ライフサイエンスコーパス: disfavor

1 te is entropically favored and enthalpically disfavored.

2 N-C(alpha) bond cleavage in zwitterions was disfavored.

3 ive elimination or sigma-bond metathesis are disfavored.

4 e Ser67, to the cis- and/or trans-enamine is disfavored.

5 tly that such a pathway would be kinetically disfavored.

6 erted into the active site, is energetically disfavored.

7 re integration in or near heterochromatin is disfavored.

8 the proline-rich ligand to the SH3 domain is disfavored.

9 other like-charged stacks would be strongly disfavored.

10 F, with the latter channel being kinetically disfavored.

11 mbranes, while liquid ordered membranes were disfavored.

12 er contributed, the more it was excluded and disfavored.

13 The disfavored [3,3]-sigmatropic rearrangement, which would

14 cycle, in this case promoting an unusual and disfavored 4-exo-trig ring closure.

15 The success of the kinetically disfavored 5-endo cyclization was attributed to the form

16 lcohols leads to fragmentation rather than a disfavored 5-endo-trig cyclization.

17 otherwise kinetically and thermodynamically disfavored 6-membered alkyl palladacycle intermediates.

18 The present results disfavor a major role for such switching in catalysis of

19 While urea clearly disfavors a compact native structure, it is not clear th

20 (pK(a)(H3O(+)) = 0), which thermodynamically disfavors a concerted proton transfer to H2O.

21 The arabino product strongly disfavors a mechanism involving a Michael addition to th

22 -trisubstituted pyrrole; when enolization is disfavored, a [1,3] rearrangement occurs prior to enoliz

23 This suggests that fish oil-enriched diets disfavor AA oxygenation by altering the composition of t

24 In addition, the human MetAPs disfavor acidic residues at the P2'-P5' positions.

25 the S/T-2 and S/T+1 positions, but strongly disfavors acidic residues (Asp or Glu) at the S/T-2 posi

26 nity heparin binding, although not enough to disfavor activation.

27 y affect methylation of the cognate site but disfavor activity at noncognate sites.

28 addition to the 14e (pincer)Ir fragments but disfavor addition to the 16e complexes (pincer)IrH(2) or

29 active intermediates is shown to support the disfavored addition to enolate acceptors to an absolutel

30 complexes, (Y-PCP)Ir(CO) or (Y-PCP)Ir(H)(2), disfavors addition of H-H or C-H bonds, in contradiction

31 e reported that YTHDC1 prefers guanosine and disfavors adenosine at the position preceding the m(6)A

32 In contrast, a widening disparity that disfavored adolescents from poor families was present in

33 ay be designed to generate thermodynamically disfavored alkenyl chlorides and fluorides in high yield

34 s the most pronounced optimum for K(+) while disfavoring all other biologically important cations (e.

35 The normally disfavored alpha,beta-unsaturated alpha-nitrosulfones ha

36 ing inter-helical interactions; and (3) non, disfavoring alpha-helical structure.

37 in, these residues play an important role in disfavoring alternate states and are especially importan

38 mistry to favor fluorophore biosynthesis and disfavor alternative reactivity, we identify strategies

39 omplexes with bulky biaryl phosphine ligands disfavor amine binding to favorable conformations of oxi

40 ervation provides a molecular basis for this disfavor and illustrate its generality.

41 hydroxyl group of HCO(3)(-) is particularly disfavored and apparently does not occur in any of the c

42 ystals in a 1:1 ratio, the polymerization is disfavored and does not go to completion.

43 the tautomeric equilibrium is enthalpically disfavored and entropically favored by the increase in s

44 mponents for Sp1-3 but is more enthalpically disfavored and entropically favored with increasing Cys

45 SSs) with 12-bp spacers, should be extremely disfavored, and the cryptic RSS used for V(H) replacemen

46 o 5,4-bicyclic products is thermodynamically disfavored, and these cyclobutenamides instead rearrange

47 or at least, it does not improperly favor or disfavor any particular method.

48 , whether the bias inappropriately favors or disfavors any method.

49 The data disfavors any model that involves protonation of sulfide

50 te is driven by enthalpy and is entropically disfavored as shown by anoxic isothermal titration calor

51 ed state to the native state is entropically disfavored at 298 K.

52 As crossovers are disfavored at such hot spots, we propose that sequence d

53 2 position, and additionally for HIV-1, A is disfavored at the -4 position.

54 substituents on the sulfonamide nitrogen are disfavored at the PNMT active site more so than at the a

55 rate-limiting and substrates that sterically disfavor attainment of the reactive conformation for dec

56 t nucleophilic attack from the alpha face is disfavored because an eclipsed H-2 will be encountered.

57 ogous interaction of P218 with human DHFR is disfavored because of three species-dependent amino acid

58 ed reversal of selectivity to form otherwise disfavored beta-aldehyde products in the hydroformylatio

59 antibody 1D4 selectively catalyzes a highly disfavored beta-elimination reaction.

60 to a wide range of statistically favored and disfavored beta-turn mutations and implicate a loosely a

61 onstrates that the chrysi ligand does indeed disfavor binding to B-DNA and generate mismatch selectiv

62 he secondary structure into an energetically disfavored, but functional, conformation and emphasize a

63 hydride transfer reaction is predicted to be disfavored by >20 kcal/mol, and the activation energy is

64 rmation of corresponding alpha-digitoxosides disfavored by 1,3-diaxial interaction.

65 r of the allowed conrotatory ring-opening is disfavored by 4-8 kcal/mol.

66 The head-to-tail arrangement was disfavored by adding site-directed mutations at F241 and

67 preferred but are nonetheless energetically disfavored by AWSEM, as well as in nature.

68 This category is expected to be maximally disfavored by charge repulsion.

69 Oxonia-Cope rearrangements can be disfavored by destabilizing the resultant oxocarbenium i

70 The pi(+)-pi EDA interaction was disfavored by electropositive alkyl substituents and by

71 the NTP through the main channel is greatly disfavored by electrostatic repulsion between the NTP an

72 tly amyloidogenic and consequently have been disfavored by evolutionary selection.

73 d make large contributions to stability, and disfavored by external A(+).C wobbles, which have high f

74 ropic orientation of the aggregates are both disfavored by high concentrations of salt (>200 mM NaCl)

75 CO to the same 16-electron complexes is also disfavored by increased electron donation from Y.

76 ne to trans-(PH3)2IrX are generally strongly disfavored by increased sigma-donation from the ligand X

77 )' subsite was greatly favored by MMP-14 but disfavored by MMP-1.

78 ssembly onto adjacent DNA sequences that are disfavored by nucleosomes but favored by ORC.

79 ated kinases; Ile/Leu at the P-1 position is disfavored by PKC-zeta but not PKC-delta.

80 Further chain growth is probably disfavored by steric crowding.

81 es-equilibrated hydroperoxide binding at Ti, disfavored by stronger surface Bronsted acidity, and rat

82 r, substrates with a net negative charge are disfavored by the channel, probably due to the negativel

83 nd the complex with weaker affinity is again disfavored by the cosolutes.

84 en tBID and BCL-XL is driven by enthalpy but disfavored by the entropy associated with the conformati

85 ions occurred in motifs that were favored or disfavored by these deaminases.

86 araldehyde and coniferaldehyde substrates is disfavored by wild-type CAD2.

87 d AGC, which are preferred by mutant AID but disfavored by WT AID.

88 orporates A opposite an AP site and strongly disfavors C.

89 rrier becomes so much higher that it is also disfavored compared to the 5- and 7-exo-dig cyclizations

90 caffold was enthalpy-driven and entropically disfavored compared to the flexible analogues.

91 amyloid-like interactions are energetically disfavored compared with the native state, but entropica

92 These disfavored conformations are usually absent from the coi

93 st-guest chemistry and favoring of otherwise disfavored conformations of large guests has been achiev

94 Disfavored conformations predicted by the model were tes

95 systematically enumerated and classified the disfavored conformations that restrict short polyalanyl

96 ed to the steric bulk of the ammonium moiety disfavoring conformations in which hydrogen-bonding to t

97 Furthermore, steric conflicts disfavor conformers that juxtapose a methyl group on sub

98 In contrast, mutations in APOBEC3F-disfavored contexts were relatively rare, whereas mutati

99 henylalanine is trapped in the energetically disfavored, coplanar conformation of the TS of the bond

100 olecular electrostatic potentials results in disfavored Coulombic interactions.

101 substrate analog is positioned such that it disfavors covalent catalysis.

102 CL4 and CCL2 contain specific sequences that disfavor CXCL8 dimerization.

103 mokine families to discover the changes that disfavor CXCL8 of quaternary structure.

104 etion conserved in the CCL4 chemokine family disfavors CXCL8 dimerization.

105 hich is similar in magnitude to the (2)H-EIE disfavoring Cys-ketimine (from which the third state for

106 as is the widely-accepted notion, but rather disfavoring defection in the global scale.

107 (2) Costly Punishment, alone, disfavors defection but decreases average payoff.

108 Introducing costly punishment to diversity disfavors defection but favors cooperation.

109 -7.6 kcal mol(-1)) while being entropically disfavored (DeltaS degrees approximately -24 cal mol(-1)

110 nism of dimerization, features that favor or disfavor dimerization, thermodynamic and kinetic factors

111 reasing the length of homology shared by the disfavored donor increases its use.

112 stigated factors that improve the use of the disfavored donor.

113 ry mode that leads to the C5-alpha epimer is disfavored due to higher levels of allylic strain betwee

114 amino groups in native proteins is markedly disfavored due to protonation of amines.

115 where condensation of Ge adatoms on SiO2 is disfavored due to the extremely short re-evaporation tim

116 The engineered enzyme is disfavored during competition for acetate.

117 Fibril growth is disfavored energetically due to cancellation of direct p

118 a particular vesicle radius; other radii are disfavored energetically.

119 termination by ETV was accomplished through disfavored energy requirements as well as steric constra

120 states on fullerenes is shown to accelerate disfavored enolate addition and exo Diels-Alder reaction

121 a more than 100-fold rate enhancement of the disfavored enolate addition reaction that coincides with

122 enthalpically driven and exhibits a strongly disfavored entropic contribution.

123 strongly favored enthalpically and strongly disfavored entropically at ambient temperature.

124 ther natural products involves a kinetically disfavored epoxide-opening cyclic ether formation, a rea

125 , coordination of NH3 to the Ir(I) center is disfavored even more strongly by increasing sigma-donati

126 on the nonpolar face of a beta-strand should disfavor fibrillar structures because such structures wo

127 This interaction increases stability and disfavors fibrillation.

128 Electrostatic interactions are found to disfavor folding.

129 on of the circular genome that is favored or disfavored for new insertions but there are notable hots

130 ssovers, although genetically silent, may be disfavored for other reasons.

131 nce of TFA, but C-protonation was relatively disfavored for this system.

132 We accurately determine preference (or disfavor) for residues at a given substrate position (su

133 itions favoring dissociation of p-cymene and disfavoring formation of aggregates of 5.

134 To test whether R-M systems favor or disfavor genetic exchanges, we analyzed their frequency

135 eractions; however, nonspecific interactions disfavor guanine, while still favoring unpaired RNA stru

136 nd binding was negated by modifications that disfavored hairpin formation.

137 region on the protein that electrostatically disfavors halogen substitutions.

138 achinery, we defined a general approach that disfavors helical transitions leading to post-fusion con

139 nuous relationship to residues that favor or disfavor helix nucleation.

140 reveal these residues to adopt a sterically disfavored helix-capping conformation.

141 Prolines slightly disfavor His-heme loop formation, presumably due to enha

142 eystone residues stabilize normally strongly disfavored homodimers.

143 ding to formation of a product that would be disfavored if the reaction proceeded by passage over kin

144 stic symbioses (the "Red Queen effect"), but disfavored in certain mutualistic symbioses (the "Red Ki

145 vely favored in the presence of arginine and disfavored in its absence.

146 complexes) are predicted to be energetically disfavored in reactions involving fluorobenzenes with a

147 acetylation, and H3 K4 methylation, but was disfavored in regions rich in transcription-inhibiting m

148 e supramolecular cavity of 1, is kinetically disfavored in the absence of 1, as evidenced by the orth

149 onfiguration, the hosts occupy binding sites disfavored in the binary complexes because of the chemic

150 tion, and is favored in blackwater lakes but disfavored in the clearwater habitat of the transplant p

151 ific surface site of D44 observed in M2TM is disfavored in the longer peptide.

152 favored in the extracellular cap region and disfavored in the periplasmic cap region.

153 l-Amino acids are strongly disfavored in these conformations, but d-amino acids are

154 be located in complemented pockets, and are disfavored in unfilled pockets.

155 kinetically significant intermediate I(1) is disfavored in urea, and moderately favored by GB.

156 formation of an R-loop structure that can be disfavored in vitro and in vivo by ribonuclease H1 overe

157 ation trans to H4 at 180 degrees is strongly disfavored, in excellent agreement with the MD results.

158 ate signalers receive social punishment that disfavors inaccuracy.

159 ith ligation of NEDD8 shifting equilibria to disfavor inactive CAND1-bound closed architectures, and

160 tant specificity determinant; it selectively disfavors interactions with dicarboxylic substrates and

161 , suggesting a role of the phosphodianion in disfavoring intermediate release and in modulation of th

162 formation, favoring outside facing sites and disfavoring inward facing sites.

163 bilizing RNAP contacts with nucleic acid and disfavoring isomerization into a paused state.

164 , THF, and CH(3)CN solutions, while slightly disfavors it in DMSO.

165 genes controlled by both NRF-1 and NRF-2 and disfavor its membership in the immediate early response

166 zed over the whole molecular framework, thus disfavoring its stabilization by interaction with the so

167 Once RPo forms, CarD also disfavors its isomerization back to RP2.

168 x, further conformational changes occur that disfavor K+ binding.

169 the inhibitory MCR.CoB7SH complex is highly disfavored (Kd = 56 mM).

170 This interface would disfavor large aliphatic side chains.

171 Increased MgCl(2) disfavored ligation of substrate intermediates that resu

172 ese data indicate that the X chromosome is a disfavored location for genes selectively expressed in m

173 ambient" conditions, to selectivity give the disfavored M2L3 helicates.

174 sm and amino acid recycling, and accordingly disfavored many genes with other functions.

175 otonated throughout the reaction coordinate, disfavoring mechanisms that involve a stable tyrosinate

176 in the absence of cyclopropyl ring opening, disfavoring mechanisms that involve unpaired electron de

177 was first arrested by adding lysolipids that disfavored membrane merger, and the lipids were subseque

178 rategy to prepare for sedentary existence by disfavoring migration away from a substrate on which a b

179 s, promoting the incorporation of siRNAs and disfavoring miRNAs as loading substrates for Drosophila

180 from which the pollen accepts inhibition and disfavors mutations in the S-RNase gene that cause the n

181 ve design are present, where the covariances disfavor non-native structures.

182 r-frequency carbon-fluorine stretching modes disfavor non-radiative relaxation pathways and boost the

183 uences that significantly delay assembly are disfavored not only because unintegrated OMPs are subjec

184 nding the phosphate surrogate is arranged to disfavor nucleophilic attack by water.

185 y regulated genes whose sequences inherently disfavor nucleosome formation within the gene but favor

186 ly because their DNA sequences intrinsically disfavor nucleosome formation.

187 curs at unprecedented densities and directly disfavors nucleosomes, contributing to nucleosome positi

188 These studies identified favored as well as disfavored nucleotides and demonstrated the previously u

189 diphosphorus tetroxide-in its energetically disfavored O2P-PO2 form-via carbene-stabilization.

190 drochloride indicates that the P25A mutation disfavors oligomerization mediated by intermolecular hem

191 ed in the formation of the thermodynamically disfavored omega-hydroxy metabolite, 2-phenyl-1-propanol

192 roxylates these substrates at the chemically disfavored omega-position.

193 which postulated metal-bound enolates, were disfavored on the basis of our observations.

194 een evolutionarily conserved to specifically disfavor one dimerization state and, as a result, indire

195 hese unfavorable motifs produce interactions disfavoring one outcome to indirectly promote another on

196 tionally constrained amino acids that favor, disfavor, or exclude the gauche (-), the gauche (+), or

197 tatic switch model for Ca(2+) activation and disfavors, or places strong constraints on, the conforma

198 tection of some antibody specificities while disfavoring others.

199 into groups, preferring their own group and disfavoring others?

200 bstituents energetically favor reduction and disfavor oxidation, and give formal potentials that corr

201 etween Y(D)* and a nearby beta-carotene that disfavors oxidation of Car(B).

202 ion that increasing sigma-donation by X also disfavors oxidative addition of N-H bonds to trans-(PH3)

203 chmidt reaction is diverted into a typically disfavored pathway by the presence of an aromatic group

204 ability to direct a chemical reaction down a disfavored pathway, even when a more favorable mechanism

205 d activates O2 , and Ag/Pt surface proximity disfavors poisoning by CO or oxidized species.

206 icates that binding of the pUp tetraanion is disfavored, possibly due to unfavorable desolvation or e

207 tert-Leucine particularly disfavored PPII.

208 ays high selectivity for what is generally a disfavored product.

209 In particular, the HOMO of [Co2(DPXM)(O2)]+ disfavors proton transfer to the bound oxygen species, f

210 tes Dmc1 loading, specifically counteracting disfavoring R-band effects.

211 ntibody-mediated catalysis into the realm of disfavored reactions and, hence, represents an important

212 the mechanistic basis for this energetically disfavored regiostereochemistry has been less clear.

213 hat a conventional inner-sphere mechanism is disfavored relative to an unusual stepwise outer-sphere

214 ate that the complex with weaker affinity is disfavored relative to the complex with higher affinity.

215 es of the constrained ligands were uniformly disfavored relative to their flexible controls, demonstr

216 lly the hydrolysis reaction is substantially disfavored relative to transesterification.

217 tide specificity highlight the importance of disfavored residues.

218 than one order of magnitude, with nucleosome-disfavoring sequences resulting in lower noise and more

219 tional structure of nucleosome favouring and disfavoring sequences with respect to their basic buildi

220 titutively active, synthetic with nucleosome-disfavoring sequences, and in the absence of RPD3, a glo

221 tion sigma(DM)/m < 0.47 cm(2)/g (95% CL) and disfavoring some proposed extensions to the standard mod

222 have alternative stable states that tend to disfavor species at low densities.

223 gate sequence-related factors that favor and disfavor stable formation of peptoid helices of this cla

224 or the introduction of steric bulk leads to disfavored steric interactions with the receptor, and/or

225 these neomycin-class antibiotics into a TAR-disfavored structure has no deleterious effect on bindin

226 avor double-strand break (DSB) formation but disfavor subsequent loading of meiotic RecA homolog, Dmc

227 itions, as is found in thymine, and strongly disfavored substitution at the 3-position.

228 transcription of both genes is statistically disfavored, suggesting mutually exclusive LCR-gene conta

229 While stereoelectronics disfavor syn-addition, a judicious choice of properly si

230 fts the equilibrium of the aptamer sensor to disfavor target binding.

231 airs, equilibration of the thermodynamically disfavored tautomer was attempted with acids and bases b

232 rade and utilize host-derived substrates and disfavor taxa that prefer complex plant polysaccharides.

233 rmation on Pb(2+) ions and electrostatically disfavor tetrahedral coordination.

234 herichia coli TL (sequence insertion 3; SI3) disfavors TH formation and stimulates pausing.

235 artially folded, paused TL conformation that disfavors TH formation.

236 o-A mutations were more frequent in APOBEC3G-disfavored than in APOBEC3G-favored contexts.

237 es favor binding of the eEF2 translocase and disfavor that of the elongation ternary complex.

238 ]-sigmatropic rearrangement, and a tactic to disfavor the [1,3] pathway and increase the efficiency o

239 y reaction conditions that thermodynamically disfavor the [2,3] rearrangement step and thereby make t

240 ubsites +1 to +5 are oriented such that they disfavor the binding of malto-oligosaccharides that bear

241 These factors disfavor the breaking of conjugation by oxa-conjugate ad

242 s of the remainder of the enzyme and solvent disfavor the catalytic reaction in both cases.

243 cleavage of a desired target sequence or to disfavor the cleavage of nontarget sequences.

244 valent residue in CD38, Thr-221, is shown to disfavor the cyclizing folding of the substrate, resulti

245 hylether as an H-cluster ligand and strongly disfavor the dithiomethylammonium as a catalytic base fo

246 ce of distracting epitopes that entropically disfavor the evolution of bnAbs.

247 ural differences in the vicinity of Cys(101) disfavor the facile oxidation of this residue that is fu

248 Branched side chains (2-hexyldecyl) disfavor the formation of lamellar mesophases and, inste

249 tion is to promote disordered aggregates and disfavor the formation of ordered nuclei and dissociatio

250 scherichia coli strains that either allow or disfavor the formation of protein disulfide bonds in the

251 Local propensities, however, strongly disfavor the formation of the C-terminal helix because m

252 Basic ligands favor the metalation step but disfavor the formation of the catalytically active sigma

253 lters how N-Myc interacts with SCF(FbxW7) to disfavor the generation of Lys48-linked polyubiquitin ch

254 develop resistant mutations that can at once disfavor the inhibitor and still recognize the substrate

255 ect the right substrate and to recognize and disfavor the reaction of an incorrect substrate.

256 ituted 1,2-diethynylbenzenes, steric effects disfavor the thermal C1-C6 diradical cyclization reactio

257 THF solvation disfavored the formation of mixed tetramers and resulted

258 While functional analysis disfavored the HIF2alpha:ARNT heterodimer-based PAS-B mo

259 r interactions in an ABC heterotrimer, while disfavoring the 26 competing oligomers (i.e., AAA, ABB,

260 t that Lys67 may be replaced by an arginine, disfavoring the conjugate base mechanism, distinguishing

261 that of transport in the opposite direction, disfavoring the efflux of solute via Lyp1.

262 cting the synthesis of proteins promoting or disfavoring the formation of biofilms.

263 Mutations appear to enhance misfolding by disfavoring the formation of correct structure rather th

264 n atypical planar conformation, both factors disfavoring the reaction of the reduced flavin with diox

265 e conformations of the bound ligand to those disfavoring the reactive geometry.

266 linkers, while an N-P motif, which strongly disfavors the attachment of N-glycans, is commonly obser

267 able electrostatic environment for acids and disfavors the bases tends to have high optimum pH and vi

268 Y promotes a helical ssDNA conformation that disfavors the binding of gp32 and initiates the assembly

269 wild-type alpha-synuclein, the plus2 variant disfavors the formation of beta-sheet-rich oligomers, in

270 Moreover, a ribose-like ring disfavors the interaction of Thr45 with a pyrimidine nuc

271 However, its presence strongly disfavors the kinetic accessibility of misfolding side-r

272 55 is not essential for turnover but greatly disfavors the mechanistically unproductive binding of l-

273 positive charge at position 15 substantially disfavors the stacked state but retains much of the bind

274 the equilibrium toward the bent states, and disfavors the straight state to the extent that it is no

275 nucleophilicity of the base in water, which disfavors the transmetalation step.

276 ectric protein cavity from the bulk solvent, disfavors the unfolded state.

277 stereoisomeric (2S,4R)-fluoroproline, which disfavors this conformation.

278 o a conformational change by the enzyme that disfavors this form in its equilibrium with Ala aldimine

279 amide carbonyl oxygen in the diastereomeric, disfavored transition state 14 is also beyond the van de

280 The presence of allylic strain in the disfavored transition state results in a torquoselective

281 essity for distortion of the catalyst in the disfavored transition state.

282 f the hydrogen-bonded aromatic ketone in the disfavored transition state.

283 sence renders RTK to a less potent enzyme by disfavoring transphosphorylation of activation loop tyro

284 that allow editing of an adenosine within a disfavored triplet.

285 olving the C(6) and C(8) substituents in the disfavored TS-2.

286 in heterodimers to adopt a conformation that disfavors tubulin incorporation.

287 are entropically favored, and enthalpically disfavored, typical of hydrophobic interactions.

288 These T-DNA insertion regions are disfavored under selective conditions.

289 ty, simultaneously favors reliable peaks and disfavors unreliable peaks using a weighted ratio betwee

290 that disrupt key intermolecular interactions disfavor vMIA's mitochondrial recruitment of Bax, and in

291 contrast, these radical processes are highly disfavored when generating unstable phenyl and primary a

292 ecule is bound in the polymerizing mode, but disfavored when it is bound in the editing mode.

293 facing transition of apo MsbA is found to be disfavored when the periplasmic gate is open and facilit

294 In these cases, 6- and 7-substitution was disfavored, whereas 8-substitution was largely tolerated

295 pockets, aliphatic hydrophobic residues are disfavored, whereas aromatic side chains are enriched.

296 elation of neutral lipid DOPE by the AuNP is disfavored which inturn promotes stability of vesicle st

297 In summary, UvrB homodimerization is disfavored, while domain 4 homodimerization and UvrB-dom

298 Cubic ice is disfavored with respect to hexagonal ice not only by a s

299 dinucleotide steps, traditionally thought to disfavor Z-DNA, can be incorporated within heterogeneous

300 rising selectivity for the thermodynamically disfavored Z-5-exo product.