ライフサイエンスコーパス: directly

1 ess people's conceptions of mental life more directly.

2 uld help them communicate with patients more directly.

3 ability of arbitrary qubit pairs to interact directly.

4 n inhibitory and excitatory spiking activity directly.

5 Treatment as Prevention (TasP) using directly-acting antivirals has been advocated for Hepati

6 We therefore hypothesize that ECs can directly activate basophils via cell-to-cell interaction

7 GABAA receptors can be directly activated and potentiated by the intravenous an

8 parallel, activation of the exchange protein directly activated by cAMP (Epac) provokes inhibition of

9 exchange protein directly activated by cAMP) directly activated by cAMP Epac pathways in the effects

10 cGMP/PKG and cAMP/PKA/Epac (exchange protein directly activated by cAMP) directly activated by cAMP E

11 ated in diseased skin and these autoantigens directly activated CD1b-autoreactive HJ1 T cells.

12 sinogen activation in acinar cells, and CTSD directly activated CTSB but not trypsinogen in vitro Dur

13 ddition to releasing bradykinin from HK, Kal directly activated monocytes to produce proinflammatory

14 We show that PHA-4 directly activates mRNA expression of a broad cohort of

15 the development of new methodologies to more directly address this problem and as a result in the dev

16 rces up to May 30, 2016 to find studies that directly addressed either outcome and any causality dime

17 rkedly increased expression of LCE3A, a gene directly adjacent to LCE3B/C-del.

18 find that tubulin acetylation alone does not directly affect kinesin-1 motility.

19 AXL signaling has been shown to directly affect the mesenchymal state and confer it with

20 Telomerase enzymatic activity was not directly affected by BRD4 inhibition.

21 the first evidence that the caspases may be directly affected by O-GlcNAcylation as a potential anti

22 hin the pancreas slice, CCK cellular actions directly affected human acinar cells.

23 a risk through excessive sIgE production and directly affected impaired lung function.

24 Physiologists have long known that CO2 directly affects acid-base and ion regulation, respirato

25 pping the cell cycle in detail, we show that directly after replication both chromosomal origin regio

26 Yet, advances directly along the patent-paper boundary are notably mor

27 We note that some facultative symbionts directly alter host thermotolerance.

28 ed in about half (60/110) and management was directly altered in nearly a quarter (26/110) of familie

29 ese results indicate that knockdown of Sin3A directly alters the expression of methionine metabolic g

30 assays revealed Abl phosphorylates Mical to directly amplify Mical Redox-mediated F-actin disassembl

31 2-AG or AEA activate NPR-19 directly and cannabinoid-dependent inhibition can be res

32 -domain, which represses Lhb gene expression directly and does not catalyze 5hmC at the gene promoter

33 ut also by clever genetic manipulations that directly and easily tested specific hypotheses.

34 sian framework accounting for these features directly and employ Markov chain Monte Carlo techniques

35 ss the progesterone receptor (PR), which can directly and globally modify ER action to attenuate tumo

36 We therefore conclude that PTH1R signaling directly and indirectly regulates the paracellular Ca(2+

37 blue light percentage were obtained for both directly and not directly light-dependent metabolite gro

38 in 5 receptor alpha monoclonal antibody that directly and rapidly depletes eosinophils, reduces asthm

39 ed diabetogenic CD8(+) T-cell responses both directly and through an intermediary nonlymphoid cell po

40 pecificity (MAKS) to identify the substrates directly and to map the phosphorylation site(s) of plant

41 re new genetic material from other organisms directly and via the environment.

42 lcium cycling, presenting the possibility to directly assess the functional impact of structural remo

43 voked potentials via electrocorticography to directly assess the responses to individual stimuli and

44 howing that 25-62% of total reactive iron is directly associated to OC through inner-sphere complexat

45 However, one group of germline genes, not directly associated with embryonic somatic tissue genesi

46 erence in usual 24-hour sodium excretion was directly associated with systolic (4.58 mm Hg; 95% confi

47 , but not the commercial mix (CAF), and were directly associated with their antioxidant activities.

48 of myopia with ultraviolet B radiation (UVB; directly associated with time outdoors and sunlight expo

49 ightened attentional selectivity, can become directly associated with, and subsequently retrieved by,

50 ter at the apical side of the inner segment, directly below the outer segment.

51 eatures, which have no prior melted material directly beneath them.

52 try techniques, we show that these molecules directly bind to two distinct sites of the SMN2 pre-mRNA

53 hit that subsequent in vitro analysis showed directly binds and inhibits purified ppGalNAc-T3 with no

54 In vitro, Polo directly binds and is required for Nuf phosphorylation a

55 In vitro studies demonstrate that Ofd1 directly binds Rps23, Nro1, and Sre1 through a consensus

56 We showed that rigosertib indeed directly binds to and destabilizes microtubules using ce

57 in Gaucher cells through the action of GBA2, directly binds to GBA2 and inhibits its activity.

58 that the DGC component dystroglycan 1 (Dag1) directly binds to the Hippo pathway effector Yap to inhi

59 The simplest robot can be directly built from the widely used Lego Education EV3 c

60 tions because the complexes are not observed directly, but rather leave a "covalent record" of the in

61 ion that allows this short motif to be bound directly by both CPSF-30 and WDR33.

62 east examination may improve early diagnosis directly by finding breast cancers at earlier stages or

63 Alternatively, 4(*) may also be synthesized directly by reaction of 1 with sulfur (in a 1:4 ratio) i

64 orests impact regional hydrology and climate directly by regulating water and heat fluxes.

65 suggest that drug nanocrystals were taken up directly by the cells, and subsequently dissolved in the

66 in part to decreased transcription mediated directly by the intronic region containing the rs7554511

67 ange can influence consumer populations both directly, by affecting survival and reproduction, and in

68 We developed a method to directly capture lipid antigens within CD1d-lipid-TCR co

69 te carrying a canonical coding sequence, can directly cause gene repression.

70 The one channel flow-cell is attached and directly changeable with electrode.

71 here the nuclease activity of MRN apparently directly cleaves the 5' strand DNA at more distal sites.

72 oval by fishes on some Singaporean reefs was directly comparable to rates reported for other inshore

73 -separated state indicates that the yield is directly comparable to that of WL-PSI.

74 independent of additional information is to directly compare unidentified tandem mass spectra.

75 We directly compared all 4 hs-cTnI-based rule-out strategie

76 w the efficacy of different candidates to be directly compared and determine the minimal antibody tit

77 ure DMPC and DMPC/cholesterol mixtures, thus directly confirming the theoretical method, and (ii) to

78 The extent of this damage directly confounds the determination of somatic variants

79 The kinase inhibitor crizotinib was directly conjugated to Dha through its piperidine motif,

80 pends on epidermal cellular protrusions that directly contact pObs only where an otherwise occluding

81 rm an intramolecular Hoogsteen base pair and directly contact WDR33.

82 Moreover, we find that She1 directly contacts the microtubule-binding domain of dyne

83 Whether these risk factors directly contribute to brain amyloid deposition is less

84 that HBD2 and HBD3 are secreted by hCVAM and directly contribute to its activity against P. aeruginos

85 e as more than a proximate mechanism that is directly controlled by genes.

86 een nearest-neighbor magnetic moments can be directly controlled, thus allowing versatile tuning of g

87 Moreover, it directly controls the sensitivity to curvature stress.

88 als in the surface-bound state were found to directly correlate with cyclic voltammetry data in aqueo

89 Inflammation was not directly correlated with distance to the healthy plane,

90 The improvements in potency directly correlated with target tubulin binding affinity

91 l and Tafel slope for catalytic HER are both directly correlated with the electron donating strength

92 Loss and gain of IL-10RA expression directly correlates with IEC barrier formation and butyr

93 te that the microporosity of molecular cages directly correlates with shape persistence.

94 acancies, especially their distribution, are directly coupled to the electromagnetic properties of ox

95 oliferation, reduced cell viability, and was directly cytotoxic, whereas the exposure of cells to equ

96 of Jebel Irhoud contains one of the earliest directly dated Middle Stone Age assemblages, and its ass

97 base pairs, their conformation could not be directly deduced from the experimental data, and alterna

98 h complements available prodrugs/donors that directly deliver a single species, including hydrogen su

99 a-high frequency ultrasound over 150 MHz can directly deliver gene and proteins into cytoplasm withou

100 ilament that extends across the periplasm to directly deliver lipopolysaccharide into the external le

101 We directly demonstrate that PCO dioxygenase activity produ

102 coccus lactis and in reconstituted liposomes directly demonstrated that SLC25A3 functions as a copper

103 s this failed to occur in Chdh(-/-) oocytes, directly demonstrating a requirement for CHDH for betain

104 The ability to directly detect double-stranded DNA (dsDNA) without sequ

105 only trace hydrogen levels when photoexcited directly, does not appear to independently sustain appre

106 BioGRID data are directly downloadable without restriction in a variety o

107 insulin secretion by beta cells, whether it directly engages nutrient signaling pathways in skeletal

108 rt an alternative grafting-from strategy for directly engineering the surfaces of live yeast and mamm

109 human, fly, and yeast profilin homologs all directly enhance microtubule growth rate by several-fold

110 e that overexpression or knockdown of RanBP9 directly enhances and reduces tau levels, respectively,

111 In vitro, purified RPA directly enhances the association of RNaseH1 with RNA:DN

112 that interactions with microbes that do not directly enter leaf epidermal cells were seemingly unalt

113 se chain reaction (dPCR) end point platforms directly estimate the number of DNA target copies per re

114 al-induced proximity assay, we find that BAF directly evicts Polycomb factors within minutes of its o

115 ramers, stained peripheral blood lymphocytes directly ex vivo, and show DQ8(+) patients with T1D have

116 and BAF values (0.05) obtained for the snail directly exposed to contaminated soil were lower than tr

117 ough the piezotronic effect from the ZPS and directly expressed by color changes in the ECD.

118 e reconstruct a map-like knowledge structure directly from a hippocampal-entorhinal functional magnet

119 Alternatively, N-Cl-DCAM can be produced directly from DCAN chlorination via nucleophilic additio

120 The formulation of nanoparticles directly from functional peptides would therefore offer

121 resent a pipeline for developing STR markers directly from high-throughput shotgun sequencing data wi

122 ies used as bait to identify viral sequences directly from metagenomic assemblies.

123 howed the assay can rapidly detect H3N2 IAVs directly from nasal wash or nasal swab samples collected

124 onstrate a low-cost method of DNA extraction directly from patient samples for M. tuberculosis WGS.

125 anate wine, vinegar, and sour sauce obtained directly from pomegranate juice are included in this rev

126 aIMP, blaKPC, blaNDM, blaOXA-48, and blaVIM) directly from rectal swab specimens.

127 concentration could in many cases be derived directly from relative emission intensity and lifetime.

128 storable fuel (e.g., hydrogen and methanol) directly from sunlight, water and CO2.

129 46/100 patients were discharged directly from the ED, of which 87% received further medi

130 Gamma frequency activity can be recorded directly from the human brain using intracranial electro

131 duction system of the Calabrian Arc, derived directly from the lower plate.

132 bility of extracting rheological information directly from traction data.

133 impact of producing the loaf of bread arises directly from wheat cultivation, with the use of ammoniu

134 mentation assays, the reporter fragments are directly fused to the interacting proteins, eliminating

135 mbled bilayers offer a promising strategy to directly harness photon upconversion via triplet-triplet

136 hese two epitopes, for the first time, to be directly identified on the polylactosamines of N-glycans

137 hemia, little is known about whether T cells directly impact cardiac fibroblasts (CFBs) to promote ca

138 roteases derived from commensal bacteria can directly impact the excitability of DRG neurons, through

139 he effect of seminal fluid on sperm velocity directly impacts paternity share and therefore reproduct

140 Our results suggest that BDV directly impacts the kynurenine pathway, an effect that

141 To confirm whether Pseudomonas species directly impair wound healing, wild-type mice were infec

142 n adaptor, is related to BicD2 and binds RZZ directly in a farnesylation-dependent but membrane-indep

143 s not been possible to map vibrational modes directly in a single nanostructure, limiting our underst

144 dG adducts have rarely if ever been observed directly in human samples using LC-MS techniques, even t

145 ent comes the ability to deploy E-AB sensors directly in situ in the veins of live animals, achieving

146 ssipated by oxidation reactions and measured directly in water-in-oil emulsions, in isothermal condit

147 s) formed under intracellular stress seem to directly induce apoptotic activity at the MOM.

148 This suggests CIRP directly induces ER stress via TLR4 activation.

149 Dysthyroidism may directly influence corneal biomechanics and represents a

150 rachromosomal interactions (hic_strength) is directly influenced by only four types of factors: dista

151 ores of coal matrix, the nano-pore structure directly influences gas storage and transport properties

152 There are currently no therapies to directly inhibit hepatic fibrosis.

153 Furthermore, EPO directly inhibited conventional T cell proliferation in

154 We find that uric acid directly inhibits uridine monophosphate synthase (UMPS)

155 l histone proteins, human intact NETs do not directly initiate or amplify coagulation in vitro.

156 system, here we show that the Dna2 nuclease directly initiates the resection of clean DSBs by cleavi

157 Here we demonstrate that cortical neurons directly innervate the brainstem to drive feedforward in

158 hotonic devices and functional microelements directly inside silicon chips.

159 domain of these transcription factors could directly interact with an NACbs, and the proteins failed

160 Correspondingly, TRIP13 was found to directly interact with Tetratricopeptide Repeat Domain 5

161 Polbeta directly interacted functionally with the mitochondrial

162 ontaining exocytic or endosomal Q-SNAREs and directly interacted with late endosomal SNARE complexes.

163 ol (SI) is a potential therapeutic for AD by directly interacting with the Abeta peptide to inhibit A

164 f ASK1 activation, and we found that TNFAIP3 directly interacts with and deubiquitinates ASK1 in hepa

165 Moreover, M1BP directly interacts with TRF2 to recruit it to the RP gen

166 increases dramatically after fertilization, directly interacts with, and relieves the inhibitory fun

167 Introducing Gbetagamma subunits directly into cones reduced EPSC amplitude.

168 Of this liberated Hg, 470 Gg were emitted directly into the atmosphere, and 74% of the air emissio

169 to transform the trichloroacetamide product directly into the corresponding amine, carbamate, and ur

170 nteract with fewer blood cells when injected directly into the vasculature or diluted into blood from

171 or if mothers avoided peanuts themselves but directly introduced peanuts by 12 months (17.6%).

172 We therefore sought to directly investigate GFAP turnover in a mouse model of A

173 Here, we directly investigate the effect of major spatio-temporal

174 However, few studies have directly investigated the role of prenatal cytokine and

175 IL-1alpha was directly involved in IL-8 production and likely contribu

176 lexes, wherein only a single metal center is directly involved in the catalysis.

177 peptides, and we observed that IFN-beta can directly kill Staphylococcus aureus Further, a mutant S.

178 tage were obtained for both directly and not directly light-dependent metabolite groups.

179 ptor tyrosine kinase at the cell surface and directly measure binding and dissociation of signalling

180 Rapid ultracentrifugation was used to directly measure LDL-C content (LDL-CD).

181 nsation between vapor and ice has never been directly measured at temperatures below 233 K (-40 degre

182 to be quickly and accurately changed, while directly measuring the droplet size allows the user to d

183 Here, we utilize three assays directly measuring the rates of mRNA and tRNA release an

184 The prepared NMP were directly mixed 20% w/v poly(vinyl pyrrolidone) (PVP) gel

185 indicates that pro-inflammatory markers can directly modulate affective behavior.

186 ch posits that top-down beta-band influences directly modulate bottom-up gamma band influences via cr

187 Conversely, stem cells are also able to directly modulate the immune response through the produc

188 Here, we directly monitor RNA proof-reading by RIG-I and we show

189 We describe a cellular reporter to directly monitor the phenotypic switch in drug-resistant

190 ultrasound examination displaying the image directly next to the transducer.

191 work models in removing the requirement of a directly observable Boolean state vector and allowing un

192 igh-resolution single-molecule microscopy to directly observe the stepping behavior of kinesin-1 and

193 erculosis (LTBI) regimen, 12 weekly doses of directly observed isoniazid and rifapentine (3HP), is as

194 n predicted for a long time, it has not been directly observed on polycrystalline silver films which

195 set of lignin-derived phenols, is performed directly on 15 mL of water sample in a microwave digesti

196 at targeting cytokine overactivity that act directly on brain function and/or treatment in early-sta

197 and anti-inflammatory properties, which acts directly on cancer cells to promote their survival and p

198 arch strategy, EigenTHREADER does not depend directly on sequence homology between the target protein

199 ere seen in 26% of MTBDRplus tests performed directly on sputum.

200 a need for high throughput sequence analysis directly on surfaces.

201 nning and modifying E. coli metabolic models directly on the EcoCyc website.

202 ification Emission, a THz field is generated directly on the surface via surface optical rectificatio

203 ic material and performed multiplexed SP-PCR directly on top of the SAF microlens array.

204 lly fledged scientific applications that run directly on web browsers.

205 Thus, human genes may influence health directly or by promoting a beneficial microbiome.

206 so be prepared to manage late effects either directly or by referral to appropriate specialists.

207 uctance is regulated by diverse stimuli that directly or indirectly gate the channel selectivity filt

208 suggest that therapeutic regulatory T cells directly or indirectly regulate their influx by altering

209 We have identified 39 proteins that interact directly or indirectly with high confidence with chlorop

210 c restorative materials, or fillings, do not directly participate in the healing process in a bioinst

211 only acts as an endocytic receptor but also directly participates in gene transcription.

212 Pkc1 directly phosphorylates Cdc55 and Igo/ENSA, and phosphor

213 Importantly, activated AKT directly phosphorylates FAF1 at Ser 582, which disrupts

214 igation assay (Duolink) indicated that PTPRO directly physically interacted with ERBB2.

215 NETs have been reported to directly promote thrombosis in animal models.

216 Addition of FSD-C10 directly promoted remyelination in a chemical-induced de

217 The measured units were directly proportional to the number of leukocytes in the

218 Intriguingly, we discovered that TrxR1/NADPH directly protects PTP1B from inactivation when present d

219 mediated electrochemical reduction (MER) to directly quantify the extents and rates of ferrihydrite,

220 Five of the individuals (directly radiocarbon dated to a time transect spanning t

221 Two "first-generation," directly radiolabeled anti-CD20 antibodies, (131)iodine-

222 " (LIDS), movement patterns are exposed that directly reflect ultradian sleep cycles and replicate th

223 e, the representation of intonation contours directly reflected the encoding of speaker-normalized re

224 when the density decreases, territories are directly reformed from the school.

225 However, whether metabolic changes directly regulate cancer development and progression rem

226 ecent evidence indicates that oncogenes also directly regulate immune responses, leading to immunosup

227 of PAI-1 is mediated through its ability to directly regulate urokinase -mediated activation of plas

228 gene critical for midfacial development, is directly regulated by Af10-dependent H3K79me, and expres

229 ue production by planarian stem cells is not directly regulated by the absence of the eye itself.

230 t PTEN interacts with DAXX and, in turn PTEN directly regulates oncogene expression by modulating DAX

231 storing the abundance of NAD(+) Thus, NAD(+) directly regulates protein-protein interactions, the mod

232 potential miR-1 targets revealed that miR-1 directly regulates the 3'UTR of the E3 ubiquitin ligase

233 inhibit ToxT, the transcription factor that directly regulates the two primary V. cholerae virulence

234 ivation of the transmembrane receptor NOTCH1 directly regulates vascular barrier function through a n

235 Twenty-two activities were categorized as directly related to patients, indirectly related to pati

236 tandard activation enthalpy and entropy, are directly related to the reference temperature and Z-valu

237 freezing efficiencies of the monolayers are directly related to their free energy of binding to ice.

238 siastic agreement that experimental data are directly relevant for determining grammar architecture,

239 Interestingly, CadC also directly represses lspB, a gene encoding a lipoprotein s

240 We previously generated directly reprogrammed induced cardiomyocyte-like cells (

241 with purified Vps13p, we show that Vps13p is directly required both for transport from the trans-Golg

242 Whether cPLA2alpha is directly responsible for neutrophil synthesis of LTB4 in

243 from large-scale European population panels (directly sequenced and imputation based).

244 the absence of KCNE1, S140G, but not V141M, directly slows voltage sensor movement, which indirectly

245 es qualities of their evidence, not observed directly, socially accessible.

246 ed amino acid residues are important both to directly stabilize the A1-GpIbalpha complex and to indir

247 ed by CO2 , consistent with reports that CO2 directly stimulates adenylyl cyclase.

248 he first time, a backbone-degradable polymer directly synthesized via CVD.

249 NSC-370284 and UC-514321 both directly target STAT3/5, transcriptional activators of T

250 83, the human ortholog of miR-263a, can also directly target the expressions of all three subunits of

251 We proved that it was directly targeted by miR-124-3p with a luciferase report

252 miR-18a directly targeted Smad4, Hif1a, and Rora, all key transc

253 y, miR-520f inhibited tumor cell invasion by directly targeting ADAM9, the TGFbeta receptor TGFBR2 an

254 m pathway, and identified miR-193a-3p, which directly targets KRas.

255 preference/reinstatement paradigm in mice to directly test the hypothesis that corticosterone potenti

256 text pre-exposure facilitation, allows us to directly test the relationship between novelty-induced a

257 mportance of these factors, few studies have directly tested their effects on performance at range li

258 Directly tethering Drp1 to the MOM bypasses the need for

259 measurements in the Kondo regime, we uncover directly the charge dynamics of this peculiar mechanism

260 Leukocytes and pathogens can pass directly through the endothelium by opening holes in end

261 oretic dye delivery from a suction electrode directly through the neuronal sheath of nerves and gangl

262 beled with (68)Ga by adding generator eluate directly to a vial containing the cold precursors THP-PS

263 cognition system that allows them to respond directly to allogeneic grafts is a topic of much debate.

264 , our results further show that MUC1-C binds directly to BMI1 and promotes occupancy of BMI1 on the C

265 tive-free method of conversion of haloarenes directly to boronic acids and esters.

266 sitive to all errors, and cannot be compared directly to diamond norm thresholds.

267 ed 91 minutes sooner if patients were routed directly to endovascular-capable centers.

268 therian mammal which, in the opossum, leads directly to parturition.

269 ot fully understood how WRN deficiency leads directly to telomere dysfunction.

270 We fit the model directly to the acquired pause-time and run-time distrib

271 -mediated innate immune response contributes directly to the development of Alzheimer's disease.

272 stence and safety of MtbDeltasigH, delivered directly to the lungs, in the setting of HIV co-infectio

273 ted proteins and show that this region binds directly to the rDNA-associated protein Csm1.

274 gent synaptic connections did not contribute directly to the vast majority of synchronized signals.

275 t astrocyte conditioned medium (ACM) applied directly to tumor cells increased tumor cell velocity, i

276 gesting that increases in photosynthesis are directly translated into yield at subambient levels of C

277 ned antitumor CD8(+) T-cell responses within directly treated tumors and proved safer and more effect

278 articular, saturated FAs (sFAs), are able to directly trigger macrophage cell death.

279 ly following doses lower than 100 mg, should directly undergo desensitization.

280 k remodeling is a host defense response that directly up-regulates production of keratin-derived AMPs

281 This influence can be exerted directly upon the primary motor (M1) and somatosensory (

282 DELLAs limit meristem size in Arabidopsis by directly upregulating the cell-cycle inhibitor KRP2 in t

283 intering were electrochemically anodized and directly used as photoanodes.

284 Testing of rectal swabs directly using the Xpert Carba-R assay is effective for

285 intravital serial imaging approach that can directly visualize drug response in an inducible RAF-dri

286 e used high-speed atomic force microscopy to directly visualize the membrane-insertion mechanism.

287 Two IN substitutions (T124N/T174I) directly weaken inhibitor binding at the dimer interface

288 , whereby this cluster was observed to react directly with a wide range of arenes in a step-wise and

289 resistant cell lines was found to correlate directly with an impact on Pgp-derived efflux.

290 taneous AT Tshb expression levels correlated directly with circulating cholesterol levels.

291 ncing (CLIP-seq) identify RNAs that interact directly with CsrA in vivo, while ribosome profiling and

292 nt of formation of genomic G4s may not track directly with G4 stability.

293 eir parent form, were conjugated quickly and directly with glutamic acid and glutamine, and further w

294 o the HAP2 fusion loop was found to interact directly with model membranes in a variety of biophysica

295 likely to motivate them to communicate more directly with patients, but many commented that changes

296 Cross-linking data were compared directly with the crystal structure of the isolated N-te

297 ivity assays, we showed that CML36 interacts directly with the regulative N terminus of the Arabidops

298 ovide evidence that the L1 protein interacts directly with viral DNA within the capsid.

299 Personal heat exposure can be measured directly with wearable monitors or estimated indirectly

300 neously detect glucose and fatty acid uptake directly within the tumor microenvironment.