ライフサイエンスコーパス: disease-related gene

1 rays have been widely used to discover novel disease related genes.

2 within RefSeq genes, especially within known disease-related genes.

3 cused on studying G4s in promotor regions of disease-related genes.

4 ely used for medical studies to detect novel disease-related genes.

5 -DNA structures are abundant in promoters of disease-related genes.

6 ession analysis may improve the detection of disease-related genes.

7 tide microarray-based mutational analysis of disease-related genes.

8 determining sequence alteration in multiple disease-related genes.

9 d 2, apolipoprotein E, and other Alzheimer's disease-related genes.

10 cerning the identification of novel melanoma disease-related genes.

11 of known muscle class-specific and inherited disease-related genes.

12 identification of developmental, aging, and disease-related genes.

13 ion of newly discovered missense variants in disease-related genes.

14 profile complex diseases and discover novel disease-related genes.

15 GEMMs for the functional characterisation of disease-related genes.

16 models have provided important links between disease-related genes and behavioral impairment.

17 We collected an initial set of known disease-related genes and built an interaction network b

18 inal feature are providing new insights into disease-related genes and developmental pathways.

19 d accumulation of our knowledge on diseases, disease-related genes and drug targets, network-based an

20 ted the predicted interactions for two human disease-related genes and identified 14 new modifiers.

21 nt, and further allows the identification of disease-related genes and pathways that play similar rol

22 cular microRNAs, have been shown to modulate disease-related genes and processes.

23 s are liable to affect the functions of core disease-related genes and that most heritability can be

24 he new function of two previously identified disease-related genes and the potential of one developme

25 for moving toward a more complete catalog of disease-related genes and variants.

26 y, we show that Satb2 and Fezf2 regulate two disease-related genes, Auts2 (Autistic Susceptibility Ge

27 ng routinely identifies missense variants in disease-related genes, but functional characterization i

28 ion, identification, and characterization of disease-related genes by means of positional cloning.

29 ation that selects and prioritizes potential disease-related genes by using a highly curated and upda

30 The glomerular disease-related gene, CD2AP, exhibited an STR replacemen

31 s the first report of an association between disease-related gene CNV and variation in protein expres

32 f hereditary sequence variants identified in disease-related genes directly affects clinical manageme

33 Co-expression of Parkinson's disease-related genes DJ-1, parkin, Pink1, UCH-L1, or sy

34 tional clues of previously unknown genes and disease-related genes during early brain development.

35 The accelerated discovery of disease-related genes emerging from genomic studies has

36 dromes, as well as the identification of new disease-related genes for dilated cardiomyopathy, idiopa

37 same number of genes, and up to 75% of human disease-related genes have Drosophila homologues [1].

38 es a high degree of connectivity among these disease-related genes, highlighting RBFOX1 as a key fact

39 to dissect the epigenetics of silencing of a disease-related gene in its natural chromosomal context.

40 uce heritable, site-specific modification of disease-related genes in human cells without purine sequ

41 uce heritable, site-specific modification of disease-related genes in human cells.

42 can be explained by segregation of Alzheimer disease-related genes in these families or shared enviro

43 gene product, are prevalent in a variety of disease-related genes, including APC (implicated in colo

44 ted with decreased expression of products of disease-related genes, including K16, iNOS, IFN-gamma, I

45 determine if STR replacements occurred near disease-related genes, including previously unstudied ST

46 rimental data suggest that BFDCA can cluster disease-related genes into functional DC subunits and es

47 However, 15 families had variants in disease-related genes not typically associated with LGMD

48 tentially susceptible rare variants within a disease-related gene or a genetic region.

49 ternative and effective approach to identify disease-related genes or loci has been verified.

50 s has documented the presence of at least 10 disease-related genes or loci linked to Parkinson's dise

51 were undiagnosed on a targeted neuromuscular disease-related gene panel did not improve our diagnosti

52 Another glomerular disease-related gene, rabphilin 3A, exhibited at least t

53 Another challenge is that determining disease-related genes requires laborious experiments.

54 To narrow the search for candidate disease-related genes, RGC genes were mapped to known di

55 Mutations in other disease-related genes suggest a potential relationship w

56 ine Mendelian Inheritance in Man database of disease-related genes, suggesting that exosome analysis

57 ative methods to have higher power to detect disease-related genes than non-integrative methods.

58 With this biosensor, we detected three disease-related genes that were the human immunodeficien

59 he identification of an increasing number of disease-related genes, the molecular defect in many case

60 contributions of critical neurodegenerative disease-related genes to neuropathogenesis.

61 Knocking down expression of disease-related genes using small interfering RNAs (siRN

62 bunits and estimate the regulatory impact of disease-related genes well.

63 ss to individual environmental antigens, and disease-related genes, which promote distinctive aspects

64 ble the study of the spatial distribution of disease-related genes within the genome.