ライフサイエンスコーパス: discover

1 remained a mystery since these enzymes were discovered.

2 ze, the smallest of a kinetoplastid thus far discovered.

3 formation about microbial communities can be discovered.

4 ITIM-containing platelet receptors have been discovered.

5 from transgenic mice where FAHFAs were first discovered.

6 ncestry-specific disease loci that have been discovered.

7 ways involved in pathogenesis continue to be discovered.

8 in layers where no hominin remains have been discovered.

9 bes, their metabolites, and the host will be discovered.

10 ions, the mechanisms involved have yet to be discovered.

11 engths of ethylene-bridged BODIPY motifs was discovered.

12 nd therefore must be addressed promptly once discovered.

13 at all nine previously described signals and discovered 17 additional variants with p </= 5 x 10(-8).

14 We recently discovered 3-amido thiazolino 2-pyridones which attenuat

15 NF-kappaB was discovered 30 years ago as a rapidly inducible transcrip

16 hensive transcription factor (TF) annotation discovered 978 TFs in 62 families, among which 404 TFs w

17 uced projectile impact testing technique, we discover a deformation-induced 9R phase with tens of nm

18 Here, in humans, we discover a large cluster of ASD-related de novo mutation

19 RNA-Seq has the potential to discover a more comprehensive set of eQTLs and illuminat

20 In this study, we discover a network regulating Claudin-4 in gastric cance

21 Ca0.5MnO3/La0.7Sr0.3MnO3 heterojunctions and discover a new spin-polarized current injection induced

22 ne in cells with this selection approach, we discover a phosphothreonyl-tRNA synthetase-tRNACUA pair

23 Unbiased exploration with VTEA enabled us to discover a population of tubular epithelial cells that e

24 In this issue of Cancer Cell, Todoric et al. discover a role for impaired autophagy in the developmen

25 We discovered a 0.6% frequency missense variant in ADCY7 th

26 We discovered a conserved interaction of THOR with IGF2BP1

27 predictions from determinations in vitro, we discovered a decline of noradrenergic projections in viv

28 study, using mass spectrometry analysis, we discovered a distinct phosphorylation site, Ser-176, on

29 Here, we discovered a dorsal-ventral distinction of actions in LO

30 Here, we discovered a fundamental role of S-phase protein kinase

31 Through a rational design approach we discovered a highly selective and potent BTK kinase inhi

32 In this study we discovered a large array of proteins not previously asso

33 bond formation and sulfoxidation, herein, we discovered a mild and metal-free C-H sulfenylation/intra

34 tic resonance imaging in macaque monkeys, we discovered a network centered in the medial and ventrola

35 apped the anatomy, modeled the function, and discovered a new behavioral role for a genetically defin

36 Thus, we have discovered a new biologically relevant, lumisterogenic p

37 We have recently discovered a new molecular mechanism of prostate cancer

38 We discovered a non-MHC-linked Ir gene in a T cell receptor

39 In this regard, we discovered a novel blue light-sensitive current in human

40 urification with TOC159 from Arabidopsis, we discovered a novel component of the chloroplast import m

41 We believe that we have discovered a novel epigenetic mechanism for altering cel

42 to identify new antidiabetic agents, we have discovered a novel family of (5-imidazol-2-yl-4-phenylpy

43 ure of an EBNA1 DNA-binding domain (DBD) and discovered a novel hexameric ring oligomeric form.

44 creening a peptide phage display library, we discovered a novel ligand (PDN1) that targets the unique

45 Scientists have recently discovered a novel pharmacologic agent that combines a N

46 We have previously discovered a novel role of calpain in mediating VEGF-ind

47 We sequenced THAP11 by Sanger sequencing and discovered a potentially pathogenic, homozygous variant,

48 pharmacology and gene knock-out methods, we discovered a previously unrecognized endogenous pathway

49 We discovered a significant IL-17A(+)IFN-gamma(+) (Th17/1)

50 We discovered a substantial number of public CDR3-TCRbeta s

51 We discovered a total of 3,484 instances of gene-trait-asso

52 In this study, we discovered a unique class of harmonic template neurons i

53 We also find that the newly discovered A. vinelandii siderophore vibrioferrin is alm

54 After discovering a small drop of food, hungry flies exhibit a

55 oors, and that there is still much yet to be discovered about their impact on indoor health and the u

56 esonance mass spectrometry (ESI-FTICRMS) and discovers additional substructural components.

57 nt in the injured axons, including the newly discovered alternative cleavage and polyadenylation of N

58 ng potent inhibitors of FXIa with a focus on discovering an acute antithrombotic agent for use in a h

59 cret tags that are difficult for defector to discover and chase after.

60 GENREs have been used to discover and interpret metabolic functions, and to engin

61 ts of extracellular volume fraction (ECV) to discover and quantify diffuse myocardial fibrosis in 25

62 ned with reverse mutagenesis technologies to discover and validate genes contributing to naturally oc

63 ysis-triggering hormone (ETH) was originally discovered and characterized as a molt termination signa

64 histidine, lysine, or cysteine residues were discovered and characterized from high-molecular weight

65 rated or slowed over orders of magnitude, by discovering and designing channelrhodopsins with altered

66 ionic, zwitterionic, and cationic PFASs were discovered, and an additional 17 previously reported cla

67 metal borohydride derivatives have also been discovered: anion-substituted compounds where the comple

68 As recently discovered, around 4% of proteins form new entangled mot

69 Hydrogen sulfide (H2S) was discovered as a third gasotransmitter in biological syst

70 utations in the RAC1 gene have recently been discovered as driver events in malignant melanoma.

71 vitro by treatment with NKH-477, a compound discovered as protective in our previous studies on Krab

72 7, Swope Supernova Survey 2017a (SSS17a) was discovered as the optical counterpart of the binary neut

73 sensitivity was 75.9% including the cancers discovered at prophylactic mastectomy (95% confidence in

74 It also suggests new possibilities for discovering BACE-1-targeted compounds with more complex

75 of end wall resistance with plant height was discovered, but found to be independent of end wall type

76 iral integration in infected cells have been discovered, but the factors that mediate alpharetroviral

77 inical features of autoimmune disorders were discovered by chance during World War II.

78 r efficacy, selectivity, and safety could be discovered by exploiting allosterism in plasmin, a prote

79 ound known to block the H3K27me3 site in EED discovered by in-house screening, Novartis scientists ha

80 tudies, approximately 1000 de novo mutations discovered by large-scale sequencing of family samples,

81 similarity of a potent G4 ligand previously discovered by our group and a congeneric PARP inhibitor,

82 Novel activities can be discovered by screening natural Bt isolates or through m

83 f of driver substitutions occur in yet-to-be-discovered cancer genes.

84 The newly discovered cascade reaction showed excellent chemoselect

85 emonstrate the scalability of SeqUnwinder to discover cell-specific sequence features from over one h

86 Further, multipotent compounds were discovered, characterized, and for example, assigned as

87 Finally, we show that a recently discovered chemical inhibitor of cry1, 3-bromo-7-nitroin

88 The recently discovered chemokine receptor CXCR7 and its ligand strom

89 ative sequences of both previously and newly discovered classes of riboswitches might reveal subgroup

90 nical multiparametric diagnostics could help discover clinically relevant biomarker combinations pivo

91 ng directed microbial culture techniques, we discovered Clostridium immunis, a previously unknown bac

92 The discovered CNVs are recurrent and rare (0.01-0.2%), with

93 or the identification of causal variants has discovered coding mutations in some AD-associated genes,

94 ning method has the ability to automatically discover complex representations of phosphorylation patt

95 To discover compounds that have anti-eIF2α-P activity

96 r to a subspecies of Homo erectus A recently discovered cranium (Aroeira 3) from the Gruta da Aroeira

97 eveloped an RNA-sequencing-based pipeline to discover differentially expressed cell-surface molecules

98 d underscore the power of using pathogens to discover disease-related cell biology.

99 research into predicting and experimentally discovering distinct classes of these materials, in whic

100 r cell identities of each subpopulation, and discover distinguishing features such as gene sets and t

101 t plasma cfDNA from DLBCL patients correctly discovered DLBCL-associated mutations that were represen

102 We report here that serum components, as discovered during growth in fetal bovine serum (FBS), el

103 used for controlling optomotor responses was discovered early.

104 ealing potential cofactors/collaborators and discovering enriched TF motifs.

105 investigated with bioinformatics methods.We discovered five novel heart rate loci, and one new indep

106 n, and oxygen and nutrient sensing have been discovered for organelles that were once thought to be s

107 Unfortunately, no such rules have been discovered for proteins.

108 ics of sunspot-producing magnetic fields and discovered for the first time that bursty and quiet seas

109 In this study, we present newly discovered fossil remains from intact archaeological lay

110 These compounds were discovered from a TNBC phenotypic screen and possess a u

111 ptors and that the addition of novel alleles discovered from genome sequence data are likely to be pa

112 iorated when exposed to luteolin, a recently discovered fructokinase inhibitor.

113 e interval for re-resection for incidentally discovered gallbladder cancer appears to be between 4 an

114 A total of 207 patients with incidentally discovered gallbladder cancer who underwent reoperation

115 ection for select patients with incidentally discovered gallbladder cancer.

116 for addressing remaining challenges, such as discovering gene function and the evolution of GRNs.

117 When validated on 99 newly-discovered genes with pathogenic mutations, the algorith

118 g to evaluate functional marker relevance of discovered genes.

119 ry rate analysis provides increased power to discover genetic variants and could elucidate shared mol

120 It is likely that many more remain to be discovered, given the density of such sequences in other

121 Cytoglobin (Cygb) is a recently discovered globin expressed in fibroblasts and smooth mu

122 a third GT module belonging to the recently discovered GT99 family.

123 Lead compounds discovered have potent and selective antiproliferative a

124 Unexpectedly, we discover high levels of somatic hypermutation in infants

125 shared goal of many researchers has been to discover how to improve health and prevent disease, thro

126 We discovered, however, that small electrolytic lesions in

127 Surveys have discovered hundreds of galaxies at these early cosmic ep

128 controversial history since its activity was discovered in 1939, has long been thought to be monomorp

129 ncer SVs and viral integration sites must be discovered in a genome-wide scale for clarifying the mec

130 0 million years after the Big Bang) that was discovered in a wide-field survey.

131 Small self-cleaving ribozymes have been discovered in all evolutionary domains of life.

132 This site is the oldest peatland yet discovered in Amazonia (peat initiation ca. 8.9 ka BP),

133 virtually all temporal patterning mechanisms discovered in Drosophila neural progenitors (neuroblasts

134 Zika virus was discovered in East Africa in 1947 by the Rockefeller Fou

135 ied this approach to drug-mediator relations discovered in EDDY-CTRP analysis and identified evidence

136 Schmallenberg virus (SBV) was discovered in Germany in late 2011 and then spread rapid

137 hetic enzymatic transformations remain to be discovered in naturally occurring enzyme 'toolboxes'.

138 uch tunneling-conductance enhancement can be discovered in other transition metal oxides and controll

139 in- and loss-of-function mutations have been discovered in primary leukemia/lymphoma and gastric canc

140 nin (OK) are related neuropeptides that were discovered in protostomian invertebrates (mollusks, arth

141 The topological phases discovered in recent years show that different phases ma

142 ases and disease-causing mutations have been discovered in several genes.

143 The dual chemistry of ARD was originally discovered in the bacterium Klebsiella oxytoca, but it h

144 Natural anion channelrhodopsins (ACRs) discovered in the cryptophyte alga Guillardia theta gene

145 ozaki-Hiyama-Takai-Kishi (NHTK) reaction was discovered in the late 1970s and, since then, its main a

146 mic microRNA regulation in cancers have been discovered in this study.

147 Some of the proteolytic changes discovered in vitro also occurred in two in vivo models

148 ated invariant T (MAIT) cells are a recently discovered, innate-like subset of T cells with cytotoxic

149 ents a novel measure of mapping ambiguity to discover interchromosomal SVs from mate-pair and pair-en

150 to hydrocarbons has called much interest in discovering its mechanism.

151 analytical methods are required, capable of discovering large co-regulated gene networks.

152 These newly discovered laws derive from the geometrical cell-membran

153 Here, we present an approach to discovering linear polyubiquitin-modified substrates by

154 temporally and spatially from the previously discovered long-term adaptation Hog1 pathway, which sign

155 ned from this work suggest an opportunity to discover low thermal conductivity materials among unexpl

156 These newly discovered MAGEA1-NICD1 and MAGEA1-FBXW7 interactions ha

157 ermediates represents lost opportunities for discovering materials or understanding how the final pro

158 method to monitor EGFR-TKI resistance and to discover mechanisms of drug resistance.

159 the 1000 Genomes Project, we also used it to discover MEIs in chimpanzees and ancient (Neanderthal an

160 In addition to using MELT to discover MEIs in modern humans as part of the 1000 Genom

161 There is therefore an urgent need to discover more effective targets for PEL management.

162 n that can be detected before birth, and for discovering more about maternofetal and placental biolog

163 constituted systems, as well as the recently discovered movement of FtsZ clusters around bacterial Z-

164 One of the most recently discovered NCRs is VISTA (V-domain Ig-containing Suppres

165 Two new protein densities were discovered near the decoding center and the peptidyl tra

166 Here we discover neoantigens in human mantle-cell lymphomas by u

167 A challenge for modern medicine will be to discover new antibiotics or strategies to combat multidr

168 electrocatalysts are not adequate, we aim to discover new catalysts by obtaining a detailed understan

169 ng complex diseases renewed opportunities to discover new or repurpose existing compounds and expedit

170 The novel findings may guide us to discover new therapeutic targets and develop effective v

171 Discovering new ways to inactivate pathogens in human wa

172 onal false discovery rate (cFDR) approach to discover novel loci associated with BMI and T2D by incor

173 rms to their biological functions as well as discovering novel proteoforms and new protein functions.

174 erstanding of cellular heterogeneity through discovering novel quality attributes, optimizing manufac

175 ofile of 2 case patients infected with newly discovered OPXV, Akhmeta virus, exhibited antibody respo

176 Ras-oncogenes were discovered over three decades ago, but there are still n

177 omote the exchange mode), and more recently, discovered partial substrates.

178 E Human metapneumovirus (HMPV) is a recently discovered pathogen that affects human populations of al

179 Discovering pathways to experimentally realize quantum p

180 rs to understand the data and, for instance, discover patterns affecting function and disease associa

181 a means to derive artificial intelligence by discovering patterns in existing data.

182 Utilizing a recently discovered precatalyst, Pd-catalyzed Suzuki-Miyaura and

183 ta confirmed that AroY utilizes the recently discovered prenylated FMN (prFMN) cofactor, and requires

184 d transcriptomic and metabolomic analyses to discover prenyltransferase genes in elicitor-treated pea

185 Our phylointeractomics screen discovers previously unknown telomere-associated protein

186 lphaproteobacterial cyclases require a newly discovered protein that we term BciE, encoded by a gene

187 the oldest "unequivocal" termitophile so far discovered, pushing back the known evolutionary history

188 Advances in methods to discover related CRMs in diverse insect species, a criti

189 ly stray from, but then return to, the newly discovered resource.

190 plore essential consequences of the recently discovered ring ultrastructure.

191 s will inform future studies of the recently discovered RV-C, which also appears to exacerbate asthma

192 Here, we discover SAV1-mediated inhibition of the PP2A complex ST

193 Through meta-analysis, we discovered similar up-regulation of neuropeptides in the

194 ation study (GWAS) of 33,536 individuals and discover six independent loci significantly associated w

195 e temporal probability distributions, and 3) discover small peaks in the probability landscape that h

196 a genome-wide local assembly algorithm that discovers somatic and germline structural variation brea

197 llerene-like nanoparticles (NPs) of WS2 were discovered some 25 years ago and are produced now on a c

198 The last two decades of network science have discovered stunning similarities in the topological char

199 nd cooperation among miRNAs when attempts to discover target sites.

200 the commoner Mendelian disorders were first discovered, technological advances in genetic analysis h

201 biochemistry, and biophysics techniques, we discover that ACT has intrinsic phospholipase A (PLA) ac

202 We discover that fibrils accumulate towards the hot side of

203 combine potential leaders and followers, we discover that leader-follower dynamics emerge from the s

204 We discover that MIC60 performs dual functions to maintain

205 uADCs) using integrative omics analyses, and discover that mRNA levels of DTL, DCAF4, 12 and 13 are c

206 Here we discover that NAD(P)H oxidase 4 (NOX4), an enzyme known

207 This enabled us to discover that neural stem cells, derived from the murine

208 Importantly, we discover that receptor tyrosine kinase AXL is a transcri

209 ne lung and two pancreatic cancer models, we discover that significant intratumoral and intertumoral

210 Also, we discover that Smurf1 directly binds to the kinase domain

211 From the analysis of the trajectories, we discover that the potential that directs the rotating le

212 We discover that whereas cell divisions drive tissue expans

213 ained virtual reality system for rodents, we discovered that a new experience increased firing of act

214 Using this approach, we discovered that a pair of two-pore potassium channel (K2

215 We discovered that A673V mutation, the only recessive AD-as

216 It was recently discovered that absence of ABCC6-mediated adenosine trip

217 We discovered that all nontransverse patterns share a commo

218 Using in silico modeling, we discovered that anisotropic proliferation might explain

219 Surprisingly, we discovered that attentional enhancements of population-l

220 As a result, we have discovered that B1 and VRK2 target a common set of subst

221 in the pathway by activating PP2A(Cdc55) We discovered that constitutively active Pkc1 can drive cel

222 ranscriptomics and bioenergetic analysis, we discovered that DF induces glycolysis and reduces mitoch

223 Furthermore, we discovered that DLX1 and DLX2 function as direct transcr

224 Here, we discovered that dual inhibition of the SHH and CXCR4 pat

225 ons, we found remarkable sex differences and discovered that female mice displayed greater gene expre

226 Mechanistically, we discovered that five bacterial mutants promote longevity

227 Then three laboratories independently discovered that FtsZ, a protein already known as a key p

228 tional penicillin binding protein PBP A1, we discovered that GpsB influences lysozyme resistance of L

229 Refuting previous theory, however, we discovered that homogeneously distributed resources supp

230 We discovered that IFNgamma is captured by phosphatidylseri

231 We recently discovered that IkappaBalpha enhances the rate of releas

232 We discovered that imposing a time-restricted feeding (TRF)

233 We discovered that in budding yeast, kinetochore inactivati

234 We recently discovered that incorporation of four-membered azetidine

235 gen that elicits protective immunity, but we discovered that it can nonetheless disrupt intestinal im

236 Here, we discovered that KCNQ2/3 channels isoform-specifically co

237 Remarkably, we discovered that linker histone H1 phosphorylated at S/T1

238 We discovered that net leaf flushing of the canopy layer ma

239 Here we have discovered that norcoclaurine synthase from Thalictrum f

240 In the current study, we have discovered that PDK4 is a short lived protein (t(1/2) ap

241 Using this approach, we discovered that plasma membrane-bound respiratory syncyt

242 well documented on some ice shelves, we have discovered that ponds often form part of widespread, lar

243 Here, we discovered that PRRSV antagonizes the JAK/STAT3 signalin

244 rearrangements in primary murine B cells and discovered that RAG1/2 causes aberrant insertions by rel

245 We discovered that RSV infection induces a complex of bromo

246 s reports of S100A4 as a reporter of EMT, we discovered that S100A4 is an upstream regulator of the m

247 We discovered that skin biopsies obtained during asymptomat

248 We previously discovered that small-molecule zinc chelators called zin

249 Here we have discovered that the bovine papillomavirus 1 (BPV-1) tran

250 from rat visual and somatosensory cortex and discovered that the connectivity was not consistent with

251 We discovered that the fruit fly olfactory circuit solves t

252 ude both A.T and G.C base pairs, we recently discovered that the heterocyclic diamidine, DB2277, form

253 In this study, we discovered that the human Piwil 2 (Hili) protein can als

254 unbiased functional screening approaches, we discovered that the Id family of helix-loop-helix protei

255 We previously discovered that the mitochondrial AAA+ unfoldase ClpX pr

256 Remarkably, we discovered that the myosin I protein in fission yeast, M

257 Interestingly, we discovered that tightening of ER-mitochondria contacts b

258 ounds was consistent with clinical data, and discovered that trimethylamine-N-oxide (TMAO) crosses th

259 PTP1B inactivation by H2O2 Intriguingly, we discovered that TrxR1/NADPH directly protects PTP1B from

260 Here, we discovered that two Drosophila slit diaphragm proteins,

261 diffraction and meta-dynamic simulation, we discovered that under high pressure, acetylene molecules

262 Here, we discovered that WHAMM interacts with alphabeta-tubulin t

263 We have also recently discovered that within the genus Cataglyphis there are i

264 We discovered that yeast has a recycling route from endosom

265 w focused libraries of TAs have been used to discover the active principles of the TA polymers that i

266 a library of derivatives was synthesized to discover the first dual G4/PARP ligand.

267 on RNA sequencing of resistant subclones, to discover the molecular mechanisms of sensitivity.

268 This model will help further discover the pathomechanisms of this devastating disease

269 is triad of symptoms and guide the reader to discover the patient's ultimate genetic diagnosis.

270 We discover the unanticipated structural requirement that T

271 The aim of this study was to discover the unique volatile compositional traits of ret

272 RNA-cleaving DNAzymes are the catalytic DNAs discovered the earliest, and they can cleave RNAs in a s

273 We discovered the first FXYD homologue in sea lamprey, a ba

274 irmed the presence of adhesive junctions and discovered the formation of desmosomes between the invad

275 In this way, we discovered the heavy-atom tunneling reaction involving s

276 We discovered the molecular underpinnings of lowered affini

277 itivity to anti-EGFR drugs, here we aimed at discovering the first compounds that block simultaneousl

278 A critical step in discovering the full extent of structural variations is

279 ion is a rich, largely untapped resource for discovering the genetic basis and architecture of plant

280 ed coat suberin synthesis offers a basis for discovering the potential transcriptional network behind

281 exploit this inherent tumor heterogeneity to discover therapeutic vulnerabilities.

282 identify small-molecule agonists of TFEB and discover three novel compounds that promote autophagolys

283 tructural features interacting with KHK were discovered through fragment-based screening and subseque

284 non-coding RNAs (lncRNAs) have been recently discovered through functional genomics studies.

285 Next, we discovered through modeling that such projection pattern

286 The human gut metagenome was recently discovered to encode vast collections of biosynthetic ge

287 mvent the surface oxide, a novel approach is discovered to print and sinter Zn nanoparticle facilitat

288 ples, which provide unique opportunities for discovering trends within and between cancer subtypes.

289 the duration of the experiment, and thereby discover trial-to-trial variability in the spike-field c

290 ta-analysis of 606,059 parents' survival, we discover two regions associated with longevity (HLA-DQA1

291 AFE-SRM), to plasma from cancer patients and discovered two peptides encoded by the peptidyl-prolyl c

292 We discovered two rare signals that strongly associate with

293 We discovered tyrosine 78 of Atoh1 is phosphorylated by a J

294 Earth-sized planets transiting the recently discovered ultracool dwarf star TRAPPIST-1 are capable o

295 We recently discovered ultralong (>10 to hundreds of microns) membra

296 alled the hypocretins or orexins, which were discovered using two different approaches.

297 , laterally situated, anastomosing channels, discovered via micro-focus computed tomography (muCT), i

298 A dual ammonia activation approach has been discovered whereby reversible M-L cooperativity and coor

299 the size of correlated gene sets they could discover within biologically heterogeneous data collecti

300 ree bilayer thick PbSe-SnSe alloy layers was discovered within [(Pbx Sn1-x Se)1+delta ]n (TiSe2 )1 he