ライフサイエンスコーパス: dispensability

1 , with some experimental data suggesting its dispensability.

2 oxical contrast to their apparent functional dispensability.

3 al properties, including its essentiality or dispensability.

4 onship with levels of expression and protein dispensability.

5 ation and replication) or not and of protein dispensability.

6 his is the dominant explanation for apparent dispensability, accounting for 37-68% of dispensable gen

7 The original datasets for protein dispensability analysis and prediction, together with re

8 lights on global characteristics of protein dispensability and evolution.

9 e analysis, the relationship between protein dispensability and evolutionary rate has remained unconf

10 hly significant relationship between protein dispensability and evolutionary rate, and explains why t

11 First, dispensability and expression have independent, signific

12 w that although we may reasonably infer that dispensability and expression have significant effects o

13 ma regarding the apparent prevalence of gene dispensability and found that most genes do contribute t

14 The dependence between PGL and gene dispensability and interactivity is much stronger than t

15 several mammals, we characterize functional dispensability as the propensity for the ancestral eleme

16 This structural dispensability but functional indispensability of Rpn10

17 can explain the long-standing paradox of ESC dispensability during postembryonic times.

18 onsequence of expression similarity and gene dispensability, each being correlated with a third facto

19 aboratory can be used to filter data sets of dispensability estimates, removing variates that are unl

20 put genomic databases that establish protein dispensability, expression and interaction networks enab

21 Several variables, including protein dispensability, expression, functional density, and gene

22 (C57BL/6 x C3H)F(1) mice, we found that the dispensability for CD4(+) T-cell help for the H-2(b)-res

23 This finding explains the YEATS domain's dispensability for leukemogenesis when ENL/AF9 is transl

24 Despite their dispensability for normal growth and development, DCs ha

25 omyces cerevisiae, we found that a protein's dispensability had significant correlations with its evo

26 red simultaneously can determine their joint dispensability, i.e., their propensity for synthetic sic

27 Its apparent dispensability in the spindle checkpoint might be due to

28 cessary stability to overcome their inherent dispensability in water environment but also fine-tuned

29 ionship is highly conserved, so that protein dispensability in yeast is also predictive of evolutiona

30 Protein dispensability is fundamental to the understanding of ge

31 In our studies, protein dispensability is represented as a fitness score that is

32 e question of what the mechanistic basis for dispensability is, and whether it is the result of selec

33 g homozygous gene knockouts that suggest the dispensability of a variety of human genes.

34 rference cells grew normally, suggesting the dispensability of activated 20 S proteasome in T. brucei

35 or native cellular IAP as a cofactor and the dispensability of caspase inhibition.

36 The results reveal the dispensability of charge in the Glu(110) locus of IL-5 f

37 The dispensability of checkpoints in multicellular organisms

38 The apparent dispensability of DExH/D-box proteins in E.coli contrast

39 nalyze the yeast data and show that the high dispensability of duplicate genes with low expression si

40 -rich repeat receptors, does not explain the dispensability of EDS1 and SID2 in defense against GPA.

41 phosphoproteins, potentially explaining the dispensability of ErbB3 for tumorigenicity and PI3K acti

42 In demonstrating the dispensability of GRP94, our finding points to the impor

43 The dispensability of Ii for control of L. major allowed gen

44 paralogs sufficiently explains the apparent dispensability of individual WGD genes.

45 ould code for homologs of KpsF, the apparent dispensability of KpsF remains provisional.

46 icient to sponge let-7, which reconciles the dispensability of LIN28B.

47 To better understand the dispensability of maternal and zygotic Sqt, we sought ou

48 tudies with HeLa cells confirm the essential dispensability of mengovirus's poly(C) tract but reveal

49 The dispensability of N(6) hydrogen bonding for proficient T

50 ated c-Rel is readily degraded, implying the dispensability of N-terminal sequence; in contrast, a se

51 The dispensability of NBD2 in the folding of more N-terminal

52 The dispensability of ORC is further supported by an examina

53 etastases on continued Wnt signaling and the dispensability of p53 for tumor regression, we find that

54 The apparent dispensability of prelamin A suggested that lamin A-rela

55 These data suggest that, despite the dispensability of proper chromosome segregation in megak

56 In contrast, the dispensability of Rad18 for TLS in chicken DT40 cells wo

57 It is re-emphasized that the dispensability of sequences is not an indicator of their

58 Using Deltaie611 MCMV, we demonstrated the dispensability of the canonical ie3 gene product pIE611

59 Using Deltaie611 MCMV, we demonstrated the dispensability of the canonical ie3 gene product pIE611

60 Here, we report the dispensability of the cotranslational SRP protein transl

61 Given the dispensability of the dynein tail in dynein motility in

62 t fraction of genes in the genome, given the dispensability of the eye for viability and fertility of

63 ver been an unequivocal demonstration of the dispensability of the latter element for this process us

64 1) deficient intestine, which confirmed the dispensability of the MLNs and PPs and the sufficiency o

65 TPase domains of human Cdc6 and Orc1 and the dispensability of the N-terminal segments of Orc1 and Or

66 A requirement for the Notch1 and dispensability of the Notch2 receptor has been demonstra

67 Skp-like protein (ASK) interactions and the dispensability of the unique N-terminal LOV domain in th

68 These results demonstrate the dispensability of the V1-V2 sequences of SIVmac239 for v

69 e from their littermate controls, indicating dispensability of these two members of the Foxo transcri

70 The dispensability of this amino acid, the only amino acid w

71 The dispensability of viral SP has allowed construction of n

72 The dispensability of Yap1 in normal intestinal homeostasis

73 Dispensability provides an advantageous genetic system t

74 It is unknown, however, whether such dispensability reflects insignificance of the ancestral

75 ene expression, gene duplication and genetic dispensability, stem cell division and cancer risk, and

76 a of mutants allow us to investigate protein dispensability systematically at the genome scale.

77 ctor machine were applied to predict protein dispensability through high-throughput data.

78 lar patterns of conditional essentiality and dispensability under various environmental conditions ca

79 Consistent with kinetoplast dispensability, V-ATPase defective cells were oligomycin

80 Each protein's dispensability was estimated by the growth rate of mutan

81 ility by generating DNA ends, shown by their dispensability when ends are provided by I-SceI endonucl

82 le gene deletions in yeast to assess protein dispensability, which we relate to evolutionary rate est