ライフサイエンスコーパス: disrupt

1 tly circadian and dysregulated when sleep is disrupted.

2 artment is altered when GSK3beta activity is disrupted.

3 virus-encoded function to suppress RNAi was disrupted.

4 responding genes, ATP5F1 and ATP5O, had been disrupted.

5 e RNASET2 variant rs2149092 was predicted to disrupt a consensus binding site for the transcription f

6 nature, we generate a HyaA-R193L variant to disrupt a proposed Arg-His cation-pi interaction in the

7 Loss of THAP1 function disrupts a core set of OL maturation genes and reduces t

8 This suggests that pAg binding disrupts a preexisting conformation of the BTN3A1 intrac

9 of root growth, were also found to have less disrupted actin filament networks after 2,4-D exposure.

10 nown as YpkA) obstructs phagocytosis through disrupting actin filament regulation processes - inhibit

11 Although Pdp1epsilon mutants disrupt activity rhythms without eliminating clock funct

12 Tofacitinib disrupted adventitial microvascular angiogenesis, reduce

13 DLS is known to be disrupted after chronic drug abuse; however, it remains

14 n trans with a previously described endosome-disrupting agent composed of the pore-forming protein Pe

15 nal records, exacerbated energy consumption, disrupted agriculture and caused severe human discomfort

16 opening the way to better treatment based on disrupting allergic inflammatory and type 2 cytokine-med

17 encode multiple antagonists that prevent or disrupt an efficient innate immune response.

18 Integration of a transgene can disrupt an endogenous gene, potentially interfering with

19 This suggests that CTR-truncation disrupts an interaction with VLDLR (very low-density lip

20 Mechanistic insight into how polycations disrupt and cross cell membranes is needed for understan

21 d, suggesting that the beta-annulus had been disrupted and that this could destabilize the capsid.

22 becomes activated when Unc-104's function is disrupted, and leads to impairment of synaptic structure

23 Mutations aimed at disrupting any of these salt bridges activated binding u

24 017) show that a secreted bacterial protease disrupts apical-junctional complexes, paving the way for

25 (TMD)1, 2, 3, and 4, but not TMD5, 6, and 7, disrupted APJ dimerization.

26 tion of APP C-terminal lysines with arginine disrupts APP ubiquitination and that an increase in the

27 eptum follow a stereotypical pattern that is disrupted around a muscular VSD.

28 -3p depletion is necessary and sufficient to disrupt auditory TC signaling in 22q11DS mice, and it ma

29 report that acute estrogen depletion rapidly disrupts auditory processing in large areas of the male

30 n this study, we demonstrated that radiation disrupted BH4, which resulted in nitric oxide synthases

31 Structure-based mutations that disrupt bifurcated substrate recognition or oligomerizat

32 Characterization of ARL2 point mutants that disrupt binding to TBCD suggested that the ARL2-TBCD int

33 Abnormal sickle-shaped erythrocytes disrupt blood flow in small vessels, and this vaso-occlu

34 evidence that synthetic ion transporters can disrupt both autophagy and induce apoptosis.

35 the function of a gene is less likely to be disrupted by a mutation close to the distal ends.

36 mutating phosphorylated p190A-Tyr(308), but disrupted by a S296A mutation, targeting the only other

37 he intron is crippled and the target gene is disrupted by a series of stop codons.

38 isoform transitions and are predicted to be disrupted by CUG(exp)-associated mechanisms in utero.

39 This interaction can be disrupted by CXCR4 antagonists.

40 x, TMC1 and TMC2, and these interactions are disrupted by deafness-causing Cib2 mutations.

41 In summary, the BBB is disrupted by downregulation of the Shh pathway and break

42 we find that the primordial clay is locally disrupted by impacts and buried by impact-ejected materi

43 lyses were done on lists of genes putatively disrupted by L1s in PDS and controls.

44 cell-type-enriched genes were preferentially disrupted by MeCP2 mutations, with upregulated and downr

45 drugs improved activity-based sleep measures disrupted by methamphetamine by decreasing sleep latency

46 after training is so unstable that it can be disrupted by subsequent new learning until after passive

47 previously reported that this association is disrupted by the binding of the second messenger Ap4A to

48 rate hypotheses on specific molecular events disrupted by the variant.

49 Scx-mutant mice demonstrated disrupted callus healing and asymmetry.

50 the cell, maintaining a homeostasis that, if disrupted, can impair cell function and lead to disease.

51 The phosphomimetic S1777D substitution disrupted catalytic activity, most likely by causing an

52 differences in their resistance to membrane disrupting cationic antimicrobial peptides (CAMPs), such

53 pse confirmed this hypothesis by revealing a disrupted CD19 membrane export in the post-endoplasmic r

54 Antibacterials that disrupt cell membrane function have the potential to era

55 Interestingly, disrupting cerebellar activity via transcranial magnetic

56 cyclases (GCs), and mutations in genes that disrupt cGMP homeostasis leads to retinal degeneration i

57 In contrast, disrupting chemical synapses has no effect on the electr

58 f perchlorate-a well-characterized endocrine-disrupting chemical-to vulnerable populations is represe

59 nt, the impact of these estrogenic endocrine disrupting chemicals (EDCs) on the immune system is uncl

60 al low-dose exposure to ubiquitous endocrine disrupting chemicals including, perfluoro-octanoic acid,

61 Endocrine disrupting chemicals induce endoplasmic reticulum stress

62 rse lipid accumulation defects in cells with disrupted cholesterol homeostasis.

63 has suggested that these chemical agents may disrupt circulating levels of total 25(OH)D in adults.

64 n unexpected outcome of neuronal injury with disrupted clathrin-dependent endocytosis and impaired re

65 Furthermore, dysregulation of CLOCK disrupts coexpressed networks of genes implicated in neu

66 Assessing how endocrine disrupting compounds (EDCs) affect population dynamics r

67 creases may affect the activity of endocrine disrupting compounds (EDCs), particularly in species wit

68 When apical constriction is disrupted, compressing force generated by a tissue-level

69 ion, post-training inhibition of PV(+) cells disrupted contextual fear memory consolidation.

70 atively altering the retinal EFNAs gradient, disrupts cortico-collicular map alignment onto the retin

71 In zebrafish, ddrgk1 deficiency disrupted craniofacial cartilage development and led to

72 hich trans -acting factors binding sites are disrupted/created and links out to the UCSC genome brows

73 predicted that all five ABCB4 variants would disrupt critical interactions in the binding of ATP and

74 "poison" oligonucleotides that specifically disrupt critical noncanonical base-pairing interactions

75 agent, with its novel mechanism of action of disrupting critical protein-protein interactions, overco

76 as the finding that the quadruplex formation disrupts CTCF protein binding, which results in an incre

77 these variables differed between control and disrupted dams, or resembled patterns seen following ear

78 Finally, amphetamine, that is thought to disrupt DAT OF conformation, reduced the concentration o

79 Disrupting Ddx5 expression improves the efficiency of iP

80 depletion of NMD factors have been shown to disrupt developmental events in organisms spanning the p

81 nes and GRE-driven reporter activity without disrupting dexamethasone-induced nuclear translocation o

82 Using chemical and genetic approaches to disrupt diacylglycerol acyltransferase (DGAT)-dependent

83 Functionally, disrupting DISC1/Ndel1 complex formation prolongs mitoti

84 ced PAF also activates cell cycle arrest and disrupts DNA repair, in part by increasing p21 expressio

85 is in response to treatment with microtubule-disrupting drugs, identifying IRS-2 as a potential bioma

86 rate abnormal oscillatory SPB movements that disrupt DSB-SPB interactions.

87 bust self-organizing system is progressively disrupted during tumor development.

88 Our findings demonstrate that variants disrupting EBF3-mediated transcriptional regulation caus

89 However, the mechanism underlying the disrupting effect of KYNA remains unclear.

90 nder fear extinction memory resistant to the disrupting effects of changes in contextual contingencie

91 als have demonstrated that ATZ has endocrine-disrupting effects on male and female reproduction in ma

92 silencing efficacy; introducing mutations to disrupt either SL attenuated miR159 efficacy, while intr

93 er studies, we demonstrated that soluble ECD disrupts endogenous DR5-DR5 interactions.

94 ic Htt acts locally at synaptic terminals to disrupt endosomal compartments, leading to aberrant wiri

95 tein are likely to be the toxic species that disrupt endosomal signaling.

96 Y1 binding sites or depletion of YY1 protein disrupts enhancer-promoter looping and gene expression.

97 loci in which transposons can insert without disrupting essential functions.

98 ise novel therapeutic strategies that aim at disrupting essential niche-LSC interactions or improve t

99 Prednisolone disrupted fecal microbiota community structure, decrease

100 When we disrupted feedback, apoptosis and divisions were uncoupl

101 resulting in a truncated N-terminal fragment disrupted for inducing cell pyroptosis.

102 ons at the interface on either CRY1 or CLOCK disrupt formation of the ternary complex, highlighting t

103 multitargeted compounds that simultaneously disrupt functions of two critical MYC-mediating factors

104 d, which leads to decreased lung compliance, disrupted gas exchange, and ultimately respiratory failu

105 ccurately calculate the growth rate for each disrupted gene in the genome to enable the discovery of:

106 ased permeability to inflammatory molecules, disrupted glutamate homoeostasis, impaired action of ant

107 The DLPFC-disrupted group showed enhanced learning of the novel ph

108 ase are risk factors for PD, indicating that disrupted GSL clearance plays a key role in alpha-syn ag

109 fness mutants that map to the surface of MF2 disrupt harmonin binding, revealing the molecular basis

110 Moreover, these same mutant alleles disrupted hp53 foci and inhibited biosensor activity, su

111 We conclude that the disrupted hydropathy or charge of residues in the heptad

112 lding of the mutant protein and subsequently disrupting hypertrophic chondrocyte differentiation.

113 Disrupting IL-17 signalling reduces RMG responsiveness t

114 c SR [Ca(2+)] are influenced by CSQ2 and are disrupted in arrhythmic conditions.

115 Synchrony is disrupted in cells with increased interspindle distances

116 rmore, we demonstrate that this mechanism is disrupted in congenital muscular dystrophy patient myotu

117 ween received and expected reinforcement) is disrupted in generalized anxiety disorder.

118 onstrate that the EphB1-ephrin-B1 pathway is disrupted in human stem cell derived astrocyte and mouse

119 PE signaling is significantly disrupted in individuals with the disorder and may lead

120 information that highlight genes, which when disrupted in mice, elicit similar T2D-relevant phenotype

121 We identify 23 genes that, when disrupted in mouse, modify the ability of tumour cells t

122 changes in Chd8(+/del5) mice across pathways disrupted in neurodevelopmental disorders, including neu

123 B2 receptor expression after PNS injury were disrupted in the absence of alphaBC.

124 to the ATP site in the propeller form and is disrupted in the quatrefoil form.

125 Residual B cell subtype distribution was disrupted in the spleen, but adoptive transfer studies i

126 udies in rodents have shown that mutants for Disrupted-In-Schizophrenia-1 (DISC1), a well-accepted ge

127 Friedman et al. find that stress disrupts inhibition of striatal circuits by prefrontal c

128 asal activation of p110delta (>300-fold) and disrupts inhibitory interactions from the nSH2, iSH2, an

129 epertoire, and does not necessarily indicate disrupted interactions between immune cells and the comm

130 Instead, it attributes the disrupted interfollicular CCL21 gradients observed in Ac

131 y, but we discovered that it can nonetheless disrupt intestinal immune homeostasis at inductive and e

132 Disrupting Intu in an oncogenic mutant Smo (SmoM2)-drive

133 mutations at evolutionarily conserved sites disrupt its deacetylation of DNA-damage response protein

134 electrostatics from the phosphoserine group disrupt its intramolecular association, resulting in poo

135 the biological effects of low GSH levels, we disrupted its synthesis both at birth by breeding a Gclc

136 in the reading frame of the dystrophin gene disrupting its protein expression.

137 the ADA2 subunit of the HAT complex SAGA and disrupts its assembly by interfering with the associatio

138 tem cells (iPSCs) with a DISC1 mutation that disrupts its interaction with Ndel1.

139 YAP O-GlcNAcylation disrupts its interaction with upstream kinase LATS1, pre

140 that hRXRalpha phosphorylation significantly disrupts its nuclear localization, interaction with VDR,

141 plasmic reticulum Ca(2+) spark frequency and disrupted JMC integrity.

142 ns (ABHD5 R299N and ABHD5 G328S) selectively disrupted lipolysis without affecting ATGL lipid droplet

143 protein accessibility and stiffness, without disrupting local structural heterogeneity.

144 rain, and morphological abnormalities: e.g., disrupted lung alveolarization, atrophy of intestinal vi

145 However, lysosomal-delivered MPO also disrupts lysosomal acidification in RPE cells, which coi

146 bjects whose frontal control was temporarily disrupted made biased choices more often than a control

147 Rodent models reveal that disrupted maternal-infant interactions yield metabolic a

148 the formation of the tripartite complex and disrupt mechanotransduction.

149 the MPS1 gene (also known as PRD2), thereby disrupting meiosis.

150 Gal80 inhibitor specifically and completely disrupted memory.

151 on of these MCAs with peritoneal mesothelium disrupts mesothelial integrity, exposing the submesothel

152 intake from an energy-dense diet is known to disrupt metabolic homeostasis and contributes to the dis

153 This study provides new evidence of disrupted microstructure of the dentate gyrus in childre

154 Contrary to predictions, inactivation disrupted model-based behavior without affecting economi

155 Disrupting motor dimerization with structure-based mutag

156 The inactivation of vri disrupts multiple output pathways thought to be importan

157 ion of INPP5K orthologs in zebrafish embryos disrupted muscle fiber morphology and resulted in abnorm

158 Importantly, a helix-disrupting mutation of W50R into residues 44-65 restored

159 iPSC lines analyzed carry at least one gene-disrupting mutation, several of which have been associat

160 l a novel mechanism by which Ca(2+) overload disrupts myofibril integrity by activating a Calcineurin

161 Here we show that disrupted networks contained topological network modules

162 resulted in silenced target gene expression, disrupted neural development, and highly significant lar

163 ith model-based functional MRI, we show that disrupting neural excitability in the rTPJ reduces behav

164 product caffeic acid phenethyl ester (CAPE) disrupts neural crest gene expression, migration, and me

165 the potential to eliminate toxicity without disrupting neuron-specific targeting, thereby creating a

166 these lysine residues and has been shown to disrupt neuronal maturation and OR expression in the dev

167 ychosis might be relevant to many aspects of disrupted neuronal and synaptic function, increased perm

168 ber of genes affected by recurrent mutations disrupting non-coding sequences was similar to that affe

169 nal antibody targeting the fragment-5 region disrupted normal wound closure in both wild-type Hsp90al

170 recurrent episodes of depression and mania, disrupting normal life and increasing the risk of suicid

171 e show that knockdown of EmMBD2/3 expression disrupts normal cellular architecture and development of

172 Cx36 deletion therefore disrupts normal regulation of sympathetic outflow with e

173 Stimulating mPFC D2R+ neurons disrupts normal social interaction.

174 es beta-catenin, leads to high Wnt tone, and disrupts Notch1 signaling and primary cilium maintenance

175 though CHD7 and CHD8 slide nucleosomes, CHD6 disrupts nucleosomes in a distinct non-sliding manner.

176 force, single-pulse TMS should also quickly disrupt ongoing eye motion.

177 We observed altered cell morphology and disrupted organization of F-actin in Li1 plant cells by

178 T-MAPK signaling also feature as recurrently disrupted pathways.

179 These results indicate that strategies for disrupting pathways that maintain stem-like and niche ce

180 The success of therapies that disrupt PD-L1-mediated tumour tolerance has highlighted

181 sults are consistent with models implicating disrupted PFC-thalamic connectivity in the pathophysiolo

182 tism-linked UBE3A mutant (UBE3A(T485A)) that disrupts phosphorylation control of UBE3A activity.

183 ulated hyperlocomotion, restored amphetamine-disrupted prepulse inhibition, improved social behavior,

184 hat binding of LIS1 to DDB does not strongly disrupt processive motility.

185 ion can also be modified as a consequence of disrupting processive DNA replication.

186 imicrobial chemical with potential endocrine-disrupting properties, may pose a risk to early embryoni

187 le for other phenols with possible endocrine-disrupting properties.

188 adation systems as an additional strategy to disrupt protein homeostasis.

189 er of genetic disorders where mutations have disrupted protein function.

190 The mutations disrupted protein stability by interfering with homodime

191 Disrupting PTPRZ1 abrogated GSC maintenance and tumorige

192 servation of the 98 amino acids of E7, which disrupts Rb function, is critical for HPV16 carcinogenes

193 n a vitamin A-free diet lose HSCs and show a disrupted re-entry into dormancy after exposure to infla

194 redox potential across the cell membrane and disrupt redox homeostasis, thereby inhibiting bacterial

195 nformation and the second monomer exhibiting disrupted regulatory metal coordination in an open non-D

196 preted here as decreased SST expression, may disrupt responses to fear and anxiety regulation in thes

197 AR15 genes were identified as loci that when disrupted result in delayed replication and condensation

198 namic environment where homeostasis is often disrupted, resulting in the common inflammatory disease

199 Surprisingly, we also find that m(6)A disrupts RNA binding by the stress granule proteins G3BP

200 hic (HCM) or dilated (DCM) cardiomyopathy by disrupting sarcomere contraction and relaxation.

201 A mismatch) enhances target slicing, despite disrupting seed pairing important for target binding.

202 ovalent modification of protein by drugs may disrupt self-tolerance, leading to lymphocyte activation

203 of acetylcholine from prefrontal cortex can disrupt short-term memory performance and is reminiscent

204 es basal cell carcinoma and Ptch1;Ptch2 loss disrupts skin and hair follicle development.

205 ronic devices at night increases, leading to disrupted sleep and circadian misalignment (i.e., social

206 onal progranulin deficiency is sufficient to disrupt social behaviour.

207 The proportion of extremely rare SNPs disrupting SREs is significantly higher in European than

208 Disrupting synapses and motor maps by infusions of aniso

209 notypes, indicating that Htt acts locally to disrupt synaptic growth.

210 peptides enabled the design of mutants that disrupt Tau interactions with phospholipids without inte

211 endent, requires upstream DNA sequences, and disrupts TECs to release the nascent RNA to solution.

212 Rgammat (RORgammat(M)) that 'preferentially' disrupted TH17 differentiation but not thymocyte develop

213 Licorice consumption is known to disrupt the ability of the placental enzyme 11beta-hydro

214 Base substitutions that disrupt the base triples reduce telomerase activity in v

215 ic anemia, and idiopathic pulmonary fibrosis disrupt the binding between the protein subunit reverse

216 We conclude that phosphorylation can disrupt the binding of an E3 ubiquitin ligase to an E2-c

217 down-regulate cell wall hydrolase genes and disrupt the biofilm formation of MRSA clearly indicated

218 receptor in the choroid plexus epithelium to disrupt the blood-CSF barrier.

219 Quinolinols are known chelators that can disrupt the BoNT/A metalloprotease zinc-containing activ

220 e region is highlighted by interactions that disrupt the cubic symmetry of the GaAs lattice, resultin

221 Variants in the SCN2A gene that disrupt the encoded neuronal sodium channel NaV1.2 are i

222 errations have been traditionally thought to disrupt the entire gene function.

223 n the immature lung, inflammation and injury disrupt the epithelial-mesenchymal interactions required

224 y is accompanied by presynaptic effects that disrupt the excitatory/inhibitory (E/I) balance.

225 However, invasive pathogens can disrupt the Golgi apparatus, interfering with secretion

226 uation of their employment would potentially disrupt the immunization programs in their countries and

227 Furthermore, EtOH and DMSO can disrupt the main driving forces of these interactions, h

228 Although these methods severely disrupt the mitochondrial electron transport chain, mtDN

229 Furthermore, loss of release did not disrupt the morphogenesis of presynaptic terminals and d

230 inators [3], but toxins in this reward could disrupt the mutualism and reduce plant fitness [4].

231 ow that IQGAP1 associates with NLRC3 and can disrupt the NLRC3-STING interaction in the cytosol of hu

232 onding regions of human nucleotidyl cyclases disrupt the normal helical domain structure.

233 ecades, largely with ex vivo approaches that disrupt the photoreceptors' subretinal microenvironment.

234 f the cancer-associated mutations, partially disrupt the POT1-TPP1 complex, which affects its ability

235 synthetic BH3 mimetics ("magic bullets") to disrupt the protein-protein interactions between anti- a

236 s that overlap with RFX footprints uniformly disrupt the RFX motifs at high-information content posit

237 lecules of the heterocyclic diamidine family disrupted the interaction of PU.1 with target gene promo

238 orylation within the type I PDZ-ligand motif disrupted the interaction, in association with reduced a

239 Using this technique, we disrupted the photoreceptor genes COP1/2, COP3 (encoding

240 Rather, mutations that disrupted the pTRS1 interaction with PKR ablated the abi

241 In one, we disrupted the S. cerevisiae INO80 protein interaction ne

242 n the OFC, but not OFC terminals in the BLA, disrupted the selective motivating influence of cue-trig

243 bolishing cell cycle asynchrony consistently disrupted the spindle orienting mechanism underpinning t

244 high intracellular calcium concentration by disrupting the actin-myosin ATPase pathway.

245 eased toxicity upon mutating UbS2 stems from disrupting the autoprotective role that pathogenic ataxi

246 ility of the BTB in brain tumors, as well as disrupting the BBB in the surrounding tissue.

247 a genetic variant deactivating enhancers by disrupting the binding of transcription factors (TFs) in

248 pests, Musca domestica and Delia radicum, by disrupting the control of apoptosis.

249 acid-base pair is initiated and preserved by disrupting the dative donation through protonation on th

250 Notably, disrupting the functionality of ENL further sensitized l

251 d excessive worry about everyday problems by disrupting the online updating ("reality check") of the

252 such as pitch and amplitude, without grossly disrupting the song.

253 simultaneously treating UTI, without notably disrupting the structural configuration of the gut micro

254 that alpha-syn impairs lysosomal function by disrupting the trafficking of lysosomal hydrolases.

255 We demonstrate that disrupting the uORFs results in markedly increased trans

256 Disrupting the YscU-YscP interaction by introducing poin

257 Successful infection is dependent on disrupting the zebrafish microbiome, highlighting that,

258 onstitution assays show that addition of FBP disrupts the association of axin and LKB1 with v-ATPase

259 g function by homodimerization, and that RIM disrupts the autoinhibitory homodimerization forming mon

260 ggest that repeated cocaine exposure in vivo disrupts the balance between excitation and inhibition i

261 r, ketoconazole binds in an orientation that disrupts the BC-loop regions at the P450 dimer interface

262 can be tunably activated by a compound that disrupts the BCL-xL-BH3 interaction within minutes.

263 g oxidative damage of the lipids, which then disrupts the bilayer, resulting in cell death.

264 em cell (GSC)-derived pericytes specifically disrupts the BTB and enhances drug effusion into brain t

265 ngly, a naturally occurring DLX3 mutant that disrupts the carboxyl-terminal domain leading to tricho-

266 l analyses indicated that the R165A mutation disrupts the characteristic long interburst closed state

267 rectly phosphorylates FAF1 at Ser 582, which disrupts the FAF1-VCP complex and reduces FAF1 at the pl

268 mponent of Orai1 channels, and its depletion disrupts the functional assembly of Orai1 multimers.

269 Brain damage causing acquired amusia disrupts the functional music processing system, creatin

270 is increasingly evident that PTEN deficiency disrupts the fundamental processes of genetic transmissi

271 ent alters innate antimicrobial defenses and disrupts the gut microbiota, which leads to overgrowth o

272 The mutant R411A(alpha) disrupts the H-bonding environment and conformation of Y

273 strate that acetaminophen, even at low-dose, disrupts the integrity of TJ and cell-matrix adhesions,

274 point mutation in the Gal1 co-activator that disrupts the interaction with the Gal80 inhibitor specif

275 ted region (UTR) of the mutant allele, which disrupts the most distal of two polyadenylation sites.

276 Here, we show that loss of PGANT4 disrupts the mucosal barrier, resulting in epithelial ex

277 of the afferent taste signal to sodium salts disrupts the normal age-dependent "pruning" of all termi

278 This disrupts the normal fluid flow intensity and pattern, wi

279 of genomic imbalance and partial genome loss disrupts the normal pattern of embryonic gene expression

280 on of NaSIPP in Nicotiana spp. pollen grains disrupts the SI by preventing pollen tube inhibition.

281 ymerization with a low dose of latrunculin A disrupts the targeting of microtubules to cell-cell junc

282 In contrast to 8oxoG which disrupts the telomeric DNA structure, Tg exhibits substa

283 ental disorder, arising from a mutation that disrupts the transcription of Fragile X Mental Retardati

284 imilarly, MD simulations suggested that TMAO disrupts the water structure to the least extent, wherea

285 etically ablating these neurons in juveniles disrupted their ability to imitate features of an adult

286 rol the behavioral repertoire, and mutations disrupting their function cause >130 brain diseases.

287 s, created by mutating Ser(311) or Ser(322), disrupt thermotaxis and suppress PKC-2-dependent cryophi

288 Treatment with CSF1R inhibitors disrupted this crosstalk and triggered a profound increa

289 Disrupting this activity either pharmacologically or by

290 Disrupting this interaction decreases levels of ataxin-3

291 pectively, but that loss of alphaII spectrin disrupts this organization.

292 d mutant TDP-43 are more viscous and exhibit disrupted transport dynamics.

293 et need for a treatment option that does not disrupt treatment regimens for underlying psychiatric il

294 mutations in E. chaffeensis were created to disrupt two genes, and also to restore one gene by anoth

295 ing RPE miRNA regulatory activity in mice by disrupting two independent and essential steps of miRNA

296 mutations upstream of the JmjC domain do not disrupt UTX demethylation.

297 t of gaze perception, the particular aspects disrupted varied idiosyncratically across individuals.

298 e products regulating these properties could disrupt vsWM function in different ways, depending on th

299 val timing and striatal ramping activity are disrupted when the medial frontal cortex is inactivated.

300 C proliferation, and CD44-null as well as HA-disrupted wild type NSCs demonstrate delayed neuronal di