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1 ic plague is a devastating and transmissible disease for which a Food and Drug Administration-approve
2 sis (ALS) is a devastating neurodegenerative disease for which a greater understanding of early disea
3 e used in the study of any neurodegenerative disease for which a mouse model exists, promising to rev
6 ribute to the development and progression of diseases for which acute or chronic inflammation has bee
7 coholic hepatitis (AH) is a life-threatening disease for which adequate oral nutritional support is r
10 s occur rapidly in kidney and cardiovascular disease, for which an in-line monitor could be beneficia
11 eficiency virus (HIV) is the only infectious disease for which anonymous testing is publicly funded,
12 nvasive mold infections are life-threatening diseases for which appropriate antifungal therapy is cru
13 of new therapeutic strategies for glomerular diseases for which available therapies are not fully eff
14 cause-specific mortality from cardiovascular diseases for which background risk varies because of oth
15 antle cell lymphoma is a generally incurable disease for which blood or marrow transplantation is fre
17 of reassurance to many patients with HCM, a disease for which clinical course is often unfavorable a
18 ome) is increasingly used for studying human disease, for which copy-number variants (CNVs) are a cri
19 , particularly in extensively drug-resistant disease for which current antibiotic regimens are largel
21 ng squamous cell carcinoma (SCC) is a deadly disease for which current treatments are inadequate.
22 antile onset represent an important class of disease for which discovery of the underlying genetic ar
23 ma gene therapy maybe effective in malignant diseases for which DNA tumor viruses are etiologic agent
24 contribute to the development of Alzheimer's disease, for which early administration of NSAIDs is pro
25 rhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is
26 hold promise for the treatment of high-risk disease for which effective therapies are currently lack
28 omes, but also for treating common metabolic diseases for which effective therapies are currently lac
29 ochondrial disorders are devastating genetic diseases for which efficacious therapies are still an un
30 d to the fragile X syndrome and Huntington's disease, for which enough quantitative data have been co
31 a brucei causes African sleeping sickness, a disease for which existing chemotherapies are limited by
32 erosis is an inflammatory, neurodegenerative disease for which experimental autoimmune encephalomyeli
35 ly viewed as a late complication of systemic disease, for which few effective treatment options exist
36 but heterogeneous subset of congenital heart disease for which gene identification has been difficult
38 are three examples of long-known infectious diseases for which global vaccination has dramatically r
39 e cancer is one of the most common malignant diseases for which health-care intervention is sought wo
41 eatment of psoriasis, and other inflammatory diseases for which IL-17 antagonists are currently teste
42 Malignant mesothelioma remains an incurable disease for which immune-modulatory therapies, such as e
43 serous ovarian carcinoma (HGSOC) is a lethal disease for which improved screening and treatment strat
45 on, autism, and dystonia represent disabling diseases for which little etiologic information is avail
46 approaches could be applied to other chronic diseases for which long-term controlled trials are not f
47 n is a hallmark feature of peripheral artery disease for which minimal therapeutic options exist.
48 ng framework can readily be applied to other diseases for which mitochondrial dysfunction has been im
50 d to data for cystic fibrosis and Huntington disease, for which mutations in disease genes have alrea
51 leukemia (CLL) is a clinically heterogeneous disease for which natural history can be predicted based
52 oma (ATC) is a highly aggressive form of the disease for which new therapeutic options are desperatel
56 isease (COPD) is a prevalent smoking-related disease for which no disease-altering therapies currentl
57 steoarthritis is a common degenerative joint disease for which no disease-modifying drugs are current
58 (HDV) is a cause of acute and chronic liver disease for which no effective therapy is currently avai
60 iabetes is a serious, genetically influenced disease for which no fully effective treatments are avai
62 threatening, tick-borne, emerging infectious disease for which no satisfactory animal model has been
65 complication of the scleroderma spectrum of disease for which no treatment has been proven effective
66 mary pulmonary hypertension is a progressive disease for which no treatment has been shown in a prosp
68 stis causes pneumonic plague, an often-fatal disease for which no vaccine is presently available.
69 e for tackling the transmission of dengue, a disease for which no vaccine, prophylaxis, or therapeuta
71 r myopathies (CNM) are non-dystrophic muscle diseases for which no effective therapy is currently ava
72 opathies (TSEs) are fatal, neurodegenerative diseases for which no effective treatments are available
73 oup of fatal transmissible neurodegenerative diseases for which no pharmacological treatment is avail
74 cause acute, often fatal, hemorrhagic fever diseases, for which no effective vaccines are currently
75 Metastatic colorectal cancer is a prevalent disease for which novel targeted therapies and biologica
77 there are many gastrointestinal and hepatic diseases for which obesity is the direct cause (eg, nona
78 ) is a genetically heterogeneous and complex disease for which only one locus, APOE, has been definit
79 tion of admixture mapping in complex genetic diseases for which only modest ethnicity risk ratios of
80 nearsightedness, is a common ocular genetic disease for which over 20 candidate genomic loci have be
81 of prevention strategies aiming at emerging diseases for which parameters are not nessecerly known i
82 spective, we review several of the lysosomal diseases for which PCs have been studied and the SAR of
83 tery disease is a potentially incapacitating disease for which pharmacological options are limited.
84 s (AAAs) are a chronic inflammatory vascular disease for which pharmacological treatments are not ava
85 mpsia are similar to those in cardiovascular disease, for which physical activity is shown to be prot
86 y (HCM) is an important genetic heart muscle disease for which prevalence in the general population h
87 family that is responsible for a fatal human disease for which preventative or therapeutic measures d
88 sus (SLE) is an uncommon, clinically complex disease for which prior experience treating similar pati
89 ectal cancer (CRC) is a highly heterogeneous disease, for which prognosis has been relegated to clini
90 t for tuberculosis, malaria, AIDS, and other diseases for which protective vaccines do not exist.
91 vere epilepsies and other neurodevelopmental diseases for which rare, often de novo, mutations play a
92 e recommendations for 13 vaccine-preventable diseases for which recommendations were in place prior t
93 tudies of vector-borne disease, such as Lyme disease, for which risk is intrinsically linked to geogr
94 of chronic diseases, such as coronary heart disease, for which rural areas now exceed urban ones.
96 a distinctive phenotype of neurodegenerative disease for which several causative genes have been iden
97 es mellitus and neurodegeneration are common diseases for which shared genetic factors are still only
98 We have made every attempt to review those diseases for which significant and confirmatory evidence
99 tory, except for diabetes and chronic kidney disease, for which smaller, but significant, risk reduct
100 -1 infection, but also numerous inflammatory diseases for which such antiplatelet therapies are curre
101 ease (PD) is a progressive neurodegenerative disease for which susceptibility is linked to genetic an
102 Otitis media (OM) is a common pediatric disease for which systemic antibiotics are often prescri
103 s leishmaniasis is an ultimately self-curing disease for which systemic therapy with pentavalent anti
105 g of this prediagnostic phase of Parkinson's disease (for which the clinical diagnostic and prognosti
108 with a recessive form of Charcot-Marie-Tooth disease for which the genetic basis had not been identif
111 pathic pulmonary fibrosis (IPF) is a complex disease for which the pathogenesis is poorly understood.
113 predispose certain individuals to infectious diseases for which the sensing of microbial cell compone
114 apply to a number of more common autoimmune diseases for which the underlying genetics and mechanism
115 identified numerous loci linked with complex diseases, for which the molecular mechanisms remain larg
116 for diseases such as the inflammatory bowel diseases, for which the pathogenesis is unknown and an e
117 on of AAV technologies to a wider variety of diseases for which therapeutic transgenes exceed the pac
119 topenia syndrome (SFTS) is an emerging viral disease for which there are currently no therapeutic opt
122 ) is the most severe form of alcoholic liver disease for which there are no effective therapies.
123 myelitis (AFM) is a devastating neurological disease for which there are no treatments of proven effi
124 atients with advanced hereditary MTC, a rare disease for which there has been no effective therapy.
125 ypertension (PAH) is a progressive and fatal disease for which there is an ever-expanding body of gen
127 ally for late-stage and androgen-independent disease for which there is currently no effective treatm
128 dystrophy (DMD) is a devastating progressive disease for which there is currently no effective treatm
129 s (NASH) is a leading cause of chronic liver disease for which there is limited therapy available.
135 drugs for treatment of infected hosts for a disease for which there is no evidence of acquired immun
136 tohepatitis (NASH) is a common chronic liver disease for which there is no known effective therapy.
139 nopathy (PVR) is a recurring and problematic disease for which there is no pharmacologic treatment.
140 heimer's disease is a common and devastating disease for which there is no readily available biomarke
141 a highly contagious, frequently fatal human disease for which there is no specific antiviral treatme
144 iva (HS) is a chronic debilitating cutaneous disease for which there is no universally effective trea
145 patients warrants further investigation in a disease for which there is no US Food and Drug Administr
146 colitis is an important worldwide parasitic disease for which there is not a well-established animal
147 K-Ras-induced lung cancer is a very common disease, for which there are currently no effective ther
148 is (ALS) is a devastating fatal motor neuron disease, for which there is currently no cure or effecti
154 osis represents one of the largest groups of diseases for which there are very few effective therapie
156 whooping cough, unlike many other childhood diseases for which there is an efficacious vaccine, has
157 y efficacious in the treatment of autoimmune diseases for which there is no association with rs180069
158 (IBDs) are a set of complex and debilitating diseases for which there is no satisfactory treatment.
161 d effective vaccines against both infectious diseases--for which there are currently no effective lic
162 yrins, and they are implicated in many human diseases, for which they serve as biomarkers and therape
163 fication policies aimed at the prevention of diseases for which this genotype is associated with incr
164 vaccines need to be developed against deadly diseases for which this strategy is often not feasible b
165 onditions as fatigue in chronic inflammatory diseases, for which to date there are no specific treatm
166 is (PSC) is a rare, but serious, cholestatic disease for which, to date, no effective therapy exists
167 phoblastic leukemia (ALL) is a heterogeneous disease, for which treatment guidelines are still evolvi
168 ntrast with the dopaminergic symptoms of the disease, for which treatment is available, non-motor sym
169 r of a novel class of disparate degenerative diseases for which UPR activation and signaling is the c
170 oid cancer, and especially intermediate-risk disease, for which use of adjuvant radioactive iodine an
172 her medically important sexually transmitted diseases for which vaccines are sought but which have pr
174 drugs and drug targets for the treatment of diseases for which validated therapeutic pathways are no
175 er neurologic, hematologic, and inflammatory diseases for which viral etiologies have been suggested.
176 ion for iron in the pathogenesis of this new disease, for which we propose the name 'neuroferritinopa
177 nable engineering of resistance in plants to diseases for which we currently lack robust genetic resi
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