ライフサイエンスコーパス: disinhibition

1 aired function of spinal inhibitory neurons (disinhibition).

2 naptic inhibition of GABAergic transmission (disinhibition).

3 part by the removal of synaptic inhibition (disinhibition).

4 eates a mechanism whereby cAMP mediates PP2A disinhibition.

5 tent with increased neuronal activity due to disinhibition.

6 vasoactive intestinal peptide (VIP)-mediated disinhibition.

7 tential long-term toxicities, and behavioral disinhibition.

8 tion of endocannabinoid-mediated peritetanic disinhibition.

9 ed Na(v) 1.1 function in interneurons causes disinhibition.

10 neralized epilepsy exhibit cerebral cortical disinhibition.

11 tic risk reflecting aggressive-disregard and disinhibition.

12 stic computational modeling, namely cortical disinhibition.

13 ns may be the cause of supraspinal GABAergic disinhibition.

14 correlated factors: aggressive-disregard and disinhibition.

15 e context for a novelty-induced reduction of disinhibition.

16 ing background inhibition to provide greater disinhibition.

17 ting of reward, another on motor or response disinhibition.

18 ral abnormalities, such as hyperactivity and disinhibition.

19 ither subregion induced a general behavioral disinhibition.

20 ibres through neural circuitry that includes disinhibition.

21 dditional excitation mediated by glycinergic disinhibition.

22 ression of synaptic inhibition and on-demand disinhibition.

23 efrontal synaptic activity toward a state of disinhibition.

24 responses using primarily AMPA receptors or disinhibition.

25 stamine-releasing neurons in the TMN through disinhibition.

26 due to peripheral hearing loss, not central disinhibition.

27 ains from psychotic patients, and suggesting disinhibition.

28 x associated with resumption of spiking upon disinhibition.

29 ation of VTA DA neurons through a process of disinhibition.

30 g that mGlu3 may also play a role in central disinhibition.

31 y under conditions of experimentally induced disinhibition.

32 esulting in unchecked movements via thalamic disinhibition.

33 excite these pyramidal neurons via parallel disinhibition.

34 ced HIV incidence in men without behavioural disinhibition.

35 and may mediate a form of local feedforward disinhibition.

36 ed by physical hyperactivity and behavioural disinhibition.

37 sociative memories can occur through focused disinhibition.

38 ariants within 3q26 in neural and behavioral disinhibition.

39 ce, respectively, through GABAergic synaptic disinhibition.

40 ggressive cancer cell behavior through Notch disinhibition.

41 increasing reasoning difficulty, apathy, and disinhibition.

42 idal cell assemblies at the theta trough via disinhibition.

43 0.0003), apathy (40% versus 4%, P < 0.0001), disinhibition (16% versus 2%, P = 0.009), irritability (

44 nds had high rates of symmetry (49%) but not disinhibition (5%).

45 ing crucial player in this implementation is disinhibition--a transient break in the balance of excit

46 lear neurons has fostered the inference that disinhibition activates these channels, synaptic inhibit

47 cussions including novelty seeking, response disinhibition, aggression, and substance abuse.

48 ve, language and visuospatial function, less disinhibition, agitation/aggression and night-time behav

49 on subtypes, ruling out either inhibition or disinhibition alone as sole mechanism for active engagem

50 Although the D2R-mediated disinhibition alone is sufficient to gate t-LTP at a nor

51 role in ocular dominance plasticity, causing disinhibition among open-eye-biased principal neurons, w

52 Stronger evidence exists for treating disinhibition and antagonism than negative affectivity,

53 ble across years, as have sex differences in Disinhibition and Boredom Susceptibility.

54 These changes produce further disinhibition and can be viewed as the aberrant response

55 ulation-specific local excitation, GABAergic disinhibition and excitation through electrical coupling

56 atients who had lower levels of 6-mo and 1-y disinhibition and hunger (beta = 0.13-0.29, P < 0.01 in

57 ore weight and reported greater decreases in disinhibition and hunger at 1- and 10-y follow-ups (all

58 ginal monograph in 1872 provided evidence of disinhibition and impaired social cognition.

59 eads to reduced release of GABA, followed by disinhibition and increased release of glutamate from ro

60 rons reliably patterned STN activity through disinhibition and inhibition, respectively.

61 opmental changes in this callosally mediated disinhibition and its association with cortical plastici

62 tion potential initiation causes multisystem disinhibition and network hyperexcitability, which can w

63 vaccination, including concerns about sexual disinhibition and potential obstacles to vaccine distrib

64 Such fast signaling through disinhibition and rebound may be a crucial specializatio

65 esynaptic CB1Rs, leading to VTA dopaminergic disinhibition and reinstatement of cocaine CPP.

66 or the apparently paradoxical combination of disinhibition and severe akinesia.

67 nic variants for association with behavioral disinhibition and the use/misuse of nicotine, alcohol, a

68 is known about interneurons specializing in disinhibition and their in vivo function.

69 d alpha6(R46W) mutation could cause neuronal disinhibition and thus increase susceptibility to genera

70 al basis for the association between dietary disinhibition and weight gain.

71 attenuating the positive association between disinhibition and weight in dieting women.

72 ted the positive association between dietary disinhibition and weight.

73 y expenditure coupled with higher hunger and disinhibition and/or delayed satiation compared with nev

74 levels of inappropriate social behaviours ('disinhibition') and demonstrated more pronounced hypomet

75 pecially poor impulse control and behavioral disinhibition), and movement (including parkinsonism and

76 a significant interaction between restraint, disinhibition, and dieting showed that restraint moderat

77 ion of the interactive effects of restraint, disinhibition, and dieting.

78 posttreatment levels of cognitive restraint, disinhibition, and hunger and 1-y changes in these eatin

79 on in eating pathology (cognitive restraint, disinhibition, and hunger).

80 of study participants, showed that euphoria, disinhibition, and nighttime behaviors were significant

81 ictors, including dietary restraint, dietary disinhibition, and self-reported dieting.

82 ated by genetic variability, neurobehavioral disinhibition, and sex.

83 APP overexpression, including hyperactivity, disinhibition, and spatial learning and memory deficits.

84 ldehyde dehydrogenase; those associated with disinhibition; and those that confer a low sensitivity t

85 treating specific DSM-5 BPD traits, notably disinhibition, antagonism, and some aspects of negative

86 e of six clinically discriminating features (disinhibition, apathy/inertia, loss of sympathy/empathy,

87 duct adherence and the possibility of sexual disinhibition are important concerns.

88 ics associated with excessive inhibition and disinhibition are observed in patients with eating disor

89 of orexin-A neurons, and their CB1-mediated disinhibition, are a consequence of leptin signaling imp

90 increasing tic symptom severity and motoric disinhibition as demonstrated by a finger tapping test.

91 avioral variant frontotemporal dementia with disinhibition as the prominent feature, with or without

92 DA neuron excitation was likely mediated by disinhibition because local antagonism of gamma-aminobut

93 Therefore, prefrontal hypoactivation and disinhibition both cause attentional deficits.

94 As POMC neurons prevent obesity, their disinhibition by leptin action on presynaptic GABAergic

95 treated cultures, leading to axon growth and disinhibition by neurotrophin-induced regulated intramem

96 Subsequent cortical disinhibition by reduced PV cell activity allows for exc

97 The branch-specific disinhibition can be achieved despite dense interneurona

98 Apart from attentional deficits, prefrontal disinhibition caused additional neurobehavioral changes

99 Thus, the disinhibition circuit was driven by the ON pathway and r

100 TP in mature ACx can be unmasked by cortical disinhibition combined with activation of cholinergic in

101 an outward current from inhibitory synapses (disinhibition) combined with an increase in an inward cu

102 Remarkably, this prefrontal disinhibition could be normalized following a single acu

103 Such disinhibition could lead to the selective amplification

104 ositive feedback, such as activity-dependent disinhibition, could provide these uncommon timing featu

105 nd that synaptic excitation, inhibition, and disinhibition couple to different calcium-dependent sign

106 (ii) Disinhibition decreases the power of gamma oscillation a

107 assessed in an open field with a measure of disinhibition defined as a greater increase in explorati

108 We named this disinhibition-dementia-parkinsonism-amyotrophy complex.

109 ety of behavioural symptoms including social disinhibition, depression and aggressive behaviour.

110 However, the mechanisms underlying this disinhibition diverge significantly as epilepsy progress

111 s report that thalamic activation occurs via disinhibition during pauses in the firing of inhibitory

112 s permanently) and are instead driven by the disinhibition exhibited in the selfie (studies 4-7).

113 ne levels of anxiety/depression, inattention/disinhibition, externalizing, subsyndromal manic, and af

114 tional status, whereas scores on the genetic disinhibition factor score were more strongly associated

115 pes were high and statistically significant (disinhibition factor=0.35, SE=0.03; symmetry factor=0.39

116 f a cued appetitive task and that behavioral disinhibition following vmPFC inactivation depends on do

117 ty pauses, which allow a transient window of disinhibition for medium spiny neurons.

118 rcuitry: intrinsic sensory hyperactivity and disinhibition give rise to frontal overload and disrupt

119 od valuation signal that was compared across disinhibition group and satiety state.

120 itual diet, those with the highest levels of disinhibition had higher BG levels after thirty minutes

121 y balance by decreasing inhibition, and thus disinhibition has emerged as a major mechanism by which

122 artate (NMDA) receptors, and pharmacological disinhibition have demonstrated that impairment of the f

123 ted states between persons with high dietary disinhibition (HD) and low dietary disinhibition (LD).

124 ation of GABA-releasing cells at the site of disinhibition holds promise for alleviating disease symp

125 ACC) excitotoxic lesions and pharmacological disinhibition; however, a causal relationship has not be

126 re-derived perceptions of dietary restraint, disinhibition, hunger, and control of eating.

127 eral homotopic cortex hinders recovery (the 'disinhibition' hypothesis).

128 ontext for a novelty-induced facilitation of disinhibition (i.e., a greater increase in exploratory a

129 ld a state of frequency-dependent prefrontal disinhibition in adulthood comparable to that seen in th

130 investigated the neural basis of behavioural disinhibition in behavioural variant frontotemporal deme

131 nmodulation plays a key role in pathological disinhibition in conditions such as ischemia and epileps

132 to spatial navigation are causally linked to disinhibition in different compartments of projection ne

133 e receptor function in second-order neurons, disinhibition in the dorsal horn and glia cell activatio

134 t, as evidenced by reduced hyperactivity and disinhibition in the P301S mice.

135 These results show a new role for disinhibition in the retina and suggest a new role for t

136 n bipolar disorder in parents and behavioral disinhibition in their offspring.

137 sclosure risks (i.e., people exhibit greater disinhibition in their selfies, studies 1 and 2).

138 balances in SynCAM 1 KO mice resulted in CA3 disinhibition, in agreement with reduced feedforward inh

139 e dependent on the suppression of sIPSCs, or disinhibition, in that blockade of inhibitory synaptic t

140 d be predicted to be produced by hippocampal disinhibition, including increased ventral tegmental are

141 Accordingly, the pattern of prefrontal LFP disinhibition induced by periadolescent MK-801 treatment

142 In addition, because disinhibition-induced allodynia shares some features wit

143 c input following MD in adult mice, and this disinhibition induces a "lower PV network configuration"

144 Dietary disinhibition is a behavioral trait associated with weig

145 Disinhibition is a cardinal feature of the behavioural v

146 g from milliseconds to days, suggesting that disinhibition is a conserved circuit mechanism contribut

147 and modeling approach suggests that cortical disinhibition is a fundamental pathological modification

148 f layer 2/3 pyramidal neurons by PV-specific disinhibition is a key step in the progression of ODP.

149 Thus, disinhibition is a rapid homeostatic plasticity mechanis

150 5 subjects revealed that callosotomy-induced disinhibition is a transient feature of early developmen

151 ur data demonstrate that callosotomy-induced disinhibition is a transient phenomenon whose disappeara

152 ning photostimulation to investigate whether disinhibition is confined to the critical period by ngr1

153 The low [Co(2+)] disinhibition is pH sensitive.

154 Furthermore, this mGlu7-mediated disinhibition is required for induction of LTP at the SC

155 ircuit functions, such as gain modulation or disinhibition, is starting to reveal canonical circuit m

156 re the ganglion cell fires, generating timed disinhibition just before the ganglion cell spikes.

157 h dietary disinhibition (HD) and low dietary disinhibition (LD).

158 Striatal disinhibition leads to the formation of motor tics resem

159 ent mice displayed increased depression- and disinhibition-like behavior, as well as deficits in soci

160 Behavioral disinhibition may be a familially transmitted predisposi

161 This restricted period of disinhibition may be a fundamental mechanism for recepti

162 These negative functional consequences of disinhibition may include reduced working memory-related

163 oupling is achieved, at least in part, via a disinhibition mechanism by which PSD-95 abolishes NMDA r

164 including serotonergic strategies to improve disinhibition.media-1vid110.1093/brain/awv133_video_abst

165 is study defines a novel mechanism of spinal disinhibition mediated by a TNFalpha-TNFR1-p38 pathway w

166 of opiates, and also challenge the canonical disinhibition model of opiate reward.

167 s during visual stimulation, challenging the disinhibition model.

168 quency tuning should render pup odor-induced disinhibition more effective for high-frequency stimuli,

169 resulting from an increase in excitation and disinhibition occurring in two respective types of senso

170 These findings suggest that the indirect disinhibition of 5-HT neuron activity by presynaptic GAB

171 orientation-selective excitation in part by disinhibition of a tonic NMDA receptor-mediated input ar

172 The latter is due, in part, to disinhibition of an excitatory polysynaptic pathway link

173 mine and cAMP-regulated signaling leading to disinhibition of ARPP-16 and increased PP2A action.

174 tentiation (LTP), which depended entirely on disinhibition of BDNF release.

175 bition by valueless objects, which generated disinhibition of cdlSNr neurons and inhibition of superi

176 or elsewhere) to CeL, ultimately leading to disinhibition of CeM neurons.

177 sult from long-term depression (LTD)-related disinhibition of cholinergic neurons in the vestibular n

178 xylase 67 and parvalbumin was accompanied by disinhibition of cortical excitatory neurons and reduced

179 kappaB), sequesters GR expression leading to disinhibition of CRF.

180 phasic muscle activity during sleep suggests disinhibition of descending motor projections in PD broa

181 subtypes, ultimately resulting in a powerful disinhibition of direct pathway MSNs.

182 ency range to a higher frequency, suggesting disinhibition of DMN activity.

183 tion of midbrain GABA neurons and consequent disinhibition of dopamine (DA) neurons in the ventral te

184 n learning, including enhanced excitation or disinhibition of dopamine neuron activity, blockade of d

185 parahippocampal gyrus, possibly related to a disinhibition of dopamine neurons.

186 on K(+)-evoked GABA release suggesting that disinhibition of dopamine release from terminals in the

187 use disorder, the end result of which may be disinhibition of downstream "effector" regions that regu

188 ch may reflect either reduced anxiety and/or disinhibition of exploratory-like behavior.

189 atal information processing, but more global disinhibition of FSIs by GP is important for initiating

190 Activation of the circuit occurs via disinhibition of GABAergic inputs onto vlPAG output neur

191 o elicit antidepressant-like behavior, using disinhibition of GABAergic interneurons.

192 tivity due, at least in part, to glycinergic disinhibition of GAD67 cells.

193 urons are a major contributor to the central disinhibition of gamma-aminobutyric acid type A receptor

194 MDAR activity on inhibitory neurons leads to disinhibition of glutamate neurons increasing synaptic a

195 hibition within the dentate gyrus leading to disinhibition of granule cells.

196 acting combinations supports the therapeutic disinhibition of individuals with strongly interacting K

197 Here we show that tonic disinhibition of left motor cortex during prism adaptati

198 actions of SRIF may serve to counteract the disinhibition of M1 ipRGCs caused by SRIF inhibition of

199 These findings raise the possibility that disinhibition of mesolimbic dopamine pathways contribute

200 Glutamatergic stimulation or disinhibition of MnPO neurons evoked thermogenic, metabo

201 on of the mTOR antagonist rapamycin leads to disinhibition of neuronal networks as measured on microe

202 in the beta-band is directly related to the disinhibition of neuronal populations involved in the co

203 Thus, disinhibition of neurons in the DMH in conscious rats re

204 elies on two mechanisms (MST-MT feedback and disinhibition of opponent motion signals in MT) to expla

205 ocesses contributing to chronic pain, spinal disinhibition of pain signaling to higher cortical cente

206 PS is a result of central sensitization with disinhibition of pain signals rather than increased peri

207 fTgDyrk1Amice, which suggests that selective disinhibition of parvalbumin interneurons would result i

208 demonstrate that salient events often elicit disinhibition of projection neurons that favors excitati

209 tioned animals and attenuate its response to disinhibition of PVN.

210 n of fast-spiking interneurons, resulting in disinhibition of pyramidal cells.

211 tor inhibition causes cortical excitation by disinhibition of pyramidal neurons.

212 through inhibitory neurons, resulting in the disinhibition of pyramidal neurons.

213 These defects are potentially explained by disinhibition of Shh activity.

214 lly mediated increase of HR and BGL suggests disinhibition of sympathetic outflow as a possible mecha

215 ation of action potentials, facilitation and disinhibition of synaptic transmission, loss of synaptic

216 thesis that the beta-band rhythm governs the disinhibition of task-relevant neuronal populations, whe

217 tic and postsynaptic activity, we found that disinhibition of thalamus may entail pallidal firing rat

218 reover, ketamine could produce inhibition or disinhibition of the 40 Hz response in a temporally dyna

219 Our results suggest that disinhibition of the Akt-signalling pathway may provide

220 This effect did not result from disinhibition of the APC/C.

221 ling within the inferior olive or reduce the disinhibition of the cerebellar cortex on the deep cereb

222 ctility was due to hyperexcitability and not disinhibition of the circuitry.

223 statin-positive (SST+) neurons suggests that disinhibition of the cortex via VIP+ cells, which inhibi

224 Here, we examined the effect of disinhibition of the DMH by unilateral microinjection of

225 In the brainstem, disinhibition of the DMH increased Fos expression in the

226 Disinhibition of the DMH resulted in dramatic increases

227 Whereas pharmacological disinhibition of the ECN unmasked wake-related reafferen

228 gonism reduces inflammatory pain through the disinhibition of the endogenous opioidergic system in mi

229 Disinhibition of the forkhead transcription factor FoxO1

230 egulation of hypothalamic levels of BDNF and disinhibition of the HPA axis.

231 r, it has been proposed that it is linked to disinhibition of the human mirror-neuron system [1-4] an

232 Importantly, the compound does not lead to disinhibition of the hypothalamus-pituitary-adrenal axis

233 d by DA D2 agonists and thus seem related to disinhibition of the indirect striatal pathway.

234 Disinhibition of the pFL with bicuculline and strychnine

235 n it was induced by hypercapnia, hypoxia, or disinhibition of the pFL.

236 e stress responses was tested via inhibition/disinhibition of the PH.

237 In RA-conditioned rats, disinhibition of the PVN increased BP, HR, minute D(EMG)

238 Thus decreased NO production and relative disinhibition of the PVN may contribute to maintenance o

239 e ingestion is promoted by glucose-dependent disinhibition of the RS1-Reg-blocked exocytotic pathway

240 ed striato-pallidal transmission, leading to disinhibition of the STN and increased activation of STN

241 eurons that project from SNpr results in the disinhibition of the targets to which these neurons proj

242 that the cortical stimulation triggers fast disinhibition of the thalamic neurons.

243 Disinhibition of the thalamus remains the primary model

244 Many of these changes may be due to disinhibition of the transcription factor, forkhead box

245 mpairment caused by PTX, indicating that the disinhibition of these neurons by PTX was responsible fo

246 tion of the direct pathway and a separate UV disinhibition of this pathway through P53-E2f1-Bcl-2.

247 ration of fluoxetine reversed the behavioral disinhibition of tPA(-/-) mice, further supporting an im

248 r findings indicate that callosotomy-induced disinhibition of twitch-related SBs is a bioassay of som

249 eriaqueductal grey that produces freezing by disinhibition of ventrolateral periaqueductal grey excit

250 t that BLA inactivation disrupts PPI through disinhibition of VP.

251 Drug-induced disinhibition of VTA DA neurons has been linked to rewar

252 ns participate in the loss of opiate-induced disinhibition of VTA DA neurons observed during protract

253 ed inhibition, providing a circuit locus for disinhibition of whisker-evoked responses observed in L2

254 2 MAPK in hippocampal mossy fiber terminals, disinhibition of zinc-sensitive MAPK tyrosine phosphatas

255 howed that restraint moderated the effect of disinhibition on weight differently in nondieters than i

256 anesthetized rats that local pharmacological disinhibition or optogenetic excitation of the RTN/pFRG

257 cal activity group reported higher levels of disinhibition (P = 0.07) and cravings for savory foods (

258 ore frequently in bvFTD than ALS-FTD: social disinhibition (p<0.001), inertia (p<0.001), loss of symp

259 The disinhibition persisted in the presence of CNQX and d-AP

260 The disinhibition played a relatively large role in driving

261 y conceivably underlie the symptoms of motor disinhibition presenting as tics and psychiatric manifes

262 This disinhibition promotes anxiety and physiological hyperar

263 intains the chosen behavior, and (3) lateral disinhibition promotes sequence transitions.

264 lement behavioral choice, (2) local feedback disinhibition provides positive feedback that consolidat

265 This critical impact of disinhibition raises the issue of what regulates the act

266 by a sequence of excitation, inhibition, and disinhibition, raising the question of how these stimuli

267 by stimulation of glutamatergic afferents is disinhibition, rather than reduced excitatory transmissi

268 l evidence for prefrontal hypoactivation and disinhibition (reduced GABAergic inhibition), possibly r

269 cular and circuit components underlying this disinhibition remain unknown.

270 e-exposed animals through GABAergic synaptic disinhibition, represent a new class of rapidly-acting a

271 of INs and suggest that the SOM IN-mediated disinhibition represents an important circuit mechanism

272 ge from baseline to 6 mo and for measures of disinhibition, restrained eating, and dieting.

273 t to elicit an enduring state of PFC network disinhibition resulting from a developmental impairment

274 early adolescence can elicit a state of mPFC disinhibition resulting from a functional impairment of

275 elated symptoms (TSC-40) were collected; the disinhibition scale of the three-factor eating questionn

276 EPSCs driven by primary afferents following disinhibition, supporting the view that the analgesic ef

277 These interactions can result in FKBP5 disinhibition that has been shown to contribute to a num

278 ed on aberrant reward learning or behavioral disinhibition, they do not offer an adequate account of

279 l derivative, reverses inflammation-mediated disinhibition through a specific interaction with hetero

280 Abeta prevents this endocannabinoid-mediated disinhibition, thus leaving synaptic inhibition more int

281 We propose that ngr1 limits disinhibition to close the critical period for OD plasti

282 eely behaving rats before and after striatal disinhibition to explore the factors underlying the timi

283 that reduce their activity during a complex (disinhibition) to allow full excitation of the muscle.

284 onse correlated with increases in behavioral disinhibition toward the logo of the consumed beverage (

285 chanisms of cognitive impairments underlying disinhibition, using horizontal saccadic latencies that

286 ng compulsions, repetitive writing tics) and disinhibition (uttering syllables/words, echolalia/palil

287 Moreover, via this lateral disinhibition, VIP cells in vivo make local and transien

288 The failure of disinhibition was associated with a loss of glutamatergi

289 Such cocaine-induced mPFC disinhibition was not observed in adult-exposed animals.

290 Such a disinhibition was not observed when MK-801 was given dur

291 To induce prefrontal hypoactivation or disinhibition, we microinfused the GABA-A receptor agoni

292 mediated neurite growth promotion and myelin disinhibition were abrogated by CRMP2 inhibition and lar

293 Dietary restraint and disinhibition were assessed by using the Eating Inventor

294 We propose a mechanism of disinhibition, wherein APs suppress Ca(2+) syntillas, wh

295 We conclude that NVHL rats present PFC disinhibition, which affects neural information processi

296 the delay reflects rapid homeostasis through disinhibition, which masks the onset of Hebbian weakenin

297 sk scores were significantly associated with disinhibition, while Tourette syndrome and ADHD risk sco

298 uron microcircuits results in pyramidal cell disinhibition with important consequences for synaptic p

299 VIP(+) interneurons balancing inhibition and disinhibition within the network.

300 s are dependent on the location of the focal disinhibition within the striatum; however, the factors