ライフサイエンスコーパス: disposition

1 dependent on both the ring size and exo/endo disposition.

2 These results were evaluated with regard to disposition.

3 10, and did not display target-mediated drug disposition.

4 ological adaptations and unique reproductive disposition.

5 that go above and beyond a general familial disposition.

6 to discharge, median survival, and discharge disposition.

7 ondary outcome measure was adverse discharge disposition.

8 lycoprotein, plays an important role in drug disposition.

9 length of stay, hospital cost, and discharge disposition.

10 ulates genes involved in drug metabolism and disposition.

11 its, marijuana source, symptoms, and patient disposition.

12 territorial hierarchy in motor unit size and disposition.

13 nded to provide the necessary management and disposition.

14 c responsiveness, and altered norepinephrine disposition.

15 e, some of the mutants show altered cellular disposition.

16 terations in its trafficking and subcellular disposition.

17 tissues may contribute to targeted mediated disposition.

18 reported by patients with cancer and genetic disposition.

19 unoglobulins possibly related to an allergic disposition.

20 ning the role of P-gp in drug absorption and disposition.

21 d locks the two porphyrins in a face-to-face disposition.

22 erated among individuals with a more anxious disposition.

23 evidence-based practice and a curbed caring disposition.

24 and systemic levels and are involved in drug disposition.

25 other genes involved in drug metabolism and disposition.

26 at curbs the ad hoc repertoire of the caring disposition.

27 opardized because of erosion of the clinical disposition.

28 bility, ICU and post-ICU healthcare use, and disposition.

29 rs' behaviour, rather than by their personal dispositions.

30 perception, and illuminate some personality dispositions.

31 length of stay, total charges, and discharge dispositions.

32 safety practices; they all include a caring disposition: (1) a configuration with a dominant caring

33 patients (21%), sporadic MI without familial disposition (10%), and rarely in unrelated real-life cat

34 nsultation (13.6%), and emergency department disposition (11.9%).

35 uring intake and ratings of appetite-related dispositions 3 h after ingestion of 300 kcal of the liqu

36 uced mortality (15% vs 26%) and more routine disposition (48% vs 41%) for SL (P < 0.001).

37 human hepatocyte model that adjusts glucose disposition according to hormonal signals.

38 sease Control and Prevention definition) and disposition (admission, discharge, observation, transfer

39 low viscus injuries and emergency department disposition after diagnosis.

40 ristics associated with variation in patient disposition after emergent surgery.

41 escaping from the well in the deep sea, its disposition after it entered the ocean, and total reserv

42 ed on potential predictors of CR and patient disposition after pembrolizumab discontinuation after CR

43 tment plan, use of resources, and changes in disposition after performing the ultrasound.

44 ith improved survival and a better discharge disposition among patients with ischemic stroke.

45 ource use (total hospital cost and discharge disposition among survivors) were analyzed.

46 on, 20 (33%) of 60 patients had unfavourable disposition and 40 (67%) had favourable disposition (p=0

47 ata indicate that, by controlling anandamide disposition and activities, FABP5 plays a key role in re

48 ED lengths of stay were calculated for each disposition and admission/discharge subcategories (criti

49 , Mrp2, and Mrp3 significantly affect tissue disposition and biliary and fecal elimination of PhIP an

50 Since disposition and biotransformation of GalNAc-conjugated o

51 ll require reinterpretation of previous drug disposition and drug-drug interaction studies where conc

52 any anticancer drugs and plays a role in the disposition and efficacy of several opiates, antidepress

53 OATPs/Oatps are involved in the disposition and elimination of numerous physiological an

54 in natural seawater (NSW) was measured while disposition and embryotoxicity were monitored within 48

55 r studies for a thorough characterization of disposition and fate of PEGylated proteins.

56 key information relevant to the issue is the disposition and fate of the PEG moiety after repeated do

57 IP6K3 is a major determinant of cytoskeletal disposition and function of cerebellar Purkinje cells.

58 in real-time whether changes in cross-bridge disposition and myosin interfilament spacing underlie th

59 stablish a molecular link between amino acid disposition and oxidative stress leading to cytotoxicity

60 t and provide mechanistic insights into drug disposition and patient-specific factors that influence

61 We reveal that impaired cross-bridge disposition and radial transfer may thus underlie the ea

62 d be expected to affect interindividual drug disposition and response.

63 aim of the present study was to investigate disposition and toxicity of polystyrene nanoparticles (N

64 n Lkb1-deficient lung ADC decreases collagen disposition and triggers extracellular matrix remodellin

65 number of acute infections, the HEV genotype disposition and viral phylogeny.

66 re measures of medical researchers' personal dispositions and 10 y of PubMed data indicating their pu

67 humans manifest analogous approach-avoidance dispositions and, if so, whether they share a homologous

68 to open procedure, length of stay, discharge disposition, and cost.

69 muscle-specific AMPK failure, restore GLUT4 disposition, and diminish protein breakdown.

70 complaints to ascertain the ED course, final disposition, and discharge diagnoses.

71 , hospital and ICU length of stay, discharge disposition, and hospital costs.

72 ource and type, clinical effects, scenarios, disposition, and length of stay.

73 ortality, perioperative morbidity, discharge disposition, and overall survival.

74 al, ICU and in-hospital mortality, discharge disposition, and rates of readmission to the ICU.

75 vels of membrane transporters may affect the disposition, and thereby treatment efficacy, of anticanc

76 entilator, ICU, and hospital days; discharge disposition; and 1-year mortality.

77 Hypotheses for how proper-name dispositions are organized within the left ATL include b

78 ten, and chromatin loops transit to a radial disposition around now-central axes.

79 demographics, clinical characteristics, and disposition associated with chief complaints related to

80 on, 33 (52%) of 63 patients had unfavourable disposition at hospital discharge (death or admission to

81 e was rate of categorised hospital discharge disposition before and after implementation of a PNCP on

82 BB penetration were identical, their central disposition (brain levels) and elimination (cerebrospina

83 drug lipophilicity or Biopharmaceutical Drug Disposition Classification System class and changes in v

84 therapeutic Ab revealed target-mediated drug disposition consistent with a high turnover of endogenou

85 For 5 of 27 (19%) vials, the final disposition could not be confirmed.

86 g; crop protection data; drug metabolism and disposition data and bioactivity data from patents.

87 mechanism of injury, injury severity, final disposition (dead vs alive), and year of admission.

88 %] vs 118 of 1338 days [8.8%]; P = .001) and disposition delays (138 of 1168 days [11.8%] vs 97 of 13

89 hours, airway concerns, and somnolence) and disposition delays (end-of-life decisions and floor bed

90 al intensive care unit (SICU) admissions and disposition delays to determine whether targeted interve

91 g to potentially avoidable admissions and/or disposition delays.

92 publications' topical coverage revealed how dispositions differentially predict depth vs. breadth.

93 verall and by patient demographics, hospital disposition (discharge destination), and neurological st

94 Sarcopenia predicted adverse discharge disposition (discharge to nursing facility or in-hospita

95 three separate domains of sociality (social disposition, dyadic relationships, and social networks)

96 tissues and it plays important roles in drug disposition, efficacy and safety.

97 ogy of aberrant postprandial hepatic glucose disposition evident under a diet-induced glucose-intoler

98 r pressure (IOP) as well as unfavorable drug disposition exerted by drug transporters before the drug

99 Any evolved disposition for fairness and cooperation would not repla

100 ween nursing characteristics and triage call disposition for patient 'same-day' appointment requests

101 Some promoters have a strong disposition for Pol II pausing and often mediate faster,

102 rs and suggests a possible different binding disposition for these complexes in the mismatch site.

103 s the idea of heteromodal (i.e., transmodal) dispositions for proper naming in the left ATL.

104 hOCT1/SLC22A1) and 2 (hOCT2/SLC22A2) in drug disposition, for example, clearance, toxicity, and drug-

105 ehensive assessment of drug delivery to, and disposition from, the lungs is required if controlled an

106 lar drug disposition is accounted for by the disposition function (DF), a model-based, nonlinear func

107 up, not attributable to variation in hepatic disposition gene expression.

108 (HR) DNA repair and are germ-line cancer pre-disposition genes that result in a syndrome of hereditar

109 ce that enables comparative analyses of drug-disposition genes.

110 potential influence of polymorphisms in drug disposition genes.

111 se boundaries of this surprisingly prosocial disposition has implications for understanding human mor

112 in glucose (PoG) delivery on hepatic glucose disposition have not been clearly defined.

113 sms underlying isomer-specific PFOS and PFOA disposition have not previously been studied.

114 ient facility) and 30 (48%) had a favourable disposition (home with or without treatment); after PNCP

115 ture anomalies, analyzed demographics and ED disposition, identified risk factors for adverse outcome

116 en parasite-stress and complex psychological dispositions implies that the social, political, and eco

117 hospital complications and adverse discharge disposition in geriatric trauma patients.

118 proteins spectrin and adducin whose altered disposition in IP6K3 knock-out mice may mediate phenotyp

119 iver microsomes and hepatocytes, and in vivo disposition in rat serum, liver, and mammary tissue.

120 himpanzees have failed to demonstrate such a disposition in several studies, leading some authors to

121 nia by ultrasound predicts adverse discharge disposition in SICU patients equally well as frailty.

122 r results reinforce the idea that grain-size disposition in subsurface sandy sediments drives the int

123 ed by considerations of in vitro and in vivo disposition in the context of controlled drug release fo

124 s of the FVIII C domains compared with their disposition in the unbound state.

125 he activity of the major human P450s in drug disposition in vivo.

126 heir secondary structure propensities, their dispositions in bilayers by neutron diffraction, and the

127 e current study examined the extent to which dispositions in justice sensitivity (i.e., how individua

128 alyzing atopic sensitization (i.e., allergic disposition) in a random sample of adolescents living in

129 nded for follow-up within the practice (call disposition), including all contact types (face-to-face,

130 The disposition index ((C)DI) decreased across NGT categorie

131 efflux/apoA-I presented significantly higher disposition index (beta = 0.056, SE = 0.026; p = 0.035).

132 47 case vs. 12,645 control subjects), higher disposition index (beta = 0.07 log10; P = 2 x 10(-11); n

133 l function, evidenced by a faster decline in disposition index (DI) and a lower DI at age 18 years.

134 per muU/mL]; P = 0.02), resulting in a lower disposition index (DI) during exendin-(9,39) infusion (1

135 Effects on insulin sensitivity (SI) and disposition index (DI) were assessed by intravenous gluc

136 cose (AIRg), insulin sensitivity index (SI), disposition index (DI), and intravenous glucose toleranc

137 he hypothesis that Colesevelam increases the disposition index (DI), and this increase is associated

138 Clinical assessment of the disposition index (DI), based on the hyperbolic law of g

139 -9) min(-1), P = 0.01) but did not alter the disposition index (DI).

140 lin sensitivity (SI) and beta-cell function [disposition index (DI)].

141 beta-cell function relative to ATIS (adipose disposition index [DI]) in obese youth with impaired glu

142 ion, and beta-cell function as determined by disposition index improved to a similar extent in both g

143 The disposition index paradigm, a widely used beta-cell func

144 Disposition index was estimated as beta-cell function in

145 beta-Cell responsivity to glucose and disposition index was higher (P < 0.01) at breakfast tha

146 which improved only after RYGB, and improved disposition index were associated with lower HbA1c in bo

147 ulin secretion, insulin sensitivity, Ra, and disposition index were measured after oral glucose toler

148 an twofold improvement in glucose tolerance (disposition index).

149 Disposition index, beta-cell function relative to IS, de

150 n secretion, resulting in a markedly reduced disposition index, indicative of pancreatic beta-cell fa

151 in subjects in G1 as compared with G2 or G3 (Disposition Index-STM, P = 0.005; DI-FSIVGTT, P = 0.006)

152 lucose effectiveness/T2D, 11p15 (KCNQ1) with disposition index/T2D, and 6p22 (CDKAL1) and 11q14 (MTNR

153 h the insulin secretion/insulin sensitivity (disposition) index increased significantly in IFG, but n

154 s new insights into how scientists' personal dispositions influence research processes and products.

155 Discharge disposition is a patient-centered quality metric that re

156 The unknown intracellular drug disposition is accounted for by the disposition function

157 The effect of RYGB on oral drug disposition is not well understood.

158 Renal potassium disposition is primarily handled by a short segment of t

159 we investigated whether this hyperaltruistic disposition is susceptible to monoaminergic control.

160 or accurate prediction of others' changeable dispositions, mentalizing is required, i.e., tracking of

161 escribed successfully by a three-compartment disposition model with flexible absorption.

162 This mode of disposition neither altered the morphology/integrity of

163 CI, 1.5-6.0; P = .001) and adverse discharge disposition (odds ratio, 1.6; 95% CI, 1.1-2.4; P = .001)

164 ossibly other transporters influence in vivo disposition of (11)C-erlotinib and thereby affect its di

165 e disposition of chiral PCBs, we studied the disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 13

166 inary translational data regarding the brain disposition of [(11)C]-(R)-3 in primates including first

167 hy-mass spectrometry method to determine the disposition of [(13)C18]-oleic acid following intravenou

168 tions that take place in the more stable syn-disposition of [4.12].

169 anion transporter-1 (OAT1) mediates the body disposition of a diverse array of clinically important d

170 ion transporter-1 (OAT1) mediates the body's disposition of a diverse array of environmental toxins a

171 viable animals active in the metabolism and disposition of a number of CYP2C9 substrates.

172 n structures introduce irregularities in the disposition of adjacent residues that facilitate the spe

173 d space in varied ways they all identify the disposition of ancestral folds to fall within this core

174 e active site features of the enzyme and the disposition of biologically active retinoids.

175 system is responsible for the metabolism and disposition of chemopreventive agents, chemical toxins a

176 of hepatic vs extrahepatic metabolism in the disposition of chiral PCBs, we studied the disposition o

177 rtant role in determining the absorption and disposition of consumed xenobiotics including various dr

178 approach seeks to mimic the orientation and disposition of critical binding residues at protein inte

179 rting polypeptide (OATP) transporters to the disposition of doxorubicin.

180 OATP1A/1B in transporter-mediated uptake and disposition of doxorubicin.

181 the number of layers incorporated and in the disposition of each layer with respect to its neighbor.

182 Signs, symptoms, diagnosis, and disposition of employees with eye complaints as well as

183 gate and analog transporter that affects the disposition of endogenous metabolites, toxins, and drugs

184 btain a universal expression for the average disposition of energy of transmission eigenchannels with

185 terindividual gut microbe variability on the disposition of environmental chemicals in humans.

186 earch gaps on how gut ecology may affect the disposition of environmental chemicals were identified.

187 Asymmetric disposition of Fab arms in the structures solved for the

188 amework as applied to disputes regarding the disposition of genetic material between the oncofertilit

189 rrent scholarship tangentially discusses the disposition of genetic material in regards to pediatric

190 ying human CP mutants reveal that the native disposition of His residues is important for conferring

191 n QA/QC opens new possibilities to study the disposition of hydrophobic chemicals at trace levels (C(

192 that reproduce the relative positioning and disposition of important binding residues, termed "hotsp

193 The frequency disposition of inhibition in the response areas of some

194 ifference was observed in the metabolism and disposition of ketamine.

195 n of Th17 cells accounting for both a higher disposition of naive T cells to differentiate toward the

196 wo-photon fluorescence imaging, to probe the disposition of nanoparticles and an associated lipophili

197 We explore how the caring disposition of nurse middle managers' habitus influences

198 odel for zebrafish describing the uptake and disposition of organic chemicals.

199 are consultations, and (5) encouraging early disposition of patients to floor beds.

200 hrome P450 (P450) enzymes play a role in the disposition of PCBs.

201 inhibitory antibodies informs on the natural disposition of Pfs25 on the surface of ookinetes and pro

202 nuclear pore complexes, we demonstrate that disposition of polyethylenimine (PEI)/DNA polyplexes tha

203 Given the error-prone disposition of PrimPol, we propose a mechanism whereby S

204 rrangements deep in the tunnel influence the disposition of residues 45A away at the exit port and ar

205 ntally incompatible with the circumferential disposition of sclerites in early molluscs, but does clo

206 ver, the effect of Gilbert's syndrome on the disposition of some drugs can lead to unexpected toxicit

207 re to ethanol has been reported to alter the disposition of tangentially migrating GABAergic cortical

208 iation of insurance status and race with the disposition of TBI patients evaluated in less specialize

209 The influence of nonmedical factors on the disposition of TBI patients initially seen in less speci

210 Brain penetration, target engagement, and disposition of the blood-brain barrier-crossing bispecif

211 d of three, so large changes in the relative disposition of the C2-domains result from changing the l

212 A pharmacokinetic model of intake and disposition of the chemicals predicted their internal co

213 , thereby maintaining the natural alymphatic disposition of the cornea.

214 the amino acids changes the relative spatial disposition of the DNA-binding domains and thereby disru

215 ow structural relationship, with a different disposition of the domains and a topologically unrelated

216 ium kinetic isotope effect on the safety and disposition of the drug substance.

217 examine the recovery efficiency and optimal disposition of the Finnish oil combating vessels in the

218 ixing assays, we surprisingly found that the disposition of the fluorescent lipids with respect to SN

219 order to restrict the flexible hinge and the disposition of the FnIII "legs." Through a separate inte

220 portant insight into the impact of pH on the disposition of the key Fe-O-O and Fe horizontal lineO fr

221 Disposition of the known membrane targeting determinants

222 Finally, our analysis reveals the disposition of the N-terminal segment of Msm sigma(A), w

223 r determining the stoichiometry and relative disposition of the protomers within protein complexes (i

224 chiral induction revealed that the geometric disposition of the quinoline ring at the C8 chiral carbo

225 eries of compounds and the cause of a unique disposition of the thioxo group at close-to-right angles

226 between vT3SSs and fT3SSs, such as relative disposition of their inner membrane-attached export plat

227 rinciples that govern brain distribution and disposition of these antibodies.

228 The disposition of TMD residues with differential effects on

229 The disposition of toxicants is often affected by their bind

230 lure is accompanied by a loss of the orderly disposition of transverse (T)-tubules and a decrease of

231 Nurse characteristics were associated with disposition of triage calls to within practice follow-up

232 has demonstrated that concepts of Bourdieu (dispositions of habitus, capital and field) help to desc

233 in were used to define the three-dimensional dispositions of individual amino acids that are subject

234 and controlling the relative conformational dispositions of redox-active units in macrocycles are ke

235 omparison enables us to explain the specific dispositions of subknots in the analyzed protein knots.

236 It revealed various configurations of dispositions of the habitus in which a caring dispositio

237 We observed three distinct configurations of dispositions of the habitus which influenced the clinica

238 The dispositions of the nurse middle managers' habitus influ

239 trained unnatural amino acids with different dispositions of the two anchor points.

240 ic derivatives with different conformational dispositions of their PMDI units and the acyclic PMDI de

241 Although the dispositions of tyrosines differ in different constructs

242 o direct the molecular-level arrangement (or disposition) of the tectons.

243 Thus, individual dispositions or traits may be determined by neural proce

244 3.22; 95% CI, 2.94 to 3.53), and a discharge disposition other than home (OR, 3.64; 95% CI, 3.46 to 3

245 length of stay, daily charges, and discharge disposition other than to home.

246 ), ICU mortality (p = 0.55), and ICU patient disposition (p = 0.22) were similar in the two groups.

247 able disposition and 40 (67%) had favourable disposition (p=0.01).

248 better than 10% in the determination of drug disposition parameters.

249 Here, we examine how vemurafenib disposition, particularly through cytochrome P450-mediat

250 ng transporter information to explain tissue disposition patterns of PrEP drugs, to interpret inter-i

251 hospitalization after injury is vital in the disposition planning for these patients.

252 ispositions of the habitus in which a caring disposition plays a crucial role.

253 re included in the model to find the optimal disposition policy that would maximize the recovery effi

254 position and physiology that can affect drug disposition, possibly leading to therapeutic failure or

255 These compounds also have good disposition properties and show no adverse toxicologic e

256 However, 1 suffers from suboptimal drug disposition properties resulting in a short half-life (t

257 ination to enhance activity and improve drug disposition properties.

258 Analyses of causes of death and busulfan disposition provided no mechanistic explanation for the

259 ation coupled with a measure of central drug disposition provides evidence that this molecule engages

260 which likely indexed variations in internal dispositions related to fatigue or satiety.

261 ) a configuration with a dominant scientific disposition showing an investigative, non-judging, analy

262 tic membrane transporter expression and drug disposition similarly in humans and rodent models of NAS

263 In vivo doxorubicin disposition studies revealed that doxorubicin plasma are

264 ive measurement of proteins involved in drug disposition, such as the UGTs, significantly improves th

265 Some familial pre-disposition suggests a germ-line contribution to CMN syn

266 t new sites (16.8% of readmissions), 25 with disposition support issues (14.5%), 23 with infections n

267 atite formed at >1000 degrees C has a glassy disposition that prevents its water-based leaching; and

268 : (1) a configuration with a dominant caring disposition that was helpful (via solving urgent matters

269 s linked to partially assimilated behavioral dispositions that act as developmental scaffolds for the

270 with an interaction of caring and collegial dispositions that led to an absence of clinical involvem

271 haviour based on the clinical and scientific dispositions that was manifested through an investigativ

272 fied in GWA studies regulate hepatic glucose disposition through siRNAs corresponding to the list of

273 son is well established as an inherent human disposition through which humans navigate the social wor

274 ont of the eye designed to somehow alter its disposition to bring about changes in focus.

275 ability but not by shared socialization, the disposition to distrust is explained by shared socializa

276 the sources of individual differences in the disposition to distrust, including how they may differ f

277 central coherence account posits an altered disposition to integrate features into a coherent whole

278 Behavioral inhibition reflects a disposition to react warily to novel situations, and has

279 re located, there are 16 that have the right disposition to react.

280 nd reveal the neural mechanism mediating the disposition to see the 'forest before the trees'.

281 are left with major questions about how the disposition to think analytically can evolve.

282 Our results demonstrate that although the disposition to trust is explained to some extent by heri

283 the sources of individual differences in the disposition to trust.

284 , predicts adult health outcomes, especially disposition toward obesity and diabetes, in yellower mic

285 d a main effect of MAOA genotype on having a disposition toward violence in both samples and for viol

286 cific differences that may explain a greater disposition towards disability in women.

287 , charges per day, length of stay, discharge disposition, tracheostomy, and need for extracorporeal m

288 (99m)Tc-mebrofenin disposition was altered after rifampicin treatments.

289 Adverse discharge disposition was defined as discharge to a skilled nursin

290 Ranibizumab disposition was determined in RVO and DME patients and c

291 In diabetic hearts cross-bridge disposition was most notably abnormal in the diastolic p

292 These changes in disposition were caused by ob/ob- and MCD diet-specific

293 length of stay, complications, and discharge disposition were collected.

294 nd the patient's preimplantation personality disposition were equally important associates of health

295 dic phospholipids induces structure, but its disposition when bound to lipid bilayers is controversia

296 of the metal and provide donor atom types or dispositions which favour the formation of particularly

297 A dominance of the caring disposition, which meant 'always' answering calls for he

298 if V to twist and order in the SaPI-inducing disposition, while the tip of motif VI is disturbed.

299 requires a better understanding of the drug disposition within a cell.

300 ng hypotheses about how scientists' personal dispositions would uniquely predict deeper vs. broader c