ライフサイエンスコーパス: displacer

1 using the 5-HT1AR antagonist WAY-100635 as a displacer.

2 ile one was determined to be a high-affinity displacer.

3 ectivity is increased in the presence of the displacer.

4 , rather than a steric mass action selective displacer.

5 paration performance of chemically selective displacers.

6 e moieties, creating a homologous library of displacers.

7 ine, nicotine, and methyllycaconitine as the displacers.

8 sful predictions for an external test set of displacers.

9 The screen also identified a new displacer, 4-methyl-2-piperazin-1-yl-quinoline, which pr

10 ed a selective binding between the selective displacers and alpha-chymotrypsinogen A, while no bindin

11 were also employed for the identification of displacers and conditions for the separation of a challe

12 ary for use as high-affinity cation-exchange displacers and DNA-binding ligands.

13 ne protein-displacer interactions with these displacers and protein pairs.

14 ly designed using known chemically selective displacers as a template.

15 The ability to exploit protein displacer binding in concert with appropriate displacer

16 for ribonuclease A, confirming that protein-displacer binding is responsible for the selectivity in

17 psinogen A remaining on the column after the displacer breakthrough.

18 nt displacers to enable online monitoring of displacer breakthroughs while also acting as efficient d

19 minor changes in the molecular design of the displacer can have a significant impact on the separatio

20 d to provided insights into the influence of displacer chemistry and concentration, resin chemistry,

21 ange systems by the appropriate selection of displacer chemistry and salt counterion.

22 experiments were carried out to examine how displacer chemistry and salt counterions affect the sele

23 The results indicate that both salt type and displacer chemistry can have a significant impact on the

24 employed to study the effects of changes in displacer chemistry on their efficacy for selective sepa

25 lacing minimal alpha-chymotrypsinogen A at a displacer concentration of 10 mM.

26 these lead compounds to study the effect of displacer concentration on the relative amounts of the p

27 ficacy as well as for providing insight into displacer design and the selection of proper mobile-phas

28 se results demonstrate how subtle changes in displacer design can be employed to fine-tune the separa

29 n be employed for the a priori prediction of displacer efficacy as well as for providing insight into

30 In fact, one of these displacers exhibited extremely high selectivity, displac

31 ble database to identify potential selective displacers for a binary protein mixture in ion exchange

32 breakthroughs while also acting as efficient displacers for protein purification.

33 icacy of the library candidates as potential displacers for protein purification.

34 pyridinium) as the marker ligand and various displacers, including the single enantiomers of verapami

35 suggest that while the chemically selective displacer interacted with alpha-chymo-trypsinogen A, it

36 xperiments were conducted to examine protein-displacer interactions with these displacers and protein

37 Displacer lead compounds were selected from a commercial

38 rary of molecular analogues to the selective displacer, N'1'-(4-methylquinolin-2-yl)ethane-1,2-diamin

39 acements only, the UK was the most important displacer overall, while the largest net exporters of em

40 In order to test the hypothesis that displacer protein binding was playing a role in these se

41 isplacer binding in concert with appropriate displacer resin affinities opens up new possibilities fo

42 , the results indicate that, by changing the displacer, salt counterion, or both, one can induce sign

43 By using different pH displacer solutions, we demonstrate for the first time t

44 work demonstrates the utility of fluorescent displacers to enable online monitoring of displacer brea

45 o investigate the binding of the fluorescent displacers to proteins.

46 gene expression by functioning as a protein 'displacer' to modulate protein-protein interactions at t

47 Of the synthesized displacers, two were found to be highly selective while

48 ot was constructed to validate that this new displacer was acting as a chemically selective, rather t

49 ent chromatography, with mecamylamine as the displacer, was used to verify that the four compounds bo

50 To this end, a set of novel fluorescent displacers were rationally designed using known chemical

51 Using this approach, low-molecular-mass displacers with affinities higher than those previously

52 umn displacements using one of the selective displacers yielded complete separation of both protein p