ライフサイエンスコーパス: disarm

1 has catastrophic effects if this feature is disarmed.

2 ow we show that in neutrophils P. gingivalis disarms a host-protective TLR2-MyD88 pathway via proteas

3 und to be in between that of the "torsional" disarmed and an armed donor.

4 The bacterium also dysregulates, disarms, and evades host immune responses to maintain ch

5 egies span from killing (new antibiotics) to disarming (antivirulence) the pathogen.

6 This modified armed-disarmed approach is relying on the observation that 2-N

7 es as opposed to classic Fraser-Reid's armed-disarmed approach leading to cis-trans and cis-cis linka

8 this study was to evaluate the potential of disarmed Atx to deliver either ASOs or siRNA.

9 S. aureus with the ability to simultaneously disarm both innate and adaptive compartments of the host

10 Thus, EBV coopts the lipid rafts to disarm both the signaling and antigen-processing functio

11 Thus, uncommitted T cells can be disarmed, but immune privilege is unable to protect from

12 ntrinsic immune defense against HCMV that is disarmed by the virus.

13 Furthermore, soluble PC5A/PACE4 can target/disarm cell surface PAR1 through cleavage at Arg46 downw

14 indings were used to perform the first armed-disarmed coupling between two benzylated glucosyl donors

15 Here, we report on a new defence system, DISARM (defence island system associated with restrictio

16 ved in plant immunity that works by directly disarming effector proteins.

17 Additional disarming groups further decreased the alpha-selectivity

18 ulosis and enteropathogenic Escherichia coli disarm host cells by injecting cell cycle inhibiting fac

19 deregulate lymphocyte receptor expression to disarm host immune control.

20 mechanism to deregulate T cell activation to disarm host immune surveillance.

21 therefore, represents a potential target for disarming immune responses.

22 bacterial toxin that targets host cells and disarms immune defenses.

23 optotic BCL-2 family proteins are frequently disarmed in relapsed and refractory cancer through genet

24 must also overcome many challenges, such as disarming innate immune signaling and accessing host nut

25 Our results suggest that DISARM is a new type of multi-gene restriction-modificat

26 DISARM is composed of five genes, including a DNA methyl

27 t leukocytes lacking cognate HLA ligands can disarm KIR+ NK cells in a manner that may decrease HLA-

28 SIGN to subvert the host immune responses by disarming MAPK pathway in DCs.

29 hat four of the five genes are essential for DISARM-mediated defence, with the fifth (PLD) being redu

30 phage DNA and that the B. paralicheniformis DISARM methylase modifies host CCWGG motifs as a marker

31 previously unrecognized capacity of SIgA to "disarm" microbial pathogens on mucosal surfaces and prev

32 t versatile evolutionary innovators, able to disarm multiple chemical plant defenses.

33 ucts, perhaps released from granulomas, from disarming myeloid cells prior to their encounter with wh

34 of the steric A-value and of its moderately disarming nature, as reflected in the pKa of propargyl a

35 The residual NPOE is converted into disarmed NPG, which is refractory to the reaction condit

36 Bacteria can indirectly disarm NSPs by protecting bacterial substrates against N

37 3-step route from 1 to a new type of highly disarmed O-4 iduronate thioglycoside, which is an effect

38 This cleavage results in a disarming of thrombin-activated calcium signaling throug

39 cid accumulation induced by infection with a disarmed pathogen.

40 ally, developing new treatments that seek to disarm pathogens without killing them, or that modulate

41 nmental optimization, and the utilization of disarmed pathogens as antagonists are strategies with po

42 is of 1,2-trans-linked oligosaccharides, the disarmed reducing end of which can be activated for imme

43 We further show that DISARM restricts incoming phage DNA and that the B. para

44 n system (T6SS) to survive in macrophages by disarming Rho-type GTPases, causing actin cytoskeletal d

45 fect tissue function by either activating or disarming signal transduction mediated by proteinase-act

46 We next explored the effects of disarming specific aspects of the immune system on the r

47 yzed co-cultivation conditions and different disarmed strains of Agrobacterium to improve transformat

48 Both depend on disarmed strains of Agrobacterium tumefaciens to deliver

49 f virulence genes were added to three common disarmed strains.

50 was incorporated into the conventional armed-disarmed strategy.

51 ivation encountered in the traditional armed-disarmed strategy.

52 We name this new approach the "inverse armed-disarmed" strategy, because it allows for the chemoselec

53 n the electron-withdrawing capability of the disarming substituent at the 6-position, i.e., on the nu

54 Both proteases interacted with and disarmed surface GEC PAR1, but there was no detectable i

55 neering the Bacillus paralicheniformis 9945a DISARM system into Bacillus subtilis has rendered the en

56 This result differs from the classic armed-disarmed technique, according to which usually cis-trans

57 ogenesis, primarily by enabling the virus to disarm the host cell type IFN defense system.

58 fs as an ARGONAUTE (AGO) hook to attract and disarm the host's essential effector of RNA silencing.

59 This ability to disarm the IFN-beta response offers an explanation for t

60 ry: to induce expression of VZV genes and to disarm the IFN-dependent antiviral defense through a nov

61 be targets MAP kinases in dendritic cells to disarm the immune response.

62 Thus, gp120 may be used by HIV-1 to disarm the monocyte response to inflammatory stimulation

63 uires the appropriate sequence of touches to disarm the system.

64 Thus, rather than disarming the antiviral activity induced by IFN-beta pre

65 herbivore for tolerating, circumventing, or disarming the defenses.

66 protein levels is important with respect to disarming the IFN response during productive infection.

67 reactive viral DNA end from the active site, disarming the viral nucleoprotein complex.

68 uggest a model whereby UV-induced DNA damage disarms the immune system in a manner similar to that ob

69 When effective, the plant immune system disarms the infectious necrotroph of its pathogenic arse

70 and response system as most DR genes do, Hm1 disarms the pathogen directly.

71 ialdehyde dehydrogenase, is responsible for 'disarming' the final aldehydic intermediate.

72 rease phagocytosis of circulating ICs, while disarming their inflammatory potential.

73 r for activation of T cells) on these cells, disarming their suppressive activity.

74 er process is shown to affect both armed and disarmed thioglycosides, cause anomerization of the carb

75 ile that can readily activate both armed and disarmed thioglycosides, via glycosyl triflates, in a ma

76 e diamondback moth (Plutella xylostella) has disarmed this elemental defense.