ライフサイエンスコーパス: discoidin domain

1 by recombinant Mfge8 containing at least one discoidin domain.

2 direct interaction of collagen with the DDR discoidin domain.

3 elical collagen and was mediated by the DDR2 discoidin domain.

4 coded by 8 exons of which three code for the discoidin domain.

5 ing collagen for cellular uptake through its discoidin domains.

6 orresponding loops of functionally unrelated discoidin domains.

7 growth factor repeats, an RGD motif, and two discoidin domains.

8 Each subunit is composed of a discoidin domain and a small N-terminal (RS1) domain.

9 The discoidin domain and PTK core of DDR-2 were essential fo

10 cid protein, retinoschisin, which contains a discoidin domain but is of unknown function.

11 to the polypeptide chain termini of the DDR2 discoidin domain constitutes the collagen recognition si

12 ligands for the previously orphan family of discoidin domain-containing receptor-like tyrosine kinas

13 Discoidin domain-containing receptors (DDRs) exhibit a u

14 Receptor tyrosine kinases of the discoidin domain family, DDR1 and DDR2, are activated by

15 y that used wild-type and mutant forms of RS discoidin domain glutathione S-transferase (GST) fusion

16 The discoidin domain has been identified in mammalian milk f

17 heir extracellular domains, and the isolated discoidin domain of DDR2 bound collagen I with high affi

18 Furthermore, the discoidin domain of DDR2, but not of DDR1, was sufficien

19 To map the collagen binding site within the discoidin domain of DDR2, mutant constructs were created

20 ted to change the amino acid sequence in the discoidin domain of the retinoschisin protein.

21 odies in the CSF targeted the laminin G1 and discoidin domains of CASPR2 in all patients.

22 Activation of discoidin domain receptor (DDR) 1 by collagen is reporte

23 Discoidin domain receptor (DDR) 1 is a receptor tyrosine

24 collagen receptors, alpha2beta1 integrin and discoidin domain receptor (DDR) 1.

25 The discoidin domain receptor (DDR) is a new class of recept

26 The discoidin domain receptor (DDR1) is characterized by a d

27 receptors on the tumor cells, including the discoidin domain receptor 1 (DDR1) and E-Cadherin (E-Cad

28 Discoidin domain receptor 1 (DDR1) belongs to a unique f

29 he expression of the novel collagen receptor discoidin domain receptor 1 (DDR1) by human MKs at both

30 ss, we identified a receptor tyrosine kinase discoidin domain receptor 1 (DDR1) expressed in granule

31 Discoidin domain receptor 1 (DDR1) is a nonintegrin coll

32 Discoidin domain receptor 1 (DDR1) is a receptor tyrosin

33 Discoidin domain receptor 1 (DDR1) is a receptor tyrosin

34 Discoidin domain receptor 1 (DDR1) is a widely expressed

35 Here, we show that Discoidin Domain Receptor 1 (DDR1), a collagen receptor

36 RNAi sensitization screen, which identified discoidin domain receptor 1 (DDR1), a collagen-activated

37 Significantly, knockdown of discoidin domain receptor 1 (DDR1), a collagen-binding p

38 We previously reported that discoidin domain receptor 1 (DDR1), a nonintegrin collag

39 on of Wnt5a, but also the phosphorylation of discoidin domain receptor 1 (Ddr1), a receptor for colla

40 esumed progenitors of HRS cells, upregulates discoidin domain receptor 1 (DDR1), a receptor tyrosine

41 iated melanocyte localization, we identified discoidin domain receptor 1 (DDR1), a receptor tyrosine

42 Discoidin domain receptor 1 (DDR1), a receptor tyrosine

43 volving latent membrane protein 1 (LMP1) and discoidin domain receptor 1 (DDR1), which is activated b

44 Discoidin domain receptor 1 tyrosine kinase (DDR1) and t

45 lagen-binding receptor tyrosine kinase DDR1 (discoidin domain receptor 1) is a drug target for a wide

46 DDR1, discoidin domain receptor 1, belongs to a subfamily of t

47 mechanical cue is transduced sequentially by discoidin domain receptor 1, c-Jun N-terminal kinase 1,

48 vestigate the relationship between increased discoidin domain receptor 2 (DDR-2) expression and carti

49 d MMP-13, degraded type II collagen, and the discoidin domain receptor 2 (DDR-2) in knee joints.

50 nvestigate the role of the collagen receptor discoidin domain receptor 2 (DDR-2) in the pathogenesis

51 In this study, we identified discoidin domain receptor 2 (DDR2) as a crucial receptor

52 ion of the tyrosine-kinase collagen receptor discoidin domain receptor 2 (DDR2) has no impact on huma

53 llular domain (ECD) of the collagen receptor discoidin domain receptor 2 (DDR2) inhibits fibrillogene

54 Discoidin domain receptor 2 (DDR2) is a receptor tyrosin

55 Discoidin domain receptor 2 (DDR2) is a tyrosine kinase

56 Discoidin domain receptor 2 (DDR2) is an unusual recepto

57 et al demonstrate that the collagen receptor Discoidin domain receptor 2 (DDR2) promotes neutrophil c

58 Increased expression of the discoidin domain receptor 2 (DDR2) results from its inte

59 Discoidin domain receptor 2 (DDR2), a collagen receptor

60 lated proteins: von Willebrand factor (VWF), discoidin domain receptor 2 (DDR2), and the extracellula

61 ression of a cell surface collagen receptor, discoidin domain receptor 2 (DDR2), is increased in chon

62 2, or collagen deglycosylation that prevents discoidin domain receptor 2 activation allowed cells to

63 t involves activation of the tyrosine kinase discoidin domain receptor 2 and is independent of effect

64 Discoidin domain receptor 2 expression was unchanged, bu

65 RNA and also used to determine the amount of discoidin domain receptor 2 mRNA in cardiac tissue.

66 c), thymocyte differentiation antigen 1, and discoidin domain receptor 2).

67 tin, procollagen I, fibronectin I, vimentin, discoidin domain receptor 2, and tenascin C, markers of

68 nase inhibitor genistein, down-regulation of discoidin domain receptor 2, or collagen deglycosylation

69 DDR1 (discoidin domain receptor tyrosine kinase 1) kinase s hi

70 -trisphosphate receptor, type 3 (ITPR3), and discoidin domain receptor tyrosine kinase 2 (DDR2).

71 taining, and up-regulated mRNA expression of discoidin domain receptor tyrosine kinase 2, fibronectin

72 drocyte responses through receptors, such as discoidin domain receptor-2 and syndecan-4.

73 gen I activates fibroblast collagen receptor discoidin domain receptor-2, contributes significantly t

74 ed growth factor receptors (PDGFRs), and the discoidin domain receptor.

75 Discoidin domain receptors (DDR) 1 and 2 represent a fam

76 Discoidin domain receptors (DDR1 and DDR2) are receptor

77 Discoidin domain receptors (DDR1 and DDR2) are widely ex

78 have recently been identified as ligands for discoidin domain receptors (DDR1 and DDR2), generating a

79 The discoidin domain receptors (DDRs) are receptor tyrosine

80 The discoidin domain receptors (DDRs) are receptor tyrosine

81 study, we found that collagen binding by the discoidin domain receptors (DDRs) requires dimerization

82 The human discoidin domain receptors (DDRs), DDR1 and DDR2, are ex

83 The widely expressed mammalian discoidin domain receptors (DDRs), DDR1 and DDR2, are un

84 The discoidin domain receptors (DDRs), DDR1 and DDR2, form a

85 The discoidin domain receptors, DDR1 and DDR2, are receptor

86 ecific secreted protein encoding a conserved discoidin domain sequence.

87 Here, we tested the role of the discoidin domain tyrosine kinase receptor 2 (DDR2), whic

88 ially adjacent surface loops within the DDR2 discoidin domain were found to be critically involved in