ライフサイエンスコーパス: disease susceptibility

1 ic variation that plays an important role in disease susceptibility.

2 ms underlying human phenotypic variation and disease susceptibility.

3 tate expression levels of HLA associate with disease susceptibility.

4 defense mechanisms that may confer increased disease susceptibility.

5 significance in in vitro cell studies and on disease susceptibility.

6 air to influence life from evolution through disease susceptibility.

7 namic changes in diversity, which can impact disease susceptibility.

8 intestinal microbiota may be associated with disease susceptibility.

9 h age-related changes in lung physiology and disease susceptibility.

10 influence host immune function and modulate disease susceptibility.

11 stic insights into functions associated with disease susceptibility.

12 diate the function of GWAS loci on postnatal disease susceptibility.

13 e as well as functionally mapping regions of disease susceptibility.

14 enic T cell response and therefore increases disease susceptibility.

15 ivate JA signaling as a mechanism to promote disease susceptibility.

16 = 1.84 x 10(-45)) as relevant positions for disease susceptibility.

17 ion is involved in human trait formation and disease susceptibility.

18 nd unveils genes governing pathogenicity and disease susceptibility.

19 ain links between microbiota composition and disease susceptibility.

20 role for nanoparticle exposure in increased disease susceptibility.

21 characterize the contribution of genetics to disease susceptibility.

22 ow genetic effects interact to contribute to disease susceptibility.

23 actor in genetic differences in pneumococcal disease susceptibility.

24 iology, the status of the immune system, and disease susceptibility.

25 ctors or mutations might result in increased disease susceptibility.

26 variants in noncoding regions is central to disease susceptibility.

27 ator of Ab production, has a minor effect on disease susceptibility.

28 e a major contributor to genetic disease and disease susceptibility.

29 WAS) have identified many loci implicated in disease susceptibility.

30 ction with MAPKKKepsilon and did not promote disease susceptibility.

31 -signaling pathways as contributors to lupus disease susceptibility.

32 t an important role for the IL-12 pathway in disease susceptibility.

33 e response to microbial exposure in Behcet's disease susceptibility.

34 have a negligible role in common autoimmune disease susceptibility.

35 t PrP is the major determinant of host prion disease susceptibility.

36 ation play a key role in gene regulation and disease susceptibility.

37 in autophagy have been implicated in Crohn's disease susceptibility.

38 ethods to predict complex phenotypes such as disease susceptibility.

39 cessible to those who wish to know their own disease susceptibility.

40 ed dynamic complexes associated with MTI and disease susceptibility.

41 g effects of genetic variation on infectious disease susceptibility.

42 the link between these genetic variants and disease susceptibility.

43 cits a resistance-like response that confers disease susceptibility.

44 lying autoimmune-disease risk and infectious-disease susceptibility.

45 ainst pathogens, and inflammatory/autoimmune disease susceptibility.

46 o mAbs depended on polymorphisms controlling disease susceptibility.

47 ects interindividual inflammatory/autoimmune disease susceptibility.

48 ndings and confirms a role for this locus in disease susceptibility.

49 IDO activity or depletion of Tregs restored disease susceptibility.

50 iods of development to potentially influence disease susceptibility.

51 tic modifier loci, Tgfbm2 and Tgfbm3, alters disease susceptibility.

52 provides insights into the genetic basis of disease susceptibility.

53 and have been observed to be associated with disease susceptibility.

54 c effects of genes that determine autoimmune disease susceptibility.

55 adian genes might play a role in determining disease susceptibility.

56 the modern environment, leading to increased disease susceptibility.

57 ent, suggesting that HO-1 is associated with disease susceptibility.

58 dysbiosis of gut microbes and contribute to disease susceptibility.

59 ntially foundational for lifelong health and disease susceptibility.

60 additional contribution of non-MHC genes to disease susceptibility.

61 can affect microbes, which in turn modulate disease susceptibility.

62 and the microbiome in order to predict human disease susceptibility.

63 regated effect of rare variants in a gene on disease susceptibility.

64 aking them likely candidates for determining disease susceptibility.

65 s declines with age, which may contribute to disease susceptibility.

66 e CCL11, with early-onset inflammatory bowel disease susceptibility.

67 de lysosomal function, enhancing Parkinson's disease susceptibility.

68 d might serve as a biomarker of exposure and disease susceptibility.

69 rovide new insights into human variation and disease susceptibility.

70 tic architecture both of gene expression and disease susceptibility.

71 l reveal additional variants contributing to disease susceptibility.

72 oms, suggesting their loss may contribute to disease susceptibility.

73 ontributing to chronic obstructive pulmonary disease susceptibility.

74 is more broadly associated with Parkinson's disease susceptibility.

75 ature of our genome in evolution, health and disease susceptibility.

76 gut that alters immune cell homeostasis and disease susceptibility.

77 differences to hepatic metabolism and liver disease susceptibility.

78 transmissible factor dramatically increased disease susceptibility.

79 le of germline variation in the IGH locus in disease susceptibility.

80 is a predictor of lifetime neuropsychiatric disease susceptibility.

81 and age-related physiological variation and disease susceptibility.

82 external influences and may thereby modulate disease susceptibility.

83 s contractility, ventricular remodeling, and disease susceptibility.

84 i, none of which showed any association with disease susceptibility.

85 ach to identifying rare variants involved in disease susceptibility.

86 with additional potential as a biomarker of disease susceptibility.

87 cover rare variants that are associated with disease susceptibility.

88 r phenotypic variation of complex traits and disease susceptibility.

89 ophils in inflammatory lesions and influence disease susceptibility.

90 n miRNAs should be explored as the basis for disease susceptibility.

91 an contact has been attributed to infectious disease susceptibility.

92 help to define principles for understanding disease susceptibility.

93 insight into its roles in human disease and disease susceptibilities.

94 rdant with known differential cardiovascular disease susceptibilities.

95 expression of plant immunity genes enhanced disease susceptibility 1 (EDS1) and isochorismate syntha

96 icylic acid (SA) pathway, including ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1), EDS1-LIKE 2 (EDL2), EDL

97 phytoalexin-deficient 4 (PAD4) and enhanced disease susceptibility 1 (EDS1), in guard cells that for

98 utoimmunity in cfs1 is dependent on ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1)-mediated effector-trigge

99 ect interaction between AvrRps4 and Enhanced Disease Susceptibility 1 after coexpression in Nicotiana

100 ect interaction between AvrRps4 and Enhanced Disease Susceptibility 1 has been implicated in activati

101 Moreover, Enhanced Disease Susceptibility 5 (EDS5), a SA transporter requir

102 epression by PLZF depended on the rs12101261 disease susceptibility allele and was increased by IFNal

103 cular interest, the ATP7B(K832R) Alzheimer's disease susceptibility allele was found, for the first t

104 netic association studies to search for rare disease susceptibility alleles.

105 k for how to deal with identified hereditary disease susceptibilities and how to return the data to p

106 cal trial of 2159 infants with HLA-conferred disease susceptibility and a first-degree relative with

107 or genetic factors, that are known to affect disease susceptibility and are independent of tested gen

108 In addition to improving prediction of disease susceptibility and broadening our understanding

109 n prion protein is well documented regarding disease susceptibility and clinical manifestations.

110 o complex diseases is crucial for predicting disease susceptibility and developing patient-tailored t

111 CNV signatures for other phenotypes such as disease susceptibility and drug response.

112 dy links a germline variant to Ewing sarcoma disease susceptibility and EWSR1-FLI1-mediated gene acti

113 into the genetic architecture of infectious disease susceptibility and identified immune molecules a

114 ad applications in modeling origin-dependent disease susceptibility and in developing bioengineered v

115 ient history now influences human infectious disease susceptibility and microbiome homeostasis, and c

116 ay be an important contributor to infectious-disease susceptibility and pathology.

117 expression has been found to be important in disease susceptibility and pharmacogenomics.

118 s largely independent of the contribution to disease susceptibility and point to a biology of prognos

119 wholly new strategy to evaluate Alzheimer's disease susceptibility and progression in the live human

120 as 'loss of function' variants, may have on disease susceptibility and quantitative levels of biomar

121 Particular alleles of HLA contribute to disease susceptibility and severity in many autoimmune c

122 ntifying bacteria that preferentially affect disease susceptibility and severity remains a major chal

123 microbiota signature capable of transmitting disease susceptibility and subject to reprogramming by e

124 implicating CEV as a biomarker of aging and disease susceptibility and suggesting that it might play

125 view evidence of the genetic contribution to disease susceptibility and the current state of molecula

126 ecular mechanisms by which these loci confer disease susceptibility and the extent to which shared lo

127 ding of the contribution of host genetics to disease susceptibility and to drug treatment.

128 tionary forces that have shaped inflammatory-disease susceptibility and to elucidate functional pathw

129 nisms underlying PF4/heparin immunogenicity, disease susceptibility, and clinical manifestations of d

130 repertoires has been associated with aging, disease susceptibility, and differential response to inf

131 ining the common genetic variants underlying disease susceptibility, and explore how improved underst

132 ice demonstrate a role for Il2 in autoimmune disease susceptibility, and for decades the proximal Il2

133 a (ALL) biology, including associations with disease susceptibility, and increased risk of central ne

134 ithin individuals may serve as a read-out of disease susceptibility, and is thus potentially a valuab

135 or exploring relationships among global DRC, disease susceptibility, and optimal treatment.

136 tabolic and regulatory pathway, drug action, disease susceptibility, and organ specificity from high-

137 iRNAs are emerging as putative biomarkers of disease, susceptibility, and perhaps dietary exposure.

138 Sex differences in physiology and disease susceptibility are commonly attributed to develo

139 We demonstrate that loci for inflammatory-disease susceptibility are enriched for genomic signatur

140 ausative relationships between infection and disease susceptibility are lacking.

141 mechanisms by which these variants increase disease susceptibility are largely unknown.

142 We explore emerging evidence that disease susceptibility arises from early changes in the

143 Indels can be deleterious and contribute to disease susceptibility as recent genome sequencing proje

144 ide a novel molecular explanation underlying disease susceptibility associated with COX-2 T8473C SNP,

145 -null mice revealed a remarkable increase in disease susceptibility associated with increased intesti

146 ants or genes that contribute to the overall disease susceptibility at a single locus.

147 atures, we have developed a method, SuSPect (Disease-Susceptibility-based SAV Phenotype Prediction),

148 few studies have directly compared metabolic disease susceptibility between NNT-deficient 6J mice and

149 ardiovascular disorders, obesity, infectious disease susceptibility, blood disorders, neurosensory di

150 suppress plant immune responses and promote disease susceptibility but has also facilitated the disc

151 ing 9 (TNRC9; TOX3) has been associated with disease susceptibility but its function is undetermined.

152 host gene mutations with altered infectious disease susceptibility, but evidence for causality is li

153 le-specific methylation (hap-ASM) can impact disease susceptibility, but maps of this phenomenon usin

154 The PRSS1 variant likely affects disease susceptibility by altering expression of the pri

155 Disease susceptibility can arise as a consequence of ada

156 to many studies of phenotypic variation and disease susceptibility, characterizing the genetic archi

157 in the miRNA binding sites, suggesting that disease susceptibilities could be attributed to ceRNA re

158 effect of multiple variants in a pathway on disease susceptibility could be large.

159 ce of Africa to studies of human origins and disease susceptibility, detailed characterization of Afr

160 ng mechanisms and patterns of variability in disease susceptibility, disease evolution, and drug resp

161 ntially be used to facilitate predictions of disease susceptibility for more precise and timely appli

162 Disease susceptibility for type 1 diabetes is strongly a

163 n APOE varepsilon3/4 and another Alzheimer's disease susceptibility gene and demonstrate in proof of

164 species of Xanthomonas exploit a single host disease susceptibility gene by altering the expression o

165 Clec16a has been identified as a disease susceptibility gene for type 1 diabetes, multipl

166 cing a shocking incident, but the underlying disease susceptibility gene networks remain poorly under

167 ction protects mice deficient in the Crohn's disease susceptibility gene Nod2 from intestinal abnorma

168 olog of the SWEET sugar transporter and rice disease susceptibility gene.

169 cell survival, our data implicate TWEAK as a disease-susceptibility gene for a humoral immunodeficien

170 he sucrose transporter gene OsSWEET13 as the disease-susceptibility gene for PthXo2 and the existence

171 ssive resistance gene xa13, an allele of the disease-susceptibility gene Os8N3 (also named Xa13 or Os

172 ny human diseases, arising from mutations of disease susceptibility genes (genetic diseases), are als

173 f host-microbe intersection, notably several disease susceptibility genes and sterol metabolism pathw

174 ent studies identified over half of the HSCR disease susceptibility genes as targets for the sex-dete

175 y between drug targets, somatic mutants, and disease susceptibility genes by utilizing directionality

176 MED18 interacts with YIN YANG1 to suppress disease susceptibility genes glutaredoxins GRX480, GRXS1

177 ctors (TALEs) that activate transcription of disease susceptibility genes in the host, inducing a sta

178 uggest that autophagy and inflammatory bowel disease susceptibility genes regulate inflammatory respo

179 s have been successfully applied to identify disease susceptibility genes with genetic markers such a

180 icated biological mechanisms and for mapping disease susceptibility genes.

181 s reside in network proximity to products of disease susceptibility genes.

182 SLC17A5, and ASAH1 as candidate Parkinson's disease susceptibility genes.

183 of Ret and loss of Sema3d, two Hirschsprung disease susceptibility genes.

184 ling is a helpful approach in the search for disease susceptibility genes.

185 end to lie upstream of somatic mutations and disease susceptibility germline variants.

186 hich genetic factors underlying inflammatory-disease susceptibility has been influenced by selective

187 Asthma and autoimmune disease susceptibility has been strongly linked to genet

188 ure research given that genetic variation in disease susceptibility has large implications for vaccin

189 immune function, inflammatory responses, and disease susceptibility have been identified in several g

190 er variation's contribution to complex human disease susceptibility have been performed.

191 the sex- and strain-dependent differences in disease susceptibility have not been described.

192 ssociated with chronic obstructive pulmonary disease susceptibility (HHIP, IREB2/CHRNA3, CYP2A6/ADCK,

193 l in identifying new loci that contribute to disease susceptibility; however, much of the heritable r

194 idate genes were tested for association with disease susceptibility in 2,101 cases and 4,202 controls

195 the different HLA-DR15 haplotype alleles on disease susceptibility in a new "humanized" model of MS

196 SPC Cre(+)) revealed a selective increase in disease susceptibility in Adora2b(loxP/loxP) SPC Cre(+)

197 lymorphism, which correlates with autoimmune disease susceptibility in humans, disrupts exon silencin

198 g genetic variation influencing inflammatory-disease susceptibility in humans.

199 ell- or tissue-specific IL-10 expression and disease susceptibility in humans.

200 ed to determine how these alterations impact disease susceptibility in L. pipiens.

201 Disease susceptibility in mice and microbial colonizatio

202 stimulation with this moiety alone overrides disease susceptibility in mice depleted of commensal bac

203 pe hypersensitivity responses and autoimmune disease susceptibility in mice.

204 bute to cognitive functions and neurological disease susceptibility in modern day humans.

205 enter stage in the study of pathogenesis and disease susceptibility in plants and humans.

206 the potential of one developmental gene for disease susceptibility in rice/Xoo interactions.

207 ciation of autophagy with inflammatory bowel disease susceptibility, increasing evidence indicates th

208 ty of effector-associated gene induction and disease susceptibility is attributable to a single nucle

209 Disease susceptibility is jointly determined by genetic

210 nical relevance of microbiome alterations on disease susceptibility is still in its infancy, but the

211 auterine conditions that influence offspring disease susceptibility is warranted to inform targeted e

212 G) allele, despite not being associated with disease susceptibility, is associated with a milder cour

213 We identified 111 additional disease-susceptibility locations, 93 of which are cosmop

214 new associations between inflammatory bowel disease susceptibility loci and gene expression.

215 were mapped and examined for enrichment for disease susceptibility loci annotated in the genome-wide

216 rs interested in mapping common and uncommon disease susceptibility loci by focusing on output linkin

217 attempting to functionally interpret complex-disease susceptibility loci by GWAS and eQTL integration

218 Many disease susceptibility loci colocalize with DNA regulato

219 additional candidate-gene annotation for 37 disease susceptibility loci for human atherosclerotic di

220 nts, such as discoveries of large numbers of disease susceptibility loci from genome-wide association

221 application to prioritize candidate genes in disease susceptibility loci identified by GWAS.

222 association studies have identified several disease susceptibility loci in lupus patients.

223 -analysis has extended the number of Crohn's disease susceptibility loci to 71.

224 Conversely, the aggregated effect of all 170 disease susceptibility loci was not associated with dise

225 a powerful tool in the investigation of new disease susceptibility loci.

226 ) can increase statistical power to identify disease susceptibility loci.

227 o the NOD2 signaling pathway and are Crohn's disease susceptibility loci.

228 tes to understanding the biology of specific disease susceptibility loci.

229 Despite the large number of identified disease-susceptibility loci, it is not known which loci

230 quantitative phenotypes to identify putative disease-susceptibility loci.

231 unctional dissection of the CD33 Alzheimer's disease susceptibility locus, we found that the rs386544

232 nd implicate the orthologous human gene as a disease susceptibility locus.

233 variants and may help to predict or explain disease susceptibility more accurately and comprehensive

234 s are predicted to play an important role in disease susceptibility of common diseases.

235 However, the lesser disease susceptibility of Hispanic populations with comp

236 tralization of CXCL10 reversed the increased disease susceptibility of Il22bp-deficient mice.

237 Disease susceptibility of influenza is determined by hos

238 ow pH, and correlates with the difference in disease susceptibility of the two species, as expected f

239 SNPs associated with disease susceptibility often reside in enhancer clusters

240 es and molecular variants that contribute to disease susceptibility; on the other candidate genes, su

241 as disease-specific biomarkers or influence disease susceptibility or progression.

242 activate the cognate host genes, leading to disease susceptibility or resistance dependent on the ge

243 autophagy responses could be associated with disease susceptibility or severity.

244 valence, indicating significant variation in disease susceptibility or tolerance.

245 rstanding how these mechanisms contribute to disease susceptibility, particularly in infants with dev

246 pects of disease natural history, as well as disease susceptibility per se.

247 ads to biallelic expression which may affect disease susceptibility possibly reflected in high levels

248 ical for signaling downstream of the Crohn's disease susceptibility protein nucleotide-binding oligom

249 Binding to the Crohn's disease susceptibility protein, NOD2, is required for TR

250 cell (SC) lines that capture the genetics of disease susceptibility provide new research tools.

251 terodimer and its potential association with disease susceptibility, provides a rationale for a poten

252 lowing inoculation and increased periodontal disease susceptibility, reflected by higher TNF levels a

253 n, while BATF and ESRRA overlap other immune disease susceptibility regions, validating our approach

254 a wide range of biological pathway related, disease susceptibility related, drug target related and

255 acteristics of ageing that lead to increased disease susceptibility remain inadequately understood.

256 majority of these, the mechanisms underlying disease susceptibility remain unknown.

257 st of the genetic factors that contribute to disease susceptibility remain unknown.

258 lecular and biological mechanisms explaining disease susceptibility remains challenging.

259 ved in gene regulation whose contribution to disease susceptibility remains to be fully understood.

260 which specific fatty acids affect infectious disease susceptibility remains unclear.

261 hylation in these AD loci contributes to the disease susceptibility remains unknown.

262 Mutations in disease susceptibility (S) genes, here referred to as re

263 y HLA-DRB1 haplotypes was correlated between disease susceptibility, severity, and mortality, but inv

264 Disease susceptibility, severity, progression and pain p

265 r's patches and the spleen was impaired, and disease susceptibility significantly reduced.

266 umour (TGCT), revealing a polygenic model of disease susceptibility strongly influenced by common var

267 ests that fungal proteins involved in either disease susceptibility such as ToxB or resistance such a

268 enome-wide association studies contribute to disease susceptibility, systems genetics is likely to be

269 ngly, we revealed appreciable differences in disease susceptibility, temporal patterns, network struc

270 urther, we identify 21 loci for inflammatory-disease susceptibility that display signatures of recent

271 roles of innate immunity, sex differences in disease susceptibility, the necessity for adjuvants in e

272 exposure may therefore shed light on complex disease susceptibility.The goal was to analyze the progr

273 bial identities and how this might determine disease susceptibility, therapeutic responses and recove

274 for analysis of the contribution of VNTRs to disease susceptibility through association studies.

275 loci, these OA loci are thought to influence disease susceptibility through the regulation of gene ex

276 affect normal animal development or increase disease susceptibility to a relevant genotoxic exposure.

277 and double-mutant plants exhibited enhanced disease susceptibility to cucumber mosaic virus when the

278 ata are consistent with a polygenic model of disease susceptibility to MGUS.

279 methasone-inducible HopQ1 exhibited enhanced disease susceptibility to virulent Pto DC3000, the Pto D

280 expression for the state of PthXo2-dependent disease susceptibility to X. oryzae pv. oryzae.

281 to a more diverse ethnic group for gallstone disease, susceptibility to biliary cancer, and show vari

282 6D phosphomimetic mutants exhibited enhanced disease susceptibility upon surface inoculation with P.

283 easures: Identification of a novel, germline disease susceptibility variant in a previously uncharact

284 Objective: To identify novel disease susceptibility variants in a familial syndrome o

285 We assessed the impact of 14 disease susceptibility variants on measures of glucose s

286 d to identify the cell-autonomous effects of disease susceptibility variants.

287 rrett esophagus family to identify candidate disease susceptibility variants.

288 So far, three common disease-susceptibility variants at the RET, SEMA3 and NR

289 Our data show that oral prion disease susceptibility was dramatically reduced in mice

290 dendritic cells was impaired and oral prion disease susceptibility was reduced.

291 the HLA-DRB1 locus, which is associated with disease susceptibility, was also associated with radiolo

292 Because Fcgamma receptors are implicated in disease susceptibility, we crossed HLA transgenic mice o

293 However, they demonstrate alterations in disease susceptibilities when exposed to a variety of va

294 accumulation studies can implicate genes in disease susceptibility when a significant burden is obse

295 utations of Nppa, Plod1, and Mthfr increased disease susceptibility, whereas Agtrap and Clcn6 mutatio

296 ironmental and genetic factors contribute to disease susceptibility, whereas the immunopathogenesis o

297 their reprogramming into Th2-like cells and disease susceptibility, whereas Treg-cell-lineage-specif

298 D have identified common variants underlying disease susceptibility, while gene expression microarray

299 uggests that at least 400 variants influence disease susceptibility, with potentially many thousands.

300 crobiome co-evolution drives homeostasis and disease susceptibility, yet regulatory principles govern