ライフサイエンスコーパス: disc

1 tal side of cells (nearest the center of the disc).

2 growth and patterning of the Drosophila wing disc.

3 ly expressed in the Drosophila wing imaginal disc.

4 tion and adhesion above the macula and optic disc.

5 ing a 1.5 x 2-mm2 area centered at the optic disc.

6 es, each one located at opposite tips of the disc.

7 th membrane proteins within the intercalated disc.

8 contribute to growth orientation in the wing disc.

9 smotic environment within the intervertebral disc.

10 or compartment boundary of the wing imaginal disc.

11 rrounded with microtubules in the attachment disc.

12 ssential for patterning of the wing imaginal disc.

13 f two adjacent vertebrae and the intervening disc.

14 e pathogenesis of rare diseases of the optic disc.

15 ure posterior region of a radially symmetric disc.

16 e diffusivity of peroxide through the enamel discs.

17 ntrast to epithelial tissues of the imaginal discs.

18 gap junction plaque size at the intercalated discs.

19 as in humans, develop as bilaminar embryonic discs.

20 was depended on cup area in medium and large discs.

21 udies used tonometer prisms and 1 used steel discs.

22 c nanostructured array of commercial Blu-ray discs.

23 gth Cx43 forward trafficking to intercalated discs.

24 ession of S phase in Drosophila eye imaginal discs.

25 isms control this response in intervertebral discs.

26 for patients with glaucoma with myopic optic discs.

27 , acid etched (SLA) Ti discs and polished Ti discs.

28 P = .008) and large (r(2) = 0.09, P = .007) discs.

29 ficked to adherens junctions at intercalated discs.

30 The scans were centered on optic discs.

31 ription activation by Trl in larval imaginal discs.

32 neration and calcification of intervertebral discs.

33 of Cx43 hemichannels to cardiac intercalated discs.

34 nables retained ectosomes to be morphed into discs.

35 he pixel size (14 mum x 28 mum) and the Airy disc (25.82 mum in diameter, calculated at the wavenumbe

36 esions included tessellation (31.7%), tilted disc (28.1%), peripapillary atrophy (7.0%), staphyloma (

37 P < 0.001), increased mean distance to optic disc (3.3 vs. 5.0 mm, P < 0.001) and foveola (3.1 vs. 4.

38 The Merkel disc, a main type of tactile end organ consisting of Mer

39 coma and optical nerve hypoplasia, and optic disc abnormalities.

40 otects Cx43 localization to the intercalated discs against acute ischemic injury.

41 The sensor consists of a thin magnet disc, aligned at the back of the electrode, in order to

42 Of note, the sarcomeric z-disc also represents a nodal point in cardiomyocyte func

43 e asymmetric amniotic sac-with the embryonic disc and amniotic ectoderm occupying opposite poles-is a

44 replicate many characteristics of the native disc and are a viable option for total disc arthroplasty

45 k the endocytosis of Wg and DFz2 in the wing disc and demonstrate that Wg is endocytosed from the api

46 depending on location relative to the optic disc and fovea.

47 rence tomography (SDOCT) images of the optic disc and macula regions at baseline and at 3 and 6 month

48 led a protrusion of the L5-S1 intervertebral disc and no apparent cause for the patient's symptoms.

49 motes development of the entire eye-antennal disc and that the retinal determination network works to

50 rse structures in nature, such as the spinal disc and the onion have many concentric layers, and are

51 Importantly, CEFIP was located at the z-disc and was up-regulated in several models of cardiomyo

52 lay in 4R-Tau expressing cells of larval eye discs and brains.

53 upted from sandblasted, acid etched (SLA) Ti discs and polished Ti discs.

54 f the posterior globe, swelling of the optic disc, and bilateral transverse sinus stenosis.

55 . delphini strains by reference broth, rapid disc, and rapid slide methods.

56 FXR1 associates with intercalated discs, and integral gap junction proteins Cx43 (connexin

57 Standard and fovea-disc angle-adjusted RNFL thicknesses showed small signif

58 rrier to fluid migration from cavitary optic disc anomalies can be safely achieved in most patients w

59 en eyes of 15 patients with congenital optic disc anomalies were enrolled in this study.

60 Congenital optic disc anomalies were identified in all 15 eyes.

61 optic neuropathies and two congenital optic disc anomalies).

62 ure and the pathogenesis of congenital optic disc anomalies.

63 ne appearance, and drusen nasal to the optic disc are more likely to have a rare variant in the CFH g

64 e functional role of the soft tissues of the disc are poorly understood.

65 ms underlying the tactile function of Merkel discs are obscured as to how MCs transmit tactile signal

66 of the effects of age, refractive error and disc area (p < 0.05).

67 ovel loci for optic nerve cup area and 6 for disc area.

68 al area of retinal nonperfusion (measured in disc areas, DA) were determined using the validated conc

69 ative disc and are a viable option for total disc arthroplasty.

70 -spaced-linear arrays of metallic-elliptical discs as whispering gallery waveguides to control artifi

71 g, autorefraction, A-scan biometry and optic disc assessment.

72 s Dpp and Notch signaling in larval imaginal discs, at least partially via regulation of thickveins a

73 Elastin was present at the disc boundary and RDT mid-body.

74 agen arrangement was most organized near the disc boundary, with disorganization increasing posterior

75 r outer segments (OS) presumably anchored to discs by palmitoylation, whereas ARL3 is an inner segmen

76 data demonstrate that cell-seeded engineered discs can replicate many characteristics of the native d

77 lls in the posterior regions of eye imaginal discs carrying a double knockdown of Mcm10 and HP1a indu

78 tinal barrier to fluid egress from the optic disc cavitation.

79 ts were designed on the microfluidic compact disc (CD) to perform 30 genetic analyses of three differ

80 and that loss of Ihog activity disrupts wing disc cell segregation, even with downstream genetic resc

81 signaling back and forth between epithelial disc cells and hemocytes by extracellular ROSs and TNF/E

82 Here we show that Drosophila wing disc cells carrying functionally unrelated loser mutatio

83 Here, the authors show that Drosophila wing disc cells carrying some loser mutations activate Nrf2 a

84 able to induce the proliferation of imaginal disc cells in vitro.

85 molecules by nucleus pulposus (NP) and other disc cells.

86 re noted during endoscopy included the optic disc characteristics, anatomic integrity of the retina,

87 hybrid biofuel cell (HBFC) with carbon paper discs coated with multiwalled carbon nanotubes.

88 Optic disc colobomas were found in 5 eyes, and the characteris

89 -OCT) in morning glory syndrome (MGS), optic disc colobomas, and optic disc pits, and to explore poss

90 e restriction at the anterior/posterior wing disc compartment boundary, as suggested by our observati

91 Intercalated discs composed of desmosomes, adherens junctions, and ga

92 that these constructs mature to match native disc composition, structure, and function with long-term

93 its adhesion area was monitored by spinning disc confocal laser microscopy.

94 Using spinning-disc confocal microscopy we visualised membrane ballooni

95 v-SNARE synaptobrevin 2 by means of spinning-disc confocal microscopy with a time resolution of 10 ms

96 unofluorescence by conventional and spinning disc confocal microscopy, electron microscopy, parathyro

97 determined progression of glaucomatous optic disc damage.

98 Subjects were categorized as having "disc defined glaucoma" if either disc demonstrated glauc

99 Intervertebral disc degeneration (IDD) causes chronic back pain and is

100 Intervertebral disc degeneration (IVDD) is linked to low back pain.

101 y site is needed to limit the progression of disc degeneration and promote disc self-regeneration cap

102 showed increased incidence of intervertebral disc degeneration with a concomitant decrease in express

103 omising strategy for treating intervertebral disc degeneration.

104 ls of PN-1 were correlated with the grade of disc degeneration.

105 as having "disc defined glaucoma" if either disc demonstrated glaucomatous features, and VF data wer

106 loss of ey and toy during early eye-antennal disc development disrupts the development of all head st

107 ssion patterns observed during wing imaginal disc development.

108 function of Pax6 in Drosophila eye-antennal disc development.

109 ts without optic nerve involvement (tumor >1 disc diameter from optic nerve), the mean (SD) largest b

110 5 (11%) study eyes at baseline, 77% within 1 disc diameter of the foveal center.

111 sed posterior pole (an area encompassing a 5 disc diameter radius centered at the fovea) and more tha

112 were measured quantitatively from 0.5 to 2.0 disc diameters.

113 robial susceptibility tests were done by the disc diffusion method according to British Society of An

114 l effects by DPPH, ABTS, FRAP, ORAC and agar disc diffusion methods, respectively.

115 reed (PBonferroni = 0.01) and intervertebral disc disease (IVDD) across breeds (PBonferroni = 4.0 x 1

116 g this transcription factor for treatment of disc disease must spare osmoprotective, prosurvival, and

117 Degenerative disc disease often causes severe low-back pain, a public

118 lternative for the treatment of degenerative disc disease that is more logistically convenient than t

119 avenue for treating advanced intervertebral disc disease.

120 inal course of temporomandibular joint (TMJ) disc displacement (DD) and degenerative joint disease (D

121 women with (+) and without (-) bilateral TMJ disc displacement (DD).

122 ) has been postulated to restrict pathologic disc displacement.

123 that the RDT is not resistive to pathologic disc displacement.

124 symptoms, typically occurring with anterior disc displacement.

125 change, and the transmitted intensity of the disc drive laser modifies according to reaction yield.

126 LAMP) and quantitative optical read-out by a disc drive.

127 es) with PPE owing to suspected buried optic disc drusen (ODD), and 3 children (6 eyes) with PPE owin

128 fundus and retinal lesions and of the optic disc during the acute phase showed no statistically sign

129 resented with normal visual acuity but optic disc edema and an enlarged blind spot in the right eye (

130 Optic disc edema and epiretinal membrane formation was found m

131 ic changes, including choroidal folds, optic disc edema, cotton-wool spots, globe flattening, and ref

132 have included unilateral and bilateral optic disc edema, globe flattening, choroidal and retinal fold

133 ed role in maintaining the high curvature of disc edges, and each function is fulfilled by a separate

134 s been 3D printed to fabricate a range of 3D disc electrode (3DE) configurations using a conventional

135 Rotating disc electrode voltammetry revealed that initial rates o

136 tionally, studies using a thin-film rotating disc electrode, identical location transmission and scan

137 c GFP fusion proteins in the Drosophila wing disc epithelium and to investigate the effect of protein

138 in the lateral plane of the Drosophila wing disc epithelium is essential for patterning of the wing

139 ring Hedgehog protein signal within imaginal disc epithelium.

140 ROSs and TNF/Eiger drives overgrowth of the disc epithelium.

141 ield first in 28 eyes (15%) and in the optic disc first in 34 eyes (18%); in 1 eye (1%), it occurred

142 eld first in 163 eyes (52%) and in the optic disc first in 39 eyes (12%); in 1 eye (0%), it was found

143 s) diverts membrane traffic to photoreceptor disc formation by inhibiting ectosome release from the c

144 or DR5 recruitment of FADD and caspase-8 for DISC formation to signal apoptosis also play an importan

145 profiles of NDCs at key stages of embryonic disc formation.

146 By photolithography, high-swelling disc gels were positioned in a non-swelling gel sheet; t

147 tch resulted in out-of-plain buckling of the disc gels.

148 ents extends also to SECM studies, where the disc geometry facilitates small tip-substrate gaps and i

149 r hypertension (OHT) and glaucoma-like optic discs (GLD)- defined as a cup to disc ratio greater than

150 atures, and VF data were combined with optic disc grading to determine "disc plus field defined glauc

151 Drosophila imaginal disc growth factor 2 (IDGF2) is a member of chitinase-li

152 pp stripe source is indeed required for wing disc growth, also during third instar larval stages.

153 ired for patterning and also for medial wing disc growth, at least in the posterior compartment.

154 r layer and/or neuroretinal rim defects, and disc haemorrhages).

155 were more likely to have pseudoexfoliation, disc haemorrhages, ocular medication changes, and IOP-lo

156 Tissue engineering TMJ discs has emerged as an alternative approach to overcomi

157 In the Drosophila wing disc, Hedgehog (Hh) produced by posterior compartment ce

158 determine the cumulative incidence of optic disc hemorrhage (ODH) before and after development of pr

159 a (CDR >/= 0.7 or the presence of a notch or disc hemorrhage) from fundus photographs taken with a no

160 tract diseases, liver cirrhosis, and spinal disc herniation); causes of mortality (all-cause, natura

161 These findings show that in the wing disc, Hh distributions and signaling are dependent upon

162 The intercalated disc (ID) is a "hot spot" for heart disease, as several

163 s camera can facilitate remote evaluation of disc images on par with standard mydriatic fundus photog

164 endoscope helped in detecting a glaucomatous disc in 10 of those eyes; 7 of them had glaucomatous opt

165 filling of the entire choroid and the optic disc in both groups of animals.

166 hypo-osmotic solutions and smooth biconcave discs in iso-osmotic solutions.

167 Formation of membrane discs in photoreceptor cells requires evagination of its

168 rt prolonged proliferation in explanted wing discs in the absence of insulin, incidentally providing

169 elatively higher H2O permeability of nascent discs in the basal rod OS.

170 Self-assembling hMSCs formed cartilage discs in Transwell inserts following isotropic chondroge

171 The death-inducing signaling complex (DISC) initiates death receptor-induced apoptosis.

172 ry of Cx43 (connexin 43) to the intercalated disc is a continuous and rapid process critical for inte

173 The z-disc is a structural component at the lateral borders of

174 The disc is self-contained for conducting sample heating wit

175 The Nanodisc, a nanoscale membrane bilayer disc, is used to stabilize the protein on the metallic p

176 Aortic discs isolated from PTP1B siRNA-transfected mice also ha

177 of functional changes in the intervertebral disc (IVD) and interaction with endplate is essential to

178 socio-economic importance and intervertebral disc (IVD) degeneration has been implicated in its patho

179 nucleus pulposus (NP) of the intervertebral disc (IVD) demonstrates substantial changes in cell and

180 n the nucleus pulposus of the intervertebral disc (IVD) during maturation.

181 Recurrence of intervertebral disc (IVD) herniation is the most important factor leadi

182 stiffness measurements of the intervertebral disc (IVD) taken throughout the day and their relationsh

183 aled that the phosphorylation state of two Z-disc kinases (striated muscle-specific serine/threonine

184 e in contact with the ventral surface of the disc lamellae implies functional importance associated w

185 aive cord blood cells preferentially recruit Disc large homolog 1 (Dlgh1) and exclude protein kinase

186 Disc large homologue-associated protein 5 (HURP/DLGAP5),

187 We find that the tumor suppressor Discs large (Dlg) links the Par complex component atypic

188 Discs Large Homolog 5 (DLG5) plays an important role in

189 on exposure was associated with differential discs, large homolog 2 (DLG2) methylation and expression

190 Toward this goal, we developed cell-seeded disc-like angle ply structures (DAPS) and showed through

191 anatomy, a silk protein-based multilayered, disc-like angle-ply construct was fabricated, consisting

192 eterotetrameric association, consisting of a disc-like homodimer of CNNM2BAT bound to two independent

193 reby report a microfluidic platform lab-on-a-disc (LOAD) to provide a sample-to-answer solution.

194 The method principle is based on in-disc loop-mediated isothermal amplification (iD-LAMP) an

195 Cavitary optic disc maculopathy develops when fluctuating pressure grad

196 ies of 22 consecutive patients with cavitary disc maculopathy evaluated by a single surgeon between 1

197 ssible antiretinal antibody leakage from the disc margin with spread of immune products under the ret

198 lace multiple copies of a temporally focused disc matching the dimensions of a neuron's cell body.

199 tervertebral bony fusion, and matched native disc mechanical function at physiologic loads in situ.

200 hrough tail-to-tail interactions between the discs, mediated through extended IXVXI motifs.

201 n of dissociated G-protein subunits from the disc membranes into the cytoplasm, and a relatively high

202 ment filled with hundreds of tightly packed "disc" membranes.

203 loss of BDNF surge in the hippocampus of DN-DISC mice, but not in wild-type mice.

204 asurements were also carried out with a gold disc microelectrode modified with a film of iridium oxid

205 A dual-function platinum disc microelectrode sensor was used for in-situ monitori

206 Using the wing imaginal disc model in Drosophila, we identified new SMO phosphos

207 ual field), and ocular hypertensives (normal disc, normal visual field, and intraocular pressure >22

208 , Massachusetts] and Amplatzer PFO Occluder [disc occluder] [AGA Medical/St. Jude Medical, St. Paul,

209 standardized fashion including exchange of a disc of full-thickness recipient cornea (up to the DSAEK

210 The flux of hydrogen peroxide through 1-mm discs of bovine enamel was measured at steady-state cond

211 We find that the micro-discs of the waveguides can be excited by terahertz freq

212 odulation was recapitulated in wing imaginal discs of transgenic Drosophila, providing evidence that

213 nd enlarged, and lie directly ventral to the disc on the dorsum of the cranium.

214 evidence for vitreous traction on the optic disc or macula was seen in any eye.

215 progenitor and endothelial cells, either on discs or in a bioreactor.

216 An ex vivo disc organ culture study supported that extracellular hy

217 ead structures derived from the eye-antennal disc, overexpression of N or tsh in the absence of Pax6

218 tions antagonistically to phosphorylation by Discs-overgrown, which activates Fat.

219 erior globe [p=0.491], swelling of the optic disc [p=0.881], and bilateral dural sinus stenosis [p=0.

220 Optic disc pallor in 9 eyes (12%) and peripapillary nodules in

221 e association meta-analysis of IOP and optic disc parameters and validated our findings in multiple s

222 some genomic regions affect both IOP and the disc parameters.

223 ening (BMO) algorithm and stereoscopic optic disc photograph readings by glaucoma specialists.

224 The ISNT rule is only valid for 37.0% of disc photograph rim assessments and 43.8% of RNFL measur

225 Diagnoses of glaucoma by disc photograph were 1.6% (3 of 180) in the CDR less tha

226 ISNT rule is only valid for about a third of disc photographs and less than half of RNFL measurements

227 ISNT variant rules, with 70.9% and 76.4% of disc photographs following the IST rule and the IS rule,

228 Optic disc photographs were read by 2 masked glaucoma speciali

229 rticipants annually using stereoscopic optic disc photographs.

230 rformed on a 15-year-old boy with deep optic disc pit and foveal detachment, before and for 10 years

231 for foveal detachment associated with optic disc pit.

232 drome (MGS), optic disc colobomas, and optic disc pits, and to explore possible correlations between

233 dependent on expression of the intercalated disc plaque protein plakoglobin (Pg) and direct phosphor

234 ed with a 2.57 times higher adjusted odds of disc plus field defined glaucoma (OR, 2.57; 95% CI, 1.43

235 nd specificity of vCDR asymmetry >/=0.20 for disc plus field defined glaucoma are 22.7% and 97.7%, re

236 oma." Association between vCDR asymmetry and disc plus field defined glaucoma.

237 mbined with optic disc grading to determine "disc plus field defined glaucoma." Association between v

238 Mutations of numerous z-disc proteins are associated with cardiomyopathies and m

239 ated with the Z-disc, with over 74% of the Z-disc proteins experiencing robust changes in phosphoryla

240 To identify additional z-disc proteins that might contribute to cardiac disease,

241 Disc quality was followed up by magnetic resonance imagi

242 ides pain relief, and significantly improves disc quality.

243 o-disc ratio >/=0.6, asymmetry of the cup-to-disc ratio >/=0.2 between eyes, presence of localized re

244 sed in pre-defined criteria (vertical cup-to-disc ratio >/=0.6, asymmetry of the cup-to-disc ratio >/

245 -9.7 vs. 17.6+/-3.6 mmHg; P < 0.001), cup-to-disc ratio (0.65+/-0.27 vs. 0.48+/-0.13; P = 0.006), and

246 %), hyperlipidemia (83.3%), and small cup-to-disc ratio (63.3%).

247 To compare cup-to-disc ratio (CDR) measurements from images taken with a p

248 genomic regions associated with vertical cup-disc ratio (VCDR) and 1 new region associated with IOP.

249 o describe the prevalence of vertical cup-to-disc ratio (vCDR) asymmetry in U.S. adults and assess th

250 evealed older age and higher vertical cup-to-disc ratio (VCDR) at presentation as predictors of rapid

251 o compare the vertical and horizontal cup-to-disc ratio (VCDR, HCDR) by an updated optical coherence

252 Vertical cup-to-disc ratio asymmetry >/=0.20 occurs in 2.1% of U.S. adul

253 Vertical cup-to-disc ratio asymmetry is predictive of prevalent glaucoma

254 Vertical cup-to-disc ratio asymmetry should initiate a more comprehensiv

255 -like optic discs (GLD)- defined as a cup to disc ratio greater than or equal to 0.6 with normal intr

256 double-ring sign, pallor, and increased cup-disc ratio in 5 patients (11.6%).

257 l clarity, corneal diameter, vertical cup-to-disc ratio, and refractive error.

258 al corneal thickness, larger vertical cup-to-disc ratio, higher intraocular pressure, and self-report

259 In addition, desmin, and intercalar disc-related proteins expression were histologically ana

260 However, broader functions of TonEBP in the disc remain unknown.

261 for future studies related to intervertebral disc replacement therapy.

262 Total disc replacement with an engineered substitute is a prom

263 performance in an in vivo rat model of total disc replacement; over 5 weeks in vivo, DAPS maintained

264 The in-disc results were comparable to those obtained by conven

265 progression of disc degeneration and promote disc self-regeneration capacities after discectomy proce

266 trigonal arrays covering the large facets of disc-shaped TPP nanocrystals.

267 g before and after stratifying eyes based on disc size (P < .001).

268 However, this process is suppressed by the disc-specific protein peripherin, which enables retained

269 (PRCD) is a photoreceptor outer segment (OS) disc-specific protein with unknown function that is asso

270 decameric arrangement of two trimer-of-dimer discs stabilized by the C-terminal tails, possibly throu

271 ta reviewed and graded the baseline and last disc stereophotographs for the presence of betaPPA at ba

272 or ocular hypertension (OHT) and at least 2 disc stereophotographs were included.

273 Disc stereophotographs.

274 diagnosed based on a masked grading of optic disc stereophotographs.

275 th, centronuclear myopathy, central cores, Z-disc streaming, and SR dilation.

276 It forms a septal pore disc structure, recruits Spa18 and ApsB to septa and is

277 l membranes, but mature transition zones and disc structures were absent.

278 ervention, Stem cells and Colorectal Cancer (DISC) Study), 75 healthy participants were supplemented

279 fferent pupillary defect, (4) observed optic disc swelling, and (5) no other etiology being found.

280 ded anterior and intermediate uveitis, optic disc swelling, and white-yellowish choroidal lesions.

281 Here, we used an in vitro leaf disc system for comparative analysis of proteins extract

282 copic photographs and OCT scans of the optic discs taken during the same visit were compared.

283 tted high-shear conditions using an adhesive disc that evolved from the dorsal fin spines typical of

284 ntercellular Ca(2+) waves in Drosophila wing discs that are also observed in vivo during organ develo

285 In epithelial cells of Drosophila imaginal discs, the Caspase-9 ortholog Dronc drives AiP via activ

286 lammonium than expected for a 30 nm diameter disc tip.

287 gical transformation of a radially symmetric disc to a bilaterally symmetric embryo.

288 rophic regimen with thyroxine, the cartilage discs underwent progressive deep-zone hypertrophy and mi

289 s could be tolerated, we tested cocktails of DISC vaccines in combinations of three or six different

290 In this report, to advance the DISC vaccines to the marketplace, we investigated differ

291 e investigated different parameters of these DISC vaccines.

292 deficient (disabled infectious single-cycle [DISC]) virus strains for a number of serotypes and repor

293 dence previously reported with other optical discs, we observed an enhancement in sensitivity and a n

294 es and imaging in concentrated solutions, Hg disc-well electrodes fill a new analytical niche for stu

295 e report a novel fabrication protocol for Hg disc-well ultramicroelectrodes (UMEs), which retain acce

296 e amalgamation and stripping behaviors of Hg disc-well UMEs are compared to those of traditional Hg s

297 tection against amalgam saturation allows Hg disc-wells to operate safely in highly concentrated envi

298 The fundus and the optic disc were evaluated by repeated ophthalmoscopy, color fu

299 context of patterning of the Drosophila wing disc, wherein apically secreted Wingless (Wg) encounters

300 d on proteins that are associated with the Z-disc, with over 74% of the Z-disc proteins experiencing