ライフサイエンスコーパス: disaggregation

1 and independently interfering with merozoite disaggregation.

2 is not primarily a result of binding, but of disaggregation.

3 eoligomerization is not required for protein disaggregation.

4 ave distinct activities in promoting protein disaggregation.

5 ation of aggregates in a state competent for disaggregation.

6 antitatively monitor protein aggregation and disaggregation.

7 04 with the mechanistic scaffold to catalyze disaggregation.

8 ously correlated to rates of aggregation and disaggregation.

9 of J-protein complexation and cooperation in disaggregation.

10 SSD1 is required for Hsp104-mediated protein disaggregation.

11 xhibited impaired aggregation accompanied by disaggregation.

12 were reflected in rapid cell aggregation and disaggregation.

13 machines involved in protein degradation and disaggregation.

14 oned normally in thermotolerance and protein disaggregation.

15 uction of HSP70, a feedback regulator of PRD disaggregation.

16 sponsive flexibility during Hsp104-catalyzed disaggregation.

17 atography were completely stable and gave no disaggregation.

18 , these chaperones cannot facilitate protein disaggregation.

19 l motion, which is indispensable for protein disaggregation.

20 limiting kinetic barrier in pressure-induced disaggregation.

21 ractions do not dominate pressure effects on disaggregation.

22 tic small-molecule drug that induces protein disaggregation.

23 f therapeutic agents for their prevention or disaggregation.

24 in aggregates targeted by metazoan Hsp70 for disaggregation.

25 rier formation close to the time of periderm disaggregation.

26 of molecular chaperones involved in protein disaggregation.

27 s inhibition of aggregation and promotion of disaggregation.

28 that blocks Abeta aggregation, and promotes disaggregation.

29 ending from nascent chain folding to protein disaggregation.

30 vbL complexes serve as chaperones in protein disaggregation.

31 l regulatory role of the ClpB NTD in protein disaggregation.

32 naK/Hsp70 system and ClpB/Hsp104 for protein disaggregation.

33 ently than Hsp104 requires Hsp70 for protein disaggregation.

34 egase activity and must separate for protein disaggregation.

35 tic roles of Hsp104 and Hsp70 during protein disaggregation.

36 ATP binding and hydrolysis to drive protein disaggregation.

37 able to cooperate with it to mediate protein disaggregation.

38 energy with its substrate proteins to drive disaggregation.

39 ial independence from the Hsp70 chaperone in disaggregation.

40 rimary wave of aggregation followed by rapid disaggregation.

41 es ClpB to inhibition and diminishes amyloid disaggregation.

42 Their disaggregation activities crucially depend on partner pr

43 s A and B unleashes highly efficient protein disaggregation activity in human and nematode HSP70 syst

44 HSP110 nucleotide exchange factor, has poor disaggregation activity in vitro.

45 pore loop tyrosine, it is not essential for disaggregation activity.

46 ClpB can collaborate with the DnaK system in disaggregation, although activity is reduced.

47 Disaggregation analyses showed that disorders were assoc

48 shock factor 1, and DAF-16 regulate opposing disaggregation and aggregation activities to promote cel

49 ng, inhibit protein aggregation, and promote disaggregation and clearance of misfolded aggregates ins

50 d was actually enhanced, but at 380 mg/L PHA disaggregation and colloidal stability were promoted.

51 us form, the Abeta peptides are resistant to disaggregation and degradation by a number of denaturing

52 otein aggregation has been well-studied, the disaggregation and dissolution of existing amyloid fibri

53 n fuel LCI by providing spatial and temporal disaggregation and enhanced chemical speciation, thereby

54 Since NO can induce platelet disaggregation and phosphoinositide 3-kinase (PI3-kinase

55 the chaperones hsp70 and hsp40 that promote disaggregation and protein degradation.

56 therefore, play an essential role in protein disaggregation and protein folding.

57 Saccharomyces cerevisiae, Hsp104 facilitates disaggregation and reactivates aggregated proteins with

58 Disaggregation and reaggregation of Xnr-2-producing tiss

59 duced distribution changes lead to community disaggregation and reassembly.

60 s of guanidine hydrochloride (GdmHCl) foster disaggregation and refolding of denatured and aggregated

61 er conditions used for optimal high pressure disaggregation and refolding, the native state is greatl

62 Surprisingly, disaggregation and resolubilization of thermally denatur

63 rotein aggregates, indicating that efficient disaggregation and/or degradation mechanisms exist.

64 ly, translocation, activation, inactivation, disaggregation, and degradation of proteins.

65 arms of the PN (protein synthesis, folding, disaggregation, and degradation), leading to the proposa

66 ynthesis, folding, trafficking, aggregation, disaggregation, and degradation.

67 Hsp70 chaperones assist in protein folding, disaggregation, and membrane translocation by binding to

68 inhibition of platelet aggregation, platelet disaggregation, and P2Y12 reactivity index.

69 membrane fusion, membrane transport, protein disaggregation, and protein refolding.

70 gregation surveillance that regulate protein disaggregation are likely to play a major role in cell s

71 ing into account DOM dynamics, bridging, and disaggregation are needed for a comprehensive modeling o

72 gh the roles of the individual chaperones in disaggregation are not well understood.

73 focuses on the less explored advantages of "disaggregation" as a novel sensing mechanism and its rec

74 reactions without agitation resulted in less disaggregation at slower rates, indicating that the prot

75 In disaggregation baicalein causes fragmentation throughout

76 ermines the specificity required for protein disaggregation both in vivo and in vitro, as well as for

77 e that the M-domain is essential for protein disaggregation, but dispensable for Hsp104 ATPase- and s

78 vision loss data from 1990 to 2015, further disaggregation by cause, and forecasts to 2020.

79 However, when we measured protein disaggregation by ClpB heterohexamers in conjunction wit

80 destabilizes Sup35 prions and promotes their disaggregation by Hsp104, Hsp70, and Hsp40.

81 the Hsp70 chaperone, which allows efficient disaggregation by supporting Hsp104 binding to aggregate

82 atory infections, and meningitis, as well as disaggregations by subcause for chronic kidney disease,

83 Disaggregation can also be monitored using detergents.

84 Anti-IL-1RI mAb inhibited disaggregation caused by IL-1alpha and IL-1beta, but not

85 Upon reoxygenation, rapid UBP1 SG disaggregation coincides with the return of the stabiliz

86 operation with IbpB, protein aggregates in a disaggregation-competent state.

87 The increased rate of PrP(Sc) disaggregation did not correlate with either the conform

88 estion that destruction of prions by protein disaggregation does not adequately explain the curing.

89 Instead, disaggregation dominates the signal turn-on, and is thus

90 resistant to fibril formation, more prone to disaggregation, enzymatic digestion and degradation by t

91 dent on the size of the aggregates, and that disaggregation experiments can provide a powerful method

92 Disaggregation followed first-order kinetics and was acc

93 Periderm disaggregation follows and recapitulates barrier pattern

94 The process from aggregation to disaggregation generally causes a recovery or enhancemen

95 nteract with topography to influence bedrock disaggregation, groundwater flow, chemical weathering, a

96 ompared to aggregation, its reverse process, disaggregation, has received much less attention and is

97 nhibiting aggregation and promoting filament disaggregation have been discovered, but knowledge of th

98 To facilitate protein disaggregation, Hsp104 cooperates with Hsp70 and Hsp40 c

99 OS(agg) with LBP and sCD14 promoted LOS(agg) disaggregation in an albumin-dependent fashion to comple

100 fy heat-triggered aggregation and subsequent disaggregation in budding yeast, identifying >170 endoge

101 ClpB middle domain are defective in protein disaggregation in collaboration with DnaK.

102 Protein disaggregation in Escherichia coli is carried out by Clp

103 reased monosome peak with moderate ribosomal disaggregation in polysome profiles and the greatly incr

104 hibited greater potential towards TTR fibril disaggregation in vitro compared to the parent drug.

105 g PPIase activity prevented its capacity for disaggregation in vitro.

106 ia, and correlate with cooperative action in disaggregation in vitro.

107 ICT), aggregation-induced emission (AIE) and disaggregation-induced emission (DIE), MICE has not been

108 Protein disaggregation involves polypeptide extraction from aggr

109 Virus aggregation-disaggregation is a complex process and predicting the b

110 The ClpB-mediated disaggregation is linked to translocation of polypeptide

111 a battery of techniques, we demonstrate that disaggregation is possible under conditions close to phy

112 ough the N domain is dispensable for protein disaggregation, it is sensitive to point mutations that

113 Our disaggregation landscape and kinetics analyses indicate

114 made possible by the presence of a powerful disaggregation machine.

115 s a tightly regulated, ATP-powered molecular disaggregation machine.

116 Although biochemical analyses identified disaggregation machinery components required for resolub

117 mammalian cells contain a cytosolic protein disaggregation machinery comprised of Hsc70, DnaJ homolo

118 [URE3], and [PIN(+)] depends on the protein disaggregation machinery that includes Hsp104, Hsp70, an

119 likely enhancing the function of a cytosolic disaggregation machinery.

120 simulation in explicit solvent to study the disaggregation mechanism of the GNNQQNY fibrils and to i

121 in an ATP- and DNAJA1-dependent manner, in a disaggregation mechanism whereby the two paralogous chap

122 balanced comparison between aggregation and disaggregation mechanism, and focuses on the less explor

123 ouse model to show that patterns of periderm disaggregation mirrors barrier formation.

124 rk together to achieve the broad folding and disaggregation needs of the cell.

125 New insights into the structural biology of disaggregation obtained from NMR studies are described,

126 Rapid disaggregation of 87V PrP(Sc) by the cell may contribute

127 osomes targeting the brain and promoting the disaggregation of Abeta assemblies and evaluated their e

128 ADP-induced platelet aggregation and induces disaggregation of ADP-stimulated platelets by an NO-medi

129 Macrophage-mediated disaggregation of aggregated and fused LDL is a mechanis

130 We studied the disaggregation of aggregates composed of B78H1 cells tra

131 Disaggregation of AgLDL was verified by gel-filtration c

132 S and produce similar macrophage release and disaggregation of AgLDL.

133 egation of the Abeta(42) peptide and promote disaggregation of amyloid fibrils, as observed by ThT fl

134 ence of a stable reactive species created by disaggregation of amyloid fibrils.

135 tion has been separated and characterized by disaggregation of amyloid fibrils.

136 nsive mutational analysis of aggregation and disaggregation of amyloid-like protofibrils of human mus

137 her, cells lacking Hsp26 are impaired in the disaggregation of an easily assayed heat-aggregated repo

138 mineral-EPS associations by inducing partial disaggregation of bentonite and aggregation of ferrihydr

139 This asymmetry is reversible upon disaggregation of blastomeres of the two- and four-cell

140 nced mesenchymal Spry1 and Spry4 expression, disaggregation of BMP4-positive mesenchymal cells and lo

141 ow sensitive detection of minority variants, disaggregation of complex parasite mixtures, and scalabl

142 ciled global glacier loss estimates enable a disaggregation of continental land mass changes and a qu

143 sistant spores, but nutrients caused partial disaggregation of fruiting bodies.

144 ain CU1000 grown attached to plastic and the disaggregation of highly autoaggregated clumps of CU1000

145 egon birth certificates that allowed for the disaggregation of hospital births into the categories of

146 thodology based on preparation and enzymatic disaggregation of intact marrow plugs, which yields dist

147 al cells and cell activation correlated with disaggregation of lipooligosaccharides.

148 inding protein- (LBP) and sCD14-dependent 1) disaggregation of LOS and 2) LOS activation of human umb

149 albumin in facilitating LBP:sCD14-dependent disaggregation of LOS(agg) or activation of endothelial

150 ton, disassembly of actin microfilaments and disaggregation of microtubules all consistently failed t

151 ion as a mitochondrial chaperone involved in disaggregation of misfolded proteins, resulting from str

152 ous squid Hsp(c)70 to mediate binding and/or disaggregation of mutant SOD1 protein, abrogating toxici

153 ectopic overexpression of PML precludes the disaggregation of ND10 but has no effect on viral replic

154 (iii) Disaggregation of ND10 structures is not an obligatory e

155 oscopy revealed that NaOH steeping increased disaggregation of parenchyma cells.

156 Demonstration of the formation and disaggregation of particle assemblies suggests strategie

157 In vitro, sHsps enhance Hsp104-catalyzed disaggregation of pathological amyloid forms of alpha-sy

158 of global mRNA translation was suggested by disaggregation of polysomes into free ribosomes, which o

159 apid inhibition of protein synthesis and the disaggregation of polysomes.

160 ssegregation in proliferating cells, but not disaggregation of polytene chromosomes in salivary gland

161 vented aggregation of A beta(42) and induced disaggregation of preformed A beta(42) fibrils down to n

162 '-beta-galactosidase and did not lead to the disaggregation of preformed inclusion bodies.

163 accharomyces cerevisiae, the Hsp104-mediated disaggregation of protein aggregates is essential for th

164 of this chaperone in mediating ATP-dependent disaggregation of protein aggregates that accumulate in

165 erones in the oligomerization, assembly, and disaggregation of proteins known to be abnormally folded

166 Significant changes in the rate of disaggregation of protofibrils in 5% TFE result not only

167 Our data suggest that the kinetics of disaggregation of PrP(Sc) following cellular uptake is i

168 Digitization, having triggered disaggregation of radiology's professional service model

169 olate (SDC) enabled efficient extraction and disaggregation of SWNT prior to NIRF analysis.

170 ted to surfactant reorganization rather than disaggregation of SWNTs bundles or shear-induced alignme

171 e to change, because digitization has caused disaggregation of the chain.

172 chemokine ligand (CCL) 19 was paralleled by disaggregation of the dermal lymphoid-like tissue.

173 adicals than free MB, possibly due to better disaggregation of the dye in solution.

174 Disaggregation of the indicators by the main equity stra

175 Disaggregation of the receptors leads to their rapid dep

176 ssociated with fructose binding, but instead disaggregation of the sensor in the presence of fructose

177 Disaggregation of the spherical nuclear bodies termed pr

178 ial uncouplers or dissipated by drug-induced disaggregation of the spheroids.

179 has been assumed to arise from the complete disaggregation of the Sup35 prion polymers.

180 cling and there is no requirement for tissue disaggregation or cell culture.

181 effect of the SBD mutation in reconstituted disaggregation or refolding reactions in vitro.

182 rted sensors and probes seem to work through disaggregation phenomena, the proper interpretation of t

183 The microscopy studies show an aggregation-disaggregation phenomenon in the presence of different e

184 ClpG exhibits high, stand-alone disaggregation potential without involving any partner c

185 protein unfolding activity of Hsp104 to the disaggregation process, providing the yeast protein-reco

186 cal model based on competing aggregation and disaggregation processes in kinetic steady-state equilib

187 However, attempts to identify protofibril disaggregation products using dynamic light scattering,

188 We used the polyGln disaggregation protocol of Wetzel et al. to dissolve the

189 With the use of a special disaggregation protocol, the highly aggregation prone A

190 etection of blood characteristics, including disaggregation, radial migration and cross-linking fibri

191 in at least two kinetic phases, with initial disaggregation (rate constant approximately 1 h(-1)) fol

192 r stress, it was found that average cellular disaggregation rates were a factor of 1.3 +/- 0.4 times

193 Aggregate disaggregation rates were obtained and compared to disso

194 es with cellular avidity, measured from cell disaggregation rates.

195 rucial for specificity and efficiency of the disaggregation reaction.

196 proteins, and possess defects in chemotaxis, disaggregation, receptor up-regulation, and bactericidal

197 proteins; and possess defects in chemotaxis, disaggregation, receptor upregulation, and bactericidal

198 ll known, and we hypothesized that much like disaggregation, refolding, degradation, and even normal

199 Disaggregation relies on Hsp70 function and on ATP-depen

200 12 AAA+ domains is co-ordinated to catalyze disaggregation remained unexplained.

201 vely during redox-controlled aggregation and disaggregation, respectively.

202 Disaggregation shows that the effects of use are largely

203 After tumor disaggregation, staining with a fluorochrome-conjugated

204 ion of Ly108 is rapidly lost after thymocyte disaggregation, suggesting dynamic contact-mediated regu

205 ta(1-11) antibody in the absence of oligomer disaggregation suggests a possible oligomer rearrangemen

206 P100 of non-metazoan HSP70-dependent protein disaggregation systems, and the human HSP70 system alone

207 ne, although at low pyridine concentrations, disaggregation takes many hours to reach equilibrium.

208 gesting that varying sensitivity to the cell disaggregation technique was not responsible.

209 sential facilitator of LBP/sCD14-induced LOS disaggregation that is required for activation of endoth

210 Essential for disaggregation, the ClpB middle domain (MD) is a coiled-

211 Upon disaggregation, the in vivo dephosphorylation of the Fce

212 blood viscosity, increased aggregation, and disaggregation threshold of GD RBCs compared with contro

213 in with a high degree of spatial and product disaggregation to assess the impacts of increasing local

214 iated cellular integrity and Hsp104-mediated disaggregation to ensure the survival of cells with fewe

215 ution of these aggregation reactions induced disaggregation to monomers as measured by size exclusion

216 structural property of CyP40 that may permit disaggregation to occur in an energy-independent manner.

217 al effects, from vasodilatation and platelet disaggregation to synaptic plasticity.

218 nude mice, and following tumor excision and disaggregation, tumor cells were cultured with the cytok

219 (TFE) are different from those that promote disaggregation under milder conditions (5% TFE).

220 unoblotting for rpS6 showed modest polysomal disaggregation upon fasting.

221 tor in serum that mediated AgLDL release and disaggregation was plasmin generated from plasminogen by

222 ric concentrations of N744 also promoted tau disaggregation when added to mature synthetic filaments.

223 why the N domain is dispensable for protein disaggregation when Hsp70/40 is present, yet essential f

224 illized state, resulting in endwise filament disaggregation when it was added to synthetic filaments.

225 y influences the conditions when aggregation/disaggregation will occur, making predictions difficult

226 e kinase and can be inhibited by FcepsilonRI disaggregation with monovalent hapten.

227 ClpB double mutant is inactive in substrate disaggregation with the DnaK system, although each singl