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1 ized cells to FdUrd, especially when UNG was disabled.
2 te degradation of the sterol side chain, are disabled.
3 rying BDBV GP in which expression of sGP was disabled.
4 uanosine triphosphatase (GTPase) activity is disabled.
5 luenza virus replication when NS1 protein is disabled.
6 territory unless their pheromone-sensing is disabled.
7 Tachyarrhythmia functions were disabled.
8 globulin, but some respond poorly and remain disabled.
9 In some cases, the weakness was severely disabling.
10 isorder (PTSD) is prevalent, persistent, and disabling.
11 More than half of all strokes (52.3%) were disabling.
12 small subset of amacrine cells that express disabled-1 (Dab1) but lack expression of glycine transpo
15 e lacking REELIN or upon clonal depletion of DISABLED-1, which compromises the inside-out radial neur
20 this decoder is robust under conditions that disabled a state-of-the-art Kalman filter-based decoder.
21 p in starch synthesis, and the suc2 mutation disables a sucrose/proton symporter that facilitates suc
22 ploids, each carrying a different gene drive disabling a gene of interest, we are able to create dipl
23 nhanced the antiviral activity of RNase L by disabling a viral protein, NS1, that inhibits the activa
26 Stroke (SWIFT PRIME) trial in patients with disabling acute ischemic stroke who underwent endovascul
27 I, 0.57-0.85] for women) and from healthy to disabled (adjusted HR, 0.52 [95% CI, 0.44-0.61] for men
30 rying a Galphai2 (G184S/G184S) mutation that disables all RGS protein/Galphai2 interactions exhibit a
33 effect, but adding the tgd1 mutation, which disables an importer of lipids into plastids to create a
34 kov model to estimate the number of years of disabled and disability-free life and life-years lost by
35 he model estimates disability prevalence and disabled and disability-free life expectancy by year.
38 in schizophrenia because these symptoms are disabling and do not respond adequately to antipsychotic
39 sociated with neurotoxicity can be subtle or disabling and frequently include disturbances in memory,
40 (SCZ) and bipolar disorder (BP) are common, disabling and heritable psychiatric diseases with a comp
42 ritis is a chronic disease that results in a disabling and painful condition as it progresses to dest
51 se of short (<25 ms) laser pulses to kill or disable anesthetized female Anopheles stephensi mosquito
52 atory proteins for degradation, whereas Cdks disable APC/C-Cdh1 through phosphorylation of the Cdh1 a
53 therapy would have died or remained severely disabled at 12 months had maximal therapy been continued
54 s; P < .001), were more likely to be dead or disabled at discharge (77% vs 65% with modified Rankin S
55 tional rationale to profile human tumors for disabling ATM mutations, particularly given their impact
57 lin-associated glycoprotein) neuropathy is a disabling autoimmune peripheral neuropathy caused by mon
58 d1(-/-) mice, deregulated ATG4B activity and disabled autophagic flux cause accumulation of defective
59 6 (28%) glaucoma patients were classified as disabled based on NEI VFQ-25 results, whereas 169 (72%)
60 ial throat will significantly assist for the disabled, because the simple throat vibrations such as h
61 care administrative data for fee-for-service disabled beneficiaries 21 to 64 years of age who were al
63 e cohorts: (1) elderly born before 1945; (2) disabled born 1945-1965; and (3) disabled born after 196
68 type p53, p53 protein function is frequently disabled by the mouse double minute 2 protein (MDM2, or
69 nt forms with the VP35 IRAD and/or VP24 IRAD disabled, causes a global block in expression of host ge
76 in managing interference are at the core of disabling cognitive deficits in neuropsychiatric disorde
78 e alerted to the increased frequency of this disabling comorbidity, and the scientific community shou
82 (PTSD) is a common, frequently chronic, and disabling condition which, along with acute stress disor
85 generalised anxiety disorder) are common and disabling conditions that mostly begin during childhood,
91 roportion of MNS disorders run a chronic and disabling course and adversely affect household welfare,
92 hemic stroke management for any patient with disabling deficits presenting within 4.5 hours from symp
94 ents with newly diagnosed ALS and a severely disabling disease certificate between January 1, 2002, a
95 haemorrhagic telangiectasia type 2 (HHT2), a disabling disease characterized by excessive angiogenesi
96 ecognizing atopic dermatitis as a common and disabling disease not only in children but also in adult
98 DSM-5 DUD is a common, highly comorbid, and disabling disorder that largely goes untreated in the Un
99 eria is a highly prevalent, highly comorbid, disabling disorder that often goes untreated in the Unit
100 ss disorder (PTSD) is a prevalent and highly disabling disorder, but there is currently no targeted p
103 ehaviours, alleviate the severity of chronic disabling disorders, and mitigate the effects of socioec
104 nal sample of community-dwelling, nonelderly disabled dual enrollees with schizophrenia (n = 5554) or
109 However, differences in hemorrhagic stroke, disabling/fatal stroke, cardiovascular/unexplained death
114 age (ICH) is one of the most devastating and disabling forms of stroke, yet effective treatments are
115 d using a claims-based algorithm: nonelderly disabled, frail elderly, major complex chronic, minor co
116 fices to keep the gate of C1C2 closed and to disable free water and ion passage through the putative
117 umber of people affected by, or who remained disabled from, stroke has increased across the globe in
122 eous intracranial hypotension produce highly disabling headaches, and threaten vision, hearing, and i
123 015, approximately half a billion people had disabling hearing loss, about 6.8% of the world's popula
127 Here, we have identified the adaptor protein disabled homolog 2 (DAB2) as a regulator of phenotypic s
128 es in the expression levels of calreticulin, disabled homolog 2, NRF2, angiopoietin-2, and proteins i
132 ating lymphocytes that had been functionally disabled in the human renal cell carcinoma environment w
134 CU-containing complexes devoid of EMRE (thus disabled) in the mitochondrial but not the SR fraction.
138 studies, we generated replication-deficient (disabled infectious single-cycle [DISC]) virus strains f
139 are a hallmark of multiple sclerosis (MS), a disabling inflammatory disease of the central nervous sy
140 imately 80% of its chromosomal locations and disable its ability to promote induced pluripotent stem
141 s the PALB2-BRCA1 interaction and completely disables its abilities to promote HR and confer resistan
144 l in which we inactivated Cic by selectively disabling its DNA-binding activity, a mutation that caus
145 Background: The total time a patient is disabled likely has a greater influence on his or her qu
148 y hazardous use of opioids or overdose among disabled Medicare beneficiaries, a population particular
151 s (zero patients with moderately or severely disabling migraine attacks vs 37% [7 patients] in the pl
154 ed functional dependence (mRS score of 3-5), disabled (mRS score of 2-5), and mRS evaluated as a cont
156 mutant virus in which formation of PtDd was disabled (mut-Ad3GFP, where GFP is green fluorescent pro
157 hree myosins to cytokinesis using a severely disabled mutation of the essential myosin-II heavy-chain
159 Cas9 D10A protein, which contains a nuclease disabling mutation in one of the two nuclease domains of
167 espiratory pathogen Streptococcus pneumoniae disables neutrophils by exploiting molecular mimicry to
168 on of noradrenergic neurons may underlie the disabling nonmotor symptoms in patients with Parkinson d
169 sing a conditional mouse genetic approach to disable nonredundant subunits of mTORC1, mTORC2, or both
171 eactivation of latent herpesviruses requires disabling of repression, but the mechanism for convertin
175 s prominent if the deceased child was either disabled or an infant, suggesting sensitive periods of e
177 or upper gastrointestinal bleeds were mostly disabling or fatal (45 [62%] of 73 patients vs 101 [47%]
179 recurrent ischaemic stroke), and outnumbered disabling or fatal intracerebral haemorrhage (n=45 vs n=
180 (0.76, 0.63-0.92, p=0.005), particularly of disabling or fatal ischaemic stroke (0.64, 0.49-0.84, p=
181 o [HR] 0.42, 95% CI 0.32-0.55, p<0.0001) and disabling or fatal ischaemic stroke by about 70% (36 of
182 aspirin group with TIA or minor stroke had a disabling or fatal ischaemic stroke vs 23 of 5726 in the
183 mated NNT for routine PPI use to prevent one disabling or fatal upper gastrointestinal bleed over 5 y
185 nd the proportions of survivors with severe, disabling, or life-threatening chronic health conditions
186 nd the proportions of survivors with severe, disabling, or life-threatening chronic health conditions
195 not dNTPase activity (Q548A) and a mutation disabling phosphorylation (T592A) did not affect antivir
198 Posttraumatic stress disorder (PTSD) is a disabling psychiatric disorder common among military per
200 ANCE STATEMENT Schizophrenia is a profoundly disabling psychiatric illness with a devastating impact
201 Furthermore, a polymerase mutation that disables recombination renders the virus more susceptibl
203 uromyelitis optica (NMO) is characterized by disabling relapses of optic neuritis and myelitis and th
204 favorable, but some patients remain severely disabled, requiring long-term immunotherapy and/or antie
205 ations in NO Overexpression 1 (NOX1), led to disabled Resistance (R) gene-mediated protection, basal
206 he mechanism, we show that Tspan3 deficiency disabled responses to CXCL12/SDF-1 and led to defects in
207 ure thymocytes with a Galphai2 mutation that disables RGS protein binding accumulated in the perivasc
210 EEG study and 11 (52%) achieved freedom from disabling seizures with a mean duration of postoperative
211 f 11 patients with MTS achieved freedom from disabling seizures, whereas 3 (30 %) of 10 patients with
214 INTRODUCTION: Aphasia is one of the most disabling sequelae after stroke, occurring in 25%-40% of
215 report here the creation of pancreatogenesis-disabled sheep by oocyte microinjection of CRISPR/Cas9 t
217 shed in 1917 for war orphans and children of disabled soldiers, we were able to study the adult morta
218 truct with two covalently linked OB-folds to disable ssDNA binding in two of the four OB-folds thus p
221 ty (Lotus, 1.9%; ES3, 1.8%; P=0.87), rate of disabling stroke (Lotus, 1.5%; ES3, 2.1%; P=0.62), or ma
222 There were no significant differences for disabling stroke (S3 1.3% versus XT 3.1%, P=0.29) and al
223 nd point was a composite of survival free of disabling stroke (with disabling stroke indicated by a m
225 term functional outcome and risk of fatal or disabling stroke are similar for stenting and endarterec
227 t was a composite of death from any cause or disabling stroke at 24 months in patients undergoing att
229 e of survival free of disabling stroke (with disabling stroke indicated by a modified Rankin score >3
233 flow LVAD with respect to survival free from disabling stroke or device removal for malfunction or fa
234 end point was survival at 2 years free from disabling stroke or device removal for malfunction or fa
235 trial primary end point (survival free of a disabling stroke or reoperation to replace the pump for
236 t, TAVR resulted in a lower rate of death or disabling stroke than surgery (hazard ratio, 0.79; 95% C
238 d acute events, and long-term care following disabling stroke were presented in 2015 U.S. dollars.
240 had similar rate of the composite of death, disabling stroke, and myocardial infarction when compare
241 n-group differences in the rates of death or disabling stroke, but reoperation for pump malfunction w
247 5% in the transfemoral access subgroup), and disabling strokes had occurred in 24 (2%), aortic valve
250 rolled wearable robots to assist elderly and disabled subjects and to improve their quality of life.
252 WWP1 to Smad7, this functional interplay is disabled, switching its monoubiquitination activity towa
253 iotic mutants is a direct consequence of the disabled symbiosis pathway rather than an indirect effec
256 e necessary to understand the impact of this disabling symptom on the health care system and to ident
262 r, patients were community dwelling and less disabled than individuals of the same age in general.
263 Finally, we discuss prevention methods to disable the attack, thus providing a solution for enhanc
264 wed that targeting sCLU via miR-378 may help disable the chemoresistance against cisplatin in lung ad
268 disease where expanded CUG repeats bind and disable the muscleblind-like family of splice regulators
273 talloproteinase-directed processing of PTHrP disables the osteolytic functions of the mature hormone
274 over a strategy whereby a bacterial pathogen disables the plant immune system with such precision as
276 on represent a major mechanism by which EBOV disables the T cell response and suggests that these sup
277 On the contrary, p.R311C Tbx20 specifically disables the Tbx20 protranscriptional activity over KCNH
280 onstrated that DC maturation is unblocked by disabling the innate response antagonizing domains (IRAD
282 smonate, ethylene, PAD4, and salicylate, are disabled, the hypersensitive response (HR) typical of ET
284 gh vestibular disorders are common and often disabling, they remain difficult to diagnose and treat.
287 1 heteromers is governed by Tmem100 and that disabling Tmem100 may be a novel pharmacologic strategy
292 coriation (skin-picking) disorder (SPD) is a disabling, underrecognized condition in which individual
293 f its high prevalence, its capacity to cause disabling vascular complications, the emergence of new n
294 his strategy may be activated in phytochrome-disabling, vegetation-dense habitats to enhance survival
296 domain and the nucleotide binding domain is disabled when the conserved P417 residue is mutated.
299 sability onset and the number of healthy and disabled years lived by adults with and without diabetes
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