ライフサイエンスコーパス: disease-related

1 licated in CHD had >70% probability of being disease related.

2 wide range of biological processes and their disease-related aberrations.

3 that are easy to administer and sensitive to disease-related abnormalities are needed to gain a bette

4 viduals (59.1%) were seropositive for celiac disease-related alleles compared with 8 (28.6%) of the 2

5 for better understanding and predicting the disease-related alterations in microbial communities.

6 pain condition, we show evidence for sex and disease-related alterations in the functional connectivi

7 Here we aimed to test sex and disease-related alterations in the intrinsic functional

8 nts, with an increased potential to identify disease-related alterations in their biomolecular compos

9 ts who underwent a major peripheral arterial disease-related amputation during the period between 200

10 re and regional rates of peripheral arterial disease-related amputation.

11 ntration and purification of the Alzheimer's disease related amyloid beta (Abeta) peptides by isoelec

12 t to impair the transport of the Alzheimer's disease-related amyloid precursor protein (APP), althoug

13 also alters the metabolism of the Alzheimer disease-related amyloid precursor protein (APP).

14 Here, we study the Alzheimer disease-related amyloid-beta (Abeta) peptide and investi

15 might influence protein misfolding for both disease-related and benign, functional prions and why th

16 or longer with regard to progression of nine disease-related and clinically meaningful mobility and u

17 Also, to examine associations with disease-related and sociodemographic factors among those

18 essions were used to explore associations of disease-related and sociodemographic factors with future

19 The rates of surgery-related, disease-related, and overall mortality within 30 days, w

20 lowing categories: demographic, behavioural, disease-related, and psychosocial factors.

21 biological domains, evolutionary signals and disease-related annotation; (vi) Additionally, we compil

22 s for other neurodegenerative diseases where disease-related assemblies of misfolded proteins might a

23 vo and in vitro, offering a window to reveal disease related biomarkers and potential insight into th

24 They both are Alzheimer's disease related biomarkers, indicating the potential and

25 itiative with measurements of 14 Alzheimer's disease-related biomarkers including cerebrospinal fluid

26 asibility of the device for the detection of disease-related biomarkers, adenovirus DNA labeled with

27 ies have demonstrated its ability to uncover disease-related biomolecular changes in rodent models of

28 Cancer is the leading disease-related cause of death among adolescents and you

29 rdiovascular/non-malignancy diseases and non-disease-related causes.

30 ore the power of using pathogens to discover disease-related cell biology.

31 ion of these methods to quantitatively study disease-related changes in human postmortem tissue has n

32 We suggest that disease-related changes in photoreception by the retina

33 e PNN alterations, and their relationship to disease-related changes in PV neurons, has not been asse

34 kely contributes to neuron and synapse loss, disease-related changes to oligodendrocytes and myelin a

35 Host and disease-related characteristics were evaluated as risk f

36 e, sex, race/ethnicity, body mass index, and disease-related characteristics.

37 nificantly more affected individuals carried disease-related CNVs (P=0.017).

38 Those with Alzheimer's disease-related cognitive impairment were younger, more

39 We tested two sets of disease-related common phenotypes for which we had stati

40 that can be used to diagnose PSC and detect disease related complications.

41 ealthcare resource utilization of infectious disease-related complications in solid organ transplant

42 e of surgery, hospital admission, or serious disease-related complications was lower at ECI practices

43 aratyphi A, B, or C) on day 8; or relapse or disease-related complications within 28 days of treatmen

44 with HCM who are at risk for (or experience) disease-related complications, a constellation of compre

45 obably remain undiagnosed, largely free from disease-related complications, although HCM may progress

46 edical therapy, and identifying a variety of disease-related complications, including strictures, fis

47 ld improve patient care by reducing rates of disease-related complications, surgery, and hospitalizat

48 At each visit, liver disease-related complications, treatment modifications,

49 Here, we report that a disease-related COQ9 mutation leads to extensive disrupt

50 ration, drug treatment and monitoring costs, disease-related costs, and quality-adjusted life years (

51 No disease-related covariates were identified by the popula

52 e the cell populations responsible for these disease-related cytokine responses.

53 elapse, and limiting overall accrual of both disease-related damage and treatment-related morbidity.

54 s important to identify patients with severe disease-related damage who should avoid pregnancy, couns

55 tendency, and autoimmunity and reduction in disease-related days of hospitalization.

56 of hepatocellular carcinoma (HCC) and liver-disease related death, in association with metabolic ris

57 ough cancer remains the most common cause of disease-related death in adolescents and young adults (A

58 rtial remission, 1.96% stable disease, 1.96% disease-related death, and 1.96% another cause of death.

59 ned as myocardial infarction, coronary heart disease-related death, or fatal or nonfatal stroke.

60 nine (3%) surgery-related deaths and 92 (3%) disease-related deaths occurred within 365 days after he

61 ty (2%) surgery-related deaths and 112 (10%) disease-related deaths occurred within 365 days after pa

62 ts died, including 1 treatment-related and 8 disease-related deaths.

63 ment, and these deficits seem to result from disease-related decreases in peripheral innervation dens

64 ling axis holds promise for slowing age- and disease-related degeneration of NMJs.

65 Disease-related differences and patient demographics, me

66 al anterior INS with the left precuneus; (3) disease-related differences in the connectivity between

67 d provides a valuable resource for assessing disease-related disruptions.

68 inson disease (PD) and may be in part due to disease-related dopamine deficiency.

69 e subjects revealed both shared and distinct disease-related effects on gene expression between cell

70 Secondary end points included additional disease-related efficacy assessments, safety, and side-e

71 ochondrial and enzyme defects predominate as disease-related etiologies.

72 ted deaths combined with life-saving aborted disease-related events was 6.4%/year, 3-fold greater tha

73 mission was mainly indicated for sickle cell disease-related events, especially acute chest syndrome.

74 has typically been considered an exogenous, disease-related factor in immunity; however, recent lite

75 Inflammation is emerging as a key disease-related factor in PAH, but to date there is no c

76 Disease-related factors (e.g. symptom severity, duration

77 ease progression and the predictive value of disease-related factors on progression, and estimated sa

78 rson to person due to individual-, drug- and disease-related factors that may in part be genetically

79 he magnitude of risk and its relation to HIV disease-related factors, including CD4 count and viral l

80 x interplay of technical, compositional, and disease-related factors.

81 erity of MI, symptoms, and comorbidities for disease-related factors; anxiety and depression for psyc

82 This pattern suggests a disease-related failure to replenish ATP from PCr throug

83 rial composition was associated with several disease-related features, including body mass index (P <

84 Based on these important disease-related findings, a large number of commercial a

85 ation based on automated discovery of novel, disease-related functional subnetworks, which would othe

86 To study normal and disease-related functions of cone Pde6h in vivo, we gene

87 were undiagnosed on a targeted neuromuscular disease-related gene panel did not improve our diagnosti

88 cular microRNAs, have been shown to modulate disease-related genes and processes.

89 s are liable to affect the functions of core disease-related genes and that most heritability can be

90 for moving toward a more complete catalog of disease-related genes and variants.

91 The accelerated discovery of disease-related genes emerging from genomic studies has

92 same number of genes, and up to 75% of human disease-related genes have Drosophila homologues [1].

93 can be explained by segregation of Alzheimer disease-related genes in these families or shared enviro

94 rimental data suggest that BFDCA can cluster disease-related genes into functional DC subunits and es

95 However, 15 families had variants in disease-related genes not typically associated with LGMD

96 ternative and effective approach to identify disease-related genes or loci has been verified.

97 With this biosensor, we detected three disease-related genes that were the human immunodeficien

98 contributions of critical neurodegenerative disease-related genes to neuropathogenesis.

99 bunits and estimate the regulatory impact of disease-related genes well.

100 ng routinely identifies missense variants in disease-related genes, but functional characterization i

101 ion of newly discovered missense variants in disease-related genes.

102 GEMMs for the functional characterisation of disease-related genes.

103 cused on studying G4s in promotor regions of disease-related genes.

104 tive test to assess mice and humans carrying disease-related genetic mutations.

105 lian randomization-based method combining 58 disease-related GWA studies to derive longevity priors f

106 understanding the functional consequence of disease-related hDNMT1 mutations.

107 Patients with disease-related hemoglobin <10 g/L, platelets <100 x 10(

108 therapy resulted in a reduction in multiple disease-related hepatic and lipid abnormalities in child

109 The incidence of nonalcoholic fatty liver disease-related hepatocellular carcinoma is increasing a

110 r, and in degree and duration of fatty liver disease-related hepatocellular carcinoma.

111 ily a result of reduced risks for infectious disease-related hospitalizations.

112 at hen egg white lysozyme, homologous to the disease-related human lysozyme, can form left-handed gia

113 ty to amyloid-beta accumulation, Alzheimer's disease-related hypometabolism is more specific to brain

114 Greater Alzheimer's disease-related hypometabolism was observed in brain reg

115 e to amyloid-beta deposition and Alzheimer's disease-related hypometabolism.

116 plications, as well as offering insight into disease-related in vivo protein aggregation.

117 We detected an age- and disease-related increase in monocyte recruitment into Dy

118 Crohn's disease-related inflammation is characterized by reduced

119 ologic analysis, blood work, and other liver disease-related information.

120 chitecture in promoting the evolutionary and disease-related instability of chromosome 15.

121 h age and render aging neurons vulnerable to disease-related insults.

122 =0.71 [IQR 0.64-0.77]) and connective tissue disease-related interstitial lung disease (kappaw=0.73 [

123 thic pulmonary fibrosis or connective tissue disease-related interstitial lung disease were risk fact

124 dies to bind different epitopes within three disease-related intrinsically disordered proteins and pe

125 We conclude that oxMIF represents the disease-related isoform of MIF; oxMIF is therefore a new

126 of the cellular prion protein (PrP(C)) into disease-related isoforms (PrP(Sc)).

127 weekly data on Tweets related to disease or disease-related keyword searches obtained from Google Tr

128 fective computational approaches to identify disease-related lncRNAs are in high demand; and would be

129 reads, we could confidently genotype several disease-related long trinucleotide STRs.

130 tabolic demand and are susceptible to age or disease-related losses in oxygen and nutrient supply.

131 Notably, a Parkinson's disease-related Lrrk2 R1441C missense mutation that impa

132 rmation of transient intermediate species of disease-related lysozyme variants, essentially due to th

133 ion of tractable models for investigation of disease-related mechanisms and potential therapies.

134 rns, demonstrating its promise for improving disease-related mechanistic understanding.

135 isorder has been evaluated using Parkinson's disease-related metabolic network.

136 s, significant biological small molecules or disease related microRNA, just by changing the sequence

137 following learning show increases in several disease-related microRNAs targeting the activin A recept

138 ediction and confirmation of the presence of disease-related miRNAs is beneficial to understand disea

139 use of experimental verification to identify disease-related miRNAs is expensive and time-consuming.

140 here are the first crystal structures of two disease-related missense variants of PGM1, along with th

141 and whether any association was affected by disease-related modification of the exposure or modified

142 ed modeling showed no consistent results for disease-related modification of the exposure.

143 ger microtubule organization and reveal that disease-related modifications of tau promote specific mi

144 enium-shows age-related, region-related, and disease-related molecular signatures and may be importan

145 ystemic inflammation, weight loss, and other disease-related morbidities associated with poor prognos

146 Disease-related morbidity and even mortality have been r

147 High case-fatality ratios, substantial disease-related morbidity, and the threat of outbreaks c

148 on-demand treatment is effective in reducing disease-related morbidity.

149 human PS-cell-derived ENS precursors rescue disease-related mortality in HSCR mice (Ednrb(s-l/s-l)),

150 other strategies have now resulted in a low disease-related mortality rate of <1%/year.

151 the clinical course, now resulting in a low disease-related mortality rate of 0.5%/year and an oppor

152 s unclear why some host species decline from disease-related mortality whereas others persist.

153 ath; when treated, it is associated with low disease-related mortality, no different than for patient

154 Ps in 36 genes significantly associated with disease-related mortality, progression-free survival, tr

155 an important risk factor for cardiovascular disease-related mortality.

156 osis, as it is a strong indicator of hepatic disease-related mortality.

157 evelopment of treatments for age-related and disease-related muscle loss might improve active life ex

158 ccumulated in the distal axon of Alzheimer's disease-related mutant human APP transgenic neurons and

159 n of exogenously expressed wild-type FUS and disease-related mutant R514G was observed.

160 ence to G167P) identified as a mitochondrial disease-related mutation in human cytochrome b.

161 Expression of dSpt1 bearing a disease-related mutation induced morphological deficits

162 e identified m.12955A > G as a mitochondrial disease-related mutation.

163 Disease related mutations and environmental factors are

164 nd provide a framework for understanding RCA disease-related mutations and immune evasion.

165 dation of the allosteric molecular basis for disease-related mutations and the discovery of novel lea

166 tions in the helical domain of Cya mimic the disease-related mutations in human proteins, recapitulat

167 past decade have revealed a large number of disease-related mutations in the MEK1 gene that lead to

168 at enabled rationalization of the effects of disease-related mutations on the protein function.

169 ion appears conserved in human cells because disease-related mutations or chemical inhibition of p97

170 Most disease-related mutations that impair cAMP protein kinas

171 We studied the molecular effect of disease-related mutations using tridimensional in silico

172 encing make it possible to identify multiple disease-related mutations, but there is currently no sys

173 Parkinson's disease-related network activity was also elevated (P<0.

174 logical strategies hold promise for tackling disease-related networks.

175 pe facilitates exploration of many basic and disease-related neuromuscular phenomena never visualized

176 pecialization, and potentially responding to disease-related neuronal dysfunction.

177 te that temporal topic trends extracted from disease-related news reports successfully capture the dy

178 elopment as well as the functional impact of disease-related noncoding genetic variants.

179 gy have improved the ability to characterize disease-related nucleic acids and proteins.

180 ut fibril architecture, atomic structures of disease-related oligomers have eluded determination.

181 conformational antibody recognizes different disease-related oligomers, despite the variations in cli

182 Disease-related or treatment-related limitations in acti

183 All studies that reported a disease-related outcome (local recurrence, nodal metasta

184 Risks of disease-related outcomes and 5-year recurrence-free, dis

185 Evidence-based estimates of the risks of disease-related outcomes comparing IPNI and CPNI are lim

186 tion analysis of microbiome composition with disease-related outcomes provides invaluable knowledge t

187 Overall risks of disease-related outcomes were generated by pooling patie

188 ntial implications for immune and infectious-disease-related outcomes.

189 , including key determinants of fibrosis and disease-related outcomes.

190 r characteristics, treatments performed, and disease-related outcomes.

191 t tests were used to evaluate differences in disease-related outcomes.

192 cacy of OXN PR for patients with Parkinson's disease-related pain and might warrant further research

193 d illustrate the important role of SOCE in a disease-related pathologic model.

194 in mitochondrial dysfunction and Alzheimer's disease-related pathological and cognitive impairments i

195 beta (TGF-beta) signaling promotes Parkinson disease-related pathologies and motor deficits, and incr

196 pathology, or after adjusting for Alzheimer disease-related pathologies.

197 hinal cortex in brain samples with Alzheimer disease-related pathology (stages I to II and stages III

198 his regard, new evidence linking Alzheimer's disease-related pathology and neuronal stem cells sugges

199 teral sclerosis who lacked neurodegenerative disease-related pathology outside of the motor system.

200 Abrogation of disease-related pathology was also evident, with reducti

201 mal pathology at early stages of Alzheimer's disease-related pathology.

202 ubjects (age 62.5+/-7.5 years) to identify a disease-related pattern and examine its evolution in 21

203 this RSN was subordinated to an independent disease-related pattern.

204 assembled in vitro from short synthetic non-disease-related peptides.

205 lood has the potential of identifying early, disease-related perturbations caused by toxic exposures

206 Protein fibers play a crucial role in many disease related phenomena and biological systems.

207 discover that nicotinamide (NAM) ameliorated disease-related phenotypes by inhibiting drusen proteins

208 Here we present disease-related phenotypes in human pluripotent stem cel

209 Alzheimer's disease-related phenotypes in mice can be rescued by blo

210 Targets, cover human de novo gene variants, disease-related phenotypes in model organisms, and a bio

211 We review disease-related phenotypes shown in patient-derived iPSC

212 with neuronal loss of Tsc2 that demonstrates disease-related phenotypes, including behavioral symptom

213 Disease-related phenotypes, including cerebral blood flo

214 g genetic and environmental contributions to disease-related phenotypes.

215 Plasma membrane ABCB6 exports a variety of disease-related porphyrins.

216 ction without detectable astrogliosis drives disease-related processes in a mouse model of Huntington

217 also observed enrichment in other key heart disease-related processes like myocarditis, fibrosis, hy

218 thway functions in diverse developmental and disease-related processes, requiring mechanisms to ensur

219 eurons, and thus prone to aggregation upon a disease-related progressive collapse of protein homeosta

220 roperties (e.g. chemical structures) or only disease-related properties (e.g. phenotypes) to calculat

221 e to the intrinsically disordered, Parkinson disease related protein alpha-synuclein.

222 ive aging to include evidence of Alzheimer's disease-related protein aggregation as an underlying mec

223 cal interaction exists between the Parkinson disease-related protein alpha-synuclein (alpha-syn) and

224 nteractions of a natively unfolded Parkinson disease-related protein, alpha-synuclein (alpha-syn) wit

225 e show that aggregation of neurodegenerative disease-related proteins (polyglutamine, huntingtin, ata

226 s, by measurement of perfusion-sensitive and disease-related proteins in post-mortem tissue from Alzh

227 Aggregation of misfolded disease-related proteins is a hallmark of neurodegenerat

228 The targeting of disease-related proteins is important for drug discovery

229 nteractome-distance between drug targets and disease-related proteins was higher in diabetes than in

230 rk position and dynamics of drug targets and disease-related proteins, and may contribute to develop

231 me cases, these SNPs are in well-established disease-related proteins, such as MST1 (macrophage stimu

232 thesized that of the three major Parkinson's disease-related proteins-alpha-synuclein, LRRK2, and Par

233 enic mechanism: the abnormal accumulation of disease-related proteins.

234 rticularly autophagy) with the metabolism of disease-related proteins.

235 how synapses decode a pattern of stimuli, a disease-related Ras allele abolished the spacing effect

236 Here, we demonstrate that the disease-related RBP hnRNPA1 undergoes liquid-liquid phas

237 wide amyloid burden were classic Alzheimer's disease-related regions: the medial and lateral parietal

238 Because they carry specific disease-related RNAs and proteins, practical application

239 disease-specific subnetworks are enriched in disease-related signalling pathways and information flow

240 immediately intuitive results: for instance, disease-related SNVs create stronger changes in localize

241 ng DM among PWCs that are homozygous for the disease-related SOD1 mutation.

242 ation between regional variation in level of disease-related spine density reduction in schizophrenia

243 an help to organize our understanding of how disease-related states, specific neuronal circuits, and

244 ight on a novel therapeutic avenue to target disease-related STKR1 mutants.

245 s that govern the cardiovascular response to disease-related stress.

246 reprogramming that occurs in the setting of disease-related stress.

247 f wide interest to researchers investigating disease-related STRs and STR evolution.

248 immune diseases has been to identify and map disease-related subphenotypes that are under simpler gen

249 = 0.02 by log-rank test) and cardiovascular disease related survival (85% vs. 95%; p = 0.03 by log-r

250 nts were to assess, in each treatment group, disease-related symptom progression rate based on the FK

251 derlying anatomy, significant differences in disease-related symptom rankings were found for only 6 o

252 sment of Cancer Therapy-Kidney Symptom Index-Disease Related Symptoms (FKSI-DRS) and European Quality

253 at addressed demographic information, celiac disease related symptoms (gastrointestinal and extrainte

254 associated with significant improvements in disease-related symptoms as measured by BFI, MDASI, and

255 Disease-related symptoms impair the quality of life of p

256 e not significantly different; however, some disease-related symptoms improved in patients receiving

257 we postulated that ruxolitinib would improve disease-related symptoms in patients with CLL.

258 r clinical progression (defined as worsening disease-related symptoms necessitating a change in antic

259 thrombocythemia (ET) address thrombocytosis, disease-related symptoms, as well as risks of thrombosis

260 ponse rate, duration of response, effects on disease-related symptoms, safety, and tolerability.

261 The ability to detect multiple disease-related targets from a single biological sample

262 Disease-related tau mutations increase the formation of

263 emia (AML) is poor and identification of new disease-related therapeutic targets remains a major goal

264 , a term used to define the global burden of disease related to all injuries, is the leading cause of

265 nd methods, we also quantified the burden of disease related to high body-mass index (BMI), according

266 e of high-grade cervical, vulvar and vaginal disease related to HPV 31, 33, 45, 52, and 58 was 0.5 ca

267 , 52, and 58) vaccine against infections and disease related to HPV 31, 33, 45, 52, and 58, and non-i

268 9vHPV vaccine did not prevent infection and disease related to HPV types beyond the nine types cover

269 e of high-grade cervical, vulvar, or vaginal disease related to HPV-31, 33, 45, 52, and 58 in a presp

270 The 9vHPV vaccine prevented infection and disease related to HPV-31, 33, 45, 52, and 58 in a susce

271 ess are at increased risk for cardiovascular disease related to increased incidence of diabetes, hype

272 hort of patients with chronic ocular surface disease related to SJS/TEN, PROSE treatment offers susta

273 Grade II to IV acute graft-versus-host disease related to steroid treatment shows a trend towar

274 , presenting the first evidence of monogenic disease related to transport of DHA in humans.

275 r the treatment of several neurodegenerative diseases related to cellular stress.

276 nd may hold the key to future treatments for diseases related to collagen cross-linking anomalies, su

277 general hypothesis that aging and cancer are diseases related to energy metabolism.

278 ew therapeutic targets for inflammatory skin diseases related to epidermal barrier defects.

279 with peeling skin syndrome type B and other diseases related to epidermal barrier dysfunction, inclu

280 ism might also be important for neurological diseases related to episodic ataxia, such as hemiplegia,

281 d mutations in sickle cell and other genetic diseases related to hemoglobin, while in Oxford, the gro

282 pe 2 diabetes, Alzheimer's disease, or other diseases related to IAPP dysfunction or cross-amyloid in

283 ese genes were over-enriched in pathways and diseases related to inflammatory response and inhibition

284 d be used for monitoring of cancer and other diseases related to oxidative stress, aberrant metabolis

285 ed previously known risk factors for retinal diseases related to oxidative stress, inflammation, and

286 revent disease or inhibit the progression of diseases related to oxidative stress.

287 ntial applications in imaging and therapy of diseases related to oxidative stress.

288 as greatly benefited from studies focused on diseases related to TFIIH mutations.

289 are for fast and reliable early diagnosis of diseases related to the presence of D-AAs.

290 mpetitive inhibitors and chaperones to treat diseases related to these enzymes requires a detailed kn

291 associated with B vitamin status or chronic diseases related to vitamin B-12 and folate metabolism.

292 ods for testing association between CNVs and disease-related traits are still under-developed due to

293 Finally, association between CNVR and disease-related traits is assessed by comparing the kern

294 ould become associated at P < 5 x 10- 8 with disease-related traits through IEB alone, if disease pre

295 osinophil counts and dysregulated esophageal disease-related transcripts in adults with EoE in a sust

296 lations analyses between these contrasts and disease-related variables and behavioral findings were p

297 formation by both wild-type TTR and a common disease-related variant, V30M TTR, as effectively as doe

298 er changes in localized frustration than non-disease related variants, and rare SNVs tend to disrupt

299 ughput genomic approach enabled detection of disease-related variants in unexpected genes; permitted

300 enriched with vitamins, in order to prevent diseases related with their deficiency, has recently inc