ライフサイエンスコーパス: disinhibit

1 iganded HCN1, which occurs as though already disinhibited.

2 nsistent with the hypothesis that mu-opioids disinhibit 5-HT neurons, an effect attenuated by direct

3 mbranes, also unclamps spontaneous fusion by disinhibiting a secondary Ca(2+) sensor.

4 Gi/o and a DA dip leads to a PKA increase by disinhibiting A2aR/Golf, but D2+ MSNs could also respond

5 e consistent with GABAA receptor antagonists disinhibiting acetylcholine release in the PnO to result

6 ose that hypoactivity in the vmPFC engenders disinhibited activity of the amygdala and, consequently,

7 RECK release disinhibits ADAM (a disintegrin and metalloproteinase) p

8 shown that axon growth through CNS myelin is disinhibited after neurotrophic factor administration by

9 r and anxiety, which in turn, is proposed to disinhibit aggressive behaviors.

10 dentate gyrus of the dorsal hippocampus are disinhibited and (2) disinhibition occurs because GABAer

11 nglia where behaviors leading to rewards are disinhibited and behaviors leading to no reward are supp

12 interneuron-->L5 pyramidal neuronal circuits disinhibited and ENGC<-->L2/3 interneuron-->L5 pyramidal

13 Networks with reduced GABA were disinhibited and had altered gamma oscillations in respo

14 ersonality change with blunting of affect or disinhibited and inappropriate behaviour; and language d

15 therefore downstream dopamine cells will be disinhibited; and thus, this could potentially result in

16 ized AMPA, NMDA receptors), unperturbed, and disinhibited (antagonized GABA(A) receptors).

17 ontributes to substance abuse and how it can disinhibit automatic behaviors, such as tics in Tourette

18 n patients with schizophrenia is abnormal or disinhibited automatic spreading activation of semantic

19 synergistically enhanced neuronal survival, disinhibited axon growth and promoted axon regeneration

20 variant frontotemporal dementia (85%), with disinhibited behavior as the prominent feature.

21 mit a nonspecific genetic risk for offspring disinhibited behavior, including tobacco use.

22 specific genetic risk to their offspring for disinhibited behavior.

23 ay prime instrumental behavior with DA while disinhibiting behavior by lowering ACh.

24 enic mice had aging-dependent repetitive and disinhibited behaviors, with synaptic deficits selective

25 Disinhibited behaviour, a risk factor for overconsumptio

26 anism by which the agonists histamine or ATP disinhibit BKA channel activity.

27 Overall, DA disinhibits BLA, at least in part, by suppressing GABA r

28 events and mirror their pattern of spread in disinhibited brain slices over millimeters.

29 hat tVTA GABA neurons lose their capacity to disinhibit, but not to inhibit, VTA DA cells after chron

30 ions of POMC cells activated by 5-HT2CRs and disinhibited by 5-HT1BRs.

31 c13s, in which the basal state of Munc13s is disinhibited by C1 domain activation into a state of fac

32 The PVN was disinhibited by microinjecting a GABA(A) receptor antago

33 Spontaneous release was disinhibited by region I mutation and found to correlate

34 Spontaneous release was disinhibited by region I mutations and found to correlat

35 time, that "presympathetic" PVN neurons are disinhibited by the neuropeptide substance P (SP) acting

36 RPP-32 neurons in IM by high dopamine levels disinhibits CeM and triggers autonomic arousal.

37 The Purkinje cell firing decrease disinhibits cerebellar nuclear cells, which then produce

38 es axon growth inhibitory signaling, thereby disinhibiting CNS axon/neurite growth.

39 tinal peptide-expressing interneurons (VIPs) disinhibit cortical pyramidal cells through inhibition o

40 doubles maximal synthase activity, partially disinhibits cytochrome c reductase activity, and lowers

41 the capacity of the tVTA to inhibit, but not disinhibit, DA cells after chronic opiate exposure may c

42 s) suppress lateral inhibition from iMSNs to disinhibit dMSNs, which are known to facilitate locomoti

43 behavioural plasticity, at least in part by disinhibiting dopamine neurons in the ventral tegmental

44 receptors (CB1Rs) on GABAergic neurons that disinhibit dopaminergic neurons in the ventral tegmental

45 referentially by BOS, suggesting that area X disinhibits dopaminergic neurons by inhibiting VP.

46 eworks support the proposition that ATD thus disinhibits dorsal raphe-originating serotonergic contro

47 stantia nigra can simultaneously inhibit and disinhibit downstream structures, while the dopaminergic

48 nhibits striatopallidal function measured as disinhibited downstream activity in the globus pallidus.

49 ther granule cells in epileptic gerbils were disinhibited during the interictal period, IPSPs were re

50 a and PAG in juveniles, we pharmacologically disinhibited each of the two subdivisions of the mPFC an

51 Disinhibited eaters were characterised by a reduced HRV

52 BG was related to hunger but only in low disinhibited eaters.

53 y the interactive effects of restrained and disinhibited eating and self-reported dieting to lose we

54 explored for the first time the influence of disinhibited eating and vagal tone (heart rate variabili

55 A behavioral index of disinhibited eating in children was used to measure chil

56 Although disinhibited eating is positively associated with higher

57 findings highlight novel mechanisms by which disinhibited eating leads to obesity and insulin resista

58 eating and dieting moderate the influence of disinhibited eating on weight change.

59 ting questionnaire (TFEQ) was used to assess disinhibited eating.

60 egree of the participants' tendencies toward disinhibited eating.

61 This could occur because CFTR loss can disinhibit ENaC, and ENaC activity can drive absorption.

62 ervates calretinin inhibitory neurons, which disinhibit excitatory neurons.

63 By using mice harboring a disinhibited form of the IL-4 receptor, we developed an

64 ecifically reducing Galpha(s) signaling also disinhibited FSHbeta expression, suggesting the presence

65 ited GABA release, whereas blocking the MORs disinhibited GABA release.

66 neurons and in the adult mouse brain in vivo disinhibited glycogen synthase kinase 3beta (GSK3beta) b

67 Estrogen transiently disinhibits hippocampal CA1 pyramidal cells in adult fem

68 dea that the dominant M1 has the capacity to disinhibit homologous representations in the contralater

69 f spatial memory and that hippocampal damage disinhibits hypothalamic-pituitary-adrenocortical (HPA)-

70 induced by paralimbic processes involved in disinhibiting impulsive motor responses to rewarding or

71 ore, beta-catenin-dependent signaling may be disinhibited in Fzd6(-) (/) (-) HSPCs.

72 r indicate that the cAMP/PKA pathway becomes disinhibited in the prefrontal cortex with advancing age

73 Whether the PFC becomes disinhibited in this model and alters decision making re

74 involving the basal ganglia and thalamus are disinhibited in Tourette syndrome patients.

75 's disease patients with greater chorea were disinhibited is consistent with the theory that chorea a

76 the OMV, whereas bicuculline, an antagonist, disinhibited it.

77 w that PD-associated LRRK2 mutations display disinhibited kinase activity and induce a progressive re

78 d that hyperactive somatostatin interneurons disinhibited layer 5 pyramidal neurons (L5-PNs) and cont

79 sm by which stress-induced vmPFC dysfunction disinhibits learning by alternate (for example, striatal

80 ation of LH neurons and is not the result of disinhibiting LH cells by disrupting transmission at GAB

81 during salient sensory stimulation, L-ITCcs disinhibit local and distant principal neurons, acting a

82 Inhibition of these GABA interneurons disinhibits medial SN and VTA dopamine neurons, producin

83 Therefore, rTMS of the experimentally disinhibited motor cortex induces within-representation

84 neurons by MRN injections of 8-OH-DPAT would disinhibit MS/DB neurons, allowing them to burst rhythmi

85 abeled with calretinin, which are thought to disinhibit neighboring excitatory neurons, suggesting fa

86 e, optogenetic silencing of DRN GABA neurons disinhibited neighboring 5-HT neurons and prevented the

87 Using the partially disinhibited neocortical slice preparation, activity is

88 prolonged and recurrent neuronal bursting in disinhibited networks.

89 lt primary DRG and retinal cultures promoted disinhibited neurite growth when cells were stimulated w

90 owth factor receptor activation and promotes disinhibited neurite outgrowth.

91 t neuronal bursting that were simulated in a disinhibited neuronal network.

92 previously unidentified mechanism that could disinhibit neurons transmitting nociceptive information

93 cleaves the ECD from both NgR and TROY, and disinhibits neurotrophic factor (NTF) stimulated RGC neu

94 ockdown of p75NTR also inactivates Rho-A and disinhibits NTF-stimulated RGC neurite outgrowth in cult

95 ndothelial inactivation, which can either be disinhibited or amplified, depending on the stimulus.

96 tex (OFC) in humans has been associated with disinhibited or socially inappropriate behaviour and emo

97 In that view, the lesions 'disinhibit' or 'release' the laughter and crying centre.

98 d been classified as behaviorally inhibited, disinhibited, or neither in laboratory assessments.

99 intestinal peptide (VIP) interneurons, which disinhibit other interneurons.

100 inobutyric acidergic (GABAergic)] neurons to disinhibit PAG output rather than directly on medullary-

101 Inhibition of GABA release from CCK neurons disinhibits parvalbumin (PV) interneurons and, as a cons

102 In RBD, degeneration of this circuitry disinhibits phasic motor commands originating from motor

103 s of opioid receptor activation would likely disinhibit POMC neuron activity and higher concentration

104 n during periadolescence elicits an enduring disinhibited prefrontal local field potential (LFP) resp

105 nic or stress-induced activity which in turn disinhibits prepotent motivated behaviors.

106 velopment rather than the manifestation of a disinhibited primitive brain.

107 ral amygdala (BLA) promotes fear learning by disinhibiting principal neurons (PNs) and enabling synap

108 d in endocannabinoid mobilization, which can disinhibit PrL-PFC projection neurons, we investigated w

109 may indicate genetic risk for a dimension of disinhibiting psychiatric disorders, including childhood

110 , lower OLM activity reduced theta power and disinhibited pyramidal cells, resulting in increased bas

111 gamma-aminobutyric acid (GABA) interneurons disinhibiting pyramidal cells may be relevant to this hy

112 pha-synuclein abnormalities in the brainstem disinhibit rapid eye movement sleep motor activity, lead

113 cal and biochemical evidence that in acutely disinhibited rat neocortical slices, robust release of g

114 ity between the two substitutions completely disinhibits reductase activity and further reduces the E

115 Neurotrophins released by AG1478 stimulated disinhibited retinal ganglion cell axon growth in centra

116 Thus, dopaminergic neurons can be disinhibited selectively by complex sensory stimuli via

117 promotes PGC-1alpha co-activator function by disinhibiting SIRT1 deacetylase activity.

118 ork modeling predicted, and experiments with disinhibited slices confirmed, that stimuli targeting up

119 iven trial, triggered network-wide bursts in disinhibited slices had remarkably similar time courses

120 ormal LTP was induced in picrotoxin-treated, disinhibited slices.

121 ompletely inhibited LTP in both standard and disinhibited slices.

122 ols of symptoms of autism spectrum disorder, disinhibited social engagement, and inattention and over

123 trum disorder, inattention and overactivity, disinhibited social engagement, conduct or emotional pro

124 and subcortical inputs and then inhibits or disinhibits specific thalamic relay cells, so that appro

125 To disinhibit SST(+) interneurons, we inactivated the gamma

126 inducing a transition from an inhibited to a disinhibited state.

127 nected with stress dysregulation, serving to disinhibit stress responses and allow for glucocorticoid

128 h higher guanfacine doses also appeared less disinhibited, suggesting enhanced ventromedial-orbital P

129 d the speed of snake recognition and clearly disinhibited sympathetic arousal as manifested by increa

130 PP2 resulted in the significant reduction of disinhibited synaptic currents to healthy control levels

131 rons in response to proteasome inhibition or disinhibiting synaptic activity with bicuculline.

132 suggest that sensorimotor beta-band rhythms disinhibit task-relevant populations, whereas alpha-band

133 hypothesis that NMDA-R blockade in RtN would disinhibit thalamocortical networks.

134 mechanism through which ethanol may globally disinhibit the DLS.

135 pharmacology was used to locally inhibit or disinhibit the PH immediately before behavioral measures

136 y be a compensatory mechanism that serves to disinhibit the reduced sensory input.

137 asts over the grating patch in an attempt to disinhibit the response.

138 the superior colliculus (SC), but they also disinhibit the saccadic system by removing the potent in

139 inhibition of the SNpr/GPi should, in turn, disinhibit the thalamus to facilitate movement.

140 at release of histamine from TMN neurons can disinhibit the TMN and suppresses the activity of sleep-

141 strated that cholinergic inhibition of NGFCs disinhibited the apical dendrites of layer 2/3 pyramidal

142 s create psychotomimetic states by similarly disinhibiting the activity of PFC pyramidal neurons.

143 nover contributes to thermal hyperalgesia by disinhibiting the channel.

144 nist could have antidepressant properties by disinhibiting the firing of these neurons, resulting in

145 onstrated its potential to control cancer by disinhibiting the immune system.

146 e neurons, which inhibit CeL output, thereby disinhibiting the medial subdivision of CeA and releasin

147 d the disinhibition hypothesis by reversibly disinhibiting the SC ipsilateral to a visual cortical le

148 xtracellular K(+) from 3.0 to 8.5 mM and (2) disinhibiting the slice using 3 mM pentylenetetrazol or

149 cular CRH inhibits the septum, which in turn disinhibits the amygdala, resulting in a constellation o

150 Ca(2+)/calmodulin (CaM) binding disinhibits the autoregulatory domain, allowing autophos

151 horizontal cell hyperpolarization with NBQX disinhibits the Ca(2+) signals produced by pH-sensitive

152 Across species, alcohol exposure disinhibits the DLS by dampening GABAergic transmission

153 g; P < 0.05), suggesting that Y2R antagonism disinhibits the NPY neuron thus stimulating feeding in o

154 knockdown of GluClalpha in principal neurons disinhibits the odor responses of these neurons.

155 corpus callosum of postnatal day (P)1-6 rats disinhibits the production of spindle bursts (SBs) withi

156 damage to the crossed nigrotectal projection disinhibits the superior colliculus ipsilateral to the c

157 tion neurons selectively in patches, thereby disinhibiting their firing in response to cortical input

158 2+) reduces photoreceptor Ca(2+) signals, it disinhibits them at 10 mum, an effect reminiscent of ear

159 oderately diminished during normal stress to disinhibit these loci.

160 y to resting levels of CSNA and HR, but when disinhibited, they can produce large increases in CSNA a

161 omelanocortin (POMC) neurons, which are also disinhibited through a 5-HT1BR-mediated suppression of l

162 n the usual care group and more signs of the disinhibited type in both groups.

163 ly to placement in foster care; signs of the disinhibited type showed less robust resolution with fos

164 Signs of the disinhibited type were highest in the usual care group,

165 inhibited type) and indiscriminately social (disinhibited type) reactive attachment disorder in Roman

166 nths) was associated with fewer signs of the disinhibited type.

167 c to VTA inhibit local GABA release, thereby disinhibiting VTA neurons.

168 This in turn disinhibits warm-PNs and sums with feed-forward excitati

169 by constitutive association with p85, and is disinhibited when the SH2 domains of p85 bind to tyrosyl