ライフサイエンスコーパス: discovery

1 ubunits has been a mystery since its initial discovery.

2 t opportunities for successful lead and tool discovery.

3 entification and optimization for early drug discovery.

4 e phenomena for cancer therapy and biomarker discovery.

5 are proving to be fruitful targets for drug discovery.

6 tis, and characterizing cohorts for antibody discovery.

7 quantitative and manipulative framework for discovery.

8 as led to renewed efforts in antibiotic drug discovery.

9 enhance the alpha-amylase inhibitor peptide discovery.

10 e-based database focused on preclinical drug discovery.

11 to direct lead optimization efforts in drug discovery.

12 romising sources of small molecules for drug discovery.

13 essed, making it a potential target for drug discovery.

14 and their resulting applications to medicine discovery.

15 l limits, it has become a tool of biological discovery.

16 elopment of cell-based assays for NMDAR drug discovery.

17 he PepSAVI-MS pipeline for bioactive peptide discovery.

18 GFR can help identify novel targets for drug discovery.

19 ng an increasingly popular strategy for drug discovery.

20 gical reagents for target validation in drug discovery.

21 e is a major cause of high attrition in drug discovery.

22 ry proteins provide a new dimension for drug discovery.

23 as a biomarker for diagnosis and novel drug discovery.

24 ng have been described, whereas others await discovery.

25 rative therapies, disease modeling, and drug discovery.

26 ditional means of diagnostic and therapeutic discovery.

27 marks that represent common targets for drug discovery.

28 the usefulness of GWAS data in guiding drug discovery.

29 science as they make unexpected, fundamental discoveries.

30 Discovery, acquisition, installation, and maintenance of

31 extually refining regulator target genes for discoveries across many contexts.

32 unique opportunity for biomarker and pathway discovery after myocardial injury.

33 nd intuitive and is the basis for many motif discovery algorithms.

34 We performed discovery analyses on plasma samples from 759 participan

35 These molecular discoveries and metabolic modeling now serve as a founda

36 Here, we review recent discoveries and, by interrogating newly available plant

37 We have also enhanced data discovery and access with a track hub registry and a sel

38 applications in precision medicine and drug discovery and aid in the development of increased and se

39 chroococcum is examined using small molecule discovery and bioinformatics.

40 Fragment-based drug discovery and continuous improvement of existing protein

41 ipidome increase the likelihood of biomarker discovery and could lead to more comprehensive understan

42 O1 as a cancer therapeutic target and on the discovery and development of a set of mechanistically di

43 ta, however, have spurred efforts toward the discovery and development of improved or novel new compo

44 balization has driven new paradigms for drug discovery and development.

45 new algorithms for phenotype driven genomic discovery and diagnostics, integration of cross-species

46 The SCOPA and META-SCOPA software enable discovery and dissection of multiple phenotype associati

47 ranslational end point in pro-cognitive drug discovery and early-phase clinical trials.

48 Here we present the discovery and evaluation of N-(5-fluoropyridin-2-yl)-6-m

49 We report here the discovery and functional characterization of two S. divi

50 This review discusses the discovery and genetics of LOX-1; describes existing evid

51 ultimately serve as an engine for biological discovery and increase our insight into cancer and its t

52 way for a broadly applicable high-throughput-discovery and materials-by-design feedback loop.

53 oms in two prospective military cohorts (one discovery and one replication data set).

54 o be another such protein through an epitope discovery and proteomics approach by comparing post-mort

55 esign is an integral part of modern day drug discovery and requires detailed structural characterizat

56 y testing tools, and overcoming obstacles in discovery and research of new antibiotics.

57 e, which offers a new platform for molecular discovery and therapy.

58 s provided to the community to assist in the discovery and translation of new therapeutic approaches

59 action is important for structure-based drug discovery and understanding protein structure-function r

60 We adopted a two-stage discovery and validation design using patients from the

61 Therefore, discovery and validation of therapeutic targets derived

62 n overview of fundamental principles, recent discoveries, and clinical implications of this promising

63 a promising candidate for anti-diabetic drug discovery; and b) provide a rational basis for the devel

64 Here, we apply a discovery approach that bypasses the culturing step enti

65 A variety of complementary discovery approaches have begun to illuminate this micro

66 therefore important not only to devise drug discovery approaches, but also to gain knowledge on TEAD

67 Importantly, recent discoveries are paving the way to the development of inn

68 he majority of breast cancer models for drug discovery are based on orthotopic or subcutaneous tumour

69 quired infections and limited new antibiotic discovery are jeopardizing human health at global scales

70 ors have gained widespread attention in drug discovery as a validated method to circumvent acquired r

71 Ever since miR-H2's discovery as a viral microRNA bearing complete sequence

72 ected to significantly accelerate Hsp70 drug discovery by providing XIAP as a pharmacodynamic biomark

73 n of new relationships between academic drug discovery centers and commercial partners, which can acc

74 y different between these groups in both the discovery cohort and the validation cohort.

75 The discovery cohort had 306 patients, the first validation

76 AREDS2 participants (discovery cohort) had detailed phenotyping for AMD; othe

77 In the discovery cohort, sex-stratified analysis identified 2 a

78 In the discovery cohort, the worst outcome was found for patien

79 slocalized or absent staining in 100% of the discovery cohort.

80 This results in discovery collections that are enriched in substances po

81 Using computer-aided drug discovery coupled with in vitro kinase assays, we identi

82 how these efforts have been critical to the discovery, design, and subsequent development of novel t

83 urdened by many uncertainties that make drug discovery difficult.

84 f applications, including clinical biomarker discovery, drug discovery, environmental chemistry, and

85 Approaches range from drug discovery efforts to big-data methods and direct-to-cons

86 including clinical biomarker discovery, drug discovery, environmental chemistry, and metabolomics.

87 iobanks provide potential to perform genetic discovery, explore the phenotypic consequences for disea

88 ics toolkits that will lead to new knowledge discovery from their data.

89 Since its discovery, graphene has held great promise as a two-dime

90 With the advent of the Internet, drug discovery has become more decentralised, bottom-up, and

91 Transcriptome-based drug discovery has identified new treatments for some complex

92 At the same time fragment-based drug discovery has matured into a powerful and widely applied

93 These discoveries have been complemented by a substantial suit

94 h much remains to be investigated, these new discoveries have changed our understanding of mechanisms

95 Recent discoveries have highlighted the importance of fatty aci

96 Recent discoveries have identified underlying disease-modifying

97 Our discovery here presented has implications for all geneti

98 This discovery highlights the role that intracellular localiz

99 iology, and genetics that have propelled new discoveries in the field.

100 Here we discuss recent discoveries in the myriad molecular pathways that govern

101 practically useful tool for novel biological discoveries in understanding the regulatory mechanisms o

102 These recent discoveries in Utah suggest that turiasaurs as a lineage

103 The serendipitous discovery in 1961 of dibenzo-18-crown-6 by Charles J.

104 Through genome-wide association discovery in 48,943 individuals, selected from extremes

105 s up a world of possibilities for scientific discovery in developmental biology as well as in transla

106 physiologically relevant approach to target discovery in glioblastoma.

107 n provide an efficient pathway for knowledge discovery in the next generation of materials design.

108 analgesics, has been a major focus for drug discovery in the recent past.

109 The discovery in this research could inspire scientists' int

110 nsiderable promise for biomarker and pathway discovery, in spite of the lack of successful applicatio

111 The second observation is the discovery, in the inner layer of the developed turbulent

112 Key discoveries include the cellular subsets that function a

113 challenges associated with progressing these discoveries into the clinic including context dependency

114 itu temperature records collected during the Discovery Investigations (1926-1938) and contemporary ca

115 ical performance of a new PET/CT system, the Discovery IQ with 5-ring detector blocks.

116 Fragment-based lead discovery is becoming an increasingly popular strategy f

117 llenging; thus, most cancer pharmacogenomics discovery is conducted in preclinical studies, typically

118 tionised medicine in many aspects, and their discovery is considered a turning point in human history

119 The history of ALS drug discovery is fraught with many stops and starts.

120 The discovery is that neuronal circuits operating reflexivel

121 Discoveries leading to an improved understanding of immu

122 Despite recent discoveries made in this area, it is unknown how the ora

123 This discovery marks an important advance in our comprehensio

124 o benchmark a variety of computer-aided drug discovery methods under identical experimental condition

125 Tests were conducted independently on two Discovery MI scanners installed at Stanford University a

126 In discovery mode, it allows detection, with supporting MS2

127 Recent discoveries of abundant conventional and unconventional

128 Discoveries of RNA demethylases, along with advances in

129 The recent discoveries of tissue-resident NK cell developmental int

130 The discovery of 2,6-diaryl-2-acetamidopyridines represents

131 The discovery of 20-HETE-GPR75 pairing presented here provid

132 Ellipsoidal analysis leads to discovery of a general switching of polyhedral distortio

133 Here we report the discovery of a group of giant viruses (Klosneuviruses) i

134 This work led to the discovery of a highly selective PI3Kbeta/delta inhibitor

135 We report the discovery of a hitherto unprecedented enzyme-promoted al

136 After further optimization, the discovery of a minor enantiomeric impurity with agonist

137 In this article, we describe the discovery of a new chemical probe, bisamide (CCT251236),

138 Here, we report the discovery of a new class of deaminases, predominantly fo

139 We here report the discovery of a nonenzymatic counterpart to this reaction

140 sights in the biology of tRNASec, led to the discovery of a novel bacterial selenoprotein family, and

141 A rice (Oryza sativa) mutant led to the discovery of a plant-specific LAZY1 protein that control

142 Herein we describe the discovery of a potent FXIa clinical candidate, 55 (FXIa

143 The recent discovery of a second class of high-Tc materials, Fe-bas

144 lysis, using cell culture assays, led to the discovery of a series of compounds belonging to the 5-al

145 Here, we report the discovery of a transient, spatially selective neural sig

146 The discovery of alpha-Gal stimulated new discussions and in

147 The recent discovery of AmbU4 (or FamC1) protein encoded in the amb

148 This innovative technique led to the discovery of an unexpected record confinement regime wit

149 We recently reported the discovery of AT-076 (1), (R)-7-hydroxy-N-((S)-1-(4-(3-hy

150 Herein, we describe the discovery of azaindoles as a new class of CSN5 inhibitor

151 igandability and facilitates the coordinated discovery of bioactive small molecules and their molecul

152 provide more supplemental candidates for the discovery of biomarkers.

153 ets and provides a powerful resource for the discovery of causal variants.

154 pioneering work of Elie Metchnikoff and the discovery of cellular immunity, the phagocytic clearance

155 mall-molecule libraries have accelerated the discovery of chemical probes for studying biological pro

156 ck of in vivo screening technologies for the discovery of compounds that affect the age-dependent neu

157 avations at the site in 2014-2015 led to the discovery of cultural remains generally associated with

158 sequencing have facilitated the large-scale discovery of de novo variants in human disease.

159 him to devote all his efforts following his discovery of dibenzo-18-crown-6 until his retirement to

160 to therapeutic pressure by BTICs impede the discovery of effective anti-BTIC therapies and limit the

161 Discovery of effective cell therapies against cancer can

162 The recent discovery of flexible graphene monolayers has triggered

163 This analysis led to the discovery of four unique type II-A CRISPR-Cas9 inhibitor

164 hin the pyroptosis field, beginning with the discovery of Gasdermin D (GSDMD) as a substrate of caspa

165 Despite the accelerated discovery of genes associated with syndromic traits, the

166 The recent discovery of gravitational waves from stellar-mass binar

167 ub for spatial information processing by the discovery of grid, border, and head-direction cells.

168 A new epoch started with the discovery of head direction cells and the realization of

169 For the discovery of hepatitis B virus integration sites from pr

170 The discovery of Higgs-boson decays in a background of stand

171 ineered into single lattices, leading to the discovery of high-entropy alloys and high-entropy oxides

172 e analogues of viridicatumtoxin B led to the discovery of highly potent, yet simpler analogues of the

173 onstrate the utility of the approach for the discovery of host proteins involved in HIV replication.

174 26.0% had Gitelman-like syndrome (fortuitous discovery of hypokalemia with hypomagnesemia and/or hypo

175 f traditional plant knowledge) has aided the discovery of important medicines.

176 Herein we report the discovery of LX2761, a locally acting SGLT1 inhibitor th

177 It is now possible to accelerate the discovery of materials with target properties, such as a

178 at 600-700 degrees C and 1.5-2.5 GPa and the discovery of methane-rich fluid inclusions in metasomati

179 other important and difficult problem is the discovery of molecular disease subtypes characterized by

180 Discovery of molecular targets or compounds that alter n

181 Such insight provides a framework to the discovery of much needed drugs that selectively target t

182 nd accumulate inside these cells, making the discovery of much-needed drugs against these pathogens c

183 ollowing immediately after the serendipitous discovery of N-confused porphyrins, remarkably diverse c

184 The discovery of Neandertals at open-air sites during the la

185 and there are unmet clinical demands for the discovery of new biomarkers and development of treatment

186 tion metal reactivity, which may lead to the discovery of new f-block catalysis.

187 The discovery of new gigantic molecules formed by self-assem

188 ic targets is a significant challenge in the discovery of new medicines.

189 reactions and provides a foundation for the discovery of new modes of reactivity of polyunsaturated

190 the utility of "admixture screening" for the discovery of new multicomponent heterogeneous Pd catalys

191 volution of nature's enzymes can lead to the discovery of new reactivity, transformations not known i

192 egy for genome-scale screens, leading to the discovery of new roles for BMP signaling in linking mito

193 disease and other biological processes, and discovery of new therapeutics.

194 This resulted in the serendipitous discovery of nine compounds that were MC3R agonists (EC5

195 nter (S)-proline-based lead 7 has led to the discovery of noncovalent reversible and selective human

196 in HIV-1 RT has been a key roadblock in the discovery of nonnucleoside RT inhibitors (NNRTIs).

197 The discovery of nonnucleoside, reversible, small-molecule i

198 There is an urgent need for discovery of novel antimicrobials and carbohydrate-based

199 In addition, the discovery of novel biomarkers may not only prove useful

200 ome) will provide opportunities for unbiased discovery of novel markers to improve diagnostic or pred

201 therapies, and frequently recur, making the discovery of novel therapeutic targets for this disease

202 localization, enabling the first large-scale discovery of O-glycosylation on signaling peptides.

203 of enantioselective transformations, yet the discovery of organic catalysts effective at low catalyst

204 e sequence homology across the PAR isoforms, discovery of PAR2 antagonists has been less successful,

205 The discovery of PhnH demonstrates that enzymes can be used

206 The discovery of physical laws consistent with empirical obs

207 nstrates that CellCognition Explorer enables discovery of rare phenotypes without user training, whic

208 Thus, the discovery of reliable biomarkers for the management of T

209 erised by progressive muscle wasting and the discovery of reliable blood-based biomarkers could be us

210 First, the discovery of risk genes and their implications, with a f

211 anticipated to improve these parameters, the discovery of selective, direct activators has proven cha

212 We report the discovery of self-assembly strategies leading to the eme

213 er-guided strategy can be used to enrich the discovery of sequence/structure/function transitions in

214 n space has been accelerated with the recent discovery of several solid solution and ordered phases i

215 These data enabled the discovery of subdominant binding motifs and an integrati

216 Experimental discovery of such solitons is hindered by the need for s

217 Here, we report our discovery of systematic spatial variation in alliance st

218 roarray analysis, and did unsupervised class discovery of test and validation cohorts to identify con

219 The recent discovery of the first doubly charmed baryon , which con

220 however, studies of keratin have seeded the discovery of the genetic basis for a large number of gen

221 This is a tale of how technology drove the discovery of the molecular basis for signal transduction

222 Here, we describe the discovery of the most potent inhibitor of sirtuin 5 (SIR

223 Discovery of the Muta1 element from Aedes aegypti and it

224 timization of 3 using SBDD culminated in the discovery of the potent and selective Brr2 inhibitor 9 w

225 The discovery of the Sry gene in 1990 triggered a revolution

226 This discovery of the stem II structural transition leads to

227 The discovery of the unexpected anomeric memory effect is fu

228 Discovery of these proteins by traditional biochemical f

229 The discovery of this previously unnoticed oscillatory behav

230 The discovery of thousands of noncoding RNAs (ncRNAs) has ex

231 The discovery of three new plant STSs is reported that produ

232 Since the discovery of topological insulators and semimetals, ther

233 obel Prize in Physiology or Medicine for her discovery of transposable elements in maize.

234 haracterize plant promoter sequences and the discovery of two root hair regulatory elements (RHE1 and

235 Here we report the experimental discovery of two structure types by computational identi

236 genomic data set through iFORM/eQTL gain new discoveries on the genetic origin of gene expression dif

237 In the context of drug discovery or drug repositioning, the methods presented h

238 ent tool to guide organic synthesis and drug discovery, particularly applicable to catalytic systems

239 optogenetics have opened new routes to drug discovery, particularly in neuroscience.

240 history of the field is surveyed from a drug discovery perspective with a focus on the key advances i

241 We furthermore present an siRNA off-target discovery pipeline that not only predicts the off-target

242 he application of our gene fusion neoantigen discovery pipeline, called INTEGRATE-Neo, by identifying

243 sment is thus a major hurdle in the compound discovery pipeline, currently involving large scale anim

244 Here we describe a discovery platform that can identify stimulus-responsive

245 nce the sensitivity of C. elegans based drug discovery platforms.

246 The discovery points to a mechanism of nucleic acid sensing

247 The discovery population comprised 1350 patients (after furt

248 Through a systematic and cost-effective PET discovery process, involving expression level (Bmax) and

249 es can greatly speed up the traditional drug discovery process.

250 Significant investments in therapeutic drug discovery programs over the past two decades have yielde

251 Our discovery prompts critical re-evaluation of prevailing u

252 applications in disease investigations, drug discovery, prosthetic design and neuropathic pain invest

253 The discovery provides new information for the clade Triadop

254 This discovery provides the first line of evidence to suggest

255 ial DNA methylation of UNC5C and ENC1 (false discovery rate < 0.05).

256 -associated changes in expression at a false-discovery rate < 0.05.

257 s more frequently in males (based on a false discovery rate < 0.1), in comparison to zero of 18,055 a

258 served sequences as short as 9 bp with false discovery rate </=0.05.

259 i) a Bonferroni adjustment and (iii) a false discovery rate (FDR) adjustment which is widely used in

260 characteristic (ROC) curve to minimize false discovery rate (FDR) and calculate the best thresholds b

261 ng procedure, named Bon-EV, to control false discovery rate (FDR) based on Bonferroni's approach.

262 at epigenome-wide significance level [false discovery rate (FDR)<0.05].

263 s improved on improvement index (>30%; false discovery rate [FDR] corrected p < 0.0008) and nontraine

264 multiple phenotypes using conditional false discovery rate analysis provides increased power to disc

265 ALS-associated loci using conditional false discovery rate analysis.

266 Genetic loci identified by conditional false discovery rate analysis.

267 d by using a general linear model with false discovery rate control for multiple comparisons.

268 ripts and genes from 1599 genes (DEGs; false discovery rate P<0.05, fold change |2|, controlling for

269 al significance (fold change>/=1.5 and false discovery rate</=0.05), to identify unique proteomic sig

270 ressed in vivo compared with in vitro (false discovery rate, </=0.001; 2-fold change) with 557 showin

271 unique cross-links at approximately 1% false discovery rate.

272 iculties replicating findings and high false discovery rates).

273 ficant covariances and also to control false discovery rates, even when the sample size is small (n=1

274 Most studies have focused on biomarker discovery rather than exosome function.

275 ical genetics in plants, with a focus on the discoveries regarding small molecules identified in scre

276 However, the physiological relevance of this discovery remained unclear, as we were unable to identif

277 Two unexpected discoveries resulted from this study.

278 This discovery reveals an unprecedented pharmacological appro

279 erformed a genomewide association study in a discovery set of samples obtained from 43,568 women of E

280 uggestive significance (P<1.0x10(-6)) in the discovery set.

281 So far, drug discovery strategies have been unsuccessful, because of

282 have been successfully applied in biomarker discovery studies, while the role of MS in translating b

283 cal proteomics and particularly to biomarker discovery studies.

284 ified via solvent mapping to aid future drug discovery studies.

285 In conclusion, drug discovery targeting the gut microbiota as well as the ch

286 The discovery that astrocytes have different types of reacti

287 t multiple cheminformatic approaches in drug discovery that can influence and triage design and execu

288 r, the understanding became blurred with the discovery that IgE antibodies were the effector molecule

289 Genomic discovery that is agnostic to preexisting knowledge has

290 e a spontaneous process, based on Anfinsen's discovery that purified proteins can fold on their own a

291 Here, we report the discovery that the microwave dielectric and the optical

292 measurements in structural biology and drug discovery, the factors that govern protein stabilities a

293 n-allelic genetic heterogeneity hampers gene discovery, this study demonstrates the utility of rare d

294 ats we need to overcome for automated causal discovery to become a part of the routine data analysis

295 Because existing motif-discovery tools typically miss these position-specific s

296 ng behind many other fields in terms of gene discovery using genome-wide association study (GWAS) met

297 Our study comprised a discovery WB cohort (n = 245, chronic) and three indepen

298 arget identification and fragment-based lead discovery with efforts to develop new antimicrobials for

299 es that silicon incorporation offers in drug discovery, with an emphasis on case studies where introd

300 isease risk, suggesting that further genetic discovery, with an emphasis on common variation, is warr