ライフサイエンスコーパス: discoidin

1 The best characterised of these, discoidin 1, is a marker of the growth-development trans

2 ologous to Dictyostellium discoideum protein discoidin 1.

3 ibodies found in these patients targeted the discoidin and laminin G1 domains of CASPR2 and always in

4 , as do truncated SED1 proteins containing a discoidin/C domain.

5 e studies illustrate that Notch-like EGF and discoidin/C domains, protein motifs that facilitate a va

6 The discoidin C2 domains of coagulation factors V and VIII a

7 Each subunit is composed of a discoidin domain and a small N-terminal (RS1) domain.

8 The discoidin domain and PTK core of DDR-2 were essential fo

9 cid protein, retinoschisin, which contains a discoidin domain but is of unknown function.

10 to the polypeptide chain termini of the DDR2 discoidin domain constitutes the collagen recognition si

11 Receptor tyrosine kinases of the discoidin domain family, DDR1 and DDR2, are activated by

12 y that used wild-type and mutant forms of RS discoidin domain glutathione S-transferase (GST) fusion

13 The discoidin domain has been identified in mammalian milk f

14 heir extracellular domains, and the isolated discoidin domain of DDR2 bound collagen I with high affi

15 Furthermore, the discoidin domain of DDR2, but not of DDR1, was sufficien

16 To map the collagen binding site within the discoidin domain of DDR2, mutant constructs were created

17 ted to change the amino acid sequence in the discoidin domain of the retinoschisin protein.

18 Activation of discoidin domain receptor (DDR) 1 by collagen is reporte

19 Discoidin domain receptor (DDR) 1 is a receptor tyrosine

20 collagen receptors, alpha2beta1 integrin and discoidin domain receptor (DDR) 1.

21 The discoidin domain receptor (DDR) is a new class of recept

22 The discoidin domain receptor (DDR1) is characterized by a d

23 receptors on the tumor cells, including the discoidin domain receptor 1 (DDR1) and E-Cadherin (E-Cad

24 Discoidin domain receptor 1 (DDR1) belongs to a unique f

25 he expression of the novel collagen receptor discoidin domain receptor 1 (DDR1) by human MKs at both

26 ss, we identified a receptor tyrosine kinase discoidin domain receptor 1 (DDR1) expressed in granule

27 Discoidin domain receptor 1 (DDR1) is a nonintegrin coll

28 Discoidin domain receptor 1 (DDR1) is a receptor tyrosin

29 Discoidin domain receptor 1 (DDR1) is a receptor tyrosin

30 Discoidin domain receptor 1 (DDR1) is a widely expressed

31 Here, we show that Discoidin Domain Receptor 1 (DDR1), a collagen receptor

32 RNAi sensitization screen, which identified discoidin domain receptor 1 (DDR1), a collagen-activated

33 Significantly, knockdown of discoidin domain receptor 1 (DDR1), a collagen-binding p

34 We previously reported that discoidin domain receptor 1 (DDR1), a nonintegrin collag

35 on of Wnt5a, but also the phosphorylation of discoidin domain receptor 1 (Ddr1), a receptor for colla

36 esumed progenitors of HRS cells, upregulates discoidin domain receptor 1 (DDR1), a receptor tyrosine

37 iated melanocyte localization, we identified discoidin domain receptor 1 (DDR1), a receptor tyrosine

38 Discoidin domain receptor 1 (DDR1), a receptor tyrosine

39 volving latent membrane protein 1 (LMP1) and discoidin domain receptor 1 (DDR1), which is activated b

40 Discoidin domain receptor 1 tyrosine kinase (DDR1) and t

41 lagen-binding receptor tyrosine kinase DDR1 (discoidin domain receptor 1) is a drug target for a wide

42 DDR1, discoidin domain receptor 1, belongs to a subfamily of t

43 mechanical cue is transduced sequentially by discoidin domain receptor 1, c-Jun N-terminal kinase 1,

44 vestigate the relationship between increased discoidin domain receptor 2 (DDR-2) expression and carti

45 d MMP-13, degraded type II collagen, and the discoidin domain receptor 2 (DDR-2) in knee joints.

46 nvestigate the role of the collagen receptor discoidin domain receptor 2 (DDR-2) in the pathogenesis

47 In this study, we identified discoidin domain receptor 2 (DDR2) as a crucial receptor

48 ion of the tyrosine-kinase collagen receptor discoidin domain receptor 2 (DDR2) has no impact on huma

49 llular domain (ECD) of the collagen receptor discoidin domain receptor 2 (DDR2) inhibits fibrillogene

50 Discoidin domain receptor 2 (DDR2) is a receptor tyrosin

51 Discoidin domain receptor 2 (DDR2) is a tyrosine kinase

52 Discoidin domain receptor 2 (DDR2) is an unusual recepto

53 et al demonstrate that the collagen receptor Discoidin domain receptor 2 (DDR2) promotes neutrophil c

54 Increased expression of the discoidin domain receptor 2 (DDR2) results from its inte

55 Discoidin domain receptor 2 (DDR2), a collagen receptor

56 lated proteins: von Willebrand factor (VWF), discoidin domain receptor 2 (DDR2), and the extracellula

57 ression of a cell surface collagen receptor, discoidin domain receptor 2 (DDR2), is increased in chon

58 2, or collagen deglycosylation that prevents discoidin domain receptor 2 activation allowed cells to

59 t involves activation of the tyrosine kinase discoidin domain receptor 2 and is independent of effect

60 Discoidin domain receptor 2 expression was unchanged, bu

61 RNA and also used to determine the amount of discoidin domain receptor 2 mRNA in cardiac tissue.

62 c), thymocyte differentiation antigen 1, and discoidin domain receptor 2).

63 tin, procollagen I, fibronectin I, vimentin, discoidin domain receptor 2, and tenascin C, markers of

64 nase inhibitor genistein, down-regulation of discoidin domain receptor 2, or collagen deglycosylation

65 DDR1 (discoidin domain receptor tyrosine kinase 1) kinase s hi

66 -trisphosphate receptor, type 3 (ITPR3), and discoidin domain receptor tyrosine kinase 2 (DDR2).

67 taining, and up-regulated mRNA expression of discoidin domain receptor tyrosine kinase 2, fibronectin

68 drocyte responses through receptors, such as discoidin domain receptor-2 and syndecan-4.

69 gen I activates fibroblast collagen receptor discoidin domain receptor-2, contributes significantly t

70 ed growth factor receptors (PDGFRs), and the discoidin domain receptor.

71 Discoidin domain receptors (DDR) 1 and 2 represent a fam

72 Discoidin domain receptors (DDR1 and DDR2) are receptor

73 Discoidin domain receptors (DDR1 and DDR2) are widely ex

74 have recently been identified as ligands for discoidin domain receptors (DDR1 and DDR2), generating a

75 The discoidin domain receptors (DDRs) are receptor tyrosine

76 The discoidin domain receptors (DDRs) are receptor tyrosine

77 study, we found that collagen binding by the discoidin domain receptors (DDRs) requires dimerization

78 The human discoidin domain receptors (DDRs), DDR1 and DDR2, are ex

79 The widely expressed mammalian discoidin domain receptors (DDRs), DDR1 and DDR2, are un

80 The discoidin domain receptors (DDRs), DDR1 and DDR2, form a

81 The discoidin domain receptors, DDR1 and DDR2, are receptor

82 ecific secreted protein encoding a conserved discoidin domain sequence.

83 Here, we tested the role of the discoidin domain tyrosine kinase receptor 2 (DDR2), whic

84 ially adjacent surface loops within the DDR2 discoidin domain were found to be critically involved in

85 ligands for the previously orphan family of discoidin domain-containing receptor-like tyrosine kinas

86 Discoidin domain-containing receptors (DDRs) exhibit a u

87 coded by 8 exons of which three code for the discoidin domain.

88 by recombinant Mfge8 containing at least one discoidin domain.

89 direct interaction of collagen with the DDR discoidin domain.

90 elical collagen and was mediated by the DDR2 discoidin domain.

91 odies in the CSF targeted the laminin G1 and discoidin domains of CASPR2 in all patients.

92 growth factor repeats, an RGD motif, and two discoidin domains.

93 ing collagen for cellular uptake through its discoidin domains.

94 orresponding loops of functionally unrelated discoidin domains.

95 inhibitor protein (RKIP), DDR-2 lacking the discoidin (DS) domain (DeltaDS-DDR-2) or the protein tyr

96 eins that contain Notch-like EGF repeats and discoidin/F5/8 type C domains.

97 cond of which contains an RGD motif) and two discoidin/Factor V/VIII C domains.

98 The DDRs contain a discoidin homology domain in their extracellular domains

99 xtracellular domain homologous to the lectin Discoidin I found Dictyostelium discoideum.

100 the TAs of the leading cell, suggesting that discoidin I is not responsible for a possible chemically

101 domain receptor (DDR1) is characterized by a discoidin I motif in the extracellular domain, an unusua

102 Cells not expressing the lectin discoidin I or moving on discoidin I-coated substrata fo

103 pressing the lectin discoidin I or moving on discoidin I-coated substrata form fewer tandems, but the

104 rosine kinase-3 ligand, EGF-like repeats and discoidin I-like domains 3, and intercellular adhesion m

105 that of the Dictyostelium discoideum protein discoidin I.

106 (altered RGD domain), Del-1 minor (truncated discoidin-I-like domain), or basic fibroblast growth fac

107 motif and a second signaling sequence in the discoidin-I-like domain.

108 This defect correlated with loss of discoidin Igamma mRNA, a starvation-induced gene, althou

109 Therefore, both ACLP and its discoidin-like domain may be novel targets for anti-myof

110 Finally, the addition of recombinant discoidin-like domain of ACLP to cultured ACLP-deficient

111 roline-rich 11-amino acid repeating motif, a discoidin-like domain, and a C-terminal domain with 39%

112 (ACLP), a collagen-associated protein with a discoidin-like domain, is expressed at high levels in hu

113 -helix, an insertion domain and a C-terminal discoidin-like domain.

114 ermal growth factor (EGF)-like repeats and 2 discoidin-like domains.

115 The lactadherin C2 domain has a discoidin-like fold containing two beta-sheets of five a

116 We determined the structure of the discoidin rings, consistent with known intramolecular an

117 , contains tandem C domains with homology to discoidin-type lectins and to membrane-binding domains o