance is a poorly under

149 ctic process, the mechanisms controlling the directed migration of slow-moving mesenchymal cells such

150 ased, knowledge-based, and experimental data-directed modeling for RNA structures and explore the new

151 AL patients who received daratumumab, a CD38-directed monoclonal antibody approved for the treatment

152 ompared to controls, energetic resources are directed more toward somatic maintenance and proteostasi

153 of vesicle mobility, and specifically of the directed motion component, is the predominant activity-e

154 reveals that the dimer's dynamics in either directed motion mode resembles a limit cycle attractor t

155 Using the directed motion of particles induced by exposure to CO2,

156 the vibration, the dimer undergoes either a directed motion toward the small (or large) grain-filled

157 ion, accompanied by corresponding changes in directed motion.

158 wever, the functional necessity of minus-end-directed movement along actin is unclear as the underlyi

159 ant of MYO6, MYO6+, which undergoes plus-end-directed movement while retaining physiological cargo in

160 Therefore, we suggest that the directed movements are a response to the physical arrang

161 e polymers in the substrate and refer to the directed movements as polymertropism.

162 Sensorimotor integration regulates goal-directed movements.

163 data and a catalytic model supported by site-directed mutagenesis allows full comparison with dicot C

164 We have carried out an extensive site-directed mutagenesis analysis of the CD16A receptor comp

165 relocated by pressure was validated by site-directed mutagenesis and by inhibition by small peptides

166 acids, which can be altered readily by site-directed mutagenesis and expressed in vitro and in vivo,

167 Site-directed mutagenesis and gene rescue studies show that A

168 By site-directed mutagenesis and structure-guided analyses, we d

169 ochondrial function, as demonstrated by site-directed mutagenesis and use of STAT3 knockout and mitoc

170 ive structure-activity relationship and site-directed mutagenesis data facilitates the prediction of

171 cysteines within the mature peptide and site-directed mutagenesis experiments demonstrated that the f

172 Molecular modeling and site-directed mutagenesis implicate several residues around t

173 ilization of the coiled-coil domains by site-directed mutagenesis increases the effective diffusivity

174 Site-directed mutagenesis indicates that tyrosine 645 in this

175 spectroscopy, heme quantification, and site-directed mutagenesis of histidine residues, we demonstra

176 Site directed mutagenesis of lysine 68 to glutamine (K68Q), m

177 Site-directed mutagenesis of PxaTPS8 revealed several catalyt

178 Site-directed mutagenesis of RadH was used to identify cataly

179 Site-directed mutagenesis of RCAR1 showed that its tyrosine r

180 Further, site directed mutagenesis of the miR-134 binding site in Sabi

181 Site-directed mutagenesis of the phytaspase cleavage sites in

182 Site-directed mutagenesis revealed that GRK2 Ser-685 phosphor

183 Extensive site-directed mutagenesis studies supported the importance of

184 cDNAs were constructed by site-directed mutagenesis that encode PORB mutant proteins wi

185 Furthermore, we show by site-directed mutagenesis that tyrosine (Y382-384) within the

186 Site-directed mutagenesis was performed by partial gene synth

187 ping was performed by pepscan analysis, site-directed mutagenesis, and hydrogen/deuterium exchange-ma

188 crystal structures, molecular docking, site-directed mutagenesis, and kinetic and thermodynamic anal

189 By combining site-directed mutagenesis, biochemical assays, and spectrosco

190 Using site-directed mutagenesis, kinetic assays, and quantitative m

191 its implications for heme transfer via site-directed mutagenesis, resonance Raman (RR), hydrogen-deu

192 ected patients (n = 168), together with site-directed mutagenesis, revealed Nef position 9 as a subty

193 combination of in silico prediction and site-directed mutagenesis, we have mapped an exosite to a non

194 uch as targeted genome modification and site-directed mutagenesis.

195 ants on both allergens was performed by site-directed mutagenesis.

196 of these binding sites was confirmed by site-directed mutagenesis.

197 site in the ion pore that we confirm by site-directed mutagenesis.

198 ype 2a-derived HCV clone (Jc1Gluc2A) by site-directed mutagenesis.

199 substituted by a cysteine codon through site-directed mutagenesis.

200 ysis of transposase proteins containing site-directed mutations revealed the importance of the conser

201 t cryo-EM structures of the unique minus-end directed myosin VI motor domain in rigor (4.6 A) and Mg-

202 -CoV S ectodomain in complex with G4, a stem-directed neutralizing antibody.

203 An in vitro CRISPR/Cas9 RNA-directed nickase system directs the specific labeling of

204 nthesis of atropisomeric biaryls by a cation-directed O-alkylation.

205 le turbulence in a channel coincide with the directed percolation universality class.

206 patial map stability and the absence of goal-directed place cell reorganization.

207 Template-directed polymerization reactions enable the accurate st

208 ing engages both attentional habits and goal-directed processes in parallel.

209 show that both habit-like attention and goal-directed processes occur in the same learning episode at

210 observed corresponding to habitual and goal-directed processes.

211 nsume free energy to break symmetry and make directed progress.

212 by MRSA status suggests that MRSA-screening-directed prophylaxis may optimize benefits while minimiz

213 d on available evidence in administering CNS-directed prophylaxis.

214 Ubiquitination-directed proteasomal degradation of synaptic proteins, p

215 somes and validated these structures by site-directed protein cross-linking and hydroxyl radical foot

216 ter periclinal cell face, pointing to a cell-directed, rather than self-organizing, mechanism for spe

217 ng) and with progression on two or more HER2-directed regimens in the advanced setting.

218 A copper-mediated picolinamide directed regioselective cross-coupling of naphthylamines

219 RAD51 promotes homology-directed repair (HDR), replication fork reversal, and st

220 Homology-directed repair and non-homologous end joining (NHEJ) ar

221 9-based targeting accuracy and high homology-directed repair efficiency by activating an endogenous,

222 indromic repeats/CRISPR-associated) homology-directed repair gene-editing.

223 that LbCpf1 significantly increases homology-directed repair in zebrafish, improving current approach

224 it is considered that noncanonical homology-directed repair regulates the SNGD-mediated gene editing

225 anded oligodeoxynucleotide-mediated homology-directed repair revealed that insulin signaling is up-re

226 y, only environmentally driven, but not self-directed, repetitive behaviors were exacerbated in lesio

227 me conditioning caused a later decay in goal-directed responding-that is, mice were unable to select

228 ns of the contralateral amygdala impede goal-directed response selection, implicating BDNF-expressing

229 Rho-kinase inhibition also rescues goal-directed response strategies, linking neural remodeling

230 infection with T. gondii on the innate virus-directed responses of human pDCs.

231 Despite increasing interest in goal-directed, restricted-volume fluid administration for maj

232 siologic consequences of automated, endpoint-directed resuscitation systems and compare them to formu

233 Here, we apply the approach of site-directed RNA editing to repair, at the mRNA level, a dis

234 presence of adenine, projection of the SHAPE-directed sampling correctly identified the on-conformati

235 modification, and point to necessary future directed sensory experiments needed to resolve the possi

236 standard test for microbial diagnosis, with directed serological testing (i.e., Q fever serology, Ba

237 Moreover, AMPK-directed SIRT1 phosphorylation is required for energy st

238 d a method for palladium-catalyzed, pyrazole-directed sp(3) C-H bond arylation by aryl iodides.

239 disoriented mice performed a classical goal-directed spatial memory task in a rectangular chamber.

240 onance spectroscopy in combination with site-directed spin labeling, we show that familial PD-associa

241 diagnosis, targeted drug and gene delivery, directed stem cell differentiation, accelerated tissue f

242 The most unique feature of the sheets is DNA-directed surface addressability, which is demonstrated t

243 ent chemotherapy alone, 850 underwent cancer-directed surgery alone, 988 underwent surgery with chemo

244 survival after treatment of MPM with cancer-directed surgery and to explore the effect surgery inter

245 wn a survival advantage to undergoing cancer-directed surgery for malignant pleural mesothelioma (MPM

246 Cancer-directed surgery, chemotherapy, and radiation therapy we

247 An unprecedented solvent-directed "switch" both in helical pattern and handedness

248 and microbiota suggests a mechanism of host-directed symbiosis throughout development.

249 Suppression depends on RelA-directed synthesis of (p)ppGpp, a signalling molecule th

250 DNA hybrid four-way junctions or by template-directed synthesis with a single-stranded DNA (ssDNA) to

251 sses given the utility of sulfides in target-directed synthesis.

252 y produced variants, while others are making directed, systematic chemical improvements on publically

253 Unfortunately, the B lymphocyte-directed T1D interventions tested to date failed to halt

254 Further, Cas9-directed tethering of mutant LDB1 to the beta-globin pro

255 tent inhibitors could lead to promising host-directed therapeutic adjuvants for tuberculosis treatmen

256 ug leads, identified as clues for Complement-directed therapeutic development, are assembled here tog

257 of CSF leukocytes could guide possible host-directed therapeutic strategies in TBM.

258 n macrophages and indicates a potential host-directed therapeutic target to limit the damaging inflam

259 tial challenge for the effective use of EGFR-directed therapeutics.

260 l growth, suggesting a new strategy for host-directed therapies against tuberculosis.

261 ing therapies may be useful adjunctive, host-directed therapies for TB.

262 tically enhanced anti-tumour effects of EGFR-directed therapies including erlotinib.

263 Retrospective data indicate prophylactic CNS-directed therapies may reduce the risk of CNS involvemen

264 s in cellular signaling pathways amenable to directed therapies.

265 Odds ratio (OR) assessment for AID-directed therapies.

266 etrospective studies suggest that metastasis-directed therapy (MDT) for oligorecurrent prostate cance

267 10b may serve as a potential target for host-directed therapy aimed at manipulating host immunity aga

268 ith mortality differences between early goal-directed therapy and control included Acute Physiology a

269 ho required acute volume resuscitation, goal-directed therapy guided by assessment of fluid responsiv

270 Early goal-directed therapy has shown discordant survival outcomes

271 athways are potential novel targets for host directed therapy in CNS TB.

272 Adjunctive host-directed therapy is therefore believed to be the only op

273 suggest that additional augmentation of CNS-directed therapy is warranted for CNS2 disease.

274 Early goal-directed therapy was associated with increased mortality

275 codes plus two treatment codes for any skin-directed therapy were likely to accurately identify pati

276 Stiff nonviable cells directed through the channel are compressed and translat

277 A clinically directed tiered testing strategy can increase sensitivit

278 ns based on sociality (how much an action is directed to another person) in proximity to person knowl

279 Initiatives directed to certain strategic and infrastructure priorit

280 or of mitochondrial movements in neurons, is directed to mitochondria of tumor cells.

281 CI is directed to PDs through its interaction with P3N-PIPO.

282 Current efforts are directed to reducing the gut dysbiosis and inflammation

283 T-cell receptor (TCR) repertoires directed to some immunodominant gluten peptides have pre

284 d congenital hemophilia A (HA) are primarily directed to the A2 and C2 domains.

285 nality, where the majority of dendrimers are directed to the endo-lysosomal compartments in both cell

286 les in the gray-matter, limited research was directed to the functional organization of the white-mat

287 Furthermore, deep brain stimulation directed to the interposed cerebellar nuclei reduced dys

288 onal, computational, and structural findings directed toward elucidating the molecular factors that d

289 fic alterations, additional testing is often directed toward identifying lines of differentiation and

290 omes, organizational interventions should be directed toward improving nurse work environments.

291 areas advantageous or obtrusive to function directed toward speech and language at a given moment.

292 h outcomes highlight a need for more support directed toward spouses bereaved by suicide.

293 By tuning the temperature, vesicles can be directed towards hot or cold, forming a highly concentra

294 Wound healing is a biological process directed towards restoration of tissue that has suffered

295 Recent research has been directed towards the potential association of vitamin D

296 e, a hallmark of cell polarization to ensure directed trafficking of promigratory factors.

297 Directed transport of biological species across the surf

298 dynein binding to APC to stimulate minus end-directed transport, which could modulate endocytic and s

299 anial pressure plus brain tissue oxygenation-directed treatment of severe traumatic brain injury is w

300 ic interventions and develop alternative CNS-directed treatment strategies.