ライフサイエンスコーパス: disintegrin

1 ghtly, and selectively to echistatin, an RGD disintegrin.

2 the conformational design of antimetastatic disintegrins.

3 Increased expression of metalloprotease-disintegrin ADAM12 is a hallmark of several pathological

4 Metalloprotease-disintegrin ADAM12 is overexpressed and frequently mutat

5 R2 is shed from cells by the metalloprotease disintegrin ADAM17, whereas NRP-1 is released by ADAM10.

6 a causes upregulation of the metalloprotease-disintegrin ADAM8 (A8) in affected brain regions, spinal

7 sess the contribution of the metalloprotease-disintegrin ADAM9 to ocular neovascularization in mice.

8 Ectodomain cleavage by A-disintegrin and -metalloproteases (ADAMs) releases many

9 This identified ADAM6, a member of the A disintegrin and A metalloprotease (ADAM) family; members

10 talloproteinase with thrombospondin motif, a disintegrin and a metalloprotease, interleukin (IL)-1bet

11 This study investigates the role of a disintegrin and a metalloproteinase (ADAM) 10 and ADAM17

12 A disintegrin and a metalloproteinase domain (ADAM) 9 is k

13 B)-EGF neutralizing antibody or abrogating a disintegrin and matrix metalloproteinase-17 (ADAM-17) ex

14 actor receptor (EGFR) and ADAM17 (a membrane disintegrin and metallopeptidase 17) in lung epithelial

15 We found that recombinant a disintegrin and metalloprotease (ADAM) 17 cleaved the ec

16 alpha(5)beta1 binds a disintegrin and metalloprotease (ADAM) 17, a metalloenzy

17 dding of HEPCAM at two alpha-sites through a disintegrin and metalloprotease (ADAM) and at one beta-s

18 Catalytically active members of the A Disintegrin And Metalloprotease (ADAM) family of membran

19 metalloproteases, especially those of the A disintegrin and metalloprotease (ADAM) family, can media

20 embrane-bound precursors by one of several a disintegrin and metalloprotease (ADAM) metalloproteases,

21 A disintegrin and metalloprotease (ADAM) proteases are imp

22 The discovery of the disintegrin and metalloprotease (ADAM) proteins, which h

23 Using a disintegrin and metalloprotease (ADAM)-17 radiation chim

24 ion of matrix metalloproteinase (MMP)- and a disintegrin and metalloprotease (ADAM)-family zinc metal

25 e evidence that human Tim-3 is a target of A disintegrin and metalloprotease (ADAM)-mediated ectodoma

26 The cytoplasmic domain of a disintegrin and metalloprotease (ADAM)10, a transmembran

27 with a TLR3 or TLR4 ligand, we identified a disintegrin and metalloprotease (ADAM)15 as a novel TRIF

28 cycle progression, and siRNA knockdown of a disintegrin and metalloprotease (ADAM)17 had a similar i

29 As a disintegrin and metalloprotease (ADAM)s have been implic

30 endogenous AXL was dependent on the sheddase disintegrin and metalloprotease 10 (ADAM10) and the gamm

31 It is reported here that a disintegrin and metalloprotease 10 (ADAM10) interacts wi

32 A disintegrin and metalloprotease 10 (ADAM10) is a ubiquit

33 A disintegrin and metalloprotease 10 (ADAM10) is a ubiquit

34 The membrane-anchored metalloproteinase a disintegrin and metalloprotease 10 (ADAM10) is required

35 he alpha-hemolysin binding to its receptor A-disintegrin and metalloprotease 10 (ADAM10) upregulates

36 by an initial shedding event catalyzed by A Disintegrin and Metalloprotease 10 (ADAM10).

37 n of the cellular receptor of alpha-toxin, a disintegrin and metalloprotease 10 (ADAM10).

38 esis or inhibition of mCD23 cleavage by an a disintegrin and metalloprotease 10 inhibitor, GI254023X,

39 (m)CD23 by the endogenous metalloprotease a disintegrin and metalloprotease 10.

40 cytoskeleton morphology and recruitment of a disintegrin and metalloprotease 10.

41 on its shedding and binding activities, the disintegrin and metalloprotease 12 (ADAM12) has been imp

42 was significantly correlated with ADAM12 (A Disintegrin And Metalloprotease 12) expression in these

43 ng enzyme type 2 (ACE2) and an increase in a disintegrin and metalloprotease 17 (ADAM17) activity in

44 Amino acid polymorphisms within a disintegrin and metalloprotease 17 (Adam17) can account,

45 A disintegrin and metalloprotease 17 (ADAM17) is a major s

46 We have directly shown that A disintegrin and metalloprotease 17 (ADAM17) is a primary

47 The TNF-alpha converting enzyme (TACE), a disintegrin and metalloprotease 17 (ADAM17), has emerged

48 HER2 trans-activation by IL-1beta required a disintegrin and metalloprotease 17 (ADAM17)-dependent sh

49 Lastly, a disintegrin and metalloprotease 17 (ADAM17; also known a

50 The metalloproteinase ADAM17 (a disintegrin and metalloprotease 17) controls EGF recepto

51 ADAM17 (a disintegrin and metalloprotease 17) controls pro- and an

52 ADAM17 (a disintegrin and metalloprotease 17) is believed to be a

53 Protein ectodomain shedding by ADAM17 (a disintegrin and metalloprotease 17), a principal regulat

54 sis factor alpha-converting enzyme ADAM17 (a disintegrin and metalloprotease 17), which demonstrates

55 vascular epithelial growth factor (VEGF), a disintegrin and metalloprotease 33 (ADAM33), and periost

56 dding is largely attributed to a family of a disintegrin and metalloprotease domain (ADAM) metallopro

57 n of collagen I, CD45, and CD34 or EGFR or a disintegrin and metalloprotease domain 17 and placed in

58 with glutamate and GABA neurotransmission: a disintegrin and metalloprotease domain 22 (Adam22) and h

59 A disintegrin and metalloprotease domain-containing protei

60 nuclear factor of activated T-cells; ADAM, a disintegrin and metalloprotease domain; OTM, orthodontic

61 superfamily characterized by the presence of disintegrin and metalloprotease domains.

62 ADAM10, a member of a disintegrin and metalloprotease family, is an alpha-secr

63 , a member of the matrix metalloproteinase/a disintegrin and metalloprotease family.

64 ed from the cell surface by proteinases of a disintegrin and metalloprotease family; however, the mec

65 ecent studies suggest that serum levels of a disintegrin and metalloprotease protein-12 (ADAM-12) can

66 he length of VWF is regulated by ADAMTS13 (a disintegrin and metalloprotease with a thrombospondin ty

67 A disintegrin and metalloprotease with a thrombospondin ty

68 ADAMTSs (a disintegrin and metalloprotease with thrombospondin doma

69 A disintegrin and metalloprotease with thrombospondin moti

70 tablished in a pilot approach, identifying a disintegrin and metalloprotease with thrombospondin moti

71 pericytes rapidly activated expression of a disintegrin and metalloprotease with thrombospondin moti

72 t out to investigate the role of ADAMTS-5 (a disintegrin and metalloprotease with thrombospondin moti

73 -21 encodes ADT-2, a member of the ADAMTS (a disintegrin and metalloprotease with thrombospondin moti

74 A disintegrin and metalloprotease with thrombospondin moti

75 rly active 29/31-kDa form of VEGF-C by the A disintegrin and metalloprotease with thrombospondin moti

76 These results identify A disintegrin and metalloprotease with thrombospondin moti

77 These proteins belong to the ADAMTS (a disintegrin and metalloprotease with thrombospondin repe

78 dothelial cell (HUVEC)-released ADAMTS-13 (a disintegrin and metalloprotease with thrombospondin repe

79 elated to a severe deficiency in ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type

80 in protein C, protein S, antithrombin and A Disintegrin and Metalloprotease with Thrombospondin type

81 a (TTP) by identifying naturally processed A Disintegrin And Metalloprotease with ThromboSpondin type

82 patients with diabetes, impaired ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type

83 unoglobulin G (IgG) autoantibodies against A Disintegrin And Metalloprotease with ThromboSpondin type

84 The protease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type

85 ulman syndrome [USS]) severe deficiency of a disintegrin and metalloprotease with thrombospondin type

86 cleavage of von Willebrand factor (VWF) by A disintegrin and metalloprotease with thrombospondin type

87 from the endothelial surface by ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type

88 (2) serum creatinine >2.25 mg/dL, and (3) a disintegrin and metalloprotease with thrombospondin type

89 encodes a metalloprotease similar to the "a disintegrin and metalloprotease with thrombospondin" (AD

90 ents, we determined whether transmembrane "a disintegrin and metalloprotease" (ADAM) proteins are exp

91 Proteolytically active ADAM (named for "a disintegrin and metalloprotease") family molecules have

92 induced shedding was abrogated by an ADAM (A disintegrin and metalloprotease) 10 and 17 selective inh

93 scular smooth muscles, KK stimulates ADAM (a disintegrin and metalloprotease) 17 activity via a PAR1/

94 latory region (NRR) that protects an ADAM (a disintegrin and metalloprotease) cleavage site.

95 zyme (TACE; ADAM17), a member of the ADAM (a disintegrin and metalloprotease) family of metalloprotea

96 disintegrin-like domain found in the ADAM (a disintegrin and metalloprotease) family of proteins.

97 eddase activity is attributed to the ADAM (a disintegrin and metalloprotease) family of proteins.

98 re we show that receptor cleavage by ADAM (A Disintegrin And Metalloprotease) metalloproteases promot

99 brane metalloproteases of the ADAM family (a disintegrin and metalloprotease), and the initiation com

100 ADAMDEC1 (Decysin-1) is a putative ADAM (a disintegrin and metalloprotease)-like metalloprotease wi

101 A disintegrin and metalloprotease-17 (ADAM17) is a major s

102 A disintegrin and metalloprotease-17 (ADAM17) is shown to

103 tream matrix metalloproteinases (MMPs) and a disintegrin and metalloproteases (ADAMs) and stimulate p

104 ng mediated by the cell surface proteases "a disintegrin and metalloproteases" (ADAM)-10 and ADAM-17,

105 todomain shedding, which was not mediated by disintegrin and metalloproteases.

106 le of TSPAN33, a tetraspanin implicated in a disintegrin and metalloproteinase (ADAM) 10 maturation,

107 in-22alpha promotor-driven deficiency of the disintegrin and metalloproteinase (ADAM) 17 (SM22-Adam17

108 A Disintegrin And Metalloproteinase (ADAM) 17 is one of th

109 Peptidases of the a-disintegrin and metalloproteinase (ADAM) family are impl

110 Prodomains of A disintegrin and metalloproteinase (ADAM) metallopeptidas

111 Serial processing of Cad6B by a disintegrin and metalloproteinase (ADAM) proteins and ga

112 Specific a disintegrin and metalloproteinase (ADAM) proteins inhibi

113 gulate ectodomain shedding mediated by the A Disintegrin And Metalloproteinase (ADAM) subfamily of pr

114 We demonstrate that a disintegrin and metalloproteinase (ADAM)10 is the primar

115 downregulation of metalloproteases mainly a disintegrin and metalloproteinase (ADAM)10, ADAM17, ADAM

116 primed B cell increased gene expression of a disintegrin and metalloproteinase (ADAM)10, which is the

117 wo major transmembrane metalloproteinases, a disintegrin and metalloproteinase (ADAM)17 and ADAM10, a

118 ch as matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase (ADAMs), are critical

119 Membrane CD23 is cleaved by a disintegrin and metalloproteinase 10 (ADAM10) and this c

120 A disintegrin and metalloproteinase 10 (ADAM10) is a ubiqu

121 A disintegrin and metalloproteinase 10 (ADAM10) is a zinc-

122 B cell A disintegrin and metalloproteinase 10 (ADAM10) is require

123 ected from skin and lung fibrosis and that a disintegrin and metalloproteinase 10 (ADAM10) is the maj

124 The proteolytic activity of a disintegrin and metalloproteinase 10 (ADAM10) regulates

125 A disintegrin and metalloproteinase 10 (ADAM10), a disinte

126 viously described mice lacking endothelial a disintegrin and metalloproteinase 10 (ADAM10), a key reg

127 es expression of the alpha toxin receptor, a disintegrin and metalloproteinase 10 (ADAM10).

128 how that TACI is sequentially processed by a disintegrin and metalloproteinase 10 and gamma-secretase

129 In addition, we found that a disintegrin and metalloproteinase 10 expression is upreg

130 estingly, the drug-induced upregulation of a disintegrin and metalloproteinase 10 on MM cells is asso

131 TACI proteolysis involved shedding by a disintegrin and metalloproteinase 10 releasing sTACI fro

132 by the alpha- and beta-secretases ADAM10 (a disintegrin and metalloproteinase 10) and BACE1 (beta-si

133 ADAM10 (a disintegrin and metalloproteinase 10) is the principal a

134 sintegrin and metalloproteinase 17 but not a disintegrin and metalloproteinase 10, respectively, whic

135 d high levels of the FcepsilonRII sheddase a disintegrin and metalloproteinase 10, which implies that

136 phiregulin, independent of metalloprotease a disintegrin and metalloproteinase 17 (ADAM17) activity.

137 A disintegrin and metalloproteinase 17 (ADAM17) is a membr

138 els of senescence that the metalloprotease A disintegrin and metalloproteinase 17 (ADAM17) is activat

139 evious studies showed that inactivation of A disintegrin and metalloproteinase 17 (ADAM17), a membran

140 viously shown that epidermal deficiency of a disintegrin and metalloproteinase 17 (ADAM17), the princ

141 onse to TSST-1 that includes the sheddase, a disintegrin and metalloproteinase 17 (ADAM17).

142 Dysregulated activity of A Disintegrin And Metalloproteinase 17 (ADAM17)/TNFalpha C

143 nverting enzyme (TACE; also referred to as a disintegrin and metalloproteinase 17 [ADAM17]), with sma

144 Indeed, inhibition of gamma-secretase and a disintegrin and metalloproteinase 17 but not a disintegr

145 embrane-anchored metalloproteinase ADAM17 (a disintegrin and metalloproteinase 17) in endothelial cel

146 ADAM17 (a disintegrin and metalloproteinase 17) is ubiquitously ex

147 n kinase C-dependent activation of ADAM17 (a disintegrin and metalloproteinase 17).

148 ADAM17 (a disintegrin and metalloproteinase 17, also referred to a

149 We found that a disintegrin and metalloproteinase 22 (ADAM22) is a compo

150 A disintegrin and metalloproteinase 8 (ADAM8) has been ide

151 A disintegrin and metalloproteinase 8 (ADAM8) is involved

152 The transmembrane ADAM8 (A Disintegrin And Metalloproteinase 8) protein is abundant

153 ng of HB-EGF by TNFalpha-converting enzyme/a disintegrin and metalloproteinase 9 (ADAM9) and ADAM17.

154 PS/TLR4-mediated generation of sMER required disintegrin and metalloproteinase ADAM17 and was indepen

155 proteinases (MMPs) and proteins containing a disintegrin and metalloproteinase domain (ADAM) are impo

156 A disintegrin and metalloproteinase domain 10 (ADAM10) is

157 A disintegrin and metalloproteinase domain 10 (Adam10), a

158 heir plasma membrane expression of ADAM17 (a disintegrin and metalloproteinase domain 17), an enzyme

159 ot only matrix metalloproteinases but also a disintegrin and metalloproteinase domain family members

160 proteinases matrix metalloproteinase-9 and a disintegrin and metalloproteinase domain-8.

161 p40 up-regulates a disintegrin and metalloproteinase domain-containing prot

162 eucine-rich, glioma-inactivated 1 (LGI1) and disintegrin and metalloproteinase domain-containing prot

163 A disintegrin and metalloproteinase domain-containing prot

164 iotensin-converting enzyme-sheddase ADAM9 (a disintegrin and metalloproteinase domain-containing prot

165 Palpha during inflammation is regulated by a disintegrin and metalloproteinase domain-containing prot

166 eases responsible for ectodomain shedding is disintegrin and metalloproteinase domain-containing prot

167 A disintegrin and metalloproteinase domain-containing prot

168 p-regulation of ADAM10, suggesting that this disintegrin and metalloproteinase mediates the chemokine

169 Genetic truncation of the transmembrane disintegrin and metalloproteinase protein ADAM11 resulte

170 tudies have elucidated the significance of a disintegrin and metalloproteinase proteins (ADAMs) in PN

171 ntegrin and metalloproteinase 10 (ADAM10), a disintegrin and metalloproteinase that resides in the po

172 ly in patients with nondeficient ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin

173 hrough continuous proteolysis by ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin

174 adults and mice have implicated ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin

175 lecular-weight rVWF multimers by ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin

176 Deficiency of a disintegrin and metalloproteinase with a thrombospondin

177 the action of the VWF protease ADAMTS-13 (a disintegrin and metalloproteinase with a thrombospondin

178 A disintegrin and metalloproteinase with a thrombospondin

179 opment of autoantibodies against ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin

180 ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin

181 A disintegrin and metalloproteinase with thrombospondin mo

182 ggrecan, matrix metalloproteinases (MMPs), a disintegrin and metalloproteinase with thrombospondin mo

183 a-inducible factor-2alpha, syndecan-4, and a disintegrin and metalloproteinase with thrombospondin mo

184 ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin mo

185 ADAMTS16 (a disintegrin and metalloproteinase with thrombospondin mo

186 oproteinase family that cleaves lecticans, a disintegrin and metalloproteinase with thrombospondin mo

187 f1), an endosulfatase gene, and CG4096, an A Disintegrin And Metalloproteinase with ThromboSpondin mo

188 y microenvironment release factors such as a disintegrin and metalloproteinase with thrombospondin mo

189 A disintegrin and metalloproteinase with thrombospondin mo

190 ecent studies have implicated the protease a disintegrin and metalloproteinase with thrombospondin mo

191 osteoarthritis include metalloproteinases, a disintegrin and metalloproteinase with thrombospondin mo

192 m whereby two distinct metalloproteinases, a disintegrin and metalloproteinase with thrombospondin mo

193 Aggrecanase-2 (a disintegrin and metalloproteinase with thrombospondin mo

194 The metalloproteinase ADAMTS-5 (A disintegrin and metalloproteinase with thrombospondin mo

195 Aggrecanases of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin mo

196 A disintegrin and metalloproteinase with thrombospondin mo

197 family of extracellular proteases (called a disintegrin and metalloproteinase with thrombospondin mo

198 The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin mo

199 in the development of osteoarthritis, and a disintegrin and metalloproteinase with thrombospondin mo

200 e Yeast Two-Hybrid approach, we identified a disintegrin and metalloproteinase with thrombospondin re

201 MAs often associated with severe ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin ty

202 One group is the ADAMTSs (a disintegrin and metalloproteinase with thrombospondin ty

203 helial activation and dysfunction, whereas a disintegrin and metalloproteinase with thrombospondin ty

204 g for 9 months and correlating with higher a disintegrin and metalloproteinase with thrombospondin-13

205 thrombospondin-13 activity and lower anti-a disintegrin and metalloproteinase with thrombospondin-13

206 Conversely, the alpha-secretase "a disintegrin and metalloproteinase" 10 (ADAM10) cleaves A

207 ADAM17, a prominent member of the 'Disintegrin and Metalloproteinase' (ADAM) family, contro

208 racterized the catalytic activity of ADAM (a disintegrin and metalloproteinase) 10 toward human CD23.

209 age of membrane-anchored proteins by ADAM (a disintegrin and metalloproteinase) endopeptidases plays

210 idate the role of key members of the ADAM (a disintegrin and metalloproteinase) enzyme family, as wel

211 Like other members of the ADAM (a disintegrin and metalloproteinase) family, the integrin-

212 ADAMs (a disintegrin and metalloproteinase) have important roles

213 Wild-type and Adam (A Disintegrin And Metalloproteinase) knockout mice were ex

214 RECK release disinhibits ADAM (a disintegrin and metalloproteinase) protease-dependent sh

215 ADAM15, a disintegrin and metalloproteinase, is capable of counter

216 nd factor (VWF) cleaving enzyme, ADAMTS13 (a disintegrin and metalloproteinase, with a thrombospondin

217 of metalloproteinase inhibitors and blocks A disintegrin and metalloproteinase-10 (ADAM-10) and ADAM-

218 s of matrix metalloproteinase-7 (MMP7) and a disintegrin and metalloproteinase-12 (ADAM12) in alpha(1

219 present study we present new evidence that a disintegrin and metalloproteinase-17 (ADAM17) is respons

220 ates the TNF-alpha convertase enzyme (TACE/a disintegrin and metalloproteinase-17), leading to activa

221 receptor (EGFR) ligand shedding by ADAM17 (a disintegrin and metalloproteinase-17).

222 To determine whether a disintegrin and metalloproteinase-8 (Adam8) regulates al

223 matrix-specific manner and is required for a disintegrin and metalloproteinase-mediated shedding of t

224 Expression of a disintegrin and metalloproteinases (ADAMs) 10 and 17, wh

225 t proteases with Cad6B in vitro shows that a disintegrin and metalloproteinases (ADAMs) ADAM10 and AD

226 A disintegrin and metalloproteinases (ADAMs) are a family

227 A Disintegrin and Metalloproteinases (ADAMs) are the princ

228 -dependent disintegrin metalloproteinases (a disintegrin and metalloproteinases (ADAMs) have been imp

229 omain cleavage of cell-surface proteins by A disintegrin and metalloproteinases (ADAMs) is highly reg

230 m the cell surface was mediated in part by a disintegrin and metalloproteinases 10 and 17.

231 Matrix metalloproteinases and a disintegrin and metalloproteinases are members of the zi

232 atrix metalloproteinases) and the related "a disintegrin and metalloproteinases" (ADAMs) promote tumo

233 ADAMs (a disintegrin and metalloproteinases) are a family of mult

234 fect on matrix metalloproteinase (MMP)-13, a disintegrin and MMP with thrombospondin motifs (ADAMTS)-

235 ADAMTS-5 truncates comprising the disintegrin and/or catalytic domains were able to compet

236 his investigation addressed the paradox that disintegrins and small RGD-ligands readily bind to the r

237 One of the proteases is the a-disintegrin-and-metalloprotease 10 (ADAM10) which acts a

238 Endothelial-specific reduction of a disintegrin-and-metalloprotease-domain-10 (Adam10) and i

239 ife-essential molecules from precursors by a-disintegrin-and-metalloproteases (ADAMs) is regulated wi

240 We also found that MMP8 cleaved a-disintegrin-and-metalloproteinase-domain-10 and that MMP

241 Knockdown of MMP8 or incubation with the a-disintegrin-and-metalloproteinase-domain-10 inhibitor GI

242 10 and that MMP8 deficiency reduced mature a-disintegrin-and-metalloproteinase-domain-10 on SPCs.

243 xpression levels of ADAM8, a metalloprotease disintegrin, are correlated with poor clinical outcome.

244 a non-protease member of the ADAM family of disintegrins, as a direct estrogen receptor (ER)-indepen

245 concave face of a rigid module formed by the disintegrin, cysteine-rich, and epidermal growth factor-

246 analysis of ADAM17 revealed that within its disintegrin/cysteine-rich region are two highly conserve

247 f migration by ADAM9-L requires a functional disintegrin domain and integrin binding.

248 matrix metalloproteinase (MT1-MMP), ADAMs (a disintegrin domain and metalloproteinases), and gamma-se

249 -like domain being regulatory and two in the disintegrin domain being structural.

250 egrins alpha6 and beta1 bind to TACE via the disintegrin domain but also that mechanical strain enhan

251 of the RGD integrin-binding sequence in the disintegrin domain of ADAM-15 (MDC-15; metargidin) highl

252 DAM) proteins inhibit reprogramming, and the disintegrin domain of ADAM29 is necessary and sufficient

253 mpetitive inhibitor of human ADAM9 catalytic/disintegrin domain with an overall inhibition constant o

254 nsists of a prodomain, a catalytic domain, a disintegrin domain, and a membrane-proximal domain as we

255 361, designed by structural modelling of the disintegrin domain, prevents ADAM8 multimerization.

256 itional O-fucosylation site was found in the disintegrin domain.

257 membrane-proximal stalk, cysteine-rich, and disintegrin domains of ADAM10 mediated its co-immunoprec

258 endent manner to both VCAM-1 and select ADAM disintegrin domains.

259 quirements for the stalk, cysteine-rich, and disintegrin domains.

260 similar to (resting) integrin binding to the disintegrin echistatin.

261 also decreased the inhibitory effect of the disintegrins, echistatin and eristostatin, and the alpha

262 Using disintegrins, echistatin, and VLO4, peptide inhibitors t

263 on of a member of the ADAM metalloproteinase disintegrins family, resulting in concomitant release of

264 n by monoclonal antibody and the met-leu-asp-disintegrin inhibited dermal human microvascular endothe

265 logy, we have recently shown that the ADAM15 disintegrin is significantly overexpressed during the me

266 ow that ADAM11, a transmembrane noncatalytic disintegrin, is the first reported Kv1-interacting prote

267 The proximal metalloprotease (M), disintegrin-like (D), thrombospondin-1 (T), Cys-rich (C)

268 domain containing 5 (Zswim5); and Adamts5 [a disintegrin-like and metallopeptidase (reprolysin type)

269 lthough UL-VWF is proteolysed by ADAMTS13 (a disintegrin-like and metalloprotease domain with thrombo

270 etermined that mice deficient in ADAMTS5, (A Disintegrin-like And Metalloprotease domain with Thrombo

271 cluding matrix metalloproteases (MMPs) and a disintegrin-like and metalloprotease with thrombospondin

272 -1beta and a resultant increase in ADAMTS (a disintegrin-like and metalloprotease with thrombospondin

273 tly, we reported a gene network of ADAMTS (A Disintegrin-like and Metalloprotease with Thrombospondin

274 activity of VWF is modulated by ADAMTS13 (a disintegrin-like and metalloprotease with thrombospondin

275 brand factor (VWF) levels are elevated and a disintegrin-like and metalloprotease with thrombospondin

276 ealed that a significant number of ADAMTS (a disintegrin-like and metalloproteinase (reprolysin type)

277 The ADAMTS (a disintegrin-like and metalloproteinase domain with throm

278 beta domain of the versican-V1 variant by a disintegrin-like and metalloproteinase domain with throm

279 ADAMTS-4 (a disintegrin-like and metalloproteinase with thrombospond

280 CM enzyme ADAMTS5, a member of the ADAMTS (A Disintegrin-like and Metalloproteinase with Thrombospond

281 ADAMTS5 is a member of the A Disintegrin-like And Metalloproteinase with ThromboSpond

282 LOC306664 is predicted to translate into A Disintegrin-like and Metalloproteinase with Thrombospond

283 tivity and protein expression of ADAMTS13 (a disintegrin-like and metalloproteinase with thrombospond

284 The discovery of a disintegrin-like and metalloproteinase with thrombospond

285 ated a recombinant soluble version of the gB disintegrin-like domain (gB-DLD).

286 Mimicry of the ADAM family disintegrin-like domain by HCMV gB represents a novel me

287 sequence similarity to the integrin-binding disintegrin-like domain found in the ADAM (a disintegrin

288 fy the surface provided by the catalytic and disintegrin-like domains of ADAMTS-5 as a legitimate tar

289 interact, and showed that the catalytic and disintegrin-like domains support these intermolecular in

290 Here, we report that melittin activates disintegrin-like metalloproteases (ADAMs) and that downs

291 A disintegrin-like metalloproteinase with thrombospondin m

292 loy some combination of ancillary C-terminal disintegrin-like, thrombospondin-1, cysteine-rich, and s

293 and cellular prion (PrP(c)) undergo similar disintegrin-mediated alpha-secretase cleavage yielding N

294 Disintegrin metalloproteases (Adam) can manipulate the s

295 etalloproteinase inhibitors or antibodies to disintegrin metalloproteinase 8 (ADAM8), a major eosinop

296 inal 385-amino acid fragment of ADAMTS-18 (a disintegrin metalloproteinase with thrombospondin motifs

297 n of the disulfide-isomerase ERp5 and of the disintegrin-metalloproteinase ADAM10, able to shed the l

298 The zinc-dependent disintegrin metalloproteinases (a disintegrin and metall

299 nases, the matrix metalloproteinases and the disintegrin metalloproteinases, have consequences well b

300 tion across the four most abundant proteins (disintegrins, phospholipase A(2)'s, serine proteinases,